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Conserved domains on  [gi|31044421|ref|NP_766166|]
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mis18-binding protein 1 isoform 1 [Mus musculus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10557545)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a SANTA domain (SANT Associated domain) which may play a role in regulating chromatin remodelling and in protein-protein interactions

CATH:  1.20.58.1880
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 336-423 1.02e-32

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


:

Pssm-ID: 462689  Cd Length: 87  Bit Score: 121.59  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31044421   336 VHLQEWMIKVINNNtaICVEGKLVDMTD-VYWHSNVIIERIKHNELRTLSGNIYILKGLIDSVSMKEAGYPCYLTRKFMF 414
Cdd:pfam09133   1 VTLKDWWLKKVSKT--LAVEGFRRDSDGiRVFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                  ....*....
gi 31044421   415 GFPHNWKEH 423
Cdd:pfam09133  79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 745-788 4.27e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.79  E-value: 4.27e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31044421 745 EWSEQELQKLHCAFTslpKHKPGFWSDVAMAVGSRTADECQKKY 788
Cdd:cd00167   1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERW 41
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 336-423 1.02e-32

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 121.59  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31044421   336 VHLQEWMIKVINNNtaICVEGKLVDMTD-VYWHSNVIIERIKHNELRTLSGNIYILKGLIDSVSMKEAGYPCYLTRKFMF 414
Cdd:pfam09133   1 VTLKDWWLKKVSKT--LAVEGFRRDSDGiRVFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                  ....*....
gi 31044421   415 GFPHNWKEH 423
Cdd:pfam09133  79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 745-788 4.27e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.79  E-value: 4.27e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31044421 745 EWSEQELQKLHCAFTslpKHKPGFWSDVAMAVGSRTADECQKKY 788
Cdd:cd00167   1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERW 41
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
744-788 8.37e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.06  E-value: 8.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 31044421    744 EEWSEQELQKLHCAFTslpKHKPGFWSDVAMAVGSRTADECQKKY 788
Cdd:smart00717   2 GEWTEEEDELLIELVK---KYGKNNWEKIAKELPGRTAEQCRERW 43
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
 336-423 1.02e-32

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 121.59  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31044421   336 VHLQEWMIKVINNNtaICVEGKLVDMTD-VYWHSNVIIERIKHNELRTLSGNIYILKGLIDSVSMKEAGYPCYLTRKFMF 414
Cdd:pfam09133   1 VTLKDWWLKKVSKT--LAVEGFRRDSDGiRVFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78


                  ....*....
gi 31044421   415 GFPHNWKEH 423
Cdd:pfam09133  79 GFPENWKEY 87
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 745-788 4.27e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.79  E-value: 4.27e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31044421 745 EWSEQELQKLHCAFTslpKHKPGFWSDVAMAVGSRTADECQKKY 788
Cdd:cd00167   1 PWTEEEDELLLEAVK---KYGKNNWEKIAKELPGRTPKQCRERW 41
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
744-788 8.37e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 41.06  E-value: 8.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 31044421    744 EEWSEQELQKLHCAFTslpKHKPGFWSDVAMAVGSRTADECQKKY 788
Cdd:smart00717   2 GEWTEEEDELLIELVK---KYGKNNWEKIAKELPGRTAEQCRERW 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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