Conserved domains on
[gi|46048300|ref|NP_705776|]
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WASH complex subunit 5 [Mus musculus]
Protein Classification
WASH complex subunit 5( domain architecture ID 10563167)
WASH complex subunit 5 (WASHC5) acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||||||
| Strumpellin | pfam10266 | Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from ... |
23-1103 | 0e+00 | |||||||||||||||
Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteriztic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies. : Pssm-ID: 463035 Cd Length: 1082 Bit Score: 1864.19 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||||||||||||
| Strumpellin | pfam10266 | Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from ... |
23-1103 | 0e+00 | |||||||||||||||
Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteriztic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies. Pssm-ID: 463035 Cd Length: 1082 Bit Score: 1864.19 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||||||||||||
| Strumpellin | pfam10266 | Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from ... |
23-1103 | 0e+00 | |||||||||||||||
Hereditary spastic paraplegia protein strumpellin; This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteriztic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies. Pssm-ID: 463035 Cd Length: 1082 Bit Score: 1864.19 E-value: 0e+00
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