NCBI Conserved Domain Search

Conserved domains on [gi|222418556|ref|NP_694700|]

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sphingosine-1-phosphate transporter SPNS2 isoform 1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085

PubMed: 26758938|26098515

SCOP: 3000310

TCDB: 2.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 527.19 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 222418556 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 527.19 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 222418556 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

95-520

2.79e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.60 E-value: 2.79e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 494
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 222418556 495 lwefLSLGYALMLCPFVVVLGGMFFL 520
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355

MFS_1

pfam07690

Major Facilitator Superfamily;

108-469

8.40e-23

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 8.40e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 222418556  427 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 469
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338

2A0114

TIGR00893

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

110-514

9.23e-17

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 82.38 E-value: 9.23e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 485
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 222418556  486 irQSTKDSPLWEFLSLGYALMLCPFVVVL 514
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

126-328

9.03e-04

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 9.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGI 205
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA--QTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 206 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATk 285
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFFFIPET- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 222418556 286 rgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 170 --LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

106-520

0e+00

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 527.19 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 505
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 222418556 506 MLCPFVVVLGGMFFL 520
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

95-520

2.79e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.60 E-value: 2.79e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 494
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 222418556 495 lwefLSLGYALMLCPFVVVLGGMFFL 520
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

95-473

4.98e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.29 E-value: 4.98e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 175 IFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2814   82 LLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 255 AAGdWHWALRVSPVLGMITGTLILILVPATKRghadqlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM 334
Cdd:COG2814  160 LFG-WRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 335 WIPLYLHraqvvqktaETCNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRtqradplVCAVGMLGSAIFICLI 414
Cdd:COG2814  229 YLPLYLQ---------EVLGLSASAA--GLLLALFGLGGVLGALLAGRLADRFGRRR-------LLLIGLLLLALGLLLL 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 222418556 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDA 473
Cdd:COG2814  291 ALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

108-520

7.64e-26

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.05 E-value: 7.64e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG-DWHWALRVS 266
Cdd:cd06174   81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 267 PVLGMITGTLILILVPATKrgHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRaqvv 346
Cdd:cd06174  159 AALALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD---- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 347 qktaetcnsppCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:cd06174  233 -----------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 427 ICIFVGETLLFSNWAITADIlmyvVIPTRRATAVALQSFTSHlLGDAGSPYLIGFISDlirqstkdsplwEFLSLGYALM 506
Cdd:cd06174  302 LLGFGLGGLLPLSFALIAEL----FPPEIRGTAFGLLNTFGF-LGGAIGPLLAGFLLA------------ATFGLTGAFL 364

                        410
                 ....*....|....
gi 222418556 507 LCPFVVVLGGMFFL 520
Cdd:cd06174  365 VLAVLLLLAAILLL 378

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

131-515

3.59e-23

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.50 E-value: 3.59e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHAD 290
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 291 QLGGQLKARTSwlrdMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETCnsppcgakdSLIFGAIT 370
Cdd:cd17325  181 RAVSAARLRSG----LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQI---------GLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 371 CFTGFLGVVTGAGATRWCRLRtqradplVCAVGMLGSAI-FICLIFVAAKTSIVGAYICIFVGETLLFSnwAITAdILMY 449
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKP-------LILIGLLLSAVaLLLLPLATSFWLLLLLLALLGLGLGLVFP--ATLA-LLAD 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222418556 450 VVIPTRRATAVAL-QSFTShlLGDAGSPYLIGFISDLIrqstkdSPLWEFLSLGYALMLCPFVVVLG 515
Cdd:cd17325  316 IVPPEGRGTAMGLfNTAFS--LGMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAVLFLLL 374

MFS_1

pfam07690

Major Facilitator Superfamily;

108-469

8.40e-23

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 8.40e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 222418556  427 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 469
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

106-514

6.34e-21

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 94.56 E-value: 6.34e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17319    6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWHWALRV 265
Cdd:cd17319   86 GFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFII 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 266 SPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLHRAqv 345
Cdd:cd17319  163 EGLLGLLLAVLWWFYL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQA-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 346 vqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAakTSIVGA 425
Cdd:cd17319  210 -------------RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--TSPVVA 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 426 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGdAGSPYLIGFISDlirqsTKDSPLWEFLSLGyAL 505
Cdd:cd17319  275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVD-----ATGSYTAAFLFLA-AV 347


                 ....*....
gi 222418556 506 MLCPFVVVL 514
Cdd:cd17319  348 ALLAALLVL 356

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

94-384

2.89e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 82.55 E-value: 2.89e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 174 GIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 253
Cdd:COG0477   85 GLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 254 QAAGdWHWALRVSPVLGMItGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALG 333
Cdd:COG0477  163 AALG-WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 222418556 334 MWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGA 384
Cdd:COG0477  241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

107-342

5.35e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 82.60 E-value: 5.35e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 107 ILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:cd17324    3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:cd17324   83 LAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222418556 267 PVLGMITGTLILILVPATKRGHADQLGgqlkartsWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHR 342
Cdd:cd17324  160 AVLALLAALLLWRLLPSLPPKKPGSLG--------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227

2A0114

TIGR00893

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

110-514

9.23e-17

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 82.38 E-value: 9.23e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 485
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 222418556  486 irQSTKDSPLWEFLSLGYALMLCPFVVVL 514
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

106-432

7.44e-15

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 76.05 E-value: 7.44e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIPQQYFWLLVLSRGLVGIGEA-SYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17380   82 PLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 265 VSPVLGMITGTLILILVPATkrghadqlggqlkartsWlrdmkALIrnrsyvfssLATSAVSFATGALGMWIPLYLHRAQ 344
Cdd:cd17380  160 FFGLLGLLWALVWLIYLPPV-----------------W-----AII---------VAHFCMNWGFYILLSWLPTYFHEVL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 345 VVQktaetcnsppcgaKDSLIFGAITCFTGFL-GVVTGAGATRWC--RLRTQRADPLVCAVGMLGSAifICLIFVAAKTS 421
Cdd:cd17380  209 VPL-------------AKGWVFNVVPWLVMFPsSNVAGWLADHLIsrGWTVTSVRKLMQSIGFLGPA--LFLLLLSHTDS 273

                        330
                 ....*....|.
gi 222418556 422 IVGAYICIFVG 432
Cdd:cd17380  274 FSLALLCMSVA 284

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

99-485

7.62e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.46 E-value: 7.62e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  99 RGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW 178
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 179 SAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGd 258
Cdd:COG2223   81 GIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 259 WHWALRVSPVLGMITGTLILILVPATKRGHAdqlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPL 338
Cdd:COG2223  158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 339 YLH-RAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTqradplvcAVGMLGSAIFICLIFVA 417
Cdd:COG2223  231 YLVdQFGLSAATA------------GLLAALFALLGALGRPLGGWLSDRIGGRRV--------LLIVFALMALGLLLLAL 290

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222418556 418 AKTSIVGAYICIFVgetlLFSNWAITADILMYVV---IPTRRATAVALQSFTSHLLGDAGSPYLIGFISDL 485
Cdd:COG2223  291 ALGSLWLFLVLFLL----LGLALGGGNGAVFALVpdiFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

121-520

5.86e-14

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.73 E-value: 5.86e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSR 200
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMlSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVspvlgMITGTLILIL 280
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPY-----LILAVLLLLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 281 VPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvqktaetcnsppcGA 360
Cdd:COG0738  178 ALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL--------------GL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 361 KDSLIFGAITCFTG--FLGVVTGAGATRWCRLRTqradplVCAVGMLGSAIFIcLIFVAAKTSIVGAYICIFVGetLLFS 438
Cdd:COG0738  244 SEATAALGLSLFWGgmTIGRFLGGFLLKRFGPVR------LLRLSALLAAVGL-LLALLAPGPWLALIGLALVG--LGLS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 439 NWAITADILMYVVIPTRRATAVALQSFTShLLGDAGSPYLIGFISDLIRqstkdsplwefLSLGYALMLCPFVVVLGGMF 518
Cdd:COG0738  315 LMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFG-----------LRAAFLVPLVCYLLILLLAL 382


                 ..
gi 222418556 519 FL 520
Cdd:COG0738  383 AL 384

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

102-514

1.41e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.41e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 102 GAAAAILSLGNVLnyldrytVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAV 181
Cdd:cd17474    5 FFATLLAVLGVSI-------VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 182 TFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHW 261
Cdd:cd17474   78 GLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRY 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 262 ALRVSPVLGMITGTLILILVPATKRghadqlgGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLH 341
Cdd:cd17474  154 PFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 342 RAQVVqktaetcnsppcgakDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVcaVGMLGSAIFICLIFVAakTS 421
Cdd:cd17474  227 LLYGI---------------SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILV--IGLLLYALSLLLLGFV--PS 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 422 IVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTsHLLGDAGSPYLIGFISDLIrqstkdSPLWEFLSL 501
Cdd:cd17474  288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV-RFLGQAVGPLLFGLLLEIF------GLSAPFLVG 360

                        410
                 ....*....|...
gi 222418556 502 GyALMLCPFVVVL 514
Cdd:cd17474  361 A-AIALAAAVLLA 372

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

107-483

1.51e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 72.25 E-value: 1.51e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 107 ILSLGNVLNYLDRYTVAGVLLDIQQHF--GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17316    3 LAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWhWALR 264
Cdd:cd17316   83 IGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD-WGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 265 VSPVLGMITGTLILILVPATkrghadqlggqlkartswlrdmkalirnrsyVFSSLATSAVSFATGALGMWIPLYLhraq 344
Cdd:cd17316  160 ILFLIGALPALLALLLRRRT-------------------------------LLLILLWFFISFGYYGLTTFLPTYL---- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 345 vvqktAETCNSPPcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQradplvcAVGMLGSAIFICLIFVAAKTSIVG 424
Cdd:cd17316  205 -----QTVLGLSP--ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-------VIGLILSGILALPLFYLLSGSPTL 270

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 425 AYICIFVGETLLFSNWAItADILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFIS 483
Cdd:cd17316  271 LLLLLFILSFFVGGVWGA-LYAYLAELFPTEvRATGVGLSYNLGRLGG-GGAPPLIALLL 328

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

121-304

2.15e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 65.67 E-value: 2.15e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 121 TVAGVLLDIQQHF-GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLS 199
Cdd:cd17473   17 AIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 200 RGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHWalrvsPVLGMITGTLILI 279
Cdd:cd17473   95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRA-----PFLVYLLALPVLI 167

                        170       180       190
                 ....*....|....*....|....*....|.
gi 222418556 280 LV------PATKRGHADQLGGQLKARTSWLR 304
Cdd:cd17473  168 LVllflpePARKSKSAASPGAATAAALPWKR 198

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

87-485

1.57e-10

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.97 E-value: 1.57e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  87 PSAPQPKPASLGRGRGAAAAILSLGNVLnyldRYTVAGV---LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGD 163
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNL----RPAITSVgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 164 RFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSG 243
Cdd:COG2807   79 RFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 244 LGYITGSSVKQAAGdWHWALRVSPVLGMITgtlILILVPATKRGHADQlggqlkARTSWLRDMKALIRNRSYVFSSLATS 323
Cdd:COG2807  156 LAAGLTVPLAAALG-WRGALAVWALLALLA---LLLWLPLLRRRPAAA------AAAPAAASLRSLWRSPLAWLLTLFFG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 324 AVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdslifGAITCFTGFLGVVTGAGATRWC-RLRTQRadPLVCAV 402
Cdd:COG2807  226 LQSLLYYAVVAWLPPILRDAGLSAATA----------------GLLLSLFQLAGIPGSLLVPLLAdRLGDRR--PLLLLL 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 403 GMLGSAIFICLIFVAAKTSIVGAyICIFVGETLLFSnwAITADILMYVVIPTRRATAVAL-QSFTShlLGDAGSPYLIGF 481
Cdd:COG2807  288 GLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFP--LALTLIGLRARTPAEAAALSGMaQSVGY--LLAALGPLLVGA 362


                 ....
gi 222418556 482 ISDL 485
Cdd:COG2807  363 LHDA 366

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

123-282

1.76e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.98 E-value: 1.76e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGL 202
Cdd:cd17323   19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN--IAMLIILRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 203 VGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLP 175

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

110-340

1.97e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 1.97e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVL 269
Cdd:TIGR00881  82 S--LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  270 GMITGTLILILV---PATK----------RGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWI 336
Cdd:TIGR00881 160 AIIVSLICFLLLrdsPQSCglppaeempnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWS 239


                  ....
gi 222418556  337 PLYL 340
Cdd:TIGR00881 240 PLYL 243

Sugar_tr

pfam00083

Sugar (and other) transporter;

104-282

2.58e-10

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 62.67 E-value: 2.58e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  104 AAAILSLGNVLNYLDRYTVAGV--LLDIQQHFGVKDR-----GAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILS 172
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFltLIDFFKNFGLSKSvsslaALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  173 CGIFFWSAVTFSSSFIPQQY-FWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSS 251
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 222418556  252 VKQAAGDWHWalRVSPVLGMITGTLILILVP 282
Cdd:pfam00083 161 LNKTSNSDGW--RIPLGLQLVPALLLIIGLL 189

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

80-299

1.50e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 1.50e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  80 CAAAAKGPSAPQPKPASLGRGRGAAAA-----ILSLGNVLNYLDRYTVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMV 153
Cdd:COG2211  200 TFFGTKERPVPEEEKVSLKESLKALLKnrpflLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 154 AAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL-------FTKNT 226
Cdd:COG2211  280 GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRR 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 227 RTLMLSVFYFAIPLGSGLGYITGSSVKQAAG---------DWHWALRVS----PVLGMITGTLILILVPATKRGHAdQLG 293
Cdd:COG2211  360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspSALTGIRLLffllPAVLLLLAALLLLFYPLTRERHA-EIR 438


                 ....*.
gi 222418556 294 GQLKAR 299
Cdd:COG2211  439 AELAAR 444

OATP

pfam03137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...

129-416

1.53e-09

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.

Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 60.29 E-value: 1.53e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFiPqqYFWLLVLSRGLVGIGEA 208
Cdd:pfam03137  27 IEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGSLLFAL-P--HFLSFFLGQLLLGIGGT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  209 SYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWH-WALRVSPV---------LGMITGTLIL 278
Cdd:pfam03137 104 PIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPKdprwvgawwLGFLIAGLLL 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  279 ILV------------------------PATKRGHADQLGGQLKARTSWLRD----MKALIRNRSYVFSSLATsaVSFATG 330
Cdd:pfam03137 184 LLTaipffffpkslpgaakrrakkkkePHSQDIADLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYMLLTLAS--VFEFLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  331 ALGMWI--PLYLhrAQVVQKTAetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSA 408
Cdd:pfam03137 262 IAGYATflPKYI--ETQFGLSA---------STANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLL 330


                  ....*...
gi 222418556  409 IFICLIFV 416
Cdd:pfam03137 331 LSLLLFFL 338

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

122-520

1.57e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 59.88 E-value: 1.57e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 201
Cdd:cd17478   15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 202 LVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSGLGYITGSSVKQaagdwHWALRVSPVLGMITGTLILIL- 280
Cdd:cd17478   93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLGLLILLIIPGLAVALLl 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 281 --VPATKRGHADQLGGQLKARTSWLRDMKALIRnrsYVFSSLATSAVSFATGALgmwIPLYLHRAQVVQKTAETCNSPpc 358
Cdd:cd17478  167 lrLRPLKKPEAKKAAAKSSARSTLKGVWRALLL---LLIIVFLRSWVLSSLTTF---LPFYLVQRGYSLVFAGLLLSL-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 359 gakdSLIFGAITCFTGflgvvtGAGATRWCRLRtqradplVCAVGMLGSAIFICLIFVaakTSIVGAYICIFVGETLLFS 438
Cdd:cd17478  239 ----FLFAGAIGTLIG------GPLSDRFGRRR-------VIIASLLLAAPFLLLFLL---TPGIWSYILLVLAGFLLFA 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 439 NWAITadiLMYV--VIPTRRATAVALQSFTSHLLGDAGSPyLIGFISDLIrqstkdsplweflSLGYALMLCPFVVVLGG 516
Cdd:cd17478  299 SFPVT---VVLAqeLLPGNVGLASGLMMGLSFGLGGIGAP-VLGALADAF-------------GLESVLLILALLPLLGA 361


                 ....
gi 222418556 517 MFFL 520
Cdd:cd17478  362 LLAF 365

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

122-277

4.62e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 58.36 E-value: 4.62e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 201
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222418556 202 LVGIGEASYsTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLI 277
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV 166

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

127-281

1.20e-08

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 1.20e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 127 LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17325  224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLG 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222418556 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILV 281
Cdd:cd17325  302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

131-339

1.26e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.83 E-value: 1.26e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17489   24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdwHWALRVSPVLGMITGTLILILVPATKRGHad 290
Cdd:cd17489  102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVA-- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 222418556 291 qlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLY 339
Cdd:cd17489  178 ------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

110-522

2.27e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.16 E-value: 2.27e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVL 269
Cdd:cd17371   85 -QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP-EIAWRVLFLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 270 GMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:cd17371  163 GALPALLVLFIrrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 347 QktaetcnsppcgAKDSLIFGAITCFTGFLG-VVTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17371  243 S------------FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNN-------FALFALGSAISILLYFFLPLSPTLIL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 426 YICIFVGETL--LFSNWAitadILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFISDLIrqstkdsplweflSLG 502
Cdd:cd17371  304 ILGFPLGFFAsgPFSGMG----AYLTELFPTAvRATAQGFCYNVGRIIG-ALFPFLVGFLATSG-------------SLG 365

                        410       420
                 ....*....|....*....|...
gi 222418556 503 YALML---CPFVVVLGGMFFLAT 522
Cdd:cd17371  366 TAIAVfaaVYYIAGLVLALLLPE 388

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

122-286

3.89e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 55.35 E-value: 3.89e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 122 VAGVLLDIQQHFGVKDRGAG---LLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSSSfipqQYFWLL 196
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRpcILLADALFTIGAIVMAAA----PNKEVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL 276
Cdd:cd17360   92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIG 171

                        170
                 ....*....|
gi 222418556 277 ILILvPATKR 286
Cdd:cd17360  172 LLFL-PESPR 180

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

153-439

4.44e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 4.44e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 153 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 232
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 233 VFYFAIPLGSGLGYITGSSVKQAAGDW-HWALRVSPVLGMItgtLILILVPATKRGHADQlggqlkARTSWLRDMKALIR 311
Cdd:cd17329  128 LLYWAINLGVAIGPLLGGLLLLYSFRLlFLAAAVLFLLAAL---VLLFLLPETRPKRRAA------EKTEILRGYKIVLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 312 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 391
Cdd:cd17329  199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---------------ESLLGLLLALNALLIVLLQFPVARLVERF 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 222418556 392 TQRADPLVCAVGMlgSAIFICLIFVAAKTSIVGAYICIFVGETLLFSN 439
Cdd:cd17329  264 RLRKILMIGILLF--AIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309

MFS_SLCO_OATP

cd17336

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...

124-250

1.25e-07

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 54.17 E-value: 1.25e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 124 GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIPQqyfwLLVLSRGLV 203
Cdd:cd17336   24 STITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSIL-MGLGCFLLALPH----FLFVGQFLL 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 222418556 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17336   99 GIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS 145

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

121-512

1.77e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.77e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFfwsaVTFSSSFIPQQYFWLLVL 198
Cdd:cd17333   14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLI----SLALALIFATPSIYLFVV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 199 SRGLVGIGEASYSTIAPTIIGDLFtKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALrvspvlgMITGTLIL 278
Cdd:cd17333   90 LMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY-------LIIGLIYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 279 ILVPATKRGHADQLGG---QLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcns 355
Cdd:cd17333  162 LLAILILLTLFPELPSarnPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV--------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 356 ppcGAKDSLIFGAITCFTGFLGVVTGAGATRwcrlrtqRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGetL 435
Cdd:cd17333  233 ---SDGLAGYLLSGFWVGITIGRLLGGPISR-------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLG--L 300

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222418556 436 LFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFIsdlIRQSTKDSPLWEFLSLgYALMLCPFVV 512
Cdd:cd17333  301 FMAALFPTILSLGISNLPYAKGKGTSVLL-AAGSIGGAIIPFIMGFI---AEAVGIQTAMLLITIL-YAIIFVLALL 372

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

144-250

1.86e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.97 E-value: 1.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17317   31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 222418556 224 KNTRTLMLSVFYFAIPLG----SGLGYITGS 250
Cdd:cd17317  109 PKYRSFVGILFGLFWALGymllALLAYLIRD 139

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

152-540

2.30e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 2.30e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 152 MVAAPIFGYLGDRFNRKV----------ILSCGIFFWsAVTFSSSFIPQQYFWLLVLSRGLVGIG----EASYSTIAPTI 217
Cdd:COG2211   60 AITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFV-LLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAEL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 218 IGDlftKNTRTLMLSVFYFAIPLGSGLGYITGSS-VKQAAGDWHWALRVSPVLGMITGTL-ILILVPATKRGHADQlggq 295
Cdd:COG2211  139 TPD---YEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPVPE---- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 296 lKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnsppcgakdSLIFGAITCFTGF 375
Cdd:COG2211  212 -EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF--KYVLGLSAAL----------VGLLLALYFLAAL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 376 LGV-VTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGE----TLLFSNWAITADILMYV 450
Cdd:COG2211  279 LGApLWPRLAKRFGKKKA-------FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGiglgAILVLPWAMLADVVDYD 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 451 VIPT---RRATAVALQSFTSHlLGDAGSPYLIGFISDLIR-QSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLataLFF 526
Cdd:COG2211  352 EWKTgrrREGLYFGIFTFAIK-LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL---LFY 427

                        410
                 ....*....|....
gi 222418556 527 LSDRAKAEQQVNQL 540
Cdd:COG2211  428 PLTRERHAEIRAEL 441

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

140-280

2.79e-07

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 53.10 E-value: 2.79e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIAPTIIG 219
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 222418556  220 DLFTKNTRTL--MLSVFYFAIplgsglGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILIL 280
Cdd:TIGR00898 207 EFLPKKQRAIvgTLIQVFFSL------GLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

108-284

3.86e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 3.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 108 LSLGNVLNYLDRY--TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17365    1 LALCFLIIVLDGFdlAVMGFVApALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALr 264
Cdd:cd17365   81 TAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF- 156

                        170       180
                 ....*....|....*....|
gi 222418556 265 vspVLGMITGTLILILVPAT 284
Cdd:cd17365  157 ---LLGGVPPLILLPLLRGT 173

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

109-280

4.46e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 4.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 109 SLGNVLNYLDRYTVAGVLLDIQQHFGVKdrGAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17315    3 ALGGLLFGYDLGVINGALLYIAKDLGFG--LSTSLQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ-AAGDWHWAL 263
Cdd:cd17315   81 SALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMF 158

                        170
                 ....*....|....*..
gi 222418556 264 RVSPVLGMITGTLILIL 280
Cdd:cd17315  159 ALAAVPALLQLLLMFFL 175

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

140-245

7.09e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.42 E-value: 7.09e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIpQQYFWLLVLSRGLVGIGeASYSTIAPTIIG 219
Cdd:cd17330   36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGL-SRNLWLLFLARFLDGLT-GGNVSVAQAYIA 112

                         90       100
                 ....*....|....*....|....*.
gi 222418556 220 DLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:cd17330  113 DITDEEERAKAFGIISAAFGLGFILG 138

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

110-281

1.43e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.35 E-value: 1.43e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:cd17312   10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVL 269
Cdd:cd17312   90 S--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPGIV 166

                        170
                 ....*....|..
gi 222418556 270 GMITGTLILILV 281
Cdd:cd17312  167 GLVVAIILFFFL 178

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

108-469

1.86e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 1.86e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSP 267
Cdd:cd17321   81 APS--LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 268 VLGMItgtlililvpatkrghadqlggqlkartswlrdmkALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvq 347
Cdd:cd17321  158 PIGLV-----------------------------------ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVL--- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 348 ktaetcNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIficLIFVAAKTSIVGAYI 427
Cdd:cd17321  200 ------GYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL---LGADSSVWLLLPGLV 268

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 222418556 428 CIFVGETLLfsnWAITADILMYVVIPTRRATAVALQSFTSHL 469
Cdd:cd17321  269 LLGLGLGLF---ATPLTNAALSSVPKEKAGAASGILNTARQL 307

MFS_DtpA_like

cd17346

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...

140-280

3.47e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 49.50 E-value: 3.47e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 140 AGLLQSVFiCSFMVAAPIF-GYLGDRF--NRKVILSCGIFFwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 216
Cdd:cd17346   42 AASIYGAY-TALVYLTPIIgGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222418556 217 IIGDLFTKN--TRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVlGMITGTLILIL 280
Cdd:cd17346  119 LVGKLYDENdpRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYGFGLAAV-GMLLGLLIFLL 182

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

152-282

5.02e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 49.11 E-value: 5.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 152 MVAAPIFGYLGDRFNRK-VILSCGIFF---WSAVTFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 227
Cdd:cd17358   55 LIGALLSGKLADRIGRKrTLLISAIPCilgWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 222418556 228 TLMLSVFYFAIPLGSGLGYITGSSVkqaagdwHWalRVSPVLGMITGTLILILVP 282
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFL-------PW--RTLALIGAIPPVVFLILLF 174

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

122-286

9.73e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.95 E-value: 9.73e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAV--TFSSSFipqqyfWLLV 197
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRktLLISAVLFFISALgsAFSPNF------TIFI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 198 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGD-------WHWALRVSPVLG 270
Cdd:cd17359   94 IARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPA 173

                        170
                 ....*....|....*.
gi 222418556 271 MITGtLILILVPATKR 286
Cdd:cd17359  174 ILFL-LGMLFIPESPR 188

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

129-286

1.57e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.57e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA 208
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222418556 209 SYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKR 286
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRETRK 363

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

144-261

1.96e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 46.90 E-value: 1.96e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEWTT 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 222418556 224 KNTRTLM--LSVFYFAIplgsglGYITGSSVKQAAGDWHW 261
Cdd:cd17374  119 PRHRALAitLTSCFFSI------GQMLLAGLAYAIRDWRL 152

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

131-245

2.88e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.88e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFssSFIPQQYFWLLVLSRGLVGIGEASY 210
Cdd:cd17370  227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL--GFALGSSLWLLLLGFILWGLYMGAQ 304

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 222418556 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:cd17370  305 ESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLA 339

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

126-328

3.36e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.41 E-value: 3.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGI 205
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS--IEQLLIARFLQGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 206 GEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMITGTLILILV 281
Cdd:cd17320  100 GAAAGSVVARAIVRDLYSGAELAKIFSllmmILAIAPALAPLLG-----GLLLLFFGWRAIFVFLALLGLLLLLLVLLFL 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 222418556 282 PATKRGHAdqlGGQLKARTswLRDMKALIRNRSYVFSSLATSAVSFA 328
Cdd:cd17320  175 PETLPEEK---RKPLLSSL--LRAYKRVLKNRRFLGYALALGLSFAG 216

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

106-272

6.25e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 45.22 E-value: 6.25e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGiFFWSAV-TFS 184
Cdd:cd17372    2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIIS-ALWTFYaGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 185 SSFIPqQYFWLLVLsRGLVGIGEASYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17372   81 SAFAP-NYMWLIIL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLA 156


                 ....*...
gi 222418556 265 VSPVLGMI 272
Cdd:cd17372  157 FSSVPSSL 164

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

129-484

1.45e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.45e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGea 208
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--VGSYPVLLVLLFLVGAG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 209 sYSTIAPT---IIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILilvpatk 285
Cdd:cd17475   98 -YGSVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFW------- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 286 RGHADQLGGQLKARTS--WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAkds 363
Cdd:cd17475  169 LFYREPPAASAATESAstLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL--------SVVAAG--- 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 364 lIFGAITCFTGFLGVVTGAGATRwcRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY-ICIFVGetLLFSNWAI 442
Cdd:cd17475  238 -ALLAVAQLGGALGRIGLGRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG--LFAIGWNG 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 222418556 443 TADILMYVVIPTRRA-TAVALqSFTSHLLGDAGSPYLIGFISD 484
Cdd:cd17475  313 LYLTLVAESAGPEQAgTALGL-ANTINFIGIAIGPPLFGLLVD 354

MFS_SLCO5_OATP5

cd17404

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...

123-250

1.53e-04

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 44.27 E-value: 1.53e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyfwLLVLSR 200
Cdd:cd17404   23 NSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAlgSFLFS---LPH----FFILAQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 222418556 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17404   96 ILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145

MFS_FEN2_like

cd17327

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...

107-282

1.63e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 107 ILSLGNVLNYLDRYTVA-GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17327    9 LLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGS--------GLGYITGSSVKQaag 257
Cdd:cd17327   89 AAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSifggllayGVFKILGVGGLA--- 163

                        170       180
                 ....*....|....*....|....*
gi 222418556 258 DWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17327  164 GWRWLFIIEGLITIIIGLVIFFWLP 188

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

131-215

3.04e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 3.04e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFN-RKVILSCGIFFWSAVTFSSSFIPQQYFWLLVlsrgLVGIGEAS 209
Cdd:cd17335   25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLL----LVILGAFF 100


                 ....*.
gi 222418556 210 YSTIAP 215
Cdd:cd17335  101 SAPVVP 106

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

141-286

3.34e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.40 E-value: 3.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTI 217
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLlisNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGFVPMY 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 218 IGDLFTKNTRTLMLSVFYFAIPLGSGLGYITG-SSVKQAAGDWHWALrVSPVLGMITGTLILILVPATKR 286
Cdd:cd17357  130 LQEISPSELRGALGSLTQIGVTLGILLGQVFGlPSVLGTETLWPYLL-FFPGIPALLQLAALPFFPESPK 198

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

121-527

3.37e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 3.37e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 121 TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKvilscGIFFWSAVTF-SSSFIP--QQYFWLL 196
Cdd:cd17503   13 TIVNVALpTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR-----RLFLTALALFtLGSLLCglAPNLASL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtl 276
Cdd:cd17503   88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRWIFYINLPIGIL---- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 277 ILILVPatkrghadqlggqlkartswLRDMKALiRNRSYVFSSLATSAVSFATGALGMWIPLYLhraQVVQKTaetcnsp 356
Cdd:cd17503  163 ALLLAP--------------------LLDLRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYL---QNVLGY------- 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 357 pcgakDSLIFGAITCFTGFLGVVTGAGATRwcrlRTQRADP-LVCAVGMLGSAIFICLIFVAAKTS----IVGAYICIFV 431
Cdd:cd17503  212 -----SAFESGLVLAPGGLASAILSPLVGR----LLDKFGPrLLLLAGLLLLALGTLLLAFLTPDTslwlIILPLFIRGL 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 432 GETLLFSnwAITADILMYVViPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFV 511
Cdd:cd17503  283 GMGLVFM--PLNTLALNSLP-PEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALIIAFN 359

                        410
                 ....*....|....*...
gi 222418556 512 V--VLGGMFFLATALFFL 527
Cdd:cd17503  360 DafLVSAILLLVGLLLAL 377

MFS_SVOPL

cd17442

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...

151-272

3.72e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 42.87 E-value: 3.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 151 FMVAAPIFGYLGDRFNRKVILScGIFFWSA-VTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTiAPTIIGDLFTKNTRTL 229
Cdd:cd17442   49 YMVFSILLGLLADRYGRWKILL-LSFVWGAyFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 222418556 230 ML---SVFYFAiplGSGLGYITGSSVKQAAGdWHWALRVSPVLGMI 272
Cdd:cd17442  125 MLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPGII 166

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

103-279

4.49e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 43.12 E-value: 4.49e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  103 AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGvKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSA 180
Cdd:pfam06609  44 ASFAAFSLNVCATYFVLQASASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRpfVIATHIIGLVGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  181 VTFSSSfipqQYFWLLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWH 260
Cdd:pfam06609 123 IVGCTA----NKFNTLLAAMTLLGVA-AGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL-AIQGNWR 196

                         170
                  ....*....|....*....
gi 222418556  261 WALRVSPVLGMITGTLILI 279
Cdd:pfam06609 197 WIFYIYIIMSAIAVLLIII 215

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

94-431

5.10e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.73 E-value: 5.10e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556   94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:TIGR00895   8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  174 GIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 253
Cdd:TIGR00895  88 SILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  254 QAAGdWHWALRVSPVLGMITGTLILILVP----------------------ATKRGHADQLGGQLKARTSWLRDMKALI- 310
Cdd:TIGR00895 166 PVFG-WRSLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKALf 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  311 ---RNRSYVFSSLATSAVSFATGALGMWIPLYLhraqvvqktAETCNSPpcgaKDSLIFGAITCFTGFLGVVTGAGATrw 387
Cdd:TIGR00895 245 qgkTARITVLLWLLYFMLLVGVYFLTNWLPKLM---------VELGFSL----SLAATGGALFNFGGVIGSIIFGWLA-- 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 222418556  388 crlrtQRADPLVCAVGMLGSAIFICLIFvAAKTSIVGAYICIFV 431
Cdd:TIGR00895 310 -----DRLGPRVTALLLLLGAVFAVLVG-STLFSPTLLLLLGAI 347

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

126-328

9.03e-04

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 9.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGI 205
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA--QTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 206 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATk 285
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFFFIPET- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 222418556 286 rgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 170 --LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208

MFS_SLCO4_OATP4

cd17403

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...

129-445

9.13e-04

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 41.86 E-value: 9.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17403   30 IEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGigSLVFA---LPH--FTVFILAQLLHGAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHwalrvspvlgmiTGTLILILVPATKR 286
Cdd:cd17403  105 ATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDID------------QVDSELGLTPDDPR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 287 --GhADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHraqvvqktaETCNSPPCGAkdSL 364
Cdd:cd17403  173 wvG-AWWLGFLISGALALIIAFPLLGFPPTFMFLNLAGASEGMLLAGFATFLPKLIE---------SQFSLSASLA--AL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 365 IFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGayICIFVGETLLFSNWAITA 444
Cdd:cd17403  241 LVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILLIYCPNAPFAG--VTVPYGNSPLEGTSNLTS 318


                 .
gi 222418556 445 D 445
Cdd:cd17403  319 T 319

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

153-297

1.15e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 1.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 153 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTL 229
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222418556 230 MLSVFYFAIPLGSGLG-YITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV--PATKRGHADQLGGQLK 297
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYhpPPRPQLHGSSTRQKLK 191

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

108-261

1.21e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 1.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRgAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFS 184
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFelgSLLCGL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222418556 185 SSFIPQqyfwlLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHW 261
Cdd:cd17502   80 APNMTM-----LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150

MFS_1

pfam07690

Major Facilitator Superfamily;

129-245

2.47e-03

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.47e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP-QQYFWLLVLSRGLVGIGE 207
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGF 305

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 222418556  208 ASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

105-279

3.16e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.93 E-value: 3.16e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 105 AAILSLGNVLNYLDRYTVAGVL--LDIQQHFGVKDRGAGLLQSV--FICSFMVAAPIFG-----YLGDRFNRKVILSCGI 175
Cdd:cd17356    3 CAFVSLGGFLFGYDTGSISGILnmKSFQKYFADNTGTYYPSSSRqgLIVSIVNLGSFFGalissFLSDRIGRKKSIQIGC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 176 FFWS-AVTFSSSFIPQQyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:cd17356   83 VIYIiGAIIQVAAIGKW--YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160

                        170       180
                 ....*....|....*....|....*
gi 222418556 255 AAGDWHWalRVSPVLGMITGTLILI 279
Cdd:cd17356  161 LDGSAQW--RIPLGLQIVWGLLLLI 183

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

98-208

3.64e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.35 E-value: 3.64e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556   98 GRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF 177
Cdd:TIGR01299 162 GRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241

                          90       100       110
                  ....*....|....*....|....*....|.
gi 222418556  178 WSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA 208
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGA 272

MFS_PhT

cd17364

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...

140-252

4.94e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 39.57 E-value: 4.94e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRK-------VILSCGIFfwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYST 212
Cdd:cd17364   41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKrvygvelIIMIIGTI---LSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYP 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 222418556 213 IAPTIIGDLFTKNTRTLMLSVFYFAIplgsGLGYITGSSV 252
Cdd:cd17364  118 LSATIMSEYANKKRRGALIAAVFAMQ----GFGILAGAIV 153

PTR2

pfam00854

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...

175-280

5.13e-03

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.

Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 39.22 E-value: 5.13e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556  175 IFFWSAVtfsSSFIPQQYFWLLVLSRGLVGIGeasYSTIAPTI---IGDLFTKNT---RTLMLSVFYFAIPLGSGLGYIT 248
Cdd:pfam00854  17 LLALSAI---PSLRPPVHVALFFIGLALIALG---TGGIKPNVssfGGDQFEETDprrRSRFFSIFYFSINAGSLISTII 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 222418556  249 GSSVKQAAGdWHWALRVsPVLGMITGTLILIL 280
Cdd:pfam00854  91 TPYLQQNYG-YPLGFGL-PAVGMIIALLVFLL 120

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

140-249

7.36e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 7.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF----WSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASySTIAP 215
Cdd:cd17390   33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtalgYVLLGFSTSLA------LLFLSRIPLGIFKHT-QSLCK 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 222418556 216 TIIGDLFTKNTRTLMLSVFYFAiplgSGLGYITG 249
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAA----SSLGFILG 135

MFS_SLCO2B_OATP2B

cd17460

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...

129-252

9.06e-03

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341018 [Multi-domain] Cd Length: 479 Bit Score: 38.60 E-value: 9.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS---FIPQQY-FWLLVLSRGLVG 204
Cdd:cd17460   29 IEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMAlphFISEPYeYGILFLGQLLLG 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 222418556 205 IGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 252
Cdd:cd17460  109 IGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAM 156

MFS_SLC22A16_CT2

cd17375

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...

140-203

9.08e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 38.58 E-value: 9.08e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222418556 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL----SCGIFFWSAVTFSS---SFIPQQYFWLLVLSRGLV 203
Cdd:cd17375   37 AKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLwftsTGQFVFGIAVAFTFdyySFVIVRFLLAMVSSGYLV 107

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

141-285

9.76e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.49 E-value: 9.76e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418556 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGD 220
Cdd:cd17362   42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVLLVGRLIYGVGIGLAMHAAPVYIAE 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222418556 221 LFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATK 285
Cdd:cd17362  120 TSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPR 184

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01