NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|22325554|ref|NP_671803|]
View 

NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
30-114 3.52e-38

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


:

Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 123.69  E-value: 3.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554    30 SNSSTYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYE 109
Cdd:pfam00507   8 GPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEVVFLFPWAVSFRELGWFGFVEMLIFIAILLVGLVYA 87


                  ....*
gi 22325554   110 WKRGA 114
Cdd:pfam00507  88 WKKGA 92
 
Name Accession Description Interval E-value
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
30-114 3.52e-38

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 123.69  E-value: 3.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554    30 SNSSTYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYE 109
Cdd:pfam00507   8 GPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEVVFLFPWAVSFRELGWFGFVEMLIFIAILLVGLVYA 87


                  ....*
gi 22325554   110 WKRGA 114
Cdd:pfam00507  88 WKKGA 92
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 36-116 6.89e-37

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 121.51  E-value: 6.89e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   36 PEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGAS 115
Cdd:PRK06602  39 REKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEAAFLFPWAVSFREIGWLGFVEAMIFILVLLVGLVYLWRKGAL 118


                 .
gi 22325554  116 D 116
Cdd:PRK06602 119 D 119
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 35-114 3.71e-34

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 114.45  E-value: 3.71e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554  35 YPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGA 114
Cdd:COG0838  35 NPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEVVFLFPWAVVFRELGWFGLIEMLVFIAILLVGLIYAWKKGA 114
 
Name Accession Description Interval E-value
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
30-114 3.52e-38

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 123.69  E-value: 3.52e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554    30 SNSSTYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYE 109
Cdd:pfam00507   8 GPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEVVFLFPWAVSFRELGWFGFVEMLIFIAILLVGLVYA 87


                  ....*
gi 22325554   110 WKRGA 114
Cdd:pfam00507  88 WKKGA 92
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 36-116 6.89e-37

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 121.51  E-value: 6.89e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   36 PEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGAS 115
Cdd:PRK06602  39 REKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEAAFLFPWAVSFREIGWLGFVEAMIFILVLLVGLVYLWRKGAL 118


                 .
gi 22325554  116 D 116
Cdd:PRK06602 119 D 119
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 35-114 3.71e-34

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 114.45  E-value: 3.71e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554  35 YPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGA 114
Cdd:COG0838  35 NPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEVVFLFPWAVVFRELGWFGLIEMLVFIAILLVGLIYAWKKGA 114
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 37-118 4.31e-29

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 101.71  E-value: 4.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGASD 116
Cdd:MTH00055  37 EKVSVYECGFDPFESSRIPFSVRFFLVGILFLIFDLEISFLFPWCVVYNQIGLFGFWVMYLFLIILTIGLIYEWVKGGLE 116


                 ..
gi 22325554  117 RE 118
Cdd:MTH00055 117 WE 118
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 37-113 4.96e-27

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 96.28  E-value: 4.96e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRG 113
Cdd:MTH00018  32 EKVSAYECGFDPFGFPGRPFSIRFFLIGILFLIFDLEISFLFPWCVLYNQIAPFGFWTMVGFLFILTLGLIYEWIKG 108
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 37-113 3.00e-22

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 83.89  E-value: 3.00e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFF--PWAVPPNKIDLFGFWSMMaFLFILTIGFLYEWKRG 113
Cdd:MTH00069  31 EKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLptPWASQLNTPTNTLFWSTL-ILILLTLGLIYEWIQG 108
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 37-114 1.55e-21

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 82.67  E-value: 1.55e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGA 114
Cdd:MTH00030  42 EKSSIYECGFDPFGKIRTPFTIKFVLVGILFMIFDIEISFLFPWSIVFNQLNLFSFWIVYTFLIVLAIGLAYEWIKGG 119
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 36-114 1.52e-20

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 79.54  E-value: 1.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   36 PEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFP--WAVPPNKIDLFGFWSMMaFLFILTIGFLYEWKRG 113
Cdd:MTH00113  31 NEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPlpWAINLTTPTTTLTWATI-ILTLLTLGLIYEWLQG 109


                 .
gi 22325554  114 A 114
Cdd:MTH00113 110 G 110
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 37-113 1.51e-19

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 77.27  E-value: 1.51e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFF--FPWAVPPNKIDLFGFWSmMAFLFILTIGFLYEWKRG 113
Cdd:MTH00136  33 EKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLlpLPWGDQLPSPLLTFFWA-TAVLILLTLGLIYEWLQG 110
PRK07928 PRK07928
NADH dehydrogenase subunit A; Validated
 38-113 4.88e-19

NADH dehydrogenase subunit A; Validated


Pssm-ID: 181171 [Multi-domain]  Cd Length: 119  Bit Score: 75.86  E-value: 4.88e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22325554   38 KLSAYECGFDPSGDARS--RFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRG 113
Cdd:PRK07928  37 KLEAYECGIEPTPQPAGggRFPVKYYLTAMLFIVFDIEIVFLYPWAVSFDALGVFGLVEMALFMLTVFVAYAYVWRRG 114
PRK08489 PRK08489
NAD(P)H-quinone oxidoreductase subunit 3;
38-114 1.09e-18

NAD(P)H-quinone oxidoreductase subunit 3;


Pssm-ID: 181448 [Multi-domain]  Cd Length: 129  Bit Score: 75.47  E-value: 1.09e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22325554   38 KLSAYECGFDPSGDArSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGA 114
Cdd:PRK08489  47 KLAIYECGPEPVKQP-NRISSHFYIMALLFILFDVEIVFMFPWAVDFKLLGLFGLIEMLLFIVLLTIGFIYAWKKGA 122
ndhC CHL00022
NADH dehydrogenase subunit 3
 36-114 2.55e-18

NADH dehydrogenase subunit 3


Pssm-ID: 176964 [Multi-domain]  Cd Length: 120  Bit Score: 74.25  E-value: 2.55e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22325554   36 PEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRGA 114
Cdd:CHL00022  38 PEKLSSYESGIEPMGDAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSAFIEALIFVLILIVGLVYAWRKGA 116
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 37-116 3.05e-18

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 73.74  E-value: 3.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAvppnkIDLFGFWSM------MAFLFILTIGFLYEW 110
Cdd:MTH00148  34 EKSSPFECGFDPISSARSPFSLRFFLLAILFLVFDVEIVLLFPVL-----QSLGSSFSVwsltslFIFLLILILGLFHEW 108


                 ....*.
gi 22325554  111 KRGASD 116
Cdd:MTH00148 109 NEGSLD 114
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 37-116 4.59e-18

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 73.39  E-value: 4.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVpPNKIDLFGFWSMMAFLFILTIGFLYEWKRGASD 116
Cdd:MTH00203  33 EKLSPYECGFDPLGSARLPFSLQFFLVALSFLLFDLEIALLLPLPW-SNQLSSLSLLLAFLFLILLTLGLIYEWLQGGLE 111
PRK07756 PRK07756
NADH-quinone oxidoreductase subunit A;
37-112 4.71e-18

NADH-quinone oxidoreductase subunit A;


Pssm-ID: 169084 [Multi-domain]  Cd Length: 122  Bit Score: 73.62  E-value: 4.71e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKR 112
Cdd:PRK07756  41 AKATTYESGIEPFHDANIRFHARYYIFALLFVIFDVETLFLYPWAVAYDKLGLFALIEMLIFVVMLLVGLAYAWKK 116
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 37-114 1.39e-17

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 72.12  E-value: 1.39e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGF-WSMMAFLFILTIGFLYEWKRGA 114
Cdd:MTH00161  32 EKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWlITSSFFILILLLGLYYEWNQGA 110
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 34-110 3.38e-17

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 71.12  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   34 TYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFF--PWAVPPNKIDLFgfwSMMAFLFI--LTIGFLYE 109
Cdd:MTH00106  29 IYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLplPWASQTNNLNTM---LTMALLLIslLALSLAYE 105


                 .
gi 22325554  110 W 110
Cdd:MTH00106 106 W 106
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 37-113 7.90e-16

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 67.70  E-value: 7.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPwaVPPNKIDLFGFWSM---MAFLFILTIGFLYEWKRG 113
Cdd:MTH00042  33 EKSSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFP--LPPATLITNPSTLLpisLIFLIILTIGLVYEWVNG 110
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 23-116 1.24e-14

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 64.49  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   23 GVPFPFASNSSTYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPwaVPPNKIDLFGFWSMMA---FL 99
Cdd:MTH00012  20 GAAWVLAARSTADREKTSPFECGFDPHKTARIPFSLRFFLLAIIFIVFDIEIVLLMP--VPTILMTSTSKTVVYTsilFL 97

                         90
                 ....*....|....*..
gi 22325554  100 FILTIGFLYEWKRGASD 116
Cdd:MTH00012  98 LILVIGLIHEWREGSLD 114
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 37-116 2.46e-14

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 63.86  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   37 EKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVPPNKIDLFGFW-SMMAFLFILTIGFLYEWKRGAS 115
Cdd:MTH00202  34 EKSSPFECGFDPKESARLPFSMRFFLLAVIFLVFDIEIALLLPLPLVLKSSWSKGGLlGGTIFLLILIGGLIHEWKEGSL 113


                 .
gi 22325554  116 D 116
Cdd:MTH00202 114 D 114
ND3 MTH00092
NADH dehydrogenase subunit 3; Provisional
 28-113 1.19e-04

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177155  Cd Length: 111  Bit Score: 38.34  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22325554   28 FASNSSTYPEKLSAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFPWAVpPNKIDLFGFWSMMAFLFiltIGFL 107
Cdd:MTH00092  24 FLSVKKFDLLKVSSFECGFESVGKIQNSFSIHFFKIMLMFVIFDLEIVMFLGLLV-SDFSSLISFFMLMIFIF---FGFY 99


                 ....*.
gi 22325554  108 YEWKRG 113
Cdd:MTH00092 100 MEWWYG 105
ND3 MTH00060
NADH dehydrogenase subunit 3; Provisional
 40-113 4.81e-03

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177132  Cd Length: 116  Bit Score: 34.10  E-value: 4.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22325554   40 SAYECGFDPSGDARSRFDIRFYLVSILFLIPDLEVTFFFpwAVPPNKIDLFGFWSMMAFLFILTIGFLYEWKRG 113
Cdd:MTH00060  39 SSFECGFFSSGLSENCFSFTYFFLLVFFVIFDLEISLLL--NMPFQGLLFYNFWYYYFFLLLLFLGFVVELFSG 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH