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Conserved domains on  [gi|22122751|ref|NP_666314|]
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zinc finger protein 768 [Mus musculus]

Protein Classification

zf-H2C2_2 and zf-C2H2 domain-containing protein( domain architecture ID 12142409)

protein containing domains zf-H2C2_2, COG5048, and zf-C2H2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-532 1.57e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 327 SQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQ-KPYKCPHCGKAFGDSSYLLRHQRTHSHE----RPY 401
Cdd:COG5048 243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPF 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 402 SCPE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHARSHAR-----EKPFKC--PECGKRFGQSS 470
Cdd:COG5048 323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDS 402

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122751 471 VLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCGKGFCRSSTLLQHH 532
Cdd:COG5048 403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 9.16e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.29  E-value: 9.16e-06
                          10        20
                  ....*....|....*....|...
gi 22122751   541 YKCDDCGKAFSQSSDLIRHQRTH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 1.20e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.20e-05
                          10        20
                  ....*....|....*....|....*
gi 22122751   304 LIQHQRIHTGEKPYKCEVCSKAFSQ 328
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
58-180 2.00e-04

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   58 PFGLEPQSPEFEPQSPEfESQSPRFEPES-PGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQS-PKYEPRSP------ 129
Cdd:PRK14086  90 PSAGEPAPPPPHARRTS-EPELPRPGRRPyEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPePGAWPRAAddygwq 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122751  130 ----GCHPRSPGCEPGSPRYEPK--SPGYGSKSPEFESQSPGYESQSPGYEPQNSGD 180
Cdd:PRK14086 169 qqrlGFPPRAPYASPASYAPEQErdREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR 225
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-532 1.57e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 327 SQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQ-KPYKCPHCGKAFGDSSYLLRHQRTHSHE----RPY 401
Cdd:COG5048 243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPF 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 402 SCPE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHARSHAR-----EKPFKC--PECGKRFGQSS 470
Cdd:COG5048 323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDS 402

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122751 471 VLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCGKGFCRSSTLLQHH 532
Cdd:COG5048 403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 7.60e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 7.60e-06
                          10        20
                  ....*....|....*....|....
gi 22122751   359 YLLRHQRTHSGQKPYKCPHCGKAF 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 9.16e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.29  E-value: 9.16e-06
                          10        20
                  ....*....|....*....|...
gi 22122751   541 YKCDDCGKAFSQSSDLIRHQRTH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 1.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.20e-05
                          10        20
                  ....*....|....*....|....*
gi 22122751   304 LIQHQRIHTGEKPYKCEVCSKAFSQ 328
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 427-478 4.14e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 4.14e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22122751 427 RPFsCGICGKSFSQRSALIpharSHAREKPFKCPECGKRFGQSSVLAIHART 478
Cdd:cd20908   1 KPW-CYYCDREFDDEKILI----QHQKAKHFKCHICHKKLYTAGGLAVHCLQ 47
dnaA PRK14086
chromosomal replication initiator protein DnaA;
58-180 2.00e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   58 PFGLEPQSPEFEPQSPEfESQSPRFEPES-PGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQS-PKYEPRSP------ 129
Cdd:PRK14086  90 PSAGEPAPPPPHARRTS-EPELPRPGRRPyEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPePGAWPRAAddygwq 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122751  130 ----GCHPRSPGCEPGSPRYEPK--SPGYGSKSPEFESQSPGYESQSPGYEPQNSGD 180
Cdd:PRK14086 169 qqrlGFPPRAPYASPASYAPEQErdREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR 225
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 60-171 6.77e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    60 GLEPQSPEFEPQSPEFESQSPRFEPESPGFESRSPGFVPPSPefAPRSPESDPQSPEFESQSPKYEPRSPGCHPRSPGCE 139
Cdd:pfam05109 484 GASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTP--AVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPA 561

                          90       100       110
                  ....*....|....*....|....*....|..
gi 22122751   140 PGSPRYEPKSPGYGSKSPEFESQSPGYESQSP 171
Cdd:pfam05109 562 VTTPTPNATIPTLGKTSPTSAVTTPTPNATSP 593
PHA00733 PHA00733
hypothetical protein
 316-363 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 22122751  316 PYKCEVCSKAFSQSSDLIKHQR--THTgerpYKCPRCGKAFADSSYLLRH 363
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRytEHS----KVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 291-335 4.61e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 4.61e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22122751 291 CGICGKSFGRGSTLIQHQRIHTgekpYKCEVCSKAFSQSSDLIKH 335
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
ZnF_C2H2 smart00355
zinc finger;
373-395 5.75e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 5.75e-03
                           10        20
                   ....*....|....*....|...
gi 22122751    373 YKCPHCGKAFGDSSYLLRHQRTH 395
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-532 1.57e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 327 SQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQ-KPYKCPHCGKAFGDSSYLLRHQRTHSHE----RPY 401
Cdd:COG5048 243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPF 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 402 SCPE--CGKCYSQNSSLRSHQRVHTGQRPFSC--GICGKSFSQRSALIPHARSHAR-----EKPFKC--PECGKRFGQSS 470
Cdd:COG5048 323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDS 402

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122751 471 VLAIHARTHLPGRTYSC--PDCGKTFNRSSTLIQHQRSHTGERPYRCavCGKGFCRSSTLLQHH 532
Cdd:COG5048 403 NLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-563 9.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 288 PNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEV--CSKAFSQSSDLIKHQRTHTGERPYKC--PRCGKAFADSSYLLRH 363
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 364 QRTHSgQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPEC----------------------GKCYSQNSSLRSHQR 421
Cdd:COG5048 113 SSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 422 VHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTF--NRSST 499
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQ 271

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22122751 500 LIQHQRSHTGER-----PYRCAVCGKGFCRSSTLLQH--HRVHSGE--RPYKCD--DCGKAFSQSSDLIRHQRTH 563
Cdd:COG5048 272 SSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 7.60e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 7.60e-06
                          10        20
                  ....*....|....*....|....
gi 22122751   359 YLLRHQRTHSGQKPYKCPHCGKAF 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 9.16e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 42.29  E-value: 9.16e-06
                          10        20
                  ....*....|....*....|...
gi 22122751   541 YKCDDCGKAFSQSSDLIRHQRTH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 1.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.20e-05
                          10        20
                  ....*....|....*....|....*
gi 22122751   304 LIQHQRIHTGEKPYKCEVCSKAFSQ 328
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-397 3.19e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 3.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 313 GEKPYKCEV--CSKAFSQSSDLiKHQRTHTGERPYKCPRCGKafadssylLRHQRTHSGQKPYKCPHCGKAFGDSSYLLR 390
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*..
gi 22122751 391 HqRTHSH 397
Cdd:COG5189 417 H-RKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
315-442 3.86e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 315 KPYKCEVCSKAFSQSSDLIKHQRT--HTGE--RPYKCP--RCGKAFADSSYLLRHQRTHSGQKPYKCP--HCGKAFGDSS 386
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 387 YLLRHQRTHSHERP-------------------------------------YSCPECGKCYSQNSSLRSHQRVHTGQRPF 429
Cdd:COG5048 368 NNEPPQSLQQYKDLkndkksetlsnscirnfkrdsnlslhiithlsfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|...
gi 22122751 430 SCGICGKSFSQRS 442
Cdd:COG5048 448 LCSILKSFRRDLD 460
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 427-478 4.14e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 4.14e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22122751 427 RPFsCGICGKSFSQRSALIpharSHAREKPFKCPECGKRFGQSSVLAIHART 478
Cdd:cd20908   1 KPW-CYYCDREFDDEKILI----QHQKAKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 373-395 4.52e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|...
gi 22122751   373 YKCPHCGKAFGDSSYLLRHQRTH 395
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-355 5.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.09e-05
                          10        20
                  ....*....|....*....|....*
gi 22122751   331 DLIKHQRTHTGERPYKCPRCGKAFA 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 485-507 6.24e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 6.24e-05
                          10        20
                  ....*....|....*....|...
gi 22122751   485 YSCPDCGKTFNRSSTLIQHQRSH 507
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 345-367 8.89e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 8.89e-05
                          10        20
                  ....*....|....*....|...
gi 22122751   345 YKCPRCGKAFADSSYLLRHQRTH 367
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 317-339 1.08e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.08e-04
                          10        20
                  ....*....|....*....|...
gi 22122751   317 YKCEVCSKAFSQSSDLIKHQRTH 339
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 398-479 1.23e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 398 ERPYSCP--ECGKCYSQNSSLRSHqRVHtgqrpfscGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIH 475
Cdd:COG5189 347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                ....
gi 22122751 476 aRTH 479
Cdd:COG5189 418 -RKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 401-423 1.30e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.30e-04
                          10        20
                  ....*....|....*....|...
gi 22122751   401 YSCPECGKCYSQNSSLRSHQRVH 423
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 341-419 1.54e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 341 GERPYKCP--RCGKAFAdSSYLLRHQRTHSgqkpykcpHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRS 418
Cdd:COG5189 346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 22122751 419 H 419
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 22122751   415 SLRSHQRVHTGQRPFSCGICGKSFSQ 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
dnaA PRK14086
chromosomal replication initiator protein DnaA;
58-180 2.00e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   58 PFGLEPQSPEFEPQSPEfESQSPRFEPES-PGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQS-PKYEPRSP------ 129
Cdd:PRK14086  90 PSAGEPAPPPPHARRTS-EPELPRPGRRPyEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPePGAWPRAAddygwq 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122751  130 ----GCHPRSPGCEPGSPRYEPK--SPGYGSKSPEFESQSPGYESQSPGYEPQNSGD 180
Cdd:PRK14086 169 qqrlGFPPRAPYASPASYAPEQErdREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDR 225
zf-H2C2_2 pfam13465
Zinc-finger double domain;
528-552 2.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.09e-04
                          10        20
                  ....*....|....*....|....*
gi 22122751   528 LLQHHRVHSGERPYKCDDCGKAFSQ 552
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 62-216 4.45e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 4.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    62 EPQSPEFEPQSPEFESQSPRFEPES-PGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQSPKYEPRSPGCHPRSPGcEP 140
Cdd:PRK10263  338 EPVTQTPPVASVDVPPAQPTVAWQPvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQ-PA 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   141 GSPRYEP---KSPGYGSKSPEFESQSPG----YESQSPGYEPQnsgdgvqnsefKTHSPEFETQSSKFQEGAEMPLSPEE 213
Cdd:PRK10263  417 QQPYYAPapeQPAQQPYYAPAPEQPVAGnawqAEEQQSTFAPQ-----------STYQTEQTYQQPAAQEPLYQQPQPVE 485


                  ...
gi 22122751   214 KNP 216
Cdd:PRK10263  486 QQP 488
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-522 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|...
gi 22122751   500 LIQHQRSHTGERPYRCAVCGKGF 522
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 60-171 6.77e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    60 GLEPQSPEFEPQSPEFESQSPRFEPESPGFESRSPGFVPPSPefAPRSPESDPQSPEFESQSPKYEPRSPGCHPRSPGCE 139
Cdd:pfam05109 484 GASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTP--AVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPA 561

                          90       100       110
                  ....*....|....*....|....*....|..
gi 22122751   140 PGSPRYEPKSPGYGSKSPEFESQSPGYESQSP 171
Cdd:pfam05109 562 VTTPTPNATIPTLGKTSPTSAVTTPTPNATSP 593
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 490-535 7.16e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 7.16e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 22122751 490 CGKTFNRSSTLIQHQRSHTgerpYRCAVCGKGFcRSSTLLQHH--RVH 535
Cdd:cd20908   7 CDREFDDEKILIQHQKAKH----FKCHICHKKL-YTAGGLAVHclQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 371-423 1.17e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.17e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 22122751 371 KPYkCPHCGKAFGDSSYLLRHQRTHsHerpYSCPECGKCYSQNSSLRSH-QRVH 423
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAK-H---FKCHICHKKLYTAGGLAVHcLQVH 49
PHA00733 PHA00733
hypothetical protein
 316-363 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 22122751  316 PYKCEVCSKAFSQSSDLIKHQR--THTgerpYKCPRCGKAFADSSYLLRH 363
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRytEHS----KVCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 454-536 2.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 454 EKPFKCP--ECGKRFGQSSVLAIHART-HLPGRTYSCPDcgktfnrsstLIQHQRSHTGERPYRCAVCGKGFcRSSTLLQ 530
Cdd:COG5189 347 GKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPS----------PEKMNIFSAKDKPYRCEVCDKRY-KNLNGLK 415


                ....*.
gi 22122751 531 HHRVHS 536
Cdd:COG5189 416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-412 2.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 22122751   387 YLLRHQRTHSHERPYSCPECGKCYSQ 412
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 17-172 2.52e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    17 SPNAVGSPEGSLKDPAGNTSENEEGEISQREGNGDYEVEEIPFGLEPQSPEFEPQSPEFESQSPRFEPESP--GFESRSP 94
Cdd:PHA03307  217 ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSssSPRERSP 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    95 GFVPP---SPEFAPRSPESDPQSPEFESQSPKYEPRSPGchPRSPGCEPGSPRYEPKSPGYGSKSPEFESQS-------- 163
Cdd:PHA03307  297 SPSPSspgSGPAPSSPRASSSSSSSRESSSSSTSSSSES--SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRkrprpsra 374


                  ....*....
gi 22122751   164 PGYESQSPG 172
Cdd:PHA03307  375 PSSPAASAG 383
PHA00733 PHA00733
hypothetical protein
 484-531 2.57e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 2.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 22122751  484 TYSCPDCGKTFNRSSTLIQHQRshTGERPYRCAVCGKGFCRSSTLLQH 531
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 513-535 2.67e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.67e-03
                          10        20
                  ....*....|....*....|...
gi 22122751   513 YRCAVCGKGFCRSSTLLQHHRVH 535
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-563 3.10e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 335 HQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQ-- 412
Cdd:COG5048 189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPta 268

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 413 NSSLRSHQRVHTGQR-----PFSCGICGKSFSQRSALIPHARS--HARE--KPFKCPE--CGKRFGQSSVLAIHARTHLP 481
Cdd:COG5048 269 SSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 482 GRTYSCP--DCGKTFNRSST-----LIQHQRSHTGERPYRCAV--CGKGFCRSSTLLQHHRVHSGERP--YKCDDCGKAF 550
Cdd:COG5048 349 ISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                       250
                ....*....|...
gi 22122751 551 SQSSDLIRHQRTH 563
Cdd:COG5048 429 NRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-396 3.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.21e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122751 327 SQSSDLIKHQRTHTGE----RPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPH--CGKAFGDSSYLLRHQRTHS 396
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 291-335 4.61e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 4.61e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22122751 291 CGICGKSFGRGSTLIQHQRIHTgekpYKCEVCSKAFSQSSDLIKH 335
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
346-547 4.65e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 39.08  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 346 KCPRCGkafadSSYLLRHQRTHSGQKPYKCPHCGKAF-GDSSYLLRHQRTHSHERpyscpeCGKCYSQNSSLRSHQRVht 424
Cdd:COG3677  18 VCPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFtVTTGTIFEGSKLPLWLQ------AIRLLLNGISLRQIARV-- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751 425 gqrpfsCGIcgksfSQRSAL--IPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQ 502
Cdd:COG3677  85 ------LGV-----SYKTVWrwLHRIREALDELVDEVDEGEGLVGEEDEKTKSKRRRKRGKKLVKGLKKGVVVKVRARGA 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 22122751 503 HQRSHTGER--PYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCG 547
Cdd:COG3677 154 RKSKLAVRLelADLLLRRIILAALVAPLATDLAVGVDSKKHELLELA 200
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-466 4.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|
gi 22122751   447 HARSHAREKPFKCPECGKRF 466
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
ZnF_C2H2 smart00355
zinc finger;
373-395 5.75e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 5.75e-03
                           10        20
                   ....*....|....*....|...
gi 22122751    373 YKCPHCGKAFGDSSYLLRHQRTH 395
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 63-255 6.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    63 PQSPEFEPQSPEFESQSPRFEPESPG----FESRSPGfVPPSPEfAPRSPESDPQSPEFESQSpkyEPRSPGCHPRSPgc 138
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEpavtSRARRPD-APPQSA-RPRAPVDDRGDPRGPAPP---SPLPPDTHAPDP-- 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   139 EPGSPRYEPKSPGYGSKSPEFESQSPGYESQSPGYEPQNsgdgvqnsefKTHSPEFETQSSKFQEGAEMPLSPEEKNPLS 218
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR----------RARRLGRAAQASSPPQRPRRRAARPTVGSLT 2696

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 22122751   219 ISLGVHPLDSFTQGFGEQPTGALPPFDMPSGALLAAP 255
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP 2733
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 457-479 6.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|...
gi 22122751   457 FKCPECGKRFGQSSVLAIHARTH 479
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03132 PHA03132
thymidine kinase; Provisional
 44-171 6.46e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 39.36  E-value: 6.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751   44 SQREGNGDYEVEEIPFG--LEPQSPEFEPQSPEFESQSPRFEPESPGFESRSPGFVPPSPEF----APRSPESDPQSPEF 117
Cdd:PHA03132  11 RWNYDSSDESPEGSRDEnfDAERDDFLTPLGSTSEATSEDDDDLYPPRETGSGGGVATSTIYtvprPPRGPEQTLDKPDS 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 22122751  118 ESQSPkyePRSPGCHPRSPGCEPG--SPRYEPKS--PGYGSKSPEFESQSPGYESQSP 171
Cdd:PHA03132  91 LPASR---ELPPGPTPVPPGGFRGasSPRLGADStsPRFLYQVNFPVILAPIGESNSS 145
PHA00733 PHA00733
hypothetical protein
 356-419 6.70e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 6.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122751  356 DSSYLLRHQRTHSgQKPYKCPHCGKAFGDSSYLLRHQRTHSHERpySCPECGKCYSQNSSLRSH 419
Cdd:PHA00733  58 ESSYLYKLLTSKA-VSPYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
PHA00733 PHA00733
hypothetical protein
 384-447 7.09e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122751  384 DSSYLLRHQRTHSHErPYSCPECGKCYSQNSSLRSHQRVHTGQRpfSCGICGKSFSQRSALIPH 447
Cdd:PHA00733  58 ESSYLYKLLTSKAVS-PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
PHA00733 PHA00733
hypothetical protein
 344-391 7.96e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 7.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 22122751  344 PYKCPRCGKAFADSSYLLRHQRTHSGQKpyKCPHCGKAFGDSSYLLRH 391
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 58-176 9.28e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 38.91  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122751    58 PFGLEPQSPEFEPQSPEFES-QSPrfEPESPGFESRSPGFVPPSPEFAPrSPESDPQSPEFESQSPKYEPRSPGCHPRSP 136
Cdd:PRK10263  377 PEGYPQQSQYAQPAVQYNEPlQQP--VQPQQPYYAPAAEQPAQQPYYAP-APEQPAQQPYYAPAPEQPVAGNAWQAEEQQ 453

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 22122751   137 GCEPGSPRYEPKSPGYGSKSPEFESQSPGYESQSPGYEPQ 176
Cdd:PRK10263  454 STFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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