forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  21 GKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIR 100
Cdd:cd22674   1 GKPPPGLHLDVVKDGKLIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYHKHLNRVFLIDLGSTHGTFVGGIR 80

                        90       100
                ....*....|....*....|....*...
gi 22122685 101 LEPHKPQQIPIDSTVSFGASTRAYTLRE 128
Cdd:cd22674  81 LEPHKPQQLPIDSTLRFGASTRRYILRE 108

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  21 GKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIR 100
Cdd:cd22674   1 GKPPPGLHLDVVKDGKLIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYHKHLNRVFLIDLGSTHGTFVGGIR 80

                        90       100
                ....*....|....*....|....*...
gi 22122685 101 LEPHKPQQIPIDSTVSFGASTRAYTLRE 128
Cdd:cd22674  81 LEPHKPQQLPIDSTLRFGASTRRYILRE 108

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22122685     49 YLFGRNPDLCDFTIDHQSCSRVHAALVYHKHlKRVFLIDLNSTHGTFLGHIRL 101
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYDGG-GRFYLIDLGSTNGTFVNGKRI 52

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  21 GKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIR 100
Cdd:cd22674   1 GKPPPGLHLDVVKDGKLIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYHKHLNRVFLIDLGSTHGTFVGGIR 80

                        90       100
                ....*....|....*....|....*...
gi 22122685 101 LEPHKPQQIPIDSTVSFGASTRAYTLRE 128
Cdd:cd22674  81 LEPHKPQQLPIDSTLRFGASTRRYILRE 108

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  28 HLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLK----------RVFLIDLNSTHGTFLG 97
Cdd:cd22676   2 RLYVFKGGEQLETIDIHRQSAYLIGRDRRVADIPLDHPSCSKQHAVIQFREVEKrnegdvieniRPYIIDLGSTNGTFLN 81

                        90       100       110
                ....*....|....*....|....*....|
gi 22122685  98 HIRLEPHKPQQIPIDSTVSFGASTRAYTLR 127
Cdd:cd22676  82 GEKIEPRRYYELREKDVLKFGLSTREYVLL 111

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  17 PTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYH---------KHLKRV--FL 85
Cdd:cd22718  26 PPEARKPKKRWRLYPFKGDEALPVLYIHRQSAYLLGRDRKIADIPIDHPSCSKQHAVLQYRlveytrpdgTKGRRVrpYI 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22122685  86 IDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTL 126
Cdd:cd22718 106 IDLESANGTFLNNKKIEPQRYYELKEKDVLKFGFSSREYVL 146

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  13 LFDCPTWAGKPPPGLHLDVVKGDKLI-EKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLK---------- 81
Cdd:cd22719   2 LFVEPPEARKPSKRWRLYVFKDGEPLnEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKeggdgmmgka 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22122685  82 -RVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTL 126
Cdd:cd22719  82 vRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVL 127

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122685    49 YLFGRNPDlCDFTIDHQSCSRVHAALVYHKHLkRVFLIDLNSTHGTFLGHIRLEPhKPQQIPIDSTVSF 117
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYDGGG-RFYLEDLGSTNGTFVNGQRLGP-EPVRLKDGDVIRL 66

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  27 LHLDVVKGDKLIEKLIIDEKKYyLFGRNPDlCDFTIDHQSCSRVHAALVYHKHlkRVFLIDLNSTHGTFLGHIRLEphKP 106
Cdd:COG1716   2 ARLVVLEGPLAGRRFPLDGGPL-TIGRAPD-NDIVLDDPTVSRRHARIRRDGG--GWVLEDLGSTNGTFVNGQRVT--EP 75

                        90
                ....*....|....*
gi 22122685 107 QQIPIDSTVSFGAST 121
Cdd:COG1716  76 APLRDGDVIRLGKTE 90

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  48 YYLFGRNPDLCDFTIDHQSC----SRVHAALvyhkHLKRV------FLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSF 117
Cdd:cd22685  29 EYRIGRNPEVCDVFLCSSQHpnliSREHAEI----HAERDgngnwkVLIEDRSTNGTYVNDVRLQDGQRRELSDGDTITF 104

                        90
                ....*....|....*..
gi 22122685 118 GASTRAYTLREKPQTLP 134
Cdd:cd22685 105 GHKNGRRVKQWPYQKSS 121

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  49 YLFGRNPdlCDFTIDH-QSCSRVHAALV---------YHKHLKRVFLIDLnSTHGTFLGHIRLEPHKPQQIPIDSTVSFG 118
Cdd:cd22667  22 YTVGRKD--CDIIIVDdSSISRKHATLTvlhpeanlsDPDTRPELTLKDL-SKYGTFVNGEKLKGGSEVTLKDGDVITFG 98

                .
gi 22122685 119 A 119
Cdd:cd22667  99 V 99

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins; Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22122685  58 CDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLP 134
Cdd:cd22725  30 CELMLQSRSVDKQHAVINYDQDTDEHWVKDLGSLNGTFVNDVRIPDQKYITLKLNDVIRFGYDSNMYVLERSQHKVP 106

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  50 LFGRnpDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLephkPQQIPID----STVSFGASTRAYT 125
Cdd:cd22704  20 FVGR--EDCDLILQSRSVDKQHAVITYDQIDNEFKIKDLGSLNGTFVNDSRI----PEQTYITlklgDSIRFGYDTNVYR 93

                ....*..
gi 22122685 126 LREKPQT 132
Cdd:cd22704  94 FEQLSLT 100

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 22122685  46 KKYYLFGRNPDlCDFTIDHQSCSRVHAALVYHKHlKRVFLIDLNSTHGTFL 96
Cdd:cd22673  20 KKSCTFGRDLS-CDIRIQLPGVSREHCRIEVDEN-GKAYLENLSTTNPTLV 68

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122685  27 LHLDVVKGDklIEKLIID----EKKYYLFGRNPDlCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLE 102
Cdd:cd22678   1 LKLEVVAGP--CEGLRFDlqpgTRLPLTIGRIQR-GDIALKDDEVSGKHARIEWNSTGSKWELVDLGSLNGTLVNGESIS 77

                        90       100
                ....*....|....*....|
gi 22122685 103 P-HKPQQIPIDSTVSFGAST 121
Cdd:cd22678  78 PnGRPVVLSSGDVITLGSET 97

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22122685  49 YLFGRNPDlCDFTIDHQSCSRVHAALvyHKHLKRVFLIDLNSTHGTFLGHIRLephkpQQIPIDS 113
Cdd:cd22694  18 VRIGRDPD-ADVRLDDPRVSRRHALL--EFDGDGWVYTDLGSRNGTYLNGRRV-----QQVKLSD 74