NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|171543890|ref|NP_666258|]
View 

leptin receptor isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 5.84e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 5.84e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                           90       100
                   ....*....|....*....|....*
gi 171543890   507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589   81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig super family cl39908
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 2.16e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


The actual alignment was detected with superfamily member pfam18589:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.10  E-value: 2.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                           90       100
                   ....*....|....*....|....*...
gi 171543890   204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589   77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 4.17e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.98  E-value: 4.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328    1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                           90
                   ....*....|....*.
gi 171543890   404 tydAVYCCNE-QACHH 418
Cdd:pfam06328   75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 171543890  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.30e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890    737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 171543890    816 GVG 818
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.17e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 171543890  612 RRLDGLGYWSNWSS 625
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 5.84e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 5.84e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                           90       100
                   ....*....|....*....|....*
gi 171543890   507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589   81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 2.16e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.10  E-value: 2.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                           90       100
                   ....*....|....*....|....*...
gi 171543890   204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589   77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 4.17e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.98  E-value: 4.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328    1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                           90
                   ....*....|....*.
gi 171543890   404 tydAVYCCNE-QACHH 418
Cdd:pfam06328   75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 171543890  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-315 2.93e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.93e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890    236 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 171543890    313 GSG 315
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.30e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890    737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 171543890    816 GVG 818
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-409 1.34e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.23  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  233 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 311
Cdd:COG3401   324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  312 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 390
Cdd:COG3401   401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                         170
                  ....*....|....*....
gi 171543890  391 FSNLKATRPRGKFTYDAVY 409
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-820 5.78e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  737 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 814
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                  ....*.
gi 171543890  815 EGVGKP 820
Cdd:cd00063    80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.17e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 171543890  612 RRLDGLGYWSNWSS 625
Cdd:cd00063    77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
237-318 1.06e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   237 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 309
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 171543890   310 RLDGSGVWS 318
Cdd:pfam00041   77 NGGGEGPPS 85
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 429-531 5.84e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 5.84e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   429 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 506
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                           90       100
                   ....*....|....*....|....*
gi 171543890   507 YTMWIRINHSLGSLDSPPTCVLPDS 531
Cdd:pfam18589   81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-231 2.16e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.10  E-value: 2.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   126 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 203
Cdd:pfam18589    1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                           90       100
                   ....*....|....*....|....*...
gi 171543890   204 LNYALLMYLEITSAGVSFQSPLMSLQPM 231
Cdd:pfam18589   77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 327-418 4.17e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 79.98  E-value: 4.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   327 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 403
Cdd:pfam06328    1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                           90
                   ....*....|....*.
gi 171543890   404 tydAVYCCNE-QACHH 418
Cdd:pfam06328   75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-328 2.29e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  236 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 171543890  313 GsgvWSDWSSPQVFTT 328
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-315 2.93e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.93e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890    236 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 312
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 171543890    313 GSG 315
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 737-818 1.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.30e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890    737 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 815
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 171543890    816 GVG 818
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-409 1.34e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.23  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  233 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 311
Cdd:COG3401   324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  312 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 390
Cdd:COG3401   401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                         170
                  ....*....|....*....
gi 171543890  391 FSNLKATRPRGKFTYDAVY 409
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 737-820 5.78e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  737 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 814
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                  ....*.
gi 171543890  815 EGVGKP 820
Cdd:cd00063    80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 535-625 7.17e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890  535 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 611
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 171543890  612 RRLDGLGYWSNWSS 625
Cdd:cd00063    77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
237-318 1.06e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543890   237 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 309
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 171543890   310 RLDGSGVWS 318
Cdd:pfam00041   77 NGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH