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Conserved domains on  [gi|22122637|ref|NP_666229|]
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leucine-rich repeat-containing protein 26 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-201 4.26e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  62 LPAVPADLSwQVRSLLLDHNRVSALPPgAFANAGALLYLDLRENRLRSVhARAFWGLGVLQWLDLSSNQLETLPPgTFAP 141
Cdd:COG4886 128 LPEELANLT-NLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGN 203

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637 142 LRALSFLSLAGNRLALLePSILGPLPLLRVLSLQDNSLSAIEAglLNNLPALDVLRLHGN 201
Cdd:COG4886 204 LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-267 3.50e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637    174 LQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRKHPRPASETETLLCVSP------RLQTLSLLTAFPD 247
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPgalagqPLLGIPLLDSGCD 81

                           90       100
                   ....*....|....*....|....*
gi 22122637    248 AAFKQC-----TQSLAARDLAVVYA 267
Cdd:TIGR00864   82 EEYVAClkdnsSGGGAARSELVIFS 106
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-201 4.26e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  62 LPAVPADLSwQVRSLLLDHNRVSALPPgAFANAGALLYLDLRENRLRSVhARAFWGLGVLQWLDLSSNQLETLPPgTFAP 141
Cdd:COG4886 128 LPEELANLT-NLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGN 203

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637 142 LRALSFLSLAGNRLALLePSILGPLPLLRVLSLQDNSLSAIEAglLNNLPALDVLRLHGN 201
Cdd:COG4886 204 LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
72-131 3.57e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 3.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637    72 QVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQL 131
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-202 1.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637 121 LQWLDLSsNQleTLPPG---TFAP--LRALS----FLSLAGNRLALLEPsiLGPLPLLRVLSLQDNSLSAIE--AGLLNN 189
Cdd:cd21340  92 LEELHIE-NQ--RLPPGeklTFDPrsLAALSnslrVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSS 166

                        90
                ....*....|...
gi 22122637 190 LPALDVLRLHGNP 202
Cdd:cd21340 167 WPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-220 5.96e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   70 SWQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLS 149
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122637  150 LAGNRLALLEPSILGPLPLLRVLSLQDN----SLSAIEAGLLNNLPALDvlrlhGNPWTCN----CALRPlCTWLRKHP 220
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNhlhgSLPSTGAFLAINASAVA-----GNIDLCGgdttSGLPP-CKRVRKTP 626
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-267 3.50e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637    174 LQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRKHPRPASETETLLCVSP------RLQTLSLLTAFPD 247
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPgalagqPLLGIPLLDSGCD 81

                           90       100
                   ....*....|....*....|....*
gi 22122637    248 AAFKQC-----TQSLAARDLAVVYA 267
Cdd:TIGR00864   82 EEYVAClkdnsSGGGAARSELVIFS 106
LRRCT smart00082
Leucine rich repeat C-terminal domain;
201-244 1.70e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 1.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 22122637    201 NPWTCNCALRPLCTWLRKHPRPaSETETLLCVSP---RLQTLSLLTA 244
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL-QDPVDLRCASPsslRGPLLELLHS 46
LRR smart00370
Leucine-rich repeats, outliers;
118-141 2.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....
gi 22122637    118 LGVLQWLDLSSNQLETLPPGTFAP 141
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-201 4.26e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  62 LPAVPADLSwQVRSLLLDHNRVSALPPgAFANAGALLYLDLRENRLRSVhARAFWGLGVLQWLDLSSNQLETLPPgTFAP 141
Cdd:COG4886 128 LPEELANLT-NLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGN 203

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637 142 LRALSFLSLAGNRLALLePSILGPLPLLRVLSLQDNSLSAIEAglLNNLPALDVLRLHGN 201
Cdd:COG4886 204 LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
72-131 3.57e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 3.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637    72 QVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQL 131
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
99-155 7.17e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 7.17e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122637    99 YLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRL 155
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-204 1.84e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  68 DLSWQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRlrsvharAFWGLGVLQWLDLSSNQLETLPPgTFAPLRALSF 147
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKE 140

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122637 148 LSLAGNRLALLePSILGPLPLLRVLSLQDNSLSAIEAGLLnNLPALDVLRLHGNPWT 204
Cdd:COG4886 141 LDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-190 3.55e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  62 LPAVPADLSwQVRSLLLDHNRVSALPPgAFANAGALLYLDLRENRLRSVhaRAFWGLGVLQWLDLSSNQLETLPPgtFAP 141
Cdd:COG4886 197 LPEPLGNLT-NLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LAN 270

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22122637 142 LRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNL 190
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319
LRR_8 pfam13855
Leucine rich repeat;
121-179 5.90e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 5.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 22122637   121 LQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSL 179
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-202 1.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637 121 LQWLDLSsNQleTLPPG---TFAP--LRALS----FLSLAGNRLALLEPsiLGPLPLLRVLSLQDNSLSAIE--AGLLNN 189
Cdd:cd21340  92 LEELHIE-NQ--RLPPGeklTFDPrsLAALSnslrVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSS 166

                        90
                ....*....|...
gi 22122637 190 LPALDVLRLHGNP 202
Cdd:cd21340 167 WPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-220 5.96e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   70 SWQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLS 149
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122637  150 LAGNRLALLEPSILGPLPLLRVLSLQDN----SLSAIEAGLLNNLPALDvlrlhGNPWTCN----CALRPlCTWLRKHP 220
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNhlhgSLPSTGAFLAINASAVA-----GNIDLCGgdttSGLPP-CKRVRKTP 626
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
60-251 5.99e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 5.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   60 LALPAVPADLSWQVRSLLLDHNRVSALPPGAFANagaLLYLDLRENRLRSVHARAfwgLGVLQWLDLSSNQLETLP---P 136
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATL---PDTIQEMELSINRITELPerlP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  137 GtfaplrALSFLSLAGNRLALLEPSilgpLPL-LRVLSLQDNSLSAIEAGL-------------LNNLPA-----LDVLR 197
Cdd:PRK15370 262 S------ALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTLPAHLpsgithlnvqsnsLTALPEtlppgLKTLE 331

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22122637  198 LHGNPWTCNCALRP--LCTWLRKHPRPASETETLlcvSPRLQTL----SLLTAFPD---AAFK 251
Cdd:PRK15370 332 AGENALTSLPASLPpeLQVLDVSKNQITVLPETL---PPTITTLdvsrNALTNLPEnlpAALQ 391
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-195 2.13e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   76 LLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRL 155
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 22122637  156 ALLEPSILGPLPLLRVLSLQDNSLSA-IEAGL--LNNLPALDV 195
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLgkHNNLTVLDL 363
LRR_8 pfam13855
Leucine rich repeat;
143-202 2.89e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   143 RALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGNP 202
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-267 3.50e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637    174 LQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRKHPRPASETETLLCVSP------RLQTLSLLTAFPD 247
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPgalagqPLLGIPLLDSGCD 81

                           90       100
                   ....*....|....*....|....*
gi 22122637    248 AAFKQC-----TQSLAARDLAVVYA 267
Cdd:TIGR00864   82 EEYVAClkdnsSGGGAARSELVIFS 106
PLN03150 PLN03150
hypothetical protein; Provisional
 121-200 9.29e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 9.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  121 LQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPaldvlrLHG 200
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRL------LHR 517
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-201 3.29e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 3.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  74 RSLLLDHNRVSALPpgAFANAGALLYLDLRENRLRSVHARAfwGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGN 153
Cdd:COG4886 231 ETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22122637 154 RLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGN 201
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-201 4.58e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   65 VPADLSwQVRSL---LLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLE-TLPPGTFA 140
Cdd:PLN00113 204 IPRELG-QMKSLkwiYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22122637  141 pLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGN 201
Cdd:PLN00113 283 -LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
PLN03150 PLN03150
hypothetical protein; Provisional
 71-170 7.45e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 7.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   71 WQVRSLLLDHNRVSALPPGAFANAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSL 150
Cdd:PLN03150 418 WFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNL 497

                         90       100
                 ....*....|....*....|
gi 22122637  151 AGNRLALLEPSILGPLPLLR 170
Cdd:PLN03150 498 NGNSLSGRVPAALGGRLLHR 517
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-196 8.92e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 8.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   69 LSWQVRSLLLDHNRVSALPPGAFAnagALLY-LDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSF 147
Cdd:PLN00113 116 TSSSLRYLNLSNNNFTGSIPRGSI---PNLEtLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEF 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 22122637  148 LSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSA---IEAGLLNNLPALDVL 196
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipYEIGGLTSLNHLDLV 244
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-182 3.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 3.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122637 121 LQWLDLSSNQLETLPPgtFAPLRALSFLSLAGNRLALLEP--SILGPLPLLRVLSLQDNSLSAI 182
Cdd:cd21340 122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKK 183
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-201 4.71e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  114 AFWGLGVLQWLDLSSNQLE-TLPPGTFAPLRALSFLSLAGNRLALLEPSilGPLPLLRVLSLQDNSLSA---IEAGLLNN 189
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGeipNDIGSFSS 165

                         90
                 ....*....|..
gi 22122637  190 LPALDvlrLHGN 201
Cdd:PLN00113 166 LKVLD---LGGN 174
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-241 6.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637  117 GLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLA-LLEPSILGpLPLLRVLSLQDNSLSAIEAGLLNNLPALDV 195
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEI 312

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 22122637  196 LRLHGNPWTcncalrplctwlRKHPRPasetetlLCVSPRLQTLSL 241
Cdd:PLN00113 313 LHLFSNNFT------------GKIPVA-------LTSLPRLQVLQL 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-180 9.56e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 9.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122637   72 QVRSLLLDHNRVSALPPGAFAnAGALLYLDLRENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLA 151
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFG-SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                         90       100
                 ....*....|....*....|....*....
gi 22122637  152 GNRLALLEPSILGPLPLLRVLSLQDNSLS 180
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 124-201 1.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.19e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22122637 124 LDLSSNQLETLppGTFAPLRALSFLSLAGNRLALLEPsiLGPLPLLRVLSLQDNSLSAIEAglLNNLPALDVLRLHGN 201
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
LRRCT smart00082
Leucine rich repeat C-terminal domain;
201-244 1.70e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 1.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 22122637    201 NPWTCNCALRPLCTWLRKHPRPaSETETLLCVSP---RLQTLSLLTA 244
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL-QDPVDLRCASPsslRGPLLELLHS 46
LRR smart00370
Leucine-rich repeats, outliers;
118-141 2.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....
gi 22122637    118 LGVLQWLDLSSNQLETLPPGTFAP 141
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
118-141 2.13e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....
gi 22122637    118 LGVLQWLDLSSNQLETLPPGTFAP 141
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-202 3.44e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 22122637   167 PLLRVLSLQDNSLSAIEagLLNNLPALDVLRLHGNP 202
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNN 34
PLN03150 PLN03150
hypothetical protein; Provisional
 124-201 4.70e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 4.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22122637  124 LDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEPSILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGN 201
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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