View
Concise Results
Standard Results
Full Results
Fanconi anemia group I protein homolog [Mus musculus]
Protein Classification
FANCI_S1-cap and FANCI domain-containing protein ( domain architecture ID 10631061 )
FANCI_S1-cap and FANCI domain-containing protein
List of domain hits
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1291
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1401.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 43 VGT LLRA V L K G SP CS E e D G A LR R Y K IYSCC I Q L VE S GD L QQD VA SE II GL L M LE VHHF PG PL LV D L ASDF V GAV R EDRLV 122
Cdd:cd11720 3 TIK LLRA I L L G LS CS P - D S A SK R L K VVKSV I N L LN S AE L STK VA FD II SR L L LE LPKL PG EQ LV E L VELC V DGI R NGDNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 123 NG KSLE LLP I IL T AL ATK KE V L a CGK G D L N G E EYK R Q L I DTL CS VR W PQRYMIQ LTS V F K D VC L TP EE M N L VV A K VLTMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE I L - YEG G E L T G A EYK S Q I I NSI CS SK W QPNILTS LTS M F R D LS L SK EE L N F VV E K LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 203 SK L N LQE I PPLVYQLLVL S SKG SRRS VL D G IIAF F RE L DKQHREEQ --- SS D E LS E LI T APAD E LYHV EGTV I LHI V FA I 279
Cdd:cd11720 161 KE L D LQE L PPLVYQLLVL C SKG DKLL VL E G LQKY F DK L YYKRLLSD ans SS T E DD E IE T SSPK E VREA EGTV L LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 280 K L D C ELG R E L LK H LK AG Q QG d P S K C L C PFS IAL LLS LT RI Q RFEEQVFD L LKT SV V K SFK DLQ L L Q G S KF L QT L V - PQ RT 358
Cdd:cd11720 241 K Q D H ELG K E F LK L LK SV Q RV - P E K A L T PFS LSV LLS MS RI N RFEEQVFD F LKT AI V R SFK EKE L Q Q N S AW L RE L L l PQ VK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 359 C V STMI L E VV R NSV HSW DHVT Q GL IEF GFIL MD SYGPK KI L D gkaveigt S L SK MTNQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VV K NSV SGR DHVT P GL VNL GFIL LE SYGPK AS L E -------- S G SK TPAPK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 439 EILEQ VL NR V VT RT S s P INHFL D LF S DIIMY APL I - L QNC SK V TE TF DYLTF L P LQTVQG LLKA V QPLLKIS M S M RDSLI 517
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P VSQYI D CL S YLVQS APL L m L EHV SK I TE LL DYLTF I P GSSAMR LLKA I QPLLKIS R S L RDSLI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 518 LVLRKA M F ASQLDA R KS AV A GFLLLLKN F K V L G SL P SSQ CTQSIGV TQ VRV DVHS R Y - S AVA NE TF CLEI IDS L K R S L G Q 596
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ SSSASSS TQ ASI DVHS Q Y s S SES NE SL CLEI LGL L R R C L T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 597 QA DI RLMLY D G F Y D V LR RN SQ LA SSIMQT L FSQL K Q F Y E PEP D L L P PLKL GA CV L TQG SQ I F LQEPL D HL LS CIQHCL AW 676
Cdd:cd11720 551 QA EV RLMLY E G L Y R V VL RN PE LA PHVLDL L LPHF K S F F E EDE D V L L PLKL ES CV T TQG DD I V LQEPL G HL IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 677 Y K SRVVPLQQGDEG eeeeeel YS E LDD MLESI TV RMIK S ELEDFELDKSADFS Q N TN VG I K NNIC A C L IM G VC EVL M EY N 756
Cdd:cd11720 631 S K QNNSGRPDAAAA ------- LL E ESL MLESI CK RMIK V ELEDFELDKSADFS V N SS VG Q K KLLN A L L LL G IY EVL I EY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 757 F S I S N F - SK SKFE EIL S LF TC Y KKFS D I lsekagkgkakmtskvsdsllslkf VS D LLT A LF RD S I Q SHE E S - L S V LRS S 834
Cdd:cd11720 704 F N I W N K v SK NACK EIL G LF KL Y ESLL D L ------------------------- VS K LLT L LF DT S V Q YAT E D q T S L LRS N 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 835 G EFM H Y AVN V T LQK I Q Q L IR T GHVS G pd GQ NPDK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQKT 914
Cdd:cd11720 759 R EFM R Y ILS V C LQK L Q S L KN T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLEI 832
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 915 FS VVLQ F Y QP K VQQ FL QAL DV MGTEE E E ag V T VTQRAS FQIR Q F Q RSL LN LLS S - EE D DF N SKE ALL LI AV LS T LS RL L E 993
Cdd:cd11720 833 LN VVLQ L Y PS K LED FL SVI DV EDGGG E K -- S T IDEQLH FQIR H F I RSL MK LLS T e EE E DF V SKE VVI LI EI LS V LS DK L P 910
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 994 P T S P Q FV QML S W TS KICKE YSQ ED A S FC K SLMN L FF SLHV LYKSPVT LL RDLS Q DIHGQ LGDID Q D V E I E K td H FAVVNL 1073
Cdd:cd11720 911 P N S T Q AK QML T W LL KICKE NEL ED S S VA K AVLT L LL SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E S -- H KLKIIN 988
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1074 R T A A PT V CL L V L SQAE KVL EE VDWLI AKI K GSA N QET L SDKV tpeda S S Q AVPPTLL IE KA I VM QL GTLV T FFH ELV Q TA 1153
Cdd:cd11720 989 E T T A ES V LT L L L ASLD KVL DD VDWLI KRL K AEL N VDQ L PGED ----- S E Q SQGNLKS IE RS I CE QL YHIA T VLT ELV N TA 1063
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1154 L P S GSC V D T LLK G L S K I Y S TL TAFV K YYLQVCQSSRGI P - NTV EKLV K L S G SH LTP VC Y S FI S YV QNKS S DAPKCSE K E K 1232
Cdd:cd11720 1064 I P P GSC A D A LLK L L I K L Y K TL SNLT K HFIARSTKNPVF P s AKF EKLV E L A G KQ LTP NI Y N FI T YV EENQ S EQDSKKK K K K 1143
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*....
gi 126722700 1233 A AVSTTMA K V LRETK P IP N L VF AIEQ Y EKFLIQLSKK S KVNLM QH MKLST S RDF K IK G S 1291
Cdd:cd11720 1144 A KSKVQRN K I LRETK L IP K L IY AIEQ F EKFLIQLSKK T KVNLM RY MKLST T RDF R IK D S 1202
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
1.14e-20
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 86.57
E-value: 1.14e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 126722700 1 MD L KILSLA TDKT T DK LQ E FLQTL KD D D L AS L LQ N Q A V KG RA VG T LLRA VL KG 53
Cdd:pfam14674 1 MD Q KILSLA AEDS T EE LQ K FLQTL TE D E L TE L IT N S A L KG KD VG A LLRA IF KG 53
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1291
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1401.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 43 VGT LLRA V L K G SP CS E e D G A LR R Y K IYSCC I Q L VE S GD L QQD VA SE II GL L M LE VHHF PG PL LV D L ASDF V GAV R EDRLV 122
Cdd:cd11720 3 TIK LLRA I L L G LS CS P - D S A SK R L K VVKSV I N L LN S AE L STK VA FD II SR L L LE LPKL PG EQ LV E L VELC V DGI R NGDNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 123 NG KSLE LLP I IL T AL ATK KE V L a CGK G D L N G E EYK R Q L I DTL CS VR W PQRYMIQ LTS V F K D VC L TP EE M N L VV A K VLTMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE I L - YEG G E L T G A EYK S Q I I NSI CS SK W QPNILTS LTS M F R D LS L SK EE L N F VV E K LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 203 SK L N LQE I PPLVYQLLVL S SKG SRRS VL D G IIAF F RE L DKQHREEQ --- SS D E LS E LI T APAD E LYHV EGTV I LHI V FA I 279
Cdd:cd11720 161 KE L D LQE L PPLVYQLLVL C SKG DKLL VL E G LQKY F DK L YYKRLLSD ans SS T E DD E IE T SSPK E VREA EGTV L LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 280 K L D C ELG R E L LK H LK AG Q QG d P S K C L C PFS IAL LLS LT RI Q RFEEQVFD L LKT SV V K SFK DLQ L L Q G S KF L QT L V - PQ RT 358
Cdd:cd11720 241 K Q D H ELG K E F LK L LK SV Q RV - P E K A L T PFS LSV LLS MS RI N RFEEQVFD F LKT AI V R SFK EKE L Q Q N S AW L RE L L l PQ VK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 359 C V STMI L E VV R NSV HSW DHVT Q GL IEF GFIL MD SYGPK KI L D gkaveigt S L SK MTNQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VV K NSV SGR DHVT P GL VNL GFIL LE SYGPK AS L E -------- S G SK TPAPK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 439 EILEQ VL NR V VT RT S s P INHFL D LF S DIIMY APL I - L QNC SK V TE TF DYLTF L P LQTVQG LLKA V QPLLKIS M S M RDSLI 517
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P VSQYI D CL S YLVQS APL L m L EHV SK I TE LL DYLTF I P GSSAMR LLKA I QPLLKIS R S L RDSLI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 518 LVLRKA M F ASQLDA R KS AV A GFLLLLKN F K V L G SL P SSQ CTQSIGV TQ VRV DVHS R Y - S AVA NE TF CLEI IDS L K R S L G Q 596
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ SSSASSS TQ ASI DVHS Q Y s S SES NE SL CLEI LGL L R R C L T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 597 QA DI RLMLY D G F Y D V LR RN SQ LA SSIMQT L FSQL K Q F Y E PEP D L L P PLKL GA CV L TQG SQ I F LQEPL D HL LS CIQHCL AW 676
Cdd:cd11720 551 QA EV RLMLY E G L Y R V VL RN PE LA PHVLDL L LPHF K S F F E EDE D V L L PLKL ES CV T TQG DD I V LQEPL G HL IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 677 Y K SRVVPLQQGDEG eeeeeel YS E LDD MLESI TV RMIK S ELEDFELDKSADFS Q N TN VG I K NNIC A C L IM G VC EVL M EY N 756
Cdd:cd11720 631 S K QNNSGRPDAAAA ------- LL E ESL MLESI CK RMIK V ELEDFELDKSADFS V N SS VG Q K KLLN A L L LL G IY EVL I EY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 757 F S I S N F - SK SKFE EIL S LF TC Y KKFS D I lsekagkgkakmtskvsdsllslkf VS D LLT A LF RD S I Q SHE E S - L S V LRS S 834
Cdd:cd11720 704 F N I W N K v SK NACK EIL G LF KL Y ESLL D L ------------------------- VS K LLT L LF DT S V Q YAT E D q T S L LRS N 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 835 G EFM H Y AVN V T LQK I Q Q L IR T GHVS G pd GQ NPDK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQKT 914
Cdd:cd11720 759 R EFM R Y ILS V C LQK L Q S L KN T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLEI 832
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 915 FS VVLQ F Y QP K VQQ FL QAL DV MGTEE E E ag V T VTQRAS FQIR Q F Q RSL LN LLS S - EE D DF N SKE ALL LI AV LS T LS RL L E 993
Cdd:cd11720 833 LN VVLQ L Y PS K LED FL SVI DV EDGGG E K -- S T IDEQLH FQIR H F I RSL MK LLS T e EE E DF V SKE VVI LI EI LS V LS DK L P 910
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 994 P T S P Q FV QML S W TS KICKE YSQ ED A S FC K SLMN L FF SLHV LYKSPVT LL RDLS Q DIHGQ LGDID Q D V E I E K td H FAVVNL 1073
Cdd:cd11720 911 P N S T Q AK QML T W LL KICKE NEL ED S S VA K AVLT L LL SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E S -- H KLKIIN 988
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1074 R T A A PT V CL L V L SQAE KVL EE VDWLI AKI K GSA N QET L SDKV tpeda S S Q AVPPTLL IE KA I VM QL GTLV T FFH ELV Q TA 1153
Cdd:cd11720 989 E T T A ES V LT L L L ASLD KVL DD VDWLI KRL K AEL N VDQ L PGED ----- S E Q SQGNLKS IE RS I CE QL YHIA T VLT ELV N TA 1063
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1154 L P S GSC V D T LLK G L S K I Y S TL TAFV K YYLQVCQSSRGI P - NTV EKLV K L S G SH LTP VC Y S FI S YV QNKS S DAPKCSE K E K 1232
Cdd:cd11720 1064 I P P GSC A D A LLK L L I K L Y K TL SNLT K HFIARSTKNPVF P s AKF EKLV E L A G KQ LTP NI Y N FI T YV EENQ S EQDSKKK K K K 1143
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*....
gi 126722700 1233 A AVSTTMA K V LRETK P IP N L VF AIEQ Y EKFLIQLSKK S KVNLM QH MKLST S RDF K IK G S 1291
Cdd:cd11720 1144 A KSKVQRN K I LRETK L IP K L IY AIEQ F EKFLIQLSKK T KVNLM RY MKLST T RDF R IK D S 1202
FANCI_S4
pfam14678 FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
1041-1295
1.10e-99
FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
Pssm-ID: 464257
Cd Length: 250
Bit Score: 318.07
E-value: 1.10e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1041 LL R DL S QD I H GQ LGDIDQD v E I E KTD HFA VV N LR TAA p T V CL L V LSQ A E K VL EE VDWLI AKI K G sanq ETL S D K VTP E DA 1120
Cdd:pfam14678 1 LL E DL A QD L H AV LGDIDQD - E V E SSK HFA II N EK TAA - S V LS L L LSQ L E S VL DD VDWLI SRL K A ---- LLS S N K LAE E ES 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1121 S S QAVPPTLLI EK AIVM QLGTLVT FFH ELVQTALP S G SCVDT LLK G L S K I Y S TLT AFV KYY LQ V CQ S SR G - I PNTV EKLV 1199
Cdd:pfam14678 75 Q S SNRDQLKSR EK SLCS QLGTLVT VLS ELVQTALP P G PAMEA LLK L L T K L Y T TLT TLT KYY IA V ST S KQ G l I SAKF EKLV 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1200 KLSG S HLTP VC Y S FI S YVQ NKS S DAPKCSE K E KA AVSTTM AKVLRETK P IPNL V FAIEQYEK F LIQLSKK S KVNLMQ H MK 1279
Cdd:pfam14678 155 KLSG K HLTP QV Y D FI T YVQ ENQ S EELSKKK K K KA KSKAAR AKVLRETK L IPNL I FAIEQYEK Y LIQLSKK T KVNLMQ Y MK 234
250
....*....|....*.
gi 126722700 1280 LSTSRDF K I KGSV L DM 1295
Cdd:pfam14678 235 LSTSRDF R I NATT L QA 250
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
1.14e-20
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 86.57
E-value: 1.14e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 126722700 1 MD L KILSLA TDKT T DK LQ E FLQTL KD D D L AS L LQ N Q A V KG RA VG T LLRA VL KG 53
Cdd:pfam14674 1 MD Q KILSLA AEDS T EE LQ K FLQTL TE D E L TE L IT N S A L KG KD VG A LLRA IF KG 53
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1291
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1401.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 43 VGT LLRA V L K G SP CS E e D G A LR R Y K IYSCC I Q L VE S GD L QQD VA SE II GL L M LE VHHF PG PL LV D L ASDF V GAV R EDRLV 122
Cdd:cd11720 3 TIK LLRA I L L G LS CS P - D S A SK R L K VVKSV I N L LN S AE L STK VA FD II SR L L LE LPKL PG EQ LV E L VELC V DGI R NGDNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 123 NG KSLE LLP I IL T AL ATK KE V L a CGK G D L N G E EYK R Q L I DTL CS VR W PQRYMIQ LTS V F K D VC L TP EE M N L VV A K VLTMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE I L - YEG G E L T G A EYK S Q I I NSI CS SK W QPNILTS LTS M F R D LS L SK EE L N F VV E K LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 203 SK L N LQE I PPLVYQLLVL S SKG SRRS VL D G IIAF F RE L DKQHREEQ --- SS D E LS E LI T APAD E LYHV EGTV I LHI V FA I 279
Cdd:cd11720 161 KE L D LQE L PPLVYQLLVL C SKG DKLL VL E G LQKY F DK L YYKRLLSD ans SS T E DD E IE T SSPK E VREA EGTV L LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 280 K L D C ELG R E L LK H LK AG Q QG d P S K C L C PFS IAL LLS LT RI Q RFEEQVFD L LKT SV V K SFK DLQ L L Q G S KF L QT L V - PQ RT 358
Cdd:cd11720 241 K Q D H ELG K E F LK L LK SV Q RV - P E K A L T PFS LSV LLS MS RI N RFEEQVFD F LKT AI V R SFK EKE L Q Q N S AW L RE L L l PQ VK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 359 C V STMI L E VV R NSV HSW DHVT Q GL IEF GFIL MD SYGPK KI L D gkaveigt S L SK MTNQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VV K NSV SGR DHVT P GL VNL GFIL LE SYGPK AS L E -------- S G SK TPAPK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 439 EILEQ VL NR V VT RT S s P INHFL D LF S DIIMY APL I - L QNC SK V TE TF DYLTF L P LQTVQG LLKA V QPLLKIS M S M RDSLI 517
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P VSQYI D CL S YLVQS APL L m L EHV SK I TE LL DYLTF I P GSSAMR LLKA I QPLLKIS R S L RDSLI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 518 LVLRKA M F ASQLDA R KS AV A GFLLLLKN F K V L G SL P SSQ CTQSIGV TQ VRV DVHS R Y - S AVA NE TF CLEI IDS L K R S L G Q 596
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ SSSASSS TQ ASI DVHS Q Y s S SES NE SL CLEI LGL L R R C L T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 597 QA DI RLMLY D G F Y D V LR RN SQ LA SSIMQT L FSQL K Q F Y E PEP D L L P PLKL GA CV L TQG SQ I F LQEPL D HL LS CIQHCL AW 676
Cdd:cd11720 551 QA EV RLMLY E G L Y R V VL RN PE LA PHVLDL L LPHF K S F F E EDE D V L L PLKL ES CV T TQG DD I V LQEPL G HL IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 677 Y K SRVVPLQQGDEG eeeeeel YS E LDD MLESI TV RMIK S ELEDFELDKSADFS Q N TN VG I K NNIC A C L IM G VC EVL M EY N 756
Cdd:cd11720 631 S K QNNSGRPDAAAA ------- LL E ESL MLESI CK RMIK V ELEDFELDKSADFS V N SS VG Q K KLLN A L L LL G IY EVL I EY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 757 F S I S N F - SK SKFE EIL S LF TC Y KKFS D I lsekagkgkakmtskvsdsllslkf VS D LLT A LF RD S I Q SHE E S - L S V LRS S 834
Cdd:cd11720 704 F N I W N K v SK NACK EIL G LF KL Y ESLL D L ------------------------- VS K LLT L LF DT S V Q YAT E D q T S L LRS N 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 835 G EFM H Y AVN V T LQK I Q Q L IR T GHVS G pd GQ NPDK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQKT 914
Cdd:cd11720 759 R EFM R Y ILS V C LQK L Q S L KN T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLEI 832
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 915 FS VVLQ F Y QP K VQQ FL QAL DV MGTEE E E ag V T VTQRAS FQIR Q F Q RSL LN LLS S - EE D DF N SKE ALL LI AV LS T LS RL L E 993
Cdd:cd11720 833 LN VVLQ L Y PS K LED FL SVI DV EDGGG E K -- S T IDEQLH FQIR H F I RSL MK LLS T e EE E DF V SKE VVI LI EI LS V LS DK L P 910
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 994 P T S P Q FV QML S W TS KICKE YSQ ED A S FC K SLMN L FF SLHV LYKSPVT LL RDLS Q DIHGQ LGDID Q D V E I E K td H FAVVNL 1073
Cdd:cd11720 911 P N S T Q AK QML T W LL KICKE NEL ED S S VA K AVLT L LL SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E S -- H KLKIIN 988
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1074 R T A A PT V CL L V L SQAE KVL EE VDWLI AKI K GSA N QET L SDKV tpeda S S Q AVPPTLL IE KA I VM QL GTLV T FFH ELV Q TA 1153
Cdd:cd11720 989 E T T A ES V LT L L L ASLD KVL DD VDWLI KRL K AEL N VDQ L PGED ----- S E Q SQGNLKS IE RS I CE QL YHIA T VLT ELV N TA 1063
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1154 L P S GSC V D T LLK G L S K I Y S TL TAFV K YYLQVCQSSRGI P - NTV EKLV K L S G SH LTP VC Y S FI S YV QNKS S DAPKCSE K E K 1232
Cdd:cd11720 1064 I P P GSC A D A LLK L L I K L Y K TL SNLT K HFIARSTKNPVF P s AKF EKLV E L A G KQ LTP NI Y N FI T YV EENQ S EQDSKKK K K K 1143
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*....
gi 126722700 1233 A AVSTTMA K V LRETK P IP N L VF AIEQ Y EKFLIQLSKK S KVNLM QH MKLST S RDF K IK G S 1291
Cdd:cd11720 1144 A KSKVQRN K I LRETK L IP K L IY AIEQ F EKFLIQLSKK T KVNLM RY MKLST T RDF R IK D S 1202
FANCI_S4
pfam14678 FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
1041-1295
1.10e-99
FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
Pssm-ID: 464257
Cd Length: 250
Bit Score: 318.07
E-value: 1.10e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1041 LL R DL S QD I H GQ LGDIDQD v E I E KTD HFA VV N LR TAA p T V CL L V LSQ A E K VL EE VDWLI AKI K G sanq ETL S D K VTP E DA 1120
Cdd:pfam14678 1 LL E DL A QD L H AV LGDIDQD - E V E SSK HFA II N EK TAA - S V LS L L LSQ L E S VL DD VDWLI SRL K A ---- LLS S N K LAE E ES 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1121 S S QAVPPTLLI EK AIVM QLGTLVT FFH ELVQTALP S G SCVDT LLK G L S K I Y S TLT AFV KYY LQ V CQ S SR G - I PNTV EKLV 1199
Cdd:pfam14678 75 Q S SNRDQLKSR EK SLCS QLGTLVT VLS ELVQTALP P G PAMEA LLK L L T K L Y T TLT TLT KYY IA V ST S KQ G l I SAKF EKLV 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 1200 KLSG S HLTP VC Y S FI S YVQ NKS S DAPKCSE K E KA AVSTTM AKVLRETK P IPNL V FAIEQYEK F LIQLSKK S KVNLMQ H MK 1279
Cdd:pfam14678 155 KLSG K HLTP QV Y D FI T YVQ ENQ S EELSKKK K K KA KSKAAR AKVLRETK L IPNL I FAIEQYEK Y LIQLSKK T KVNLMQ Y MK 234
250
....*....|....*.
gi 126722700 1280 LSTSRDF K I KGSV L DM 1295
Cdd:pfam14678 235 LSTSRDF R I NATT L QA 250
FANCI_HD2
pfam14680 FANCI helical domain 2; This is the helical domain 2 (HD2) of the Fanconi anemia group I ...
554-785
9.27e-95
FANCI helical domain 2; This is the helical domain 2 (HD2) of the Fanconi anemia group I protein.
Pssm-ID: 464259
Cd Length: 233
Bit Score: 303.84
E-value: 9.27e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 554 SS QCT Q SI G V TQV R VDVHSRY SAV ANE TF CLEI IDS L K R S L G QQAD IRL MLY D G F YDV LR RN S QLA S S IMQT L FSQL K QF 633
Cdd:pfam14680 1 SS SSS Q AS G S TQV Q VDVHSRY NKA ANE AL CLEI LGI L R R C L S QQAD VKI MLY E G L YDV VT RN P QLA E S VLDM L LPHF K RY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 634 YE PEP D L LPPLKL GA C VLT QG S Q IF LQEPL D HLLSCI QHC L AWYK S RVVPLQQG D eg E E E EE E L YS EL D D M LES ITV RMI 713
Cdd:pfam14680 81 YE EDE D V LPPLKL DK C ITA QG D Q VV LQEPL A HLLSCI SCI L LKLQ S FDSFSPSQ D -- N E G EE S L VD EL A D I LES LCR RMI 158
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126722700 714 K SE LEDFELDKSAD F S QN T N VG I KN NIC A C L IM G VC EVL M EYNFSI S N F SK S K --- F EEILSLF TC Y K K F S D IL S 785
Cdd:pfam14680 159 K CD LEDFELDKSAD L S SA T S VG V KN LLY A Q L VL G IY EVL I EYNFSI G N W SK E K eed A EEILSLF KG Y S K L S E IL K 233
FANCI_S1
pfam14675 FANCI solenoid 1; This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein.
62-280
2.06e-87
FANCI solenoid 1; This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein.
Pssm-ID: 464254
Cd Length: 221
Bit Score: 282.99
E-value: 2.06e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 62 A LR R Y K I Y SCCI QL V ESG D L QQDV AS E IIG L LMLE V H H F P G PL LV D L ASDFVG A V RE DRLVN GK S L E LLP II L TA L A t KK 141
Cdd:pfam14675 1 A SK R L K V Y KSVL QL L ESG E L SEKQ AS D IIG R LMLE L H K F S G DH LV E L VELCLD A I RE GDAKC GK W L D LLP KV L SV L S - EE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 142 E V L AC G K G D L N GEEYK R Q L I DT LCS V RWP QRYM I Q L T S V F K D VC L TP EE MNL VV A K V L T M FS KL N LQE I PPLVYQLL V L S 221
Cdd:pfam14675 80 E R L NY G G G E L S GEEYK S Q I I NS LCS S RWP PQIV I S L A S M F R D LP L SK EE LEF VV N K L L R M LK KL D LQE L PPLVYQLL L L C 159
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126722700 222 SKGS RRSV L D G I I AF F R E LDKQHREEQ S --- S DELSELI T APAD EL YH VEGTV I LHI V FA I K 280
Cdd:pfam14675 160 SKGS KKVI L E G L I KY F A E NYYKRQDSN S esn S NDFDSIE T VSDK EL RE VEGTV L LHI N FA A K 221
FANCI_S3
pfam14677 FANCI solenoid 3; This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein.
803-1028
1.51e-79
FANCI solenoid 3; This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein.
Pssm-ID: 464256
Cd Length: 216
Bit Score: 260.67
E-value: 1.51e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 803 L L S L K FVS D LLT A LFRDS I Q - S HEESLSVLRS SG EF MH YA VN V T LQK I QQL IR T gh VS GP D GQN PD K I F Q NLCDITRVL L 881
Cdd:pfam14677 1 I L D L G FVS R LLT L LFRDS V Q w A HEESLSVLRS NK EF VR YA LS V A LQK V QQL RE T -- TD GP E GQN SK K T F K NLCDITRVL Y 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 882 WR Y ts IP TS VEESGK KE K gk S ISLL C LE GLQKTFSVVL Q F Y QP K VQQ FL Q A L D vm G T E E E eagvt V T QRAS F Q IRQFQR S 961
Cdd:pfam14677 79 WR C -- IP SA VEESGK FD K -- Q ISLL A LE CFLEILNTAQ Q L Y PS K FSE FL K A I D -- E T D E D ----- L T EQLK F L IRQFQR V 147
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126722700 962 L L N L LS SE E D DF N -- SK E ALLL IAV LS T LS RL LEP T S P QFVQML S W TS KICKE YSQ EDA SF CK S L MN L F 1028
Cdd:pfam14677 148 L V N Q LS ED E E DF S ia SK L ALLL VNI LS L LS KH LEP N S R QFVQML T W LV KICKE NNL EDA AV CK G L LS L L 216
FANCI_S2
pfam14676 FANCI solenoid 2; This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein.
378-540
6.16e-64
FANCI solenoid 2; This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein.
Pssm-ID: 464255 [Multi-domain]
Cd Length: 154
Bit Score: 213.97
E-value: 6.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 378 V T QGL IEF GF I L M DSYG PKKI ldgkaveigt S L SK MTN Q H A CK LG AN ILLE T FK I H E MIR Q EILEQ VL NR V V TRT SSP IN 457
Cdd:pfam14676 1 V V QGL VQL GF V L L DSYG KASG ---------- S K SK TPA Q R A WQ LG IK ILLE L FK K H D MIR S EILEQ LV NR I V SKS SSP QQ 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 458 H FL DL F S DIIMY APL I L QNC - SK VT E TF DYL T FLPL Q T V Q G LL K AVQPL L K I SMS M RDSLILVLRKA M F ASQ LDARK S AV 536
Cdd:pfam14676 71 H YI DL L S KLVKS APL L L LEH s SK LK E LL DYL S FLPL S T A Q R LL T AVQPL I K V SMS L RDSLILVLRKA L F SRE LDARK M AV 150
....
gi 126722700 537 A GFL 540
Cdd:pfam14676 151 S GFL 154
FANCI_HD1
pfam14679 FANCI helical domain 1; This is the helical domain 1 (HD1) of the Fanconi anemia group I ...
284-370
1.59e-35
FANCI helical domain 1; This is the helical domain 1 (HD1) of the Fanconi anemia group I protein.
Pssm-ID: 464258
Cd Length: 86
Bit Score: 130.05
E-value: 1.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722700 284 ELGRELLK H LK AG Q q GD P SKC L C PF SI ALLLS LT RI Q RFEEQVFDLLKT SV VKSFKD L Q L LQGSK F L QT L V P QRTC VS TM 363
Cdd:pfam14679 1 ELGRELLK Y LK SD Q - NV P ERI L S PF TV ALLLS VA RI P RFEEQVFDLLKT AI VKSFKD E Q K LQGSK W L RD L L P DSCD VS QI 79
....*..
gi 126722700 364 IL E VV R N 370
Cdd:pfam14679 80 IL K VV K N 86
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
1.14e-20
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 86.57
E-value: 1.14e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 126722700 1 MD L KILSLA TDKT T DK LQ E FLQTL KD D D L AS L LQ N Q A V KG RA VG T LLRA VL KG 53
Cdd:pfam14674 1 MD Q KILSLA AEDS T EE LQ K FLQTL TE D E L TE L IT N S A L KG KD VG A LLRA IF KG 53
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
