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Conserved domains on  [gi|31542010|ref|NP_659112|]
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WD repeat-containing protein 36 isoform 3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-577 2.45e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 2.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319 231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVRE 565
Cdd:COG2319 288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367

                       410
                ....*....|..
gi 31542010 566 FSGHHGQINDMV 577
Cdd:COG2319 368 LTGHTGAVTSVA 379
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-577 2.45e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 2.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319 231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVRE 565
Cdd:COG2319 288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367

                       410
                ....*....|..
gi 31542010 566 FSGHHGQINDMV 577
Cdd:COG2319 368 LTGHTGAVTSVA 379
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-367 1.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 1.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 102 VHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKISTILHpstyLNKVLLGSEQGSLQL 178
Cdd:cd00200   2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 179 WNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPC 258
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 259 GHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDgpagEGRLLRFRMGHSASLTKIRYyGQN 338
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230

                       250       260       270
                ....*....|....*....|....*....|
gi 31542010 339 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 367
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 204-288 1.68e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010   204 PAVDVVAIGLVSGQVVIHNIkydetlmKFHQDWG--------PITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQm 275
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRL-------NWQRVWTlspdkedlEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH- 75

                          90
                  ....*....|...
gi 31542010   276 RNAHSTAISGLTF 288
Cdd:pfam12894  76 FSAGSDLITCLGW 88
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-577 2.45e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 2.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319 231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVRE 565
Cdd:COG2319 288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367

                       410
                ....*....|..
gi 31542010 566 FSGHHGQINDMV 577
Cdd:COG2319 368 LTGHTGAVTSVA 379
WD40 COG2319
WD40 repeat [General function prediction only];
96-352 2.52e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010  96 ARNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKIStiLHPStylNKVLL-GS 171
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVA--FSPD---GKLLAsGS 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 172 EQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHPI 251
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 252 MAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHSASLTK 331
Cdd:COG2319 304 ASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTS 377

                       250       260
                ....*....|....*....|.
gi 31542010 332 IRYyGQNGQQILSASQDGTLQ 352
Cdd:COG2319 378 VAF-SPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-367 1.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 1.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 102 VHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKISTILHpstyLNKVLLGSEQGSLQL 178
Cdd:cd00200   2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 179 WNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPC 258
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 259 GHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDgpagEGRLLRFRMGHSASLTKIRYyGQN 338
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230

                       250       260       270
                ....*....|....*....|....*....|
gi 31542010 339 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 367
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 COG2319
WD40 repeat [General function prediction only];
117-518 2.65e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 2.65e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 117 PFGDHVISVDTDSVLIIWHIYSEEEYLQLTFDKSVFKISTILHPSTYLnkvLLGSEQGSLQLWNIKSNKLLYTFPGWKVG 196
Cdd:COG2319  46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLLLRTLTGHTGA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 197 VTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQMR 276
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLT 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 277 nAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHSASLTKIRyYGQNGQQILSASQDGTLQSFST 356
Cdd:COG2319 202 -GHTGAVRSVAFSPDGKLLASGSADGTVRLW----DLATGKLLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRLWDL 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 357 VHEKFNKSLGH--GLVNkkivkrkglqntmSVRLPPITQFAAEearqSDWDGIIachqgkrscSTWNYQRStigayflKP 434
Cdd:COG2319 276 ATGELLRTLTGhsGGVN-------------SVAFSPDGKLLAS----GSDDGTV---------RLWDLATG-------KL 322

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 435 RGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAV--DGlnQLVVTAGSERLLK 512
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFspDG--RTLASGSADGTVR 397


                ....*.
gi 31542010 513 FWNFKS 518
Cdd:COG2319 398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-351 4.75e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 4.75e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010  74 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQL 145
Cdd:cd00200  12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 146 T-FDKSVFKIStiLHPSTYLnkVLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIK 224
Cdd:cd00200  90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 225 YDETLMKF--HQDWgpITSISFRTDGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADN 302
Cdd:cd00200 166 TGKCVATLtgHTGE--VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31542010 303 ALRIWifDGPAGEgRLLRFRmGHSASLTKIRYYGqNGQQILSASQDGTL 351
Cdd:cd00200 242 TIRVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
167-577 1.36e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.36e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHS 326
Cdd:COG2319  89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL------------------ 188

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAH 486
Cdd:COG2319 189 -------------WDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGH 245

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319 246 SGSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                       410
                ....*....|....
gi 31542010 564 REFSGHHGQINDMV 577
Cdd:COG2319 324 RTLTGHTGAVRSVA 337
WD40 COG2319
WD40 repeat [General function prediction only];
79-307 9.09e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 9.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010  79 ADGRLVFAAYGN----VFSAfaRNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLTF-DKSV 151
Cdd:COG2319 172 PDGKLLASGSDDgtvrLWDL--ATGKLLRTLTGHTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 152 FKIStiLHPStylNKVLL-GSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLM 230
Cdd:COG2319 250 RSVA--FSPD---GRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31542010 231 KFHQDWGPITSISFRTDGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-576 1.13e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 1.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 279 HSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHSASLTKIRYYGqNGQQILSASQDGTLQSFSTVH 358
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 359 EKFNKSL-GHglvnkkivkrkgLQNTMSVRLPPITQFAAeearQSDWDGIIACHQGK--RSCSTWNYQRSTIgayflkpr 435
Cdd:cd00200  83 GECVRTLtGH------------TSYVSSVAFSPDGRILS----SSSRDKTIKVWDVEtgKCLTTLRGHTDWV-------- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 436 gvktnsnltaTAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWN 515
Cdd:cd00200 139 ----------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542010 516 FKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDM 576
Cdd:cd00200 206 LSTGKCLGTLrGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-307 2.69e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.69e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010  97 RNKEIVHTFKGHKAEIH--LLQPFGDHVISVDTDSVLIIWHIysEEEYLQLTFD---KSVFKIStiLHPStylNKVLLGS 171
Cdd:cd00200  81 ETGECVRTLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVASS 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 172 EQ-GSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHp 250
Cdd:cd00200 154 SQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY- 232

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31542010 251 IMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-525 5.34e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 5.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 237 GPITSISFRTDGhPIMAAGSPCGHIGLWDLEDKKLINQMRNaHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageG 316
Cdd:cd00200  10 GGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET----G 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 317 RLLRFRMGHSASLTKIRYYgQNGQQILSASQDGTLQSFSTVHEKFNKSL-GH-GLVNkkivkrkglqntmSVRLPPITQF 394
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLrGHtDWVN-------------SVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 395 AAeearQSDWDGIIachqgkrscSTWNyqrstigayflkPRGVKTNSNLTATAVDITSC-----GNFAIIGLSSGAVDVY 469
Cdd:cd00200 150 VA----SSSQDGTI---------KLWD------------LRTGKCVATLTGHTGEVNSVafspdGEKLLSSSSDGTIKLW 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31542010 470 NMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL 525
Cdd:cd00200 205 DLSTGKCLGTL---RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-576 1.61e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 484 KAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKI 562
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90
                ....*....|....
gi 31542010 563 VREFSGHHGQINDM 576
Cdd:cd00200  86 VRTLTGHTSYVSSV 99
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 204-288 1.68e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010   204 PAVDVVAIGLVSGQVVIHNIkydetlmKFHQDWG--------PITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQm 275
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRL-------NWQRVWTlspdkedlEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH- 75

                          90
                  ....*....|...
gi 31542010   276 RNAHSTAISGLTF 288
Cdd:pfam12894  76 FSAGSDLITCLGW 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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