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Conserved domains on  [gi|20270289|ref|NP_620092|]
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protein HEXIM1 [Mus musculus]

Protein Classification

HEXIM domain-containing protein( domain architecture ID 10633900)

HEXIM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 161-297 6.93e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


:

Pssm-ID: 464638  Cd Length: 136  Bit Score: 189.21  E-value: 6.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   161 WKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKS---DDTSDED 237
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGssfDSSSEDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   238 FVEEAGEEdggsdGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSR 297
Cdd:pfam15313  81 YFESEPDE-----DLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQ 135
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 161-297 6.93e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 189.21  E-value: 6.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   161 WKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKS---DDTSDED 237
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGssfDSSSEDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   238 FVEEAGEEdggsdGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSR 297
Cdd:pfam15313  81 YFESEPDE-----DLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQ 135
 
Name Accession Description Interval E-value
HEXIM pfam15313
Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that ...
 161-297 6.93e-60

Hexamethylene bis-acetamide-inducible protein; HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.


Pssm-ID: 464638  Cd Length: 136  Bit Score: 189.21  E-value: 6.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   161 WKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKS---DDTSDED 237
Cdd:pfam15313   1 WKPYSKLSWEEKKQLDERETQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDKEEPDLNTELGPRRSRSRGssfDSSSEDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20270289   238 FVEEAGEEdggsdGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSR 297
Cdd:pfam15313  81 YFESEPDE-----DLGSDGGEFLEKDFSETYERYHAERLQNMSKQELIQEYLELEKKLSQ 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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