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Conserved domains on  [gi|34147529|ref|NP_612378|]
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biorientation of chromosomes in cell division protein 1 isoform a [Homo sapiens]

Protein Classification

BOD1/SHG1 domain-containing protein( domain architecture ID 10525142)

BOD1/SHG1 domain-containing protein similar to biorientation of chromosomes in cell division 1 (BOD1) which corrects aberrant syntelic attachments in mitotic spindles and is required for proper chromosome biorientation, and to yeast Shg1p which is a component of the COMPASS (complex proteins associated with Set1p) complex which methylates lysine 4 on histone H3 and controls the silencing of telomeric regions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 55-148 3.96e-34

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


:

Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 116.14  E-value: 3.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34147529    55 IVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGML---EAGVDR 131
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81

                          90
                  ....*....|....*....
gi 34147529   132 IISQVV--DPKLNHIFRPQ 148
Cdd:pfam05205  82 LIDQVLdiEPKIREIRRPE 100
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 55-148 3.96e-34

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 116.14  E-value: 3.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34147529    55 IVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGML---EAGVDR 131
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81

                          90
                  ....*....|....*....
gi 34147529   132 IISQVV--DPKLNHIFRPQ 148
Cdd:pfam05205  82 LIDQVLdiEPKIREIRRPE 100
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 55-148 3.96e-34

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 116.14  E-value: 3.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34147529    55 IVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGML---EAGVDR 131
Cdd:pfam05205   2 LVHEFKKKGGFDKLRKDILADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYkkaEAGVDR 81

                          90
                  ....*....|....*....
gi 34147529   132 IISQVV--DPKLNHIFRPQ 148
Cdd:pfam05205  82 LIDQVLdiEPKIREIRRPE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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