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Conserved domains on  [gi|229608935|ref|NP_612187|]
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nucleoside diphosphate kinase 7 isoform 1 [Mus musculus]

Protein Classification

NDPk7A and NDPk7B domain-containing protein( domain architecture ID 12218339)

protein containing domains DM10, NDPk7A, and NDPk7B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 111-241 1.73e-84

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239878  Cd Length: 131  Bit Score: 253.14  E-value: 1.73e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 190
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229608935 191 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 257-390 3.13e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239875  Cd Length: 134  Bit Score: 239.84  E-value: 3.13e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:cd04412    1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608935 337 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd04412   81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 22-110 1.45e-30

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 112.79  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935    22 QSERFAFIAEWYDPNA--SLLRRYELLFYPTDGSVEMH--DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKV 85
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 229608935    86 NVFSRQLVLIDYgDQYTARQLGSRK 110
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 111-241 1.73e-84

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 253.14  E-value: 1.73e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 190
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229608935 191 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 257-390 3.13e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 239.84  E-value: 3.13e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:cd04412    1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608935 337 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd04412   81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 111-244 6.02e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.85  E-value: 6.02e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935   111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935   189 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:smart00562  81 KTWRTLMGPTDPREA---APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
111-244 2.67e-58

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 186.15  E-value: 2.67e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935  111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935  189 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 257-394 3.73e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 157.33  E-value: 3.73e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935   257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGK-PFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 229608935   337 TKTFREFCGPADPeiaRHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILD 394
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 111-242 6.71e-46

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 154.45  E-value: 6.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMeILR-DDA 187
Cdd:COG0105    3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAM-VLEgENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229608935 188 ICEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 242
Cdd:COG0105   82 VAVVRKLMGATN---PAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 111-244 1.67e-44

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 150.64  E-value: 1.67e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 229608935 189 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:PRK00668  82 AKVRELMGatnPAEA------APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDK pfam00334
Nucleoside diphosphate kinase;
259-391 3.60e-32

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 117.97  E-value: 3.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935  259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 229608935  339 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 22-110 1.45e-30

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 112.79  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935    22 QSERFAFIAEWYDPNA--SLLRRYELLFYPTDGSVEMH--DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKV 85
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 229608935    86 NVFSRQLVLIDYgDQYTARQLGSRK 110
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 259-391 9.85e-22

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 90.13  E-value: 9.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:COG0105    5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 339 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:COG0105   84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 259-391 4.78e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 82.80  E-value: 4.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYkGVVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:PRK14542   4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 339 TFREFCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PRK14542  83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 111-241 1.73e-84

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 253.14  E-value: 1.73e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 190
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229608935 191 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 257-390 3.13e-79

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 239.84  E-value: 3.13e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:cd04412    1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608935 337 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd04412   81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 111-241 9.61e-67

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 207.98  E-value: 9.61e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVS--KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:cd00595    1 ERTLALIKPDAVAegLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 189 CEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd00595   81 GEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 111-244 6.02e-64

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 200.85  E-value: 6.02e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935   111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935   189 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:smart00562  81 KTWRTLMGPTDPREA---APGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
111-244 2.67e-58

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 186.15  E-value: 2.67e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935  111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935  189 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 257-390 2.29e-57

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 183.71  E-value: 2.29e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:cd00595    1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGR-PFFPDLVQFMSSGPVVAMILEKDNA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608935 337 TKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd00595   80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 111-242 1.61e-49

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 163.38  E-value: 1.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICE 190
Cdd:cd04418    1 ERTLAIIKPDAVHKAEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 229608935 191 WKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 242
Cdd:cd04418   81 WKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 257-394 3.73e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 157.33  E-value: 3.73e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935   257 NCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNP 336
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGK-PFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 229608935   337 TKTFREFCGPADPeiaRHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILD 394
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 111-241 4.46e-46

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 154.55  E-value: 4.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:cd04413    1 ERTLVIIKPDGVQRglIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 189 CEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd04413   81 KTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 111-242 6.71e-46

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 154.45  E-value: 6.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMeILR-DDA 187
Cdd:COG0105    3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAM-VLEgENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229608935 188 ICEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 242
Cdd:COG0105   82 VAVVRKLMGATN---PAEAAPGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 111-244 1.67e-44

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 150.64  E-value: 1.67e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 229608935 189 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSS 244
Cdd:PRK00668  82 AKVRELMGatnPAEA------APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 111-241 8.67e-42

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 143.50  E-value: 8.67e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVS-KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAIC 189
Cdd:cd04416    1 EYTLALIKPDAVAeKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 229608935 190 EWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:cd04416   81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 111-242 1.07e-40

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 140.61  E-value: 1.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVS---KAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 187
Cdd:cd04414    1 QLTLALIKPDAVAhplALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229608935 188 ICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFP 242
Cdd:cd04414   81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 108-241 2.84e-36

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 130.33  E-value: 2.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 108 SRKEKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRD 185
Cdd:PLN02931  27 SEEERTLAMIKPDGLSGnyTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKE 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935 186 DAICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PLN02931 107 NAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF 162
NDK pfam00334
Nucleoside diphosphate kinase;
259-391 3.60e-32

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 117.97  E-value: 3.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935  259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 229608935  339 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 22-110 1.45e-30

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 112.79  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935    22 QSERFAFIAEWYDPNA--SLLRRYELLFYPTDGSVEMH--DVKNR----RTFLKRTKY--------EDLRLEDLFIGNKV 85
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNSgilqGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 229608935    86 NVFSRQLVLIDYgDQYTARQLGSRK 110
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 111-241 1.03e-29

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 111.69  E-value: 1.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:PRK14542   2 SRTFIMIKPDGVKNkhVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 189 CEWKRLLGPANsglSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PRK14542  82 LHWREVIGATD---PKEAAAGTIRALYAESKEANAVHGSDSDANAALEISFFF 131
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 110-241 1.33e-28

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 109.04  E-value: 1.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 110 KEKTLALIKPDAVSK--AGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 187
Cdd:PTZ00093   2 SERTFIMVKPDGVQRglVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608935 188 ICEWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PTZ00093  82 VKQGRKLLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 110-241 1.60e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 108.37  E-value: 1.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 110 KEKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDA 187
Cdd:PRK14540   2 KERTFVALKPDAVERKliGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229608935 188 ICEWKRLLGPANSglsrTDA-PGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PRK14540  82 ISTVRKMIGKTNP----AEAePGTIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 112-241 5.61e-26

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 101.91  E-value: 5.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 112 KTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAIC 189
Cdd:PRK14545   5 RTFTMIKPDAVENGhiGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 229608935 190 EWKRLLGPANSGLSrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PRK14545  85 DFRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 111-241 8.69e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 98.48  E-value: 8.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:PRK14541   2 ERTLTILKPDCVRKQliGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935 189 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PRK14541  82 ADFRTLIGatdPAEA------AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 258-390 6.01e-24

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 96.13  E-value: 6.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 258 CTCCIIKPHAISEGMLgKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPT 337
Cdd:cd04416    2 YTLALIKPDAVAEKKD-EILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEE-DYFEDLVEFMTSGPSLILVLSKENAV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 338 KTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd04416   80 EEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 259-391 9.85e-22

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 90.13  E-value: 9.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:COG0105    5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 339 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:COG0105   84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 259-391 4.78e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 82.80  E-value: 4.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYkGVVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:PRK14542   4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 339 TFREFCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PRK14542  83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 262-391 1.07e-16

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 75.91  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 262 IIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTKTFR 341
Cdd:PRK00668   7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKE-KPFFGELVEFMTSGPVVVMVLEGENAIAKVR 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 229608935 342 EFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PRK00668  86 ELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 111-241 2.99e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 76.39  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHS--------------------------- 161
Cdd:PRK14544   4 ERTLVILKPDAVKRGlvGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEEwyrsvgnkllkayqelgidprarlgtd 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 162 ------RPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPAnsgLSRTDAPGSIRALFGTDG----------VRNAAH 225
Cdd:PRK14544  84 dpvevgKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPT---SPHKAPPGTIRGDYSIDSpdlaaeegrvVYNLVH 160

                        170
                 ....*....|....*.
gi 229608935 226 GPDTFASAAREMELFF 241
Cdd:PRK14544 161 ASDSPEEAEREIKFWF 176
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 259-391 5.09e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 74.09  E-value: 5.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:PRK14540   5 TFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKG-KEFYERLINFMTSGRIVAMVIEGENAIS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 339 TFREFCGPADPEIArhlRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PRK14540  84 TVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 256-390 8.47e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 73.79  E-value: 8.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 256 TNCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGvVSEYNDMVTELCSGPCVAIEIQQSN 335
Cdd:PRK14545   3 GNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAE-RPFYGELVEFMSRGPIVAAILEKEN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 229608935 336 PTKTFREFCGPADPEIARHlrpETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:PRK14545  82 AVEDFRTLIGATNPADAAE---GTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PLN02619 PLN02619
nucleoside-diphosphate kinase
 111-241 7.48e-15

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 73.34  E-value: 7.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAI 188
Cdd:PLN02619  89 ERTFIAIKPDGVQRGliSEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEGVI 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608935 189 CEWKRLLG---PANSglsrtdAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFF 241
Cdd:PLN02619 169 KYGRKLIGatdPQKS------EPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 259-390 9.06e-15

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 70.51  E-value: 9.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISE-GMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSeYNDMVTELCSGPCVAIEIQQSNPT 337
Cdd:cd04414    3 TLALIKPDAVAHpLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFF-YDRLVSFMTSGPSWALILAHENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 229608935 338 KTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:cd04414   82 KTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFF 134
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 259-390 1.16e-14

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 70.36  E-value: 1.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPTK 338
Cdd:PRK14541   4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRER-PFYGELVEFMSSGPCVPMILEKENAVA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 229608935 339 TFREFCGPADPEIARHlrpETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFF 390
Cdd:PRK14541  83 DFRTLIGATDPAEAAE---GTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 111-241 6.17e-09

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 54.90  E-value: 6.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 111 EKTLALIKPDAVSKA--GEIIEMINKSGFTITKLRMMTLTRKEAADFH-----VDHHSRPFYNELIQFITSGPVIAMEIL 183
Cdd:PRK14543   6 QKTLCIIKPDGVRRGliGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVFVFVVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 229608935 184 RDDAICEWKRLLGPANSGLSrtdAPGSIRALFGTD----------GVRNAAHGPDTFASAAREMELFF 241
Cdd:PRK14543  86 GVESVEVVRKFCGSTEPKLA---IPGTIRGDFSYHsfnyanekgfSVYNVIHASANEDDALREIPIWF 150
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 259-391 8.22e-09

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 54.51  E-value: 8.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYeVYKGVV-----SEYNDMVTELCSGPCVAIEIQQ 333
Cdd:PRK14543   8 TLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY-LYDDIAvrhgeAVWKSLIKFISSSPVFVFVVEG 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 229608935 334 SNPTKTFREFCGPADPEIArhlRPETLRAIFG----------KTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PRK14543  87 VESVEVVRKFCGSTEPKLA---IPGTIRGDFSyhsfnyanekGFSVYNVIHASANEDDALREIPIWFK 151
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 259-391 1.01e-08

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 54.43  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 259 TCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFY----EVYKGVVSE----YNDM------------- 317
Cdd:PRK14544   6 TLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseEWYRSVGNKllkaYQELgidprarlgtddp 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 318 -----------VTELCSGPCVAIEIQQSNPTKTFREFCGPADPEIArhlRPETLRAIFG----------KTKVQNAVHCT 376
Cdd:PRK14544  86 vevgkkvkeslVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSidspdlaaeeGRVVYNLVHAS 162

                        170
                 ....*....|....*
gi 229608935 377 DLPEDGLLEVQYFFK 391
Cdd:PRK14544 163 DSPEEAEREIKFWFR 177
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 263-391 8.49e-07

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 48.18  E-value: 8.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608935 263 IKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVvSEYNDMVTELCSGPCVAIEIQQSNPTKTFRE 342
Cdd:PTZ00093   9 VKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGK-PFFPGLVKYISSGPVVCMVWEGKNVVKQGRK 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 229608935 343 FCGPADPEIARhlrPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFK 391
Cdd:PTZ00093  88 LLGATNPLESA---PGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFK 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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