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Conserved domains on  [gi|32189346|ref|NP_598919|]
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CMRF-35-like molecule 4 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 27-119 2.71e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 84.76  E-value: 2.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346  27 GPSTITGAVGESLSVSCQYEEKFKTKDKFWCRGSlKVLCKDIVKTSSSeeVRNGRVTIRDHPDNLTFTVTYESLTLEDAD 106
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|...
gi 32189346 107 TYMCAVDISLFDG 119
Cdd:cd05716  80 WYWCGVGDDGDRG 92
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 27-119 2.71e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 84.76  E-value: 2.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346  27 GPSTITGAVGESLSVSCQYEEKFKTKDKFWCRGSlKVLCKDIVKTSSSeeVRNGRVTIRDHPDNLTFTVTYESLTLEDAD 106
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|...
gi 32189346 107 TYMCAVDISLFDG 119
Cdd:cd05716  80 WYWCGVGDDGDRG 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-112 2.04e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 2.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346    27 GPSTITGAVGESLSVSCQY--EEKFKTKDKFWCRGSLKVLCKDIV---KTSSSEEVRNGRVTIRDHPDNLTFTVTYESLT 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 32189346   102 LEDADTYMCAV 112
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 28-120 3.23e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 3.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346     28 PSTITGAVGESLSVSCQYEEkFKTKDKFWCRGSLKVLCKDivktssseevrnGRVTIRDHPDNLTFTVTyeSLTLEDADT 107
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQGGKLLAES------------GRFSVSRSGSTSTLTIS--NVTPEDSGT 65

                           90
                   ....*....|...
gi 32189346    108 YMCAVDISLFDGS 120
Cdd:smart00410  66 YTCAATNSSGSAS 78
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 27-119 2.71e-21

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 84.76  E-value: 2.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346  27 GPSTITGAVGESLSVSCQYEEKFKTKDKFWCRGSlKVLCKDIVKTSSSeeVRNGRVTIRDHPDNLTFTVTYESLTLEDAD 106
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAG 79

                        90
                ....*....|...
gi 32189346 107 TYMCAVDISLFDG 119
Cdd:cd05716  80 WYWCGVGDDGDRG 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-112 2.04e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 2.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346    27 GPSTITGAVGESLSVSCQY--EEKFKTKDKFWCRGSLKVLCKDIV---KTSSSEEVRNGRVTIRDHPDNLTFTVTYESLT 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 32189346   102 LEDADTYMCAV 112
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 28-120 3.23e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 3.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346     28 PSTITGAVGESLSVSCQYEEkFKTKDKFWCRGSLKVLCKDivktssseevrnGRVTIRDHPDNLTFTVTyeSLTLEDADT 107
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQGGKLLAES------------GRFSVSRSGSTSTLTIS--NVTPEDSGT 65

                           90
                   ....*....|...
gi 32189346    108 YMCAVDISLFDGS 120
Cdd:smart00410  66 YTCAATNSSGSAS 78
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 29-125 1.38e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 42.89  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346  29 STITGAVGESLSVSCQYEEKFKTKDKFWCR----GSLKVLckdIVKTSSSEEVRNGRVTIRDHPDNLTFTVTYESLTLED 104
Cdd:cd07706   7 PDVSVQVGEEVTLNCRYETSWTNYYLFWYKqlpsGEMTFL---IRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLED 83

                        90       100
                ....*....|....*....|.
gi 32189346 105 ADTYMCAVDISLFDGSLGFDK 125
Cdd:cd07706  84 SAKYFCALSLPYDTDKLIFGK 104
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 28-127 1.57e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.01  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189346  28 PSTITGAVGESLSVSCQYEEKFKTKDKFWCR----GSLKVLCKDIVKTSSSEEVRNGRVTIRdHPDNLTFTVTYESLTLE 103
Cdd:cd00099   5 PRSLSVQEGESVTLSCEVSSSFSSTYIYWYRqkpgQGPEFLIYLSSSKGKTKGGVPGRFSGS-RDGTSSFSLTISNLQPE 83

                        90       100
                ....*....|....*....|....
gi 32189346 104 DADTYMCAVdislFDGSLGFDKYF 127
Cdd:cd00099  84 DSGTYYCAV----SESGGTDKLTF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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