KICSTOR complex protein ITFG2 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Itfg2 | pfam15907 | Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as ... |
49-382 | 0e+00 | ||||||
Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as being integrin-alpha FG-GAP repeat-containing protein 2. : Pssm-ID: 464933 [Multi-domain] Cd Length: 331 Bit Score: 595.55 E-value: 0e+00
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| BBS2_Mid super family | cl47183 | Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ... |
22-54 | 1.09e-05 | ||||||
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia. The actual alignment was detected with superfamily member pfam14783: Pssm-ID: 405473 [Multi-domain] Cd Length: 108 Bit Score: 44.18 E-value: 1.09e-05
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| Name | Accession | Description | Interval | E-value | ||||||
| Itfg2 | pfam15907 | Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as ... |
49-382 | 0e+00 | ||||||
Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as being integrin-alpha FG-GAP repeat-containing protein 2. Pssm-ID: 464933 [Multi-domain] Cd Length: 331 Bit Score: 595.55 E-value: 0e+00
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| BBS2_Mid | pfam14783 | Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ... |
22-54 | 1.09e-05 | ||||||
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia. Pssm-ID: 405473 [Multi-domain] Cd Length: 108 Bit Score: 44.18 E-value: 1.09e-05
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| Name | Accession | Description | Interval | E-value | ||||||
| Itfg2 | pfam15907 | Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as ... |
49-382 | 0e+00 | ||||||
Integrin-alpha FG-GAP repeat-containing protein 2; Members of this family are annotated as being integrin-alpha FG-GAP repeat-containing protein 2. Pssm-ID: 464933 [Multi-domain] Cd Length: 331 Bit Score: 595.55 E-value: 0e+00
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| BBS2_Mid | pfam14783 | Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ... |
22-54 | 1.09e-05 | ||||||
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia. Pssm-ID: 405473 [Multi-domain] Cd Length: 108 Bit Score: 44.18 E-value: 1.09e-05
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| BBS2_Mid | pfam14783 | Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ... |
129-159 | 4.12e-04 | ||||||
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia. Pssm-ID: 405473 [Multi-domain] Cd Length: 108 Bit Score: 39.56 E-value: 4.12e-04
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| PHTB1_N | pfam14727 | PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a ... |
12-119 | 7.75e-03 | ||||||
PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis. Pssm-ID: 464284 Cd Length: 416 Bit Score: 38.42 E-value: 7.75e-03
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