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Conserved domains on  [gi|229608920|ref|NP_473418|]
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prolargin precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-337 3.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 3.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 102 YLYLQNNFITELPlESFQNATGLRWVNLDNNRIRKVDqRVLGKLPSLAFLYMEKNQLEEVPSALPR--NLEQLRLSQNLI 179
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 180 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRKMPPKVPQ--AIHQLYLDSNKIETIPNgy 257
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 258 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISNVpaisnKLEHLYLNNNSIEKINGTQICPNNLVAFHD 337
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-103 5.82e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 229608920    68 DCPRECYCPPdfpSALYCDSRNLRRVPVIPPRIHYL 103
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-337 3.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 3.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 102 YLYLQNNFITELPlESFQNATGLRWVNLDNNRIRKVDqRVLGKLPSLAFLYMEKNQLEEVPSALPR--NLEQLRLSQNLI 179
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 180 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRKMPPKVPQ--AIHQLYLDSNKIETIPNgy 257
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 258 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISNVpaisnKLEHLYLNNNSIEKINGTQICPNNLVAFHD 337
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLILL 317
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
129-349 7.55e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 7.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 129 LDNNRIRKVDQRVLGKLPSLaflYMEKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLdlqHNRLSdgvF 208
Cdd:PRK15370 206 LDNNELKSLPENLQGNIKTL---YANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS---C 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 209 KADTFQglKNLMQLNLAHNILRKMPPKVPQAIHQLYLDSNKI----ETIPngyfkdfPNLAFIRMNYNKLSD--RGLPkn 282
Cdd:PRK15370 277 LPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP-- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 229608920 283 sfniSNLLVLHLSHNKISNVP-AISNKLEHLYLNNNSIEKIngtqicPNNLVA--------FHDFSSDLENVPHLR 349
Cdd:PRK15370 346 ----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNALTNL------PENLPAalqimqasRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-356 2.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  99 RIHYLYLQNNFITELP-LESFQNATGLRwvnLDNNRIRKVDQrvLGKLPSLAFLYMEKNQLEEVP--SALpRNLEQLRLS 175
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLY---LYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 176 QNLISRIppgvfsklenlllldlqhnrlsDGvfkadtFQGLKNLMQLNLAHNILrkmPPKvpqaiHQLYLDSNKIETIPN 255
Cdd:cd21340   77 GNRISVV----------------------EG------LENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAALSN 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 256 gyfkdfpnlafirmnynklsdrglpknsfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKingtqicpnnlv 333
Cdd:cd21340  121 --------------------------------SLRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                        250       260
                 ....*....|....*....|...
gi 229608920 334 aFHDFSSDLENVPHLRYLRLDGN 356
Cdd:cd21340  157 -LEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
98-158 2.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 229608920   98 PRIHYLYLQNNFITELPLESFQNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQL 158
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-103 5.82e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 229608920    68 DCPRECYCPPdfpSALYCDSRNLRRVPVIPPRIHYL 103
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-98 1.13e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 229608920   68 DCPRECYCPPdfpSALYCDSRNLRRVPVIPP 98
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-337 3.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 3.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 102 YLYLQNNFITELPlESFQNATGLRWVNLDNNRIRKVDqRVLGKLPSLAFLYMEKNQLEEVPSALPR--NLEQLRLSQNLI 179
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 180 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRKMPPKVPQ--AIHQLYLDSNKIETIPNgy 257
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 258 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISNVpaisnKLEHLYLNNNSIEKINGTQICPNNLVAFHD 337
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-359 2.42e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 2.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 105 LQNNFITELPLESFQNATGLRWVNLDNNRIrkvdqrvLGKLPSLAFLYMEKNQLEEVPSALPR--NLEQLRLSQNLISRI 182
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 183 PPgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQLNLAHNILRKMPPKVPQ--AIHQLYLDSNKIETIPNGyFKD 260
Cdd:COG4886  152 PE---------------------------PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 261 FPNLAFIRMNYNKLSDrgLPKNSFNISNLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKIngtqicpnnlvafhdf 338
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDL---------------- 265

                        250       260
                 ....*....|....*....|.
gi 229608920 339 sSDLENVPHLRYLRLDGNFLK 359
Cdd:COG4886  266 -PPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-354 1.58e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  83 LYCDSRNLRRVP-VIP--PRIHYLYLQNNFITELPlESFQNATGLRWVNLDNNRIRKVDQrVLGKLPSLAFLYMEKNQLE 159
Cdd:COG4886  141 LDLSNNQLTDLPePLGnlTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 160 EVPSALPR--NLEQLRLSQNLISRIPpgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQLNLAHNILRKMPPKVP 237
Cdd:COG4886  219 DLPEPLANltNLETLDLSNNQLTDLP----------------------------ELGNLTNLEELDLSNNQLTDLPPLAN 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 238 -QAIHQLYLDSNKIETIP----NGYFKDFPNLAFIRMNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHL 312
Cdd:COG4886  271 lTNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 229608920 313 YLNNNSIEKINGTQICPNNLVAFHDFSSDLENVPHLRYLRLD 354
Cdd:COG4886  351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
168-359 2.69e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 2.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 168 NLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLMQLNLAHNI-----------------LR 230
Cdd:COG4886   47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEelsnltnlesldlsgnqLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 231 KMPPKVPQ--AIHQLYLDSNKIETIPNGyFKDFPNLAFIRMNYNKLSDrgLPKNSFNISNLLVLHLSHNKISNVP-AISN 307
Cdd:COG4886  127 DLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPePLGN 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608920 308 --KLEHLYLNNNSIEkingtqicpnnlvafhDFSSDLENVPHLRYLRLDGNFLK 359
Cdd:COG4886  204 ltNLEELDLSGNQLT----------------DLPEPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-332 4.38e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 4.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  98 PRIHYLYLQNNFITELPlESFQNATGLRWVNLDNNRIRKVDQrVLGKLPSLAFLYMEKNQLEEVP--SALPrNLEQLRLS 175
Cdd:COG4886  182 TNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLS 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 176 QNLISRIPPgvFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLMQLNLAHNILRKMPPKVPQAIHQLYLDSNKIETIPN 255
Cdd:COG4886  259 NNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 229608920 256 -GYFKDFPNLAFIRMNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPNNL 332
Cdd:COG4886  337 lTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
129-349 7.55e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 7.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 129 LDNNRIRKVDQRVLGKLPSLaflYMEKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLdlqHNRLSdgvF 208
Cdd:PRK15370 206 LDNNELKSLPENLQGNIKTL---YANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS---C 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 209 KADTFQglKNLMQLNLAHNILRKMPPKVPQAIHQLYLDSNKI----ETIPngyfkdfPNLAFIRMNYNKLSD--RGLPkn 282
Cdd:PRK15370 277 LPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP-- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 229608920 283 sfniSNLLVLHLSHNKISNVP-AISNKLEHLYLNNNSIEKIngtqicPNNLVA--------FHDFSSDLENVPHLR 349
Cdd:PRK15370 346 ----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNALTNL------PENLPAalqimqasRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-356 2.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  99 RIHYLYLQNNFITELP-LESFQNATGLRwvnLDNNRIRKVDQrvLGKLPSLAFLYMEKNQLEEVP--SALpRNLEQLRLS 175
Cdd:cd21340    3 RITHLYLNDKNITKIDnLSLCKNLKVLY---LYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 176 QNLISRIppgvfsklenlllldlqhnrlsDGvfkadtFQGLKNLMQLNLAHNILrkmPPKvpqaiHQLYLDSNKIETIPN 255
Cdd:cd21340   77 GNRISVV----------------------EG------LENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAALSN 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 256 gyfkdfpnlafirmnynklsdrglpknsfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKingtqicpnnlv 333
Cdd:cd21340  121 --------------------------------SLRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                        250       260
                 ....*....|....*....|...
gi 229608920 334 aFHDFSSDLENVPHLRYLRLDGN 356
Cdd:cd21340  157 -LEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
98-158 2.03e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 229608920   98 PRIHYLYLQNNFITELPLESFQNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQL 158
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-297 1.30e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  86 DSRNLRRVpvippRIHylylQNNFITELPlesfQNATGLRWVNL----DNNRIRKVDQRVLgKLPSLAFLYMEKNQ-LEE 160
Cdd:PLN00113 402 ACRSLRRV-----RLQ----DNSFSGELP----SEFTKLPLVYFldisNNNLQGRINSRKW-DMPSLQMLSLARNKfFGG 467

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 161 VP-SALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILRKmppkvpqa 239
Cdd:PLN00113 468 LPdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLSHNQLSG-------- 537

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 229608920 240 ihqlyldsnkieTIPNGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHN 297
Cdd:PLN00113 538 ------------QIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-367 1.55e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  99 RIHYLYLQNNFIT-ELPLeSFQNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQLE-EVPSALPR--NLEQLRL 174
Cdd:PLN00113 165 SLKVLDLGGNVLVgKIPN-SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGltSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 175 S-QNLISRIPPGVFSKLENLLLLDLQhNRLSDGVFKadTFQGLKNLMQLNLAHNILRKMPPKVP---QAIHQLYLDSNKI 250
Cdd:PLN00113 244 VyNNLTGPIPSSLGNLKNLQYLFLYQ-NKLSGPIPP--SIFSLQKLISLDLSDNSLSGEIPELViqlQNLEILHLFSNNF 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 251 E-TIPNGyFKDFPNLAFIRMNYNKLSDrGLPKNSFNISNLLVLHLSHN----KISNVPAISNKLEHLYLNNNSIEkingT 325
Cdd:PLN00113 321 TgKIPVA-LTSLPRLQVLQLWSNKFSG-EIPKNLGKHNNLTVLDLSTNnltgEIPEGLCSSGNLFKLILFSNSLE----G 394

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 229608920 326 QICPnnlvafhdfssDLENVPHLRYLRLDGNFLKPPIPLDLM 367
Cdd:PLN00113 395 EIPK-----------SLGACRSLRRVRLQDNSFSGELPSEFT 425
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-346 3.34e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.55  E-value: 3.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  75 CPPDFPSALYCDSRNLRRVPVIPPRIHYLYLQNNFITELPLEsfqnATGLRWVNLDNNRIRKvdqrvLGKLPS-LAFLYM 153
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVL----PPGLLELSIFSNPLTH-----LPALPSgLCKLWI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 154 EKNQLEEVPsALPRNLEQLRLSQNLISRIP--PGVFSKLENLLLLDLQHNRLSDGvfkadtfqglknLMQLNLAHNILRK 231
Cdd:PRK15387 290 FGNQLTSLP-VLPPGLQELSVSDNQLASLPalPSELCKLWAYNNQLTSLPTLPSG------------LQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 232 MpPKVPQAIHQLYLDSNKIETIPngyfkdfpnlafirmnynklsdrGLPknsfniSNLLVLHLSHNKISNVPAISNKLEH 311
Cdd:PRK15387 357 L-PTLPSELYKLWAYNNRLTSLP-----------------------ALP------SGLKELIVSGNRLTSLPVLPSELKE 406

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 229608920 312 LYLNNNsieKINGTQICPNNLVAFHDFSSDLENVP 346
Cdd:PRK15387 407 LMVSGN---RLTSLPMLPSGLLSLSVYRNQLTRLP 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
76-220 7.47e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 7.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  76 PPDFPSAL-YCD--SRNLRRVPV-IPPRIHYLYLQNNFITELP---------LESFQNA---------TGLRWVNLDNNR 133
Cdd:PRK15370 278 PENLPEELrYLSvyDNSIRTLPAhLPSGITHLNVQSNSLTALPetlppglktLEAGENAltslpaslpPELQVLDVSKNQ 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 134 IRKVDQRVlgkLPSLAFLYMEKNQLEEVPSALPRNLEQLRLSQNLISRIP---PGVFSKLENLLLLDLQHNRLSDgvfka 210
Cdd:PRK15370 358 ITVLPETL---PPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPeslPHFRGEGPQPTRIIVEYNPFSE----- 429

                        170
                 ....*....|
gi 229608920 211 DTFQGLKNLM 220
Cdd:PRK15370 430 RTIQNMQRLM 439
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 240-370 5.19e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 240 IHQLYLDSNKIETIPNgyFKDFPNLAFIRMNYNKLSD-RGLPKNSfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNN 316
Cdd:cd21340    4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKiENLEFLT----NLTHLYLQNNQIEKIENLENlvNLKKLYLGG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 229608920 317 NSIEKINGtqicpnnlvafhdfssdLENVPHLRYLRLDGNFLkppiPLDLMMCF 370
Cdd:cd21340   78 NRISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-366 5.54e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  98 PRIHYLYLQNNFIT-ELPLESFQNATGLRWVNLDNNRIRKVDQRvlGKLPSLAFLYMEKNQLE-EVPSALP--RNLEQLR 173
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSgEIPNDIGsfSSLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 174 LSQN-LISRIPPGVfSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILR-KMPPKVPQAIHQLYLD---SN 248
Cdd:PLN00113 171 LGGNvLVGKIPNSL-TNLTSLEFLTLASNQLVGQI--PRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlvyNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 249 KIETIPNGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPAISNKLEhlylnnnsiekingtqi 327
Cdd:PLN00113 248 LTGPIPSS-LGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQ----------------- 308

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 229608920 328 cpnNLVAFHDFSSD--------LENVPHLRYLRLDGNFLKPPIPLDL 366
Cdd:PLN00113 309 ---NLEILHLFSNNftgkipvaLTSLPRLQVLQLWSNKFSGEIPKNL 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-229 1.08e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  98 PRIHYLYL-QNNFITELPlESFqNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQLE-EVPSALP--RNLEQLR 173
Cdd:PLN00113 452 PSLQMLSLaRNKFFGGLP-DSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLD 529

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608920 174 LSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKadTFQGLKNLMQLNLAHNIL 229
Cdd:PLN00113 530 LSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPK--NLGNVESLVQVNISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 98-359 2.14e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  98 PRIHYLYLQNNFITEL---PLESFQNATGLRWVNLDNNRIRKvdqrvlGKLPSLAflymeknqleEVPSALPRNLEQLRL 174
Cdd:cd00116   81 CGLQELDLSDNALGPDgcgVLESLLRSSSLQELKLNNNGLGD------RGLRLLA----------KGLKDLPPALEKLVL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 175 SQNLISrippgvfsklenlllldlqhNRLSDGVfkADTFQGLKNLMQLNLAHNILRkmppkvPQAIHQLYLDsnkietip 254
Cdd:cd00116  145 GRNRLE--------------------GASCEAL--AKALRANRDLKELNLANNGIG------DAGIRALAEG-------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 255 ngyFKDFPNLAFIRMNYNKLSDRG-------LPKNSFnisnLLVLHLSHNKISNVPA---------ISNKLEHLYLNNNS 318
Cdd:cd00116  189 ---LKANCNLEVLDLNNNGLTDEGasalaetLASLKS----LEVLNLGDNNLTDAGAaalasallsPNISLLTLSLSCND 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 229608920 319 IEkingtqicpnnLVAFHDFSSDLENVPHLRYLRLDGNFLK 359
Cdd:cd00116  262 IT-----------DDGAKDLAEVLAEKESLLELDLRGNKFG 291
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-103 5.82e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 229608920    68 DCPRECYCPPdfpSALYCDSRNLRRVPVIPPRIHYL 103
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 90-326 3.50e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 46.02  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920   90 LRRVPVIPPRIHYLYLQNNFITELPlesfqnaTGLRWVNLDN-----NRIRKVDQRV--LGKL-----PSLAFLYMEKNQ 157
Cdd:PLN03210  717 LKSFPDISTNISWLDLDETAIEEFP-------SNLRLENLDElilceMKSEKLWERVqpLTPLmtmlsPSLTRLFLSDIP 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  158 -LEEVPSALpRNLEQL-RLS----QNLISrIPPGVfsklenlllldlqhnrlsdgvfkadtfqGLKNLMQLNLAHNILRK 231
Cdd:PLN03210  790 sLVELPSSI-QNLHKLeHLEiencINLET-LPTGI----------------------------NLESLESLDLSGCSRLR 839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  232 MPPKVPQAIHQLYLDSNKIETIPnGYFKDFPNLAFIRMNynklSDRGLPKNSFNISNLlvLHLSHNKISNVPAISnkleH 311
Cdd:PLN03210  840 TFPDISTNISDLNLSRTGIEEVP-WWIEKFSNLSFLDMN----GCNNLQRVSLNISKL--KHLETVDFSDCGALT----E 908

                         250
                  ....*....|....*
gi 229608920  312 LYLNNNSIEKINGTQ 326
Cdd:PLN03210  909 ASWNGSPSEVAMATD 923
LRR_8 pfam13855
Leucine rich repeat;
287-356 5.14e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.14e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 229608920  287 SNLLVLHLSHNKISNVPAIS----NKLEHLYLNNNSIEKINGtqicpnnlVAFHDFssdlenvPHLRYLRLDGN 356
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkglSNLKVLDLSNNLLTTLSP--------GAFSGL-------PSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
243-299 6.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 229608920  243 LYLDSNKIETIPNGYFKDFPNLAFIRMNYNKLSdrGLPKNSF-NISNLLVLHLSHNKI 299
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFsGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-373 1.52e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  96 IPP------RIHYLYL-QNNFITELPLESFqNATGLRWVNLDNNRIRKVDQRVLGKLPSLAFLYMEKNQLE-EVP---SA 164
Cdd:PLN00113 252 IPSslgnlkNLQYLFLyQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPvalTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 165 LPRnLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILRKMPPK---VPQAIH 241
Cdd:PLN00113 331 LPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGEIPKslgACRSLR 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 242 QLYLDSNKIE-TIPNGYFKdFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPAI--SNKLEHLYLNNN 317
Cdd:PLN00113 408 RVRLQDNSFSgELPSEFTK-LPLVYFLDISNNNLQGR-INSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRLENLDLSRN 485

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 229608920 318 sieKINGTqiCPNNLVAFhdfssdlenvPHLRYLRLDGNFLKPPIPLDLMMCFRLL 373
Cdd:PLN00113 486 ---QFSGA--VPRKLGSL----------SELMQLKLSENKLSGEIPDELSSCKKLV 526
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-304 1.57e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  98 PRIHYLYL-QNNFITELP--LESFQNATGLrwvNLDNNRIRkvdqrvlGKLP-------SLAFLYMEKNQLE-EVPSALP 166
Cdd:PLN00113 332 PRLQVLQLwSNKFSGEIPknLGKHNNLTVL---DLSTNNLT-------GEIPeglcssgNLFKLILFSNSLEgEIPKSLG 401

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 167 --RNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNilrKMPPKVPQA----- 239
Cdd:PLN00113 402 acRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI--NSRKWDMPSLQMLSLARN---KFFGGLPDSfgskr 476

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229608920 240 IHQLYLDSNKI-ETIPNGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPA 304
Cdd:PLN00113 477 LENLDLSRNQFsGAVPRK-LGSLSELMQLKLSENKLSGE-IPDELSSCKKLVSLDLSHNQLSgQIPA 541
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-98 1.13e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 229608920   68 DCPRECYCPPdfpSALYCDSRNLRRVPVIPP 98
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 288-324 1.15e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 229608920  288 NLLVLHLSHNKISNVPAISN--KLEHLYL-NNNSIEKING 324
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKlpNLETLDLsGNNKITDLSD 41
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 96-319 1.16e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920  96 IPPRIHYLYLQNNFITELPLESF----QNATGLRWVNLDNNRIRkvDQRVLGKLPSLAF------LYMEKNQLEE----- 160
Cdd:COG5238  206 QNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIG--DEGVIALAEALKNnttvetLYLSGNQIGAegaia 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 161 VPSALPRN--LEQLRLSQNLIsrippgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQlNLAHNilrkmppkvpQ 238
Cdd:COG5238  284 LAKALQGNttLTSLDLSVNRI--------------------------------GDEGAIALAE-GLQGN----------K 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229608920 239 AIHQLYLDSNKI---------ETIpngyfKDFPNLAFIRMNYNKLSDRG---LPKNSFNISNLLVLHLSHNKISNVPAIS 306
Cdd:COG5238  321 TLHTLNLAYNGIgaqgaialaKAL-----QENTTLHSLDLSDNQIGDEGaiaLAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                        250       260
                 ....*....|....*....|
gi 229608920 307 -------NKLEHLYLNNNSI 319
Cdd:COG5238  396 lidalqtNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
167-227 1.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 229608920  167 RNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSdgVFKADTFQGLKNLMQLNLAHN 227
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
199-250 4.18e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 4.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 229608920  199 QHNRLSdgVFKADTFQGLKNLMQLNLAHNILRKMPPKVPQAIHQ---LYLDSNKI 250
Cdd:pfam13855   9 SNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSlryLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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