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Conserved domains on  [gi|124286841|ref|NP_444303|]
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low-density lipoprotein receptor-related protein 8 isoform a precursor [Mus musculus]

Protein Classification

LY and Ldl_recept_b domain-containing protein( domain architecture ID 10819326)

protein containing domains LDLa, FXa_inhibition, LY, and Ldl_recept_b

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 585-625 2.99e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.99e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124286841  585 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 625
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-564 1.16e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.16e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124286841   523 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 564
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 6.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 609-651 6.39e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 124286841   609 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 651
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 1.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.29e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-325 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.06e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841 291 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 325
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 6.01e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 124286841 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 672-712 3.34e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.34e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 124286841  672 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 712
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 6.57e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.57e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 373-407 4.03e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 4.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124286841  373 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 407
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 2.19e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.89  E-value: 2.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 124286841 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
329-365 6.50e-06

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 124286841  329 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 365
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
409-439 3.24e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.24e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   409 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 439
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 478-513 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124286841   478 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 513
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 730-767 3.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.07  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124286841  730 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 767
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 585-625 2.99e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.99e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124286841  585 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 625
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-564 1.16e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.16e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124286841   523 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 564
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 6.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 609-651 6.39e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 124286841   609 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 651
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 566-608 2.54e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 2.54e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 124286841   566 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 608
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 543-582 5.65e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 5.65e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124286841  543 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 582
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 9.32e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 9.32e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841    40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 1.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.29e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-325 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.06e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841 291 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 325
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 6.01e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 124286841 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
256-286 6.63e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.63e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 124286841  256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 6.76e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 6.76e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 124286841  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
290-325 1.33e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 1.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124286841  290 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 325
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 2.80e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 2.80e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 124286841   41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 672-712 3.34e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.34e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 124286841  672 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 712
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 526-710 4.01e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 526 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 594
Cdd:cd05819   51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 595 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 666
Cdd:cd05819  129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 124286841 667 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 710
Cdd:cd05819  201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 291-322 5.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.84e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 124286841   291 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 322
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 6.57e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.57e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 200-233 8.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 8.21e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 124286841 200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-283 1.78e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.78e-07
                           10        20
                   ....*....|....*....|....*...
gi 124286841   256 QFTCRSGECIHLGWRCDGDRDCKDKSDE 283
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 629-671 1.79e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.79e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124286841  629 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 671
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 2.46e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 2.46e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124286841   78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 373-407 4.03e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 4.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124286841  373 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 407
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 2.19e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.89  E-value: 2.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 124286841 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
200-233 5.95e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 5.95e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124286841  200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
329-365 6.50e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 124286841  329 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 365
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
541-692 1.05e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 541 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 616
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 617 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 692
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 333-363 2.97e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 2.97e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 124286841 333 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 363
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
409-439 3.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.24e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   409 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 439
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 333-363 4.19e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 4.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 124286841   333 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 363
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 1.03e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 124286841   120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 478-513 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124286841   478 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 513
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-442 1.08e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.08e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 124286841 409 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 442
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 1.10e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.31  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 124286841  121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 730-767 3.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.07  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124286841  730 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 767
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 585-625 2.99e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.99e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124286841  585 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 625
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-564 1.16e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.16e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 124286841   523 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 564
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 6.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 609-651 6.39e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 124286841   609 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 651
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 566-608 2.54e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 2.54e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 124286841   566 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 608
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 543-582 5.65e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 5.65e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124286841  543 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 582
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 9.32e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 9.32e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841    40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 1.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.29e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841    79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-325 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.06e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124286841 291 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 325
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 256-286 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 6.01e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 124286841 256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
256-286 6.63e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.63e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 124286841  256 QFTCRSGECIHLGWRCDGDRDCKDKSDEADC 286
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 6.76e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 6.76e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 124286841  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
290-325 1.33e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 1.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124286841  290 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 325
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 2.80e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 2.80e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 124286841   41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 672-712 3.34e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 3.34e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 124286841  672 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 712
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 526-710 4.01e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 526 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 594
Cdd:cd05819   51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 595 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 666
Cdd:cd05819  129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 124286841 667 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 710
Cdd:cd05819  201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 526-710 5.09e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.40  E-value: 5.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 526 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMY-----------W 589
Cdd:cd05819    4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYvadtgnhriqkF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 590 SDWGfqAKIEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGnrkmLIF-------STDFLS 662
Cdd:cd05819   82 DPDG--NFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGE----FLTtfgsggsGPGQFN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124286841 663 HPFGVAVF-EDKVFWTDLENEAI--FSAnrlNGLEIAILAEN------LNNPHDIVI 710
Cdd:cd05819  150 GPTGVAVDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 291-322 5.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.84e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 124286841   291 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 322
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 200-232 6.57e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.57e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDE 232
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 200-233 8.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 8.21e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 124286841 200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 256-283 1.78e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.78e-07
                           10        20
                   ....*....|....*....|....*...
gi 124286841   256 QFTCRSGECIHLGWRCDGDRDCKDKSDE 283
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 629-671 1.79e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.79e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124286841  629 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 671
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 2.46e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 2.46e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124286841   78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 373-407 4.03e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 4.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124286841  373 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 407
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 2.19e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.89  E-value: 2.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 124286841 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112    1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
200-233 5.95e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 5.95e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124286841  200 CPPREFRCGGGgTCIPERWVCDRQFDCEDRSDEA 233
Cdd:pfam00057   3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
329-365 6.50e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 124286841  329 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 365
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
541-692 1.05e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 541 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 616
Cdd:COG3391   79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 617 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 692
Cdd:COG3391  152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 526-678 2.36e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.31  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 526 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRcTLF------SRELSEPRAIAVDPlRGFMYWSDWG------ 593
Cdd:cd05819   98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFL-TTFgsggsgPGQFNGPTGVAVDS-DGNIYVADTGnhriqv 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 594 ------FQAKIEKAGLNGADRQTlvsdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNG------GNRkmlIFSTDFL 661
Cdd:cd05819  175 fdpdgnFLTTFGSTGTGPGQFNY--------PTGIAVD-SDGNIYVADSGNNRVQVFDPDGagfggnGNF---LGSDGQF 242

                        170
                 ....*....|....*...
gi 124286841 662 SHPFGVAVFED-KVFWTD 678
Cdd:cd05819  243 NRPSGLAVDSDgNLYVAD 260
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 333-363 2.97e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 2.97e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 124286841 333 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 363
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
409-439 3.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.24e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 124286841   409 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 439
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 333-363 4.19e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 4.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 124286841   333 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 363
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 528-684 9.08e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.35  E-value: 9.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 528 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPLrGFMYWSD-WGFqaKIEKA 601
Cdd:cd14956   11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 602 GLNGADRQTL-VSDNIE----WPNGITLDllSQRLYWVdsklhqlssIDFngGNRKMLIFSTD--FLS------------ 662
Cdd:cd14956   87 TLTGELQTIGgSSGSGPgqfnAPRGVAVD--ADGNLYV---------ADF--GNQRIQKFDPDgsFLRqwggtgiepgsf 153

                        170       180
                 ....*....|....*....|....
gi 124286841 663 -HPFGVAVFEDKVFW-TDLENEAI 684
Cdd:cd14956  154 nYPRGVAVDPDGTLYvADTYNDRI 177
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 1.03e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 124286841   120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 478-513 1.04e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.66  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124286841   478 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 513
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-442 1.08e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.08e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 124286841 409 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 442
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 1.10e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.31  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 124286841  121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 493-669 1.61e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.50  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 493 ATNRIYWCDLSYRKIYSAHMDkasipDEQVVLIDEQLHSPEGLAVD-----WVhkhiywTDSGNKTISVATTDGRRR--C 565
Cdd:COG3386   17 PDGRLYWVDIPGGRIHRYDPD-----GGAVEVFAEPSGRPNGLAFDpdgrlLV------ADHGRGLVRFDPADGEVTvlA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 566 TLFSRELSEPRAIAVDPlRGFMYWSDwgFQAKIEKAGL---NGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 642
Cdd:COG3386   86 DEYGKPLNRPNDGVVDP-DGRLYFTD--MGEYLPTGALyrvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIY 162

                        170       180       190
                 ....*....|....*....|....*....|.
gi 124286841 643 SIDFNG----GNRKMLIFSTDFLSHPFGVAV 669
Cdd:COG3386  163 RFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 526-713 3.34e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.43  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 526 DEQLHSPEGLAVDWvhKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDWGFQaKIEK 600
Cdd:cd14963    6 GDPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPgtgpgEFKYPYGIAVDS-DGNIYVADLYNG-RIQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 601 AGLNGADRQTLVSD----NIEWPNGITLDllSQRLYWVDSKLHQLSSIDFNGgnRKMLIFST--DF---LSHPFGVAVFE 671
Cdd:cd14963   82 FDPDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KLLLEFGKpgSEpgeLSYPNGIAVDE 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124286841 672 DK-VFWTDLENEAI--FSAN-----RLNGLEIAilAENLNNP------------------HDIVIFHE 713
Cdd:cd14963  158 DGnIYVADSGNGRIqvFDKNgkfikELNGSPDG--KSGFVNPrgiavdpdgnlyvvdnlsHRVYVFDE 223
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 449-639 5.89e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.96  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 449 AVAGKSPSLIF---TNRHEVRRIDLVKRDYSRLIP----MLKNVVALDVEVAtNRIYWCDLSYRKIYsaHMDkasiPDEQ 521
Cdd:cd14962   16 GVAADGRGRIYvadTGRGAVFVFDLPNGKVFVIGNagpnRFVSPIGVAIDAN-GNLYVSDAELGKVF--VFD----RDGK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 522 VV-LIDE--QLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDwG 593
Cdd:cd14962   89 FLrAIGAgaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgpgEFNLPTDLAVDR-DGNLYVTD-T 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124286841 594 FQAKIEKAGLNGADRQT-----LVSDNIEWPNGITLDlLSQRLYWVDSKLH 639
Cdd:cd14962  167 MNFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAFD 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 495-539 9.82e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 9.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 124286841  495 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIDEQLHSPEGLAVDW 539
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
460-593 1.53e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286841 460 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYsahmdKASIPDEQVVLIDEQLHSPEGLAVDW 539
Cdd:COG3391   87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVS-----VIDTATGKVVATIPVGAGPHGIAVDP 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124286841 540 VHKHIYWTDSGNKTISV-----ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWG 593
Cdd:COG3391  162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 730-767 3.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.07  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124286841  730 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 767
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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