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Conserved domains on  [gi|16445029|ref|NP_443100|]
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immunoglobulin superfamily member 8 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-149 4.75e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029    28 REVLVPEGplyrvagTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaVFKSRVvagEVQVQRLQG 107
Cdd:pfam07686   4 REVTVALG-------GSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 16445029   108 DAVvLKIARLQAQDAGIYECHTPSTDTRYLGSysgKVELRVL 149
Cdd:pfam07686  72 DGS-LTIQNLTLSDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 451-545 2.42e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 451 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 530
Cdd:cd00099   9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                        90
                ....*....|....*
gi 16445029 531 LHSLGPEDEGVYHCA 545
Cdd:cd00099  77 ISNLQPEDSGTYYCA 91
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 318-419 1.23e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 318 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 396
Cdd:cd00099  12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                        90       100
                ....*....|....*....|....*....
gi 16445029 397 RPGDAGTYRCLAKA------YVRGSGTRL 419
Cdd:cd00099  81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
PksD super family cl43841
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 158-600 4.18e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


The actual alignment was detected with superfamily member COG3321:

Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 40.24  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  158 APPGPRGRQAPTSPPrmtvhEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAER 237
Cdd:COG3321  854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  238 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 317
Cdd:COG3321  929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  318 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 397
Cdd:COG3321 1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  398 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 477
Cdd:COG3321 1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  478 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 557
Cdd:COG3321 1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 16445029  558 YQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLG 600
Cdd:COG3321 1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-149 4.75e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029    28 REVLVPEGplyrvagTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaVFKSRVvagEVQVQRLQG 107
Cdd:pfam07686   4 REVTVALG-------GSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 16445029   108 DAVvLKIARLQAQDAGIYECHTPSTDTRYLGSysgKVELRVL 149
Cdd:pfam07686  72 DGS-LTIQNLTLSDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 451-545 2.42e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 451 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 530
Cdd:cd00099   9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                        90
                ....*....|....*
gi 16445029 531 LHSLGPEDEGVYHCA 545
Cdd:cd00099  77 ISNLQPEDSGTYYCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-148 1.19e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 1.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029     35 GPLYRVAGTAVSISCNVTGYEGPaqqNFEWFLYRPEAPDTALGIVSTKDtqfsyavfksrvvagevqvqrlqGDAVVLKI 114
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP---EVTWYKQGGKLLAESGRFSVSRS-----------------------GSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 16445029    115 ARLQAQDAGIYECHTpstdTRYLGSYSGKVELRV 148
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 318-419 1.23e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 318 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 396
Cdd:cd00099  12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                        90       100
                ....*....|....*....|....*....
gi 16445029 397 RPGDAGTYRCLAKA------YVRGSGTRL 419
Cdd:cd00099  81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 158-600 4.18e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 40.24  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  158 APPGPRGRQAPTSPPrmtvhEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAER 237
Cdd:COG3321  854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  238 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 317
Cdd:COG3321  929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  318 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 397
Cdd:COG3321 1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  398 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 477
Cdd:COG3321 1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  478 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 557
Cdd:COG3321 1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 16445029  558 YQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLG 600
Cdd:COG3321 1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 309-420 8.45e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029   309 VGPGERRIGPGEPLELLCnvsgALPPAGRHAAYSVGWEMAPAGApGPGRLVA-QLDTEGVGSLGPGYEGRHIAMEKVASr 387
Cdd:pfam07686   1 QTPREVTVALGGSVTLPC----TYSSSMSEASTSVYWYRQPPGK-GPTFLIAyYSNGSEEGVKKGRFSGRGDPSNGDGS- 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 16445029   388 tyrLRLEAARPGDAGTYRCLA---KAYVRGSGTRLR 420
Cdd:pfam07686  75 ---LTIQNLTLSDSGTYTCAVipsGEGVFGKGTRLT 107
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-149 4.75e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029    28 REVLVPEGplyrvagTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaVFKSRVvagEVQVQRLQG 107
Cdd:pfam07686   4 REVTVALG-------GSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 16445029   108 DAVvLKIARLQAQDAGIYECHTPSTDTRYLGSysgKVELRVL 149
Cdd:pfam07686  72 DGS-LTIQNLTLSDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 451-545 2.42e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 451 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 530
Cdd:cd00099   9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                        90
                ....*....|....*
gi 16445029 531 LHSLGPEDEGVYHCA 545
Cdd:cd00099  77 ISNLQPEDSGTYYCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-148 1.19e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 1.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029     35 GPLYRVAGTAVSISCNVTGYEGPaqqNFEWFLYRPEAPDTALGIVSTKDtqfsyavfksrvvagevqvqrlqGDAVVLKI 114
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP---EVTWYKQGGKLLAESGRFSVSRS-----------------------GSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 16445029    115 ARLQAQDAGIYECHTpstdTRYLGSYSGKVELRV 148
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 318-419 1.23e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029 318 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 396
Cdd:cd00099  12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                        90       100
                ....*....|....*....|....*....
gi 16445029 397 RPGDAGTYRCLAKA------YVRGSGTRL 419
Cdd:cd00099  81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 158-600 4.18e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 40.24  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  158 APPGPRGRQAPTSPPrmtvhEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAER 237
Cdd:COG3321  854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  238 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 317
Cdd:COG3321  929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  318 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 397
Cdd:COG3321 1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  398 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 477
Cdd:COG3321 1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029  478 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 557
Cdd:COG3321 1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 16445029  558 YQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLG 600
Cdd:COG3321 1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 309-420 8.45e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445029   309 VGPGERRIGPGEPLELLCnvsgALPPAGRHAAYSVGWEMAPAGApGPGRLVA-QLDTEGVGSLGPGYEGRHIAMEKVASr 387
Cdd:pfam07686   1 QTPREVTVALGGSVTLPC----TYSSSMSEASTSVYWYRQPPGK-GPTFLIAyYSNGSEEGVKKGRFSGRGDPSNGDGS- 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 16445029   388 tyrLRLEAARPGDAGTYRCLA---KAYVRGSGTRLR 420
Cdd:pfam07686  75 ---LTIQNLTLSDSGTYTCAVipsGEGVFGKGTRLT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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