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Conserved domains on  [gi|14249168|ref|NP_116025|]
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proline/serine-rich coiled-coil protein 1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GTSE1_N super family cl21116
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
8-122 1.10e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


The actual alignment was detected with superfamily member pfam15259:

Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.95  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168     8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14249168    83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
98-333 3.15e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   98 SAGEGLGPRRVK---PSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSG-KRPSNMKR 173
Cdd:PRK07003 366 GAPGGGVPARVAgavPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATAdRGDDAADG 445
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  174 ESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAP--QPSTSNSQRLPRPQGAAAKSSSQLPIPS 251
Cdd:PRK07003 446 DAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRaaAPSAATPAAVPDARAPAAASREDAPAAA 525
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  252 AIPRPASRMPLTSRSVPPGRGALPPDSL----------STRKGLPRPSTAGHRVRESGHKVPVSQRLNLPV--MGATRSN 319
Cdd:PRK07003 526 APPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVptPRARAAT 605
                        250
                 ....*....|....
gi 14249168  320 LQPPRKVAVPGPTR 333
Cdd:PRK07003 606 GDAPPNGAARAEQA 619
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
8-122 1.10e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.95  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168     8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14249168    83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
98-333 3.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   98 SAGEGLGPRRVK---PSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSG-KRPSNMKR 173
Cdd:PRK07003 366 GAPGGGVPARVAgavPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATAdRGDDAADG 445
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  174 ESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAP--QPSTSNSQRLPRPQGAAAKSSSQLPIPS 251
Cdd:PRK07003 446 DAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRaaAPSAATPAAVPDARAPAAASREDAPAAA 525
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  252 AIPRPASRMPLTSRSVPPGRGALPPDSL----------STRKGLPRPSTAGHRVRESGHKVPVSQRLNLPV--MGATRSN 319
Cdd:PRK07003 526 APPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVptPRARAAT 605
                        250
                 ....*....|....
gi 14249168  320 LQPPRKVAVPGPTR 333
Cdd:PRK07003 606 GDAPPNGAARAEQA 619
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
148-312 5.53e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 38.63  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   148 LRSNDRKGSVRALRatSGKRPsnMKRESPTCNLFPAskspassplTRSTPPVRGRAGpsgrAAASPPTPIR-SVLAPQPS 226
Cdd:TIGR01628 362 QRKEQRRAHLQDQF--MQLQP--RMRQLPMGSPMGG---------AMGQPPYYGQGP----QQQFNGQPLGwPRMSMMPT 424
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   227 TSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRgalppdSLSTRKGLPRPSTAGHRVRESghKVPVSQ 306
Cdd:TIGR01628 425 PMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQ------SLPLSQDLPQPQSTASQGGQN--KKLAQV 496

                  ....*.
gi 14249168   307 RLNLPV 312
Cdd:TIGR01628 497 LASATP 502
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
8-122 1.10e-11

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 61.95  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168     8 VRFIVDETLDFGgLSPSDSREEEDITVLVTPEKPLRRGLS-----HRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEAN 82
Cdd:pfam15259   1 VLLLADEKFDFD-LSLSPSSANEDDEVFVGPVGHKERCVAasvelNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAH 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14249168    83 RLAAQLEQCALQDRESAGEGLGP----------------------RRVKPSPR---RETFVLKDS 122
Cdd:pfam15259  80 LLALQLESSSKNEAAKAAQPEDPssqgvekfvqdsklklnlfekeKEMEKSPRsikRETYCVQDS 144
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
98-333 3.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   98 SAGEGLGPRRVK---PSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSG-KRPSNMKR 173
Cdd:PRK07003 366 GAPGGGVPARVAgavPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATAdRGDDAADG 445
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  174 ESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAP--QPSTSNSQRLPRPQGAAAKSSSQLPIPS 251
Cdd:PRK07003 446 DAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRaaAPSAATPAAVPDARAPAAASREDAPAAA 525
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  252 AIPRPASRMPLTSRSVPPGRGALPPDSL----------STRKGLPRPSTAGHRVRESGHKVPVSQRLNLPV--MGATRSN 319
Cdd:PRK07003 526 APPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVptPRARAAT 605
                        250
                 ....*....|....
gi 14249168  320 LQPPRKVAVPGPTR 333
Cdd:PRK07003 606 GDAPPNGAARAEQA 619
PHA03247 PHA03247
large tegument protein UL36; Provisional
128-331 1.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   128 LPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTcnlfpASKSPASSPLTRSTPPVRGRAGPSG 207
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA-----PPAAPAAGPPRRLTRPAVASLSESR 2795
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   208 RAAASPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLtsrsvPPGrGALPPDSLSTRKGLPR 287
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-----PLG-GSVAPGGDVRRRPPSR 2869
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 14249168   288 PSTAGHRVREsghKVPVSQRLNLPVMGATRSNLQPPRKVAVPGP 331
Cdd:PHA03247 2870 SPAAKPAAPA---RPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
137-277 1.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  137 STPSPSSLTPRlrsNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPV---RGRAGPSGRAAASP 213
Cdd:PRK12323 372 AGPATAAAAPV---AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEalaAARQASARGPGGAP 448
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14249168  214 PTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPD 277
Cdd:PRK12323 449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPA 512
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
181-307 4.86e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.54  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  181 FPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRM 260
Cdd:PRK14951 364 FKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 14249168  261 PLTSRSVPPGRGALPPDSLSTRKGlPRPSTAGHRVRESGHKVPVSQR 307
Cdd:PRK14951 444 AVALAPAPPAQAAPETVAIPVRVA-PEPAVASAAPAPAAAPAAARLT 489
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
148-312 5.53e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 38.63  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   148 LRSNDRKGSVRALRatSGKRPsnMKRESPTCNLFPAskspassplTRSTPPVRGRAGpsgrAAASPPTPIR-SVLAPQPS 226
Cdd:TIGR01628 362 QRKEQRRAHLQDQF--MQLQP--RMRQLPMGSPMGG---------AMGQPPYYGQGP----QQQFNGQPLGwPRMSMMPT 424
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168   227 TSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRgalppdSLSTRKGLPRPSTAGHRVRESghKVPVSQ 306
Cdd:TIGR01628 425 PMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQPVMYPPNYQ------SLPLSQDLPQPQSTASQGGQN--KKLAQV 496

                  ....*.
gi 14249168   307 RLNLPV 312
Cdd:TIGR01628 497 LASATP 502
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
182-292 5.73e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249168  182 PASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRM- 260
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPa 455
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 14249168  261 --------PLTSRSVPPGRGALPPDSLSTRKGLPRPSTAG 292
Cdd:PRK12323 456 aapaaaarPAAAGPRPVAAAAAAAPARAAPAAAPAPADDD 495
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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