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Conserved domains on  [gi|70887605|ref|NP_083436|]
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sperm-associated antigen 16 protein isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-638 1.21e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.21e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 352 LNNIFRLHELPVSCIVMHPCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDL 431
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 432 NKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLS 511
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 512 VWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASAN 591
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 592 GIIHLLDLKSGQIHK-LVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:cd00200 241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-638 1.21e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.21e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 352 LNNIFRLHELPVSCIVMHPCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDL 431
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 432 NKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLS 511
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 512 VWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASAN 591
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 592 GIIHLLDLKSGQIHK-LVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:cd00200 241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
355-638 9.99e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 252.91  E-value: 9.99e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 355 IFRLHELPVSCIVMHPCRDYLISCSED---RLWKmvgLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDL 431
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADgtvRLWD---LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 432 NKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLS 511
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 512 VWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASAN 591
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 592 GIIHLLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 352 GTVRLWDLATGElLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PTZ00421 PTZ00421
coronin; Provisional
 410-572 4.88e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 68.77  E-value: 4.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  410 FHP-SGSKLATSSGDSTIKLWDL-------NKGECTLTLEGHNHAVWSCTWH-SCGDFVASASLDMTSKIWDVNSERCRY 480
Cdd:PTZ00421  83 FNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGKAVE 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  481 TLYGHTDSVNSIEFFPFSNILLTASADKTLSVWDARTGKCEQSLYGHMHSVND-ATFTPRGHIIASCdarGVTK------ 553
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITL---GCSKsqqrqi 239

                        170       180
                 ....*....|....*....|.
gi 70887605  554 -LWDFRKLI-PIVSIDVGPSS 572
Cdd:PTZ00421 240 mLWDTRKMAsPYSTVDLDQSS 260
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 475-514 6.75e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 6.75e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 70887605    475 SERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWD 514
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
434-472 1.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 70887605   434 GECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWD 472
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-638 1.21e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.21e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 352 LNNIFRLHELPVSCIVMHPCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDL 431
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 432 NKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLS 511
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 512 VWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASAN 591
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 592 GIIHLLDLKSGQIHK-LVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:cd00200 241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
355-638 9.99e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 252.91  E-value: 9.99e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 355 IFRLHELPVSCIVMHPCRDYLISCSED---RLWKmvgLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDL 431
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADgtvRLWD---LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 432 NKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLS 511
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 512 VWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASAN 591
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 592 GIIHLLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 352 GTVRLWDLATGElLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
351-638 4.24e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 4.24e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 351 KLNNIFRLHELPVSCIVMHPCRDYLISCSED---RLWKmvgLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIK 427
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADgtvRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 428 LWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASAD 507
Cdd:COG2319 146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 508 KTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQ 587
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 70887605 588 ASANGIIHLLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 306 GSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
356-638 1.89e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 223.25  E-value: 1.89e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 356 FRLHELPVSCIVMHPCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDLNKGE 435
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 436 CTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWDA 515
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 516 RTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASANGIIH 595
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 70887605 596 LLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 272 LWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
370-638 1.54e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.06  E-value: 1.54e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 370 PCRDYLISCSEDRLWKMVGLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWDLNKGECTLTLEGHNHAVWS 449
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 450 CTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWDARTGKCEQSLYGHMH 529
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 530 SVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVGPSSGNEVNFDQSGRVLAQASANGIIHLLDLKSGQ-IHKLV 608
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKlLRTLT 243

                       250       260       270
                ....*....|....*....|....*....|
gi 70887605 609 GHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 351-556 1.59e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 1.59e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 351 KLNNIFRLHELPVSCIVMHPCRDYLISCSED---RLWKmvgLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIK 427
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDktiKVWD---VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 428 LWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNILLTASAD 507
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 70887605 508 KTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWD 556
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
410-638 1.46e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 1.46e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 410 FHPSGSKLATSSGDSTIKLWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSV 489
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 490 NSIEFFPFSNILLTASADKTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDVG 569
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 570 PSSGNEVNFDQSGRVLAQASANGIIHLLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
351-475 1.27e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 1.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605 351 KLNNIFRLHELPVSCIVMHPCRDYLISCSED---RLWKmvgLPQGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIK 427
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgtvRLWD---LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 70887605 428 LWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNS 475
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 410-572 4.88e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 68.77  E-value: 4.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  410 FHP-SGSKLATSSGDSTIKLWDL-------NKGECTLTLEGHNHAVWSCTWH-SCGDFVASASLDMTSKIWDVNSERCRY 480
Cdd:PTZ00421  83 FNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGKAVE 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  481 TLYGHTDSVNSIEFFPFSNILLTASADKTLSVWDARTGKCEQSLYGHMHSVND-ATFTPRGHIIASCdarGVTK------ 553
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITL---GCSKsqqrqi 239

                        170       180
                 ....*....|....*....|.
gi 70887605  554 -LWDFRKLI-PIVSIDVGPSS 572
Cdd:PTZ00421 240 mLWDTRKMAsPYSTVDLDQSS 260
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 475-514 6.75e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 6.75e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 70887605    475 SERCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWD 514
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 391-430 1.25e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.25e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 70887605    391 QGNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWD 430
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-472 1.41e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.41e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 70887605    433 KGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWD 472
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
434-472 1.47e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.47e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 70887605   434 GECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWD 472
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
477-514 5.96e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 5.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 70887605   477 RCRYTLYGHTDSVNSIEFFPFSNILLTASADKTLSVWD 514
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
392-430 8.40e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.40e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 70887605   392 GNVLLTGSGHTDWLSGCCFHPSGSKLATSSGDSTIKLWD 430
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 603-638 2.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 70887605    603 QIHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 405-599 8.88e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 8.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  405 LSGCCFHPS-GSKLATSSGDSTIKLWDLNKGECTLTLEGHNHAVWSCTWHSCG-DFVASASLDMTSKIWDVN-------- 474
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINqgvsigti 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  475 ------------SERCRY-----------------------TLYGHTDSVNSIEFFPfSNILLTASADKTLSVWD---AR 516
Cdd:PLN00181 615 ktkaniccvqfpSESGRSlafgsadhkvyyydlrnpklplcTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDlsmSI 693

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887605  517 TGKCEQSLYGHMHSVNDATF----TPRGHIIASCDARGVtklWDFRKLIPIVSI-----DVGPSSGNEVNfDQS------ 581
Cdd:PLN00181 694 SGINETPLHSFMGHTNVKNFvglsVSDGYIATGSETNEV---FVYHKAFPMPVLsykfkTIDPVSGLEVD-DASqfissv 769

                        250       260
                 ....*....|....*....|...
gi 70887605  582 -----GRVLAQASANGIIHLLDL 599
Cdd:PLN00181 770 cwrgqSSTLVAANSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
603-638 1.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 70887605   603 QIHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 517-556 7.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 70887605    517 TGKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWD 556
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 400-472 1.16e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.16e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 70887605  400 GHTDWLSGCCFHPSGSKLATSSG-DSTIKLWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWD 472
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
518-556 3.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 3.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 70887605   518 GKCEQSLYGHMHSVNDATFTPRGHIIASCDARGVTKLWD 556
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 351-385 7.74e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 7.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 70887605    351 KLNNIFRLHELPVSCIVMHPCRDYLISCSED---RLWK 385
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgtiKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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