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Conserved domains on  [gi|154146249|ref|NP_083174|]
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regulatory-associated protein of mTOR isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Raptor_N pfam14538
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 55-206 5.21e-96

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


:

Pssm-ID: 464202  Cd Length: 152  Bit Score: 304.20  E-value: 5.21e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249    55 MKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLC 134
Cdd:pfam14538    1 LKTVSVALVLCLNIGVDPPDVVKTKPCARLECWIDPSSMSPQKALEEIGKNLQDQYESWQPRARYKQSLDPSVEDVKKLC 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146249   135 TSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 206
Cdd:pfam14538   81 SKLRRNAKDERVLFHYNGHGVPRPTSNGEIWVFNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1027-1322 1.89e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1027 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 1103
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1104 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1183
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1184 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1261
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249 1262 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1322
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
HEAT COG1413
HEAT repeat [General function prediction only];
563-670 1.86e-08

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.25  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  563 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 642
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 154146249  643 nvammLAQLINDGSPMVRKELVVALSHL 670
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
COG5096 super family cl34899
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 472-696 1.97e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG5096:

Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  472 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 542
Cdd:COG5096    56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  543 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 622
Cdd:COG5096   120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249  623 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 696
Cdd:COG5096   190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
 
Name Accession Description Interval E-value
Raptor_N pfam14538
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 55-206 5.21e-96

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


Pssm-ID: 464202  Cd Length: 152  Bit Score: 304.20  E-value: 5.21e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249    55 MKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLC 134
Cdd:pfam14538    1 LKTVSVALVLCLNIGVDPPDVVKTKPCARLECWIDPSSMSPQKALEEIGKNLQDQYESWQPRARYKQSLDPSVEDVKKLC 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146249   135 TSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 206
Cdd:pfam14538   81 SKLRRNAKDERVLFHYNGHGVPRPTSNGEIWVFNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1027-1322 1.89e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1027 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 1103
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1104 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1183
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1184 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1261
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249 1262 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1322
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
1038-1331 3.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1038 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 1113
Cdd:COG2319   135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1114 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 1193
Cdd:COG2319   200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1194 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 1271
Cdd:COG2319   274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154146249 1272 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
Cdd:COG2319   349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
HEAT COG1413
HEAT repeat [General function prediction only];
563-670 1.86e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.25  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  563 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 642
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 154146249  643 nvammLAQLINDGSPMVRKELVVALSHL 670
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 563-668 3.52e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.48  E-value: 3.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249   563 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 641
Cdd:pfam13646    5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                           90       100
                   ....*....|....*....|....*..
gi 154146249   642 HnvamMLAQLINDGSPMVRKELVVALS 668
Cdd:pfam13646   66 A----LLELLRDDDDDVVRAAAAEALA 88
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 472-696 1.97e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  472 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 542
Cdd:COG5096    56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  543 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 622
Cdd:COG5096   120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249  623 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 696
Cdd:COG5096   190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
 
Name Accession Description Interval E-value
Raptor_N pfam14538
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 55-206 5.21e-96

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


Pssm-ID: 464202  Cd Length: 152  Bit Score: 304.20  E-value: 5.21e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249    55 MKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLC 134
Cdd:pfam14538    1 LKTVSVALVLCLNIGVDPPDVVKTKPCARLECWIDPSSMSPQKALEEIGKNLQDQYESWQPRARYKQSLDPSVEDVKKLC 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146249   135 TSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 206
Cdd:pfam14538   81 SKLRRNAKDERVLFHYNGHGVPRPTSNGEIWVFNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1027-1322 1.89e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1027 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 1103
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1104 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1183
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1184 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1261
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249 1262 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1322
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1123-1330 6.91e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1123 RGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRmalSEC 1202
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1203 RVMTYREHTAWVvkAYLQKHPEGHIVSVS-VNGDVRFFDPRMPESVNVMQ-IVKGLTALDIHPQANLIACGSMNQFTAIY 1280
Cdd:cd00200    85 CVRTLTGHTSYV--SSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 154146249 1281 NG-NGELINNIKYYDGFmgqrvgaISCLAFHPHWPHLAVGSNDYYISVYSV 1330
Cdd:cd00200   163 DLrTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
1038-1331 3.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1038 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 1113
Cdd:COG2319   135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1114 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 1193
Cdd:COG2319   200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1194 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 1271
Cdd:COG2319   274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154146249 1272 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
Cdd:COG2319   349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1019-1331 2.18e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1019 LNRNPGVPSVVKFHPFTPCIAVADKD-SICFWDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRV 1095
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLLLRTLtgHTGAVRSVAFSP-------DGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1096 WknfaDLEKNPEMVTawqglsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCD 1175
Cdd:COG2319   147 W----DLATGKLLRT--------LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1176 SHRSLIVAGLGDGSIRVYDrrMALSECrVMTYREHTAWVVK-AYlqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQIV 1253
Cdd:COG2319   214 PDGKLLASGSADGTVRLWD--LATGKL-LRTLTGHSGSVRSvAF---SPDGrLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1254 KG-LTALDIHPQANLIACGSMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
Cdd:COG2319   288 SGgVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1029-1240 1.86e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1029 VKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNprytrVTAMEYLngQDCSLLLTATDDGAIRVWknfaDLEKN 1105
Cdd:cd00200    57 VAASADGTYLASGSSDKTIRlWDLETGECVRTLtgHTSY-----VSSVAFS--PDGRILSSSSRDKTIKVW----DVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1106 pEMVTAWQGLSDmlpttrgAGMVVDWEQETGLLMSSGDVRIVRIWDT--------------------------------- 1152
Cdd:cd00200   126 -KCLTTLRGHTD-------WVNSVAFSPDGTFVASSSQDGTIKLWDLrtgkcvatltghtgevnsvafspdgekllssss 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1153 DRETKVQDIPTGADSC--------VTSLSCDSHRSLIVAGLGDGSIRVYDRRMAlsECrVMTYREHTAWVVKAYLqkHPE 1224
Cdd:cd00200   198 DGTIKLWDLSTGKCLGtlrghengVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--EC-VQTLSGHTNSVTSLAW--SPD 272

                         250
                  ....*....|....*..
gi 154146249 1225 GH-IVSVSVNGDVRFFD 1240
Cdd:cd00200   273 GKrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1025-1331 1.91e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1025 VPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMeylngQDCSLLLTATDDGAIRVWknfaDLEk 1104
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLW----DLA- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1105 NPEMVTAWQGLSDMLPTtrgagmvVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAG 1184
Cdd:COG2319   109 TGLLLRTLTGHTGAVRS-------VAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1185 LGDGSIRVYDrrmALSECRVMTYREHTAWVVK-AYlqkHPEGH-IVSVSVNGDVRFFDprmPESVNVMQIVKG----LTA 1258
Cdd:COG2319   181 SDDGTVRLWD---LATGKLLRTLTGHTGAVRSvAF---SPDGKlLASGSADGTVRLWD---LATGKLLRTLTGhsgsVRS 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154146249 1259 LDIHPQANLIACGSMNQFTAIYN-GNGELInnikyydGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDlATGELL-------RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
1110-1331 9.52e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1110 TAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQdIPTGADSCVTSLSCDSHRSLIVAGLGDGS 1189
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1190 IRVYDrrmALSECRVMTYREHTAWVVKAYLqkHPEGH-IVSVSVNGDVRFFDPRMPESVNVMQIVKG-LTALDIHPQANL 1267
Cdd:COG2319   102 VRLWD---LATGLLLRTLTGHTGAVRSVAF--SPDGKtLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFSPDGKL 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154146249 1268 IACGSMNQFTAIYN-GNGELINNIKYYDgfmgqrvGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
Cdd:COG2319   177 LASGSDDGTVRLWDlATGKLLRTLTGHT-------GAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
HEAT COG1413
HEAT repeat [General function prediction only];
563-670 1.86e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.25  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  563 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 642
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 154146249  643 nvammLAQLINDGSPMVRKELVVALSHL 670
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1038-1333 3.15e-07

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 53.77  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1038 IAVADKD-SICFWDWEKGEKLDYFHNGNPRYT-----RVTAMEYLNGQdcslLLTATDDGAIRVWKNFADLEKNPEmVTA 1111
Cdd:cd22857    47 LAVARKNgTVEVLDPENGDLLASFSDSEPATKlseedHFVGLHLFSGT----LLTCTSKGSLRSTKLPDDSTASSS-PTA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1112 WQGLSDMLPTTRGagmvvdwEQETGLLMSSGDVRIVRIWDTdrETKVQDI---------------PTgadsCVTS---LS 1173
Cdd:cd22857   122 WVCLGGNLLCMRV-------DPNENYFAFGGKEVELNVWDL--EEKPGKIwraknvpndslglrvPV----WVTDltfLS 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1174 CDSHRSlIVAGLGDGSIRVYD----RRmalsecRVM--TYREHTAWVVkaylQKHPEGHIVSVSVN-GDVRFFDPRmpes 1246
Cdd:cd22857   189 KDDHRK-IVTGTGYHQVRLYDtraqRR------PVVsvDFGETPIKAV----AEDPDGHTVYVGDTsGDLASIDLR---- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249 1247 vnvmqivkgltaldihpqanliacgsmnqftaiyngNGELINNikyYDGFMGqrvGAISCLAFHPHWPHLAVGSNDYYIS 1326
Cdd:cd22857   254 ------------------------------------TGKLLGC---FKGKCG---GSIRSIARHPELPLIASCGLDRYLR 291


                  ....*..
gi 154146249 1327 VYSVEKR 1333
Cdd:cd22857   292 IWDTETR 298
HEAT COG1413
HEAT repeat [General function prediction only];
563-670 6.32e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 6.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  563 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 642
Cdd:COG1413    22 IAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALG--------RIGDPEAVPA 82

                          90       100
                  ....*....|....*....|....*...
gi 154146249  643 nvammLAQLINDGSPMVRKELVVALSHL 670
Cdd:COG1413    83 -----LIAALKDEDPEVRRAAAEALGRL 105
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 563-668 3.52e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.48  E-value: 3.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249   563 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 641
Cdd:pfam13646    5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                           90       100
                   ....*....|....*....|....*..
gi 154146249   642 HnvamMLAQLINDGSPMVRKELVVALS 668
Cdd:pfam13646   66 A----LLELLRDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
559-624 3.69e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 3.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154146249  559 IAICLEQLSDPHPLLRQWVAICLGRIWqnfdsarwcgvRDSAHEKLYSLLSDPIPEVRCAAVFALG 624
Cdd:COG1413    80 VPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALG 134
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 472-696 1.97e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  472 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 542
Cdd:COG5096    56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146249  543 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 622
Cdd:COG5096   120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154146249  623 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 696
Cdd:COG5096   190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
HEAT COG1413
HEAT repeat [General function prediction only];
598-670 1.69e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154146249  598 DSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDHnvammLAQLINDGSPMVRKELVVALSHL 670
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALG--------RLGDPRAVPA-----LLEALKDPDPEVRAAAAEALGRI 74
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 604-627 6.01e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.58  E-value: 6.01e-03
                           10        20
                   ....*....|....*....|....
gi 154146249   604 LYSLLSDPIPEVRCAAVFALGTFV 627
Cdd:pfam02985    5 LLKLLNDPSPEVREAAAEALGELA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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