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Conserved domains on  [gi|241982800|ref|NP_083127|]
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uncharacterized protein LOC74279 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 100-252 1.51e-17

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 78.85  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  100 KAEILYMVIRGYE-DHFPAIFTKASECLRLTFGLEIIE--------------------RNPRVHSYSLVNALGLTYDGM- 157
Cdd:pfam01454  17 REDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVElpakeekkttvtsqqrraaaKSSRSKSYILVSTLPPEYRVPa 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  158 ----------LHGFRGVPKIGLLIIVLCIIFIQDNCASEQELWRILNNMGLyagRDHFIYGDPGVLIT-----EHFVQEG 222
Cdd:pfam01454  97 iiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGI---DTDGTKEIPPLNGNtddllKRLVKQG 173

                         170       180       190
                  ....*....|....*....|....*....|..
gi 241982800  223 YLECRQVPGSDP--PTREYLWGPRAHAETTKM 252
Cdd:pfam01454 174 YLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
MAGE_N super family cl13827
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 16-66 1.10e-03

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


The actual alignment was detected with superfamily member pfam12440:

Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 37.28  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982800   16 HSERETRDLE-----AGEEEASTS------GDVLGSS---------QGAQRASFPST--AGVP---SVEASGSQIE 66
Cdd:pfam12440  13 QARSETQGLEgaqatAAEEEESPSsssplsGGTPESSpaagspstpQSPQGAPSTTTaaAAVSstrSDEGASSQDE 88
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 100-252 1.51e-17

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 78.85  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  100 KAEILYMVIRGYE-DHFPAIFTKASECLRLTFGLEIIE--------------------RNPRVHSYSLVNALGLTYDGM- 157
Cdd:pfam01454  17 REDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVElpakeekkttvtsqqrraaaKSSRSKSYILVSTLPPEYRVPa 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  158 ----------LHGFRGVPKIGLLIIVLCIIFIQDNCASEQELWRILNNMGLyagRDHFIYGDPGVLIT-----EHFVQEG 222
Cdd:pfam01454  97 iiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGI---DTDGTKEIPPLNGNtddllKRLVKQG 173

                         170       180       190
                  ....*....|....*....|....*....|..
gi 241982800  223 YLECRQVPGSDP--PTREYLWGPRAHAETTKM 252
Cdd:pfam01454 174 YLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
MAGE_N pfam12440
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 16-66 1.10e-03

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 37.28  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982800   16 HSERETRDLE-----AGEEEASTS------GDVLGSS---------QGAQRASFPST--AGVP---SVEASGSQIE 66
Cdd:pfam12440  13 QARSETQGLEgaqatAAEEEESPSsssplsGGTPESSpaagspstpQSPQGAPSTTTaaAAVSstrSDEGASSQDE 88
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 100-252 1.51e-17

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 78.85  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  100 KAEILYMVIRGYE-DHFPAIFTKASECLRLTFGLEIIE--------------------RNPRVHSYSLVNALGLTYDGM- 157
Cdd:pfam01454  17 REDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVElpakeekkttvtsqqrraaaKSSRSKSYILVSTLPPEYRVPa 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982800  158 ----------LHGFRGVPKIGLLIIVLCIIFIQDNCASEQELWRILNNMGLyagRDHFIYGDPGVLIT-----EHFVQEG 222
Cdd:pfam01454  97 iiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGI---DTDGTKEIPPLNGNtddllKRLVKQG 173

                         170       180       190
                  ....*....|....*....|....*....|..
gi 241982800  223 YLECRQVPGSDP--PTREYLWGPRAHAETTKM 252
Cdd:pfam01454 174 YLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
MAGE_N pfam12440
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 16-66 1.10e-03

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 37.28  E-value: 1.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 241982800   16 HSERETRDLE-----AGEEEASTS------GDVLGSS---------QGAQRASFPST--AGVP---SVEASGSQIE 66
Cdd:pfam12440  13 QARSETQGLEgaqatAAEEEESPSsssplsGGTPESSpaagspstpQSPQGAPSTTTaaAAVSstrSDEGASSQDE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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