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Conserved domains on  [gi|28076919|ref|NP_081185|]
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THAP domain-containing protein 7 [Mus musculus]

Protein Classification

THAP domain-containing protein( domain architecture ID 10659521)

THAP domain-containing protein may act as a DNA-binding transcription regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-93 6.96e-22

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 87.49  E-value: 6.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919      4 HCSAAGCctrDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDptseYIYFCSKHFEENCFELVGisgyHR 83
Cdd:smart00980   1 KCCVPGC---GNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDPNRKPKK----RSRICSRHFEPDDFDNSG----RR 69

                           90
                   ....*....|
gi 28076919     84 LKEGAVPTIF 93
Cdd:smart00980  70 LKPGAVPTLF 79
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 111-221 3.28e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919   111 PPGLPDVSRLRRCRKRCSERQGPTTPFSPPPRADIICFPVEEASAPATLPASPAVRLDPGLNSPFSDLLGPLGAQADEAG 190
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110
                  ....*....|....*....|....*....|.
gi 28076919   191 CSTQPSPEqhPSPLEPQPASPSAYMLRLPPP 221
Cdd:PHA03247 2821 AASPAGPL--PPPTSAQPTAPPPPPGPPPPS 2849
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-93 6.96e-22

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 87.49  E-value: 6.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919      4 HCSAAGCctrDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDptseYIYFCSKHFEENCFELVGisgyHR 83
Cdd:smart00980   1 KCCVPGC---GNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDPNRKPKK----RSRICSRHFEPDDFDNSG----RR 69

                           90
                   ....*....|
gi 28076919     84 LKEGAVPTIF 93
Cdd:smart00980  70 LKPGAVPTLF 79
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-93 1.25e-19

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 81.43  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919     5 CSAAGCCTRDTRetrNRGISFHRLPKkDNPRRGLWLANCQRldpsgQGLWDPTSEYIyfCSKHFEENCFElvGISGYHRL 84
Cdd:pfam05485   1 CSVPGCTNRKKK---NPRTSFHKFPK-DPERRKKWLNACKR-----KDLPPPSNSYV--CSLHFEENDFE--KSGGKRKL 67


                  ....*....
gi 28076919    85 KEGAVPTIF 93
Cdd:pfam05485  68 KPGAIPTLF 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-221 3.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919   111 PPGLPDVSRLRRCRKRCSERQGPTTPFSPPPRADIICFPVEEASAPATLPASPAVRLDPGLNSPFSDLLGPLGAQADEAG 190
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110
                  ....*....|....*....|....*....|.
gi 28076919   191 CSTQPSPEqhPSPLEPQPASPSAYMLRLPPP 221
Cdd:PHA03247 2821 AASPAGPL--PPPTSAQPTAPPPPPGPPPPS 2849
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-93 6.96e-22

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 87.49  E-value: 6.96e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919      4 HCSAAGCctrDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDptseYIYFCSKHFEENCFELVGisgyHR 83
Cdd:smart00980   1 KCCVPGC---GNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDPNRKPKK----RSRICSRHFEPDDFDNSG----RR 69

                           90
                   ....*....|
gi 28076919     84 LKEGAVPTIF 93
Cdd:smart00980  70 LKPGAVPTLF 79
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-93 1.25e-19

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 81.43  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919     5 CSAAGCCTRDTRetrNRGISFHRLPKkDNPRRGLWLANCQRldpsgQGLWDPTSEYIyfCSKHFEENCFElvGISGYHRL 84
Cdd:pfam05485   1 CSVPGCTNRKKK---NPRTSFHKFPK-DPERRKKWLNACKR-----KDLPPPSNSYV--CSLHFEENDFE--KSGGKRKL 67


                  ....*....
gi 28076919    85 KEGAVPTIF 93
Cdd:pfam05485  68 KPGAIPTLF 76
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
25-93 1.27e-13

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 64.25  E-value: 1.27e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28076919     25 FHRLPKkDNPRRGLWLANCqRLDPSGQGLWdptseYIYFCSKHFEENCFelvgiSGYHRLKEGAVPTIF 93
Cdd:smart00692   1 LFRFPK-DPELLKKWEHNL-RLSPDEKKLK-----NSRICSRHFEPECF-----GKRRRLKPGAVPTLE 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-221 3.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28076919   111 PPGLPDVSRLRRCRKRCSERQGPTTPFSPPPRADIICFPVEEASAPATLPASPAVRLDPGLNSPFSDLLGPLGAQADEAG 190
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110
                  ....*....|....*....|....*....|.
gi 28076919   191 CSTQPSPEqhPSPLEPQPASPSAYMLRLPPP 221
Cdd:PHA03247 2821 AASPAGPL--PPPTSAQPTAPPPPPGPPPPS 2849
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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