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Conserved domains on  [gi|27229077|ref|NP_081068|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [Mus musculus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0016020
PubMed:  18287005|18931347|18718904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.24e-71

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 220.96  E-value: 2.24e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  63 LFFFENYTGVQILLYGDLPK-NKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077 142 KRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNAtytKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSH 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTE---EKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 27229077 222 LDAIYDVTVVYEGNEKgsgkysnPPSMTEFLCKQCPKLHIHFD 264
Cdd:cd07990 158 VDAVYDVTIAYPDGKP-------PSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 260-328 2.16e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.04  E-value: 2.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229077   260 HIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYdspdpeRRNKFPGKSVHSRLSVKKTLPSVLI 328
Cdd:pfam16076  11 HMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFY------ETGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.24e-71

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 220.96  E-value: 2.24e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  63 LFFFENYTGVQILLYGDLPK-NKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077 142 KRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNAtytKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSH 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTE---EKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 27229077 222 LDAIYDVTVVYEGNEKgsgkysnPPSMTEFLCKQCPKLHIHFD 264
Cdd:cd07990 158 VDAVYDVTIAYPDGKP-------PSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 64-363 1.47e-48

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 167.95  E-value: 1.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077   64 FFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKR 143
Cdd:PLN02510  71 FLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVER 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  144 SAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYnaTYTKLLsASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSHLD 223
Cdd:PLN02510 151 KWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDY--TEAKCQ-RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLD 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  224 AIYDVTVVYEgnekgsgkySNPPSMTEFLCKQCP-KLHIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYdspdp 302
Cdd:PLN02510 228 AVYDVTIGYK---------HRCPSFLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY----- 293

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229077  303 eRRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMlmtesgrklymgtwLYGTLLGCLWFVI 363
Cdd:PLN02510 294 -AQGHFPNEGTEGELSTLKCLANFLAVIALTTVF--------------TYLTLFSSVWFKI 339
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-200 3.76e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 84.71  E-value: 3.76e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077     87 VIYLANHQSTVDWIVADMLAARQDalGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSakfNDKEMRSKLQSYVNA-GTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKL--GRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVELlKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 27229077    166 MYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVL 200
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 16-176 6.19e-17

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 78.51  E-value: 6.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  16 LPSVLLLGSAPTYLLAWTLWRVLSALMPARLyqRVDDRlycvyqnmvlfffENytgvqillygdLPKNKeNVIYLANHQS 95
Cdd:COG0204   1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRV--RVEGL-------------EN-----------LPADG-PVLIVANHQS 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  96 TVDWIVADMLAARqdalgHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAGTPmyLVIFPEGT 175
Cdd:COG0204  54 WLDILLLLAALPR-----PVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGT 126


                .
gi 27229077 176 R 176
Cdd:COG0204 127 R 127
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-195 3.78e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 65.76  E-value: 3.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077    83 NKENVIYLANHQSTVDWIVADMLAARQDALghVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNA 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLRE 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 27229077   163 GtpMYLVIFPEGTRYNATYTKLLSASQAFAAQR 195
Cdd:pfam01553  90 G--KLVVIFPEGTRSREGELLPFKKGAFRLAIE 120
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 1.75e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 58.13  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077    71 GVQILLYG--DLPKnKENVIYLANHQSTVDWIVADMLAARQdalghVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLDPLTLSAAFPPP-----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 27229077   149 DKEMRSKLQSYVNAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 260-328 2.16e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.04  E-value: 2.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229077   260 HIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYdspdpeRRNKFPGKSVHSRLSVKKTLPSVLI 328
Cdd:pfam16076  11 HMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFY------ETGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.24e-71

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 220.96  E-value: 2.24e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  63 LFFFENYTGVQILLYGDLPK-NKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077 142 KRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNAtytKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSH 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTE---EKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 27229077 222 LDAIYDVTVVYEGNEKgsgkysnPPSMTEFLCKQCPKLHIHFD 264
Cdd:cd07990 158 VDAVYDVTIAYPDGKP-------PSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 64-363 1.47e-48

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 167.95  E-value: 1.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077   64 FFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKR 143
Cdd:PLN02510  71 FLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVER 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  144 SAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYnaTYTKLLsASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSHLD 223
Cdd:PLN02510 151 KWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDY--TEAKCQ-RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLD 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  224 AIYDVTVVYEgnekgsgkySNPPSMTEFLCKQCP-KLHIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYdspdp 302
Cdd:PLN02510 228 AVYDVTIGYK---------HRCPSFLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY----- 293

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229077  303 eRRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMlmtesgrklymgtwLYGTLLGCLWFVI 363
Cdd:PLN02510 294 -AQGHFPNEGTEGELSTLKCLANFLAVIALTTVF--------------TYLTLFSSVWFKI 339
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 45-332 4.59e-43

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 153.36  E-value: 4.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077   45 RLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPK----NKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLK 120
Cdd:PLN02380  40 SLYRRINRAVAELLWLELIWLVDWWAGVKVQLYADEETfelmGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMK 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  121 DKLKWLPLYGF--YFAQHggIYVKRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYnaTYTKLLSAsQAFAAQRGLA 198
Cdd:PLN02380 120 KSSKFLPVIGWsmWFSEY--VFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRF--TQAKLLAA-QEYAASRGLP 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  199 VLKHVLTPRIKATHVAFDSMKSHLDAIYDVTVVYEgnekgsgKYSNPPSMTEFLCKQCPKLHIHFDRIDRNEVPEEQEHM 278
Cdd:PLN02380 195 VPRNVLIPRTKGFVSAVSNMRSFVPAIYDVTVAVP-------KGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGI 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27229077  279 KKWLHERFEIKDRLLIEFydspdpERRNKFPGKSVHSRLSVKKTLPSVLILGSL 332
Cdd:PLN02380 268 AQWCKDVFVAKDALLDKH------FAEDTFGDQEYQDIGRPKKSLIVVISWACL 315
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-200 3.76e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 84.71  E-value: 3.76e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077     87 VIYLANHQSTVDWIVADMLAARQDalGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSakfNDKEMRSKLQSYVNA-GTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKL--GRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVELlKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 27229077    166 MYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVL 200
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 16-176 6.19e-17

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 78.51  E-value: 6.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  16 LPSVLLLGSAPTYLLAWTLWRVLSALMPARLyqRVDDRlycvyqnmvlfffENytgvqillygdLPKNKeNVIYLANHQS 95
Cdd:COG0204   1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRV--RVEGL-------------EN-----------LPADG-PVLIVANHQS 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  96 TVDWIVADMLAARqdalgHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAGTPmyLVIFPEGT 175
Cdd:COG0204  54 WLDILLLLAALPR-----PVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGT 126


                .
gi 27229077 176 R 176
Cdd:COG0204 127 R 127
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 84-176 1.57e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 71.15  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  84 KENVIYLANHQSTVDWIVadMLAArqdALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAG 163
Cdd:cd07989  23 KGPVIIVANHQSYLDPLV--LGAA---LPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREALREAIEALKEG 97

                        90
                ....*....|...
gi 27229077 164 TPmyLVIFPEGTR 176
Cdd:cd07989  98 ES--VVIFPEGTR 108
PRK14014 PRK14014
putative acyltransferase; Provisional
 89-293 3.09e-14

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 72.19  E-value: 3.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077   89 YL--ANHQSTVDWIVADMLAARQDALghVRYVLKDKLKWLPLYG-------FYFAQ-HGGIYVKRSAKFNDKEMRS---- 154
Cdd:PRK14014  89 YLviSNHQSWVDILVLQYVFNRRIPM--LKFFLKQELIWVPFLGlawwaldFPFMKrYSKAYLAKNPELKGKDLETtrra 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  155 --KLQSyvnagTPMYLVIFPEGTRYnaTYTKLLSASQAFaaqrglavlKHVLTPriKATHVAF--DSMKSHLDAIYDVTV 230
Cdd:PRK14014 167 ceKFKR-----MPTTIVNFVEGTRF--TPEKHQQQQSPY---------QHLLKP--KAGGIAFalNAMGEQFDGLLDVTI 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27229077  231 VYEGNEkgsgkysnpPSMTEFLCKQCPKLHIHFDRIDRNEV--------PEEQEHMKKWLHERFEIKDRLL 293
Cdd:PRK14014 229 VYPDGR---------PSFWDLLSGRVKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLI 290
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-195 3.78e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 65.76  E-value: 3.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077    83 NKENVIYLANHQSTVDWIVADMLAARQDALghVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNA 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLRE 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 27229077   163 GtpMYLVIFPEGTRYNATYTKLLSASQAFAAQR 195
Cdd:pfam01553  90 G--KLVVIFPEGTRSREGELLPFKKGAFRLAIE 120
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 1.75e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 58.13  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077    71 GVQILLYG--DLPKnKENVIYLANHQSTVDWIVADMLAARQdalghVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLDPLTLSAAFPPP-----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 27229077   149 DKEMRSKLQSYVNAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 260-328 2.16e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.04  E-value: 2.16e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27229077   260 HIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYdspdpeRRNKFPGKSVHSRLSVKKTLPSVLI 328
Cdd:pfam16076  11 HMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFY------ETGTFFPGKEHIIPRRLKSLLVFIF 73
PLN02833 PLN02833
glycerol acyltransferase family protein
 56-182 9.25e-06

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 47.08  E-value: 9.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077   56 CVYQNMVLFFFENYTGVqILLYGDLPKNKENVIYLANHQSTVDWIVADMLAA----RQDALGHVRYVLKDKLKWLplygf 131
Cdd:PLN02833 135 KLVELICSAFVASWTGV-IKYHGPRPSRRPKQVFVANHTSMIDFIVLEQMTPfaviMQKHPGWVGFLQNTILESV----- 208

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27229077  132 yfaqhGGIYVKRSaKFNDKEM-RSKLQSYVNAGTPMYLVIFPEGTRYNATYT 182
Cdd:PLN02833 209 -----GCIWFNRT-EAKDREVvAKKLRDHVQDPDRNPLLIFPEGTCVNNEYT 254
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 78-181 1.56e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 45.29  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  78 GDLPKNKENVIYLANHQSTVDWIVADMLaarqdalGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQ 157
Cdd:cd07991  17 GKPDPPEAPRIIVANHTSFIDPLILFSD-------LFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIK 89

                        90       100
                ....*....|....*....|....
gi 27229077 158 SYVNAGTPMYLVIFPEGTRYNATY 181
Cdd:cd07991  90 ERATDPNWPPILIFPEGTTTNGKA 113
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 78-176 9.37e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 42.20  E-value: 9.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  78 GDLPKNKENVIYLANHQSTVDWIVAdMLAArqDALG-HVRYVLKDKLKWLPLyGFYFAQHGGIYVKRSAKFND-KEMRSK 155
Cdd:cd07988  14 GEPPNKPKFVVIGAPHTSNWDFVLG-LLAA--FALGlKISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLvEQVVEE 89

                        90       100
                ....*....|....*....|.
gi 27229077 156 LQSYvnagTPMYLVIFPEGTR 176
Cdd:cd07988  90 FRRR----EEFVLAIAPEGTR 106
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 85-195 3.34e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 38.16  E-value: 3.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229077  85 ENVIYLANHQSTVDWIV---ADMLAARQDALGHVRYVLKDKLK-WLPLYGFYFAQHGGIYVKRSAkfndKEMRSKLQSYV 160
Cdd:cd06551  26 GPVLFVSNHSSWWDGLIlflLLERGLRRDVYGLMDEELLERYPfFTRLGAFSVDRDSPRSAAKSL----KYVARLLSKPG 101

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 27229077 161 NAgtpmyLVIFPEGTRYN-ATYTKLLSASQAFAAQR 195
Cdd:cd06551 102 SV-----VWIFPEGTRTRrDKRPLQFKPGVAHLAEK 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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