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Conserved domains on  [gi|21311961|ref|NP_080945|]
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bax inhibitor 1 [Mus musculus]

Protein Classification

BI-1 domain-containing protein( domain architecture ID 10179631)

BI-1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 16-228 3.25e-99

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


:

Pssm-ID: 198412  Cd Length: 213  Bit Score: 287.58  E-value: 3.25e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  16 FSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFiqAGLLSALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLT 95
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI--GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  96 GVGLGPALELCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:cd10430  79 GASLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELY 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21311961 176 LGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFN 228
Cdd:cd10430 159 LGLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 16-228 3.25e-99

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 287.58  E-value: 3.25e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  16 FSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFiqAGLLSALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLT 95
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI--GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  96 GVGLGPALELCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:cd10430  79 GASLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELY 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21311961 176 LGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFN 228
Cdd:cd10430 159 LGLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 24-225 1.31e-32

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 117.66  E-value: 1.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961    24 QQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMI--------WLMATPHSHETEQKRLGLLAGFAFLT 95
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIaplgllfgALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961    96 GVGLGPaleLCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYlFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:pfam01027  81 GLTLGP---LLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLS-FLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21311961   176 LGLLVMCGFVLFDTQLIIEKAEH-GDKDYIWHCVDLFLDFVTLFRKLMLIL 225
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEyGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 1-226 7.35e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 81.76  E-value: 7.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961   1 MNIFDRKINFDAllkfSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMI-------WLMA 73
Cdd:COG0670   1 MNNFDRNAGAAA----AASDAGLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLiaplglvFLLS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  74 TPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVN-PSILPTAFMGTAMIFTCFSLSAlYARRRSYLFLGGILMSAMS 152
Cdd:COG0670  77 KLANRANSAAALALLFAYTALMGLTLSPILLVYTGLSgPASIAQAFGGTAATFGGLSLYG-YTTKRDLSFLGSFLFMGLI 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21311961 153 LMLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKAEHgDKDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:COG0670 156 GLIIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-NKQYIMAALSLYLDFINLFLSLLRLLG 228
PRK10447 PRK10447
FtsH protease modulator YccA;
77-227 1.49e-07

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 50.61  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961   77 SHETEQKRLGLLAGFAF--LTGVGLGPALELCIAVNP-SILPTAFMGTAMIFTCFSLSALyARRRSYLFLGGILMSAMSL 153
Cdd:PRK10447  66 TYKTANKPTGILSAFAFtgFLGYILGPILNTYLSAGMgDVIALALGGTALVFFCCSAYVL-TTRKDMSFLGGMLMAGIVV 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21311961  154 MLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKaehGDKDYIWHCVDLFLDFVTLFRKLMLILAF 227
Cdd:PRK10447 145 VLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIHG---GETNYIRATVSLYVSLYNIFVSLLSILGF 215
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 16-228 3.25e-99

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 287.58  E-value: 3.25e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  16 FSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFiqAGLLSALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLT 95
Cdd:cd10430   1 FNQISPSVQQHLKKVYLTLAVALLAAAVGAYVHMVINI--GGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  96 GVGLGPALELCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:cd10430  79 GASLGPLLDLVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELY 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21311961 176 LGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFN 228
Cdd:cd10430 159 LGLLVFCGFVLFDTQMIIEKAENGDRDYIWHALDLFVDFVALFRRLLIILAKK 211
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 22-226 2.94e-58

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 183.38  E-value: 2.94e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  22 STQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMIWLMATPHSHETEQK-RLGLLAGFAFLTGVGLG 100
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPALMGLLTSMLALMATAAMIRAKMPvNLILLFGFTGLMGYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961 101 PALELCiavNPSILPTAFMGTAMIFTCFSLSALYARRrSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLV 180
Cdd:cd06181  81 PLLFFY---GPTILLRALGGTALVFFGLTVYALQARK-DFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVL 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 21311961 181 MCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:cd06181 157 FCGFLLYDTQLIIHKAEVGPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 24-225 1.31e-32

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 117.66  E-value: 1.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961    24 QQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMI--------WLMATPHSHETEQKRLGLLAGFAFLT 95
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIaplgllfgALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961    96 GVGLGPaleLCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYlFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:pfam01027  81 GLTLGP---LLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLS-FLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21311961   176 LGLLVMCGFVLFDTQLIIEKAEH-GDKDYIWHCVDLFLDFVTLFRKLMLIL 225
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEyGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 1-226 7.35e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 81.76  E-value: 7.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961   1 MNIFDRKINFDAllkfSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMI-------WLMA 73
Cdd:COG0670   1 MNNFDRNAGAAA----AASDAGLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLiaplglvFLLS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  74 TPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVN-PSILPTAFMGTAMIFTCFSLSAlYARRRSYLFLGGILMSAMS 152
Cdd:COG0670  77 KLANRANSAAALALLFAYTALMGLTLSPILLVYTGLSgPASIAQAFGGTAATFGGLSLYG-YTTKRDLSFLGSFLFMGLI 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21311961 153 LMLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKAEHgDKDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:COG0670 156 GLIIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYET-NKQYIMAALSLYLDFINLFLSLLRLLG 228
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 22-226 8.17e-17

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 76.06  E-value: 8.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  22 STQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLAL------MIWLMATPHsHETEQKRLGLLAGFAFLT 95
Cdd:cd10432   1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGSPLMWVLLiaelalVFGLSFRIN-KMSVATALPLFFAFAALT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  96 GVGLGPALELCIAVnpsILPTAFMGTAMIFTCFSLSAlYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLY 175
Cdd:cd10432  80 GLTLSPILLVYTGA---SIAQAFFTTAATFGGLSLYG-YTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21311961 176 LGLLVMCGFVLFDTQLIIEKAEHGD-----KDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:cd10432 156 IGVLIFSGLIAYDTQRIKRMYEAGGgesgyKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 22-227 1.56e-13

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 66.84  E-value: 1.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  22 STQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMIWLMatphsHETEQKRLGLLAGFAF--LTGVGL 99
Cdd:cd10433   2 STNKVLRNTYMLLSMTLAFSALGAGVSMAGGSPIMGLLLTLVGAYGLLFLI-----EKTRNSAWGIVLVFAFtgFMGYTL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961 100 GPALELCIAVN--PSILPTAFMGTAMIFTCFSLSALyARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLG 177
Cdd:cd10433  77 GPILNMYLALPngGQIIMTALGGTAAIFFGLSAYAL-TTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAF 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 21311961 178 LLVMCGFVLFDTQLIIEKaehGDKDYIWHCVDLFLDFVTLFRKLMLILAF 227
Cdd:cd10433 156 VLFSSGFILYDTSRIIHG---GETNYIMATVSLYVSIYNLFVSLLNLLGA 202
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 89-226 5.00e-12

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 63.55  E-value: 5.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  89 AGFAFLTGVGLGPaleLCIaVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFF---- 164
Cdd:cd10431 114 LGHSGVQGAVLAP---LCF-LGGPLLIRAALYTAGIVGGLSTVAACAPSEKFLYMGGPLAIGLGVVFASSLGSMFLpptt 189

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21311961 165 -GSIWLFQANLYLGLLVMCGFVLFDTQLIIEKAE----HGDKDY--IWHCVDLFLDFVTLFRKLMLILA 226
Cdd:cd10431 190 aLGAGLYSVSLYGGLVLFGGFLLYDTQKIIKRAEthplYGVRKYdpINASMSIYMDTINIFIRLVTILA 258
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 68-226 1.70e-11

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 61.85  E-value: 1.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961  68 MIWLMATPHSHETeqkRLGLLAGFAFLTGVGLGPAlelCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGIL 147
Cdd:cd10429  80 LIALYWKRHSHPV---NLILLSLFTLCEAYTVGLV---VSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLF 153

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21311961 148 MSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKaeHGDKDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:cd10429 154 ILLWALILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKR--LSPDEYILAAISLYLDIINLFLSILRILA 230
PRK10447 PRK10447
FtsH protease modulator YccA;
77-227 1.49e-07

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 50.61  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961   77 SHETEQKRLGLLAGFAF--LTGVGLGPALELCIAVNP-SILPTAFMGTAMIFTCFSLSALyARRRSYLFLGGILMSAMSL 153
Cdd:PRK10447  66 TYKTANKPTGILSAFAFtgFLGYILGPILNTYLSAGMgDVIALALGGTALVFFCCSAYVL-TTRKDMSFLGGMLMAGIVV 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21311961  154 MLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKaehGDKDYIWHCVDLFLDFVTLFRKLMLILAF 227
Cdd:PRK10447 145 VLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIHG---GETNYIRATVSLYVSLYNIFVSLLSILGF 215
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 117-226 2.22e-03

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 37.91  E-value: 2.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311961 117 AFMGTAMIftCFSLSaLYARRRSYLF--LGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLII- 193
Cdd:cd10428 107 AVGITAVV--CLGLT-LFAFQTKYDFtsCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLMg 183

                        90       100       110
                ....*....|....*....|....*....|....
gi 21311961 194 -EKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILA 226
Cdd:cd10428 184 gRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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