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Conserved domains on  [gi|21312920|ref|NP_080489|]
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tetratricopeptide repeat protein 33 [Mus musculus]

Protein Classification

M48 family metallopeptidase( domain architecture ID 11469162)

M48 family metallopeptidase such as beta-barrel assembly-enhancing protease, which functions as both a chaperone and a metalloprotease, maintaining the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100
                ....*....|....*....|....*...
gi 21312920 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783  82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100
                ....*....|....*....|....*...
gi 21312920 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783  82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 38-162 4.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920    38 GNWLQASKRRKETLQEGCKQRSQQLKDEGAQLAENkRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAE 117
Cdd:TIGR02917 513 GNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG-NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILN 591

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21312920   118 MAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPE 162
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-164 1.16e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100
                ....*....|....*....|....*...
gi 21312920 137 QLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG4783  82 LLKAGDYDEALALLEKALKLDPEHPEAY 109
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 60-185 1.75e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  60 QQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLG 139
Cdd:COG3914  79 ALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRR 158

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 21312920 140 LGEIVLAIRSFQIALHIYPMNPELWkedLSWARKLQEQQKVAQRIE 185
Cdd:COG3914 159 LGRLEEAIAALRRALELDPDNAEAL---NNLGNALQDLGRLEEAIA 201
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 66-164 1.76e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                        90
                ....*....|....*....
gi 21312920 146 AIRSFQIALHIYPMNPELW 164
Cdd:COG3914 199 AIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-164 1.92e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 1.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90
                ....*....|....*....
gi 21312920 146 AIRSFQIALHIYPMNPELW 164
Cdd:COG0457  95 ALEDYDKALELDPDDAEAL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-188 7.03e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 7.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG0457  49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21312920 146 AIRSFQIALHIYPMNPELWkEDLSWARKLQEQQKVAQRIENKE 188
Cdd:COG0457 129 AIEAYERALELDPDDADAL-YNLGIALEKLGRYEEALELLEKL 170
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 66-160 1.79e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 1.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  66 GAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVL 145
Cdd:COG4783  45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                        90
                ....*....|....*
gi 21312920 146 AIRSFQIALHIYPMN 160
Cdd:COG4783 125 AIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 69-159 1.92e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143

                        90
                ....*....|.
gi 21312920 149 SFQIALHIYPM 159
Cdd:COG5010 144 ALQRALGTSPL 154
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
57-164 1.05e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.15  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  57 QRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRA 136
Cdd:COG4785  71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                        90       100       110
                ....*....|....*....|....*....|
gi 21312920 137 QLGLGEIVLAIRSFQIALHIYPMNPE--LW 164
Cdd:COG4785 151 LYYLGRYELAIADLEKALELDPNDPEraLW 180
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 69-162 1.11e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 1.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG4235  27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                        90
                ....*....|....
gi 21312920 149 SFQIALHIYPMNPE 162
Cdd:COG4235 107 AWQKLLALLPADAP 120
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
69-158 5.01e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 5.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEmFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR-YDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                        90
                ....*....|
gi 21312920 149 SFQIALHIYP 158
Cdd:COG3063  81 YLERALELDP 90
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 60-186 5.72e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 5.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  60 QQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLG 139
Cdd:COG3914  45 LLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21312920 140 LGEIVLAIRSFQIALHIYPMNPELWkedLSWARKLQEQQKVAQRIEN 186
Cdd:COG3914 125 LGRLEEALAALRRALALNPDFAEAY---LNLGEALRRLGRLEEAIAA 168
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 77-164 1.14e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  77 EAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHI 156
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                ....*...
gi 21312920 157 YPMNPELW 164
Cdd:COG4235  81 DPDNPEAL 88
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 36-185 1.58e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  36 EDGNWLQASK--RRKETLQEGCKQRSQQLkdeGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAV 113
Cdd:COG2956 122 QEGDWEKAIEvlERLLKLGPENAHAYCEL---AELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21312920 114 HAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPELwkedLSWARKLQEQQKVAQRIE 185
Cdd:COG2956 199 AALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL----LALADLLERKEGLEAALA 266
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 67-189 3.19e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.80  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  67 AQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLA 146
Cdd:COG5010  28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEA 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21312920 147 IRSFQIALHIYPMNPELWkEDLSWARKLQEQQKVAQRIENKEM 189
Cdd:COG5010 108 KEYYEKALALSPDNPNAY-SNLAALLLSLGQDDEAKAALQRAL 149
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 38-191 6.51e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 6.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  38 GNWLQASKRRKETLQegCKQRSQQLKDEGAQ--------LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEM 109
Cdd:COG3914 119 GNLLLALGRLEEALA--ALRRALALNPDFAEaylnlgeaLRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920 110 FPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRsFQIALHIYPMNPELWK-------EDLSWARKLQEQQKVAQ 182
Cdd:COG3914 197 EEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR-FEELLAALARGPSELSpfallylPDDDPAELLALARAWAQ 275


                ....*....
gi 21312920 183 RIENKEMPP 191
Cdd:COG3914 276 LVAAAAAPE 284
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 65-186 1.43e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  65 EGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIV 144
Cdd:COG2956  14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21312920 145 LAIRSFQIALHIYPMNPELWKEDLSWARKLQEQQK---VAQRIEN 186
Cdd:COG2956  94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKaieVLERLLK 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-185 2.65e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 2.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG2956 120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21312920 149 SFQIALHIYPMNPELWKEDLSWARKLQEQQKVAQRIE 185
Cdd:COG2956 200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLR 236
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
86-164 7.09e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 7.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21312920  86 LQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPELW 164
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
102-183 2.06e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920 102 VLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRsFQIALHIYPMNPELWKEdLSWARKLQEQQKVA 181
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN-LAELLLELGDYDEA 78


                ..
gi 21312920 182 QR 183
Cdd:COG3063  79 LA 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 73-185 4.81e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 4.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  73 KRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQI 152
Cdd:COG2956  56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                        90       100       110
                ....*....|....*....|....*....|...
gi 21312920 153 ALHIYPMNPELWKEdlsWARKLQEQQKVAQRIE 185
Cdd:COG2956 136 LLKLGPENAHAYCE---LAELYLEQGDYDEAIE 165
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 38-162 4.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920    38 GNWLQASKRRKETLQEGCKQRSQQLKDEGAQLAENkRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAE 117
Cdd:TIGR02917 513 GNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG-NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILN 591

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21312920   118 MAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPE 162
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-185 7.41e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.91  E-value: 7.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21312920  69 LAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIR 148
Cdd:COG0457 120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21312920 149 SFQIALHIYPMNPELWKEDLSWARKLQEQQKVAQRIE 185
Cdd:COG0457 200 LLALEQALRKKLAILTLAALAELLLLALALLLALRLA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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