extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385422  15 GSSAQALKCHECSGIEDCYKPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDINHVTANSKSSCCNTDLCNSARNLH 94
Cdd:cd23552   1 GSSAQALKCHECKGIEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESLANSKASCCNTDLCNSAVSRS 80

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385422  15 GSSAQALKCHECSGIEDCYKPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDINHVTANSKSSCCNTDLCNSARNLH 94
Cdd:cd23552   1 GSSAQALKCHECKGIEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESLANSKASCCNTDLCNSAVSRS 80

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385422     21 LKCHECSGIED--CYKPKTCSSQSLYCLT--NWYTPPGQQTTVTKTCAYT--CP-----DINHVTANSKSSCCNTDLCNS 89
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEECRSPDDVCLTvvAEVISDSRGSVVYKGCATSpiCPgshgyEINLTIAFLKVSCCQTDLCNA 80

                   ...
gi 13385422     90 ARN 92
Cdd:smart00134  81 AGP 83

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385422  15 GSSAQALKCHECSGIEDCYKPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDINHVTANSKSSCCNTDLCNSARNLH 94
Cdd:cd23552   1 GSSAQALKCHECKGIEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPESLANSKASCCNTDLCNSAVSRS 80

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13385422  20 ALKCHECSG---IEDCYKPKTCSSQSLYCLTN---WYTPPGQQTTVTKTCAYTCPDINHVTANSKS--SCCNTDLCN 88
Cdd:cd23575   2 SLKCYTCVSahsNSDCLTETNCSSSDTYCKTLvasASGGSGSLTTITKWCASSCTPSTRTVEGTKVtvSCCQTDLCN 78

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13385422  31 DCYKPKTCSSQSLYCLTNWYTPPGQQT---TVTKTCAYTCPDINHVT--ANSKSSCCNTDLCN 88
Cdd:cd23543  16 NCLKPTKCSDNDKYCVTTVASGGTGSSsgvRITKKCSPKCPETNVNIgiASVSTSCCQSSLCN 78

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13385422  21 LKCHECSGIeDCYKPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDinhVTANSKSSCCNTDLCN 88
Cdd:cd00206   1 LICYNCPSS-TCPTTKTCPPGENLCYKKWWRDGPRGKRIERGCAATCPK---PKPGEKVKCCSTDKCN 64

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13385422  20 ALKCHECS-GIEDCYKPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDINH---VTANSKSSCCNTDLCN 88
Cdd:cd23585   1 ALDCHVCAyNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYdgySKHASTTSCCQYDLCN 73

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385422  21 LKCHECSGIEDCY------KPKTCSSQSLYCLTNWYTPPGQQTTVTKTCAYTCPDIN-------HVTANSKSSCCNTDLC 87
Cdd:cd00117   1 LKCYQCNSSNDPNccnsspTLVTCSSPETFCRKIVGKVGGGETLVIRGCATECECGCteccsgtGTSGTTCTSCCDTDLC 80

                .
gi 13385422  88 N 88
Cdd:cd00117  81 N 81

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13385422  21 LKCHECS---GIEDCYKPKTCSSQSLYCLTNWYT-----PPGQQTTVTKTCAYTC--PDINHVTANSKSSCCNTDLCN 88
Cdd:cd23560   1 LRCYTCPeptDSSLCTTIVNCSPNETACKTTLYSvdsgyPFFGNITVTRGCASECipSDPDGIGETHPISCCNTDLCN 78