Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853    46 VKDCIHTVLKEELASAE-YSPDEMPQLTKRLSEMIKDKLKELGYDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNYTH 124
Cdd:pfam03645   2 VKEIIKEVLEEVLGGGEtYDHEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYAS 81

                          90
                  ....*....|....*
gi 21426853   125 DVFMNDSLFCVVAAF 139
Cdd:pfam03645  82 YKFENKSLFAVVTVF 96

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853  41 FRPSVVKDCIHTVLKEELASAEYSPDEMPQLTKRLSEMIKDKLKELGYDRYKMVVQVVIGEQRGEGVFMAARCFWDADTD 120
Cdd:cd21451   1 FNPEKVKKIIKEVLEERLENVTYDPEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 21426853 121 NYTHDVFMNDSLFCVVAAFGC 141
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853  40 RFRPSVVKDCIHTVLKEELASAEYSPDEMPQLTKRLSEMIKDKLKELGYDRYKMVVQVVIGEQRGEGVFMAARCFWDADT 119
Cdd:cd21461  10 RFDASRVQQILEATLDSYLGGARYSPATCGQLSQGLSELVRSKVKDLSPPRYKLVCQVVLGQCGNQGLRVASRCLWDPER 89

                        90       100
                ....*....|....*....|....
gi 21426853 120 DNYTHDVFMNDSLFCVVAAFGCFY 143
Cdd:cd21461  90 DNFASASFQNASLFAVATVHGVYF 113

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853  46 VKDCIHTVLKEELASAEYSPDEMPQLTKRLSEMIKDKLKELGYDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNYTHD 125
Cdd:cd21449   2 IREIIKEVLESILDDKEYDPLKLKEIAKKISEEIKEKLKELSPSRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVSE 81

                        90
                ....*....|....*
gi 21426853 126 VFMNDSLFCVVAAFG 140
Cdd:cd21449  82 VYENDNIICTVTVFG 96

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853  44 SVVKDCIHTVLKEElasaEYSPDEMPQLTKRLSEMIKDKLKELGyDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNYT 123
Cdd:cd21455   5 SIVKEAIEAVLGDK----TYSHSKVNQWSNSIVEEILKRLAKLN-KPFKYIVTCVIMQKTGAGLHTASSCYWDPTTDGSV 79

                        90
                ....*....|....*...
gi 21426853 124 HDVFMNDSLFCVVAAFGC 141
Cdd:cd21455  80 TVRWENKTMYCIVTVFGL 97

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins; Dynein light chain Tctex-type 3 (DYNLT3), also called rp3, or protein 91/23, or T-complex-associated testis-expressed 1-like, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It has a potential role in chromosome congression in human mitosis and is required for chromosome alignment during mouse oocyte meiotic maturation. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426853  45 VVKDCIHTVLkeelASAEYSPDEMPQLTKRLSEMIKDKLKELGyDRYKMVVQVVIGEQRGEGVFMAARCFWDADTDNYTH 124
Cdd:cd21463   6 VVKECIEGIL----GGVDYNHNKINQWTAAIVEQSLTHLVKLG-KPFKYIVTCAVMQKSGAGLHTASSCFWDTTTDGSCT 80

                        90
                ....*....|....*
gi 21426853 125 DVFMNDSLFCVVAAF 139
Cdd:cd21463  81 VRWENRTMYCVVSVF 95