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Conserved domains on  [gi|84662738|ref|NP_075609|]
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guanine nucleotide-binding protein subunit beta-like protein 1 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 1.63e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.63e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  91 LCLWDLEEG---RNTIMDSVQLDSVGFCR-GSILVRGqqcwmlavpgkGSD-EVQILEMPSKTSVCTLKPEADArpgmPM 165
Cdd:COG2319 186 VRLWDLATGkllRTLTGHTGAVRSVAFSPdGKLLASG-----------SADgTVRLWDLATGKLLRTLTGHSGS----VR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 166 CLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQ 243
Cdd:COG2319 251 SVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLR 324

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 244 VKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 325 TLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 1.63e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.63e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  91 LCLWDLEEG---RNTIMDSVQLDSVGFCR-GSILVRGqqcwmlavpgkGSD-EVQILEMPSKTSVCTLKPEADArpgmPM 165
Cdd:COG2319 186 VRLWDLATGkllRTLTGHTGAVRSVAFSPdGKLLASG-----------SADgTVRLWDLATGKLLRTLTGHSGS----VR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 166 CLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQ 243
Cdd:COG2319 251 SVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLR 324

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 244 VKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 325 TLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-321 9.22e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 9.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSqaagnPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  91 LCLWDLEEGR---------NTIMDSVQLDSvgfcrGSILVrgqqcwmlavpGKGSD-EVQILEMPSKTSVCTLKPEADAr 160
Cdd:cd00200  75 IRLWDLETGEcvrtltghtSYVSSVAFSPD-----GRILS-----------SSSRDkTIKVWDVETGKCLTTLRGHTDW- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 161 pgmPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQ 240
Cdd:cd00200 138 ---VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 241 SLQVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISI 319
Cdd:cd00200 211 CLGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRI 287


                ..
gi 84662738 320 WS 321
Cdd:cd00200 288 WD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 9.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 9.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  173 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 251
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84662738  252 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 322
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 3.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 84662738    283 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
284-321 1.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 84662738   284 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 1.63e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 1.63e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  91 LCLWDLEEG---RNTIMDSVQLDSVGFCR-GSILVRGqqcwmlavpgkGSD-EVQILEMPSKTSVCTLKPEADArpgmPM 165
Cdd:COG2319 186 VRLWDLATGkllRTLTGHTGAVRSVAFSPdGKLLASG-----------SADgTVRLWDLATGKLLRTLTGHSGS----VR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 166 CLGLwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQ 243
Cdd:COG2319 251 SVAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLR 324

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 244 VKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 325 TLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-321 9.22e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 9.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSqaagnPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  91 LCLWDLEEGR---------NTIMDSVQLDSvgfcrGSILVrgqqcwmlavpGKGSD-EVQILEMPSKTSVCTLKPEADAr 160
Cdd:cd00200  75 IRLWDLETGEcvrtltghtSYVSSVAFSPD-----GRILS-----------SSSRDkTIKVWDVETGKCLTTLRGHTDW- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 161 pgmPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQ 240
Cdd:cd00200 138 ---VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 241 SLQVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISI 319
Cdd:cd00200 211 CLGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRI 287


                ..
gi 84662738 320 WS 321
Cdd:cd00200 288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-322 2.41e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 2.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738   8 PPGPRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGR 87
Cdd:COG2319  67 AGALLATLLGHTAAVLSVAFSPDGR-----LLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSA 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  88 DLRLCLWDLEEGR--NTIMD-SVQLDSVGFCR-GSILVRGqqcwmlavpgkGSDE-VQILEMPSKTSVCTLKPEADarpg 162
Cdd:COG2319 141 DGTVRLWDLATGKllRTLTGhSGAVTSVAFSPdGKLLASG-----------SDDGtVRLWDLATGKLLRTLTGHTG---- 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 163 mpmclglWQTNSSLRP---LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLD 237
Cdd:COG2319 206 -------AVRSVAFSPdgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLL--ASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 238 DQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQR 316
Cdd:COG2319 277 TGELLRTLTGH---SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSDDGT 353


                ....*.
gi 84662738 317 ISIWSL 322
Cdd:COG2319 354 VRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
33-322 4.37e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 4.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  33 AAGNPLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGQgVIWLKTLPQGHQLLSQGRDLRLCLWDLEEGRNTIMDSVQLDSV 112
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAA-VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 113 GFCRGSILVRgqqcwmLAVPGKGSDEVQILEMPSKTSVCTLKPEADARPGMpmclglwqtnsSLRP---LLLAGYEDGSV 189
Cdd:COG2319  82 LSVAFSPDGR------LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV-----------AFSPdgkTLASGSADGTV 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 190 TLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKIL 267
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKLL 219

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 84662738 268 ATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
14-283 9.12e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 9.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  14 VLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLRLCL 93
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGK-----LLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  94 WDLEEGR--NTIM-DSVQLDSVGFCR-GSILVRGqqcwmlavpgkGSD-EVQILEMPSKTSVCTLKPEADARPGMpmclg 168
Cdd:COG2319 231 WDLATGKllRTLTgHSGSVRSVAFSPdGRLLASG-----------SADgTVRLWDLATGELLRTLTGHSGGVNSV----- 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 169 lwqtnsSLRP---LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVK 245
Cdd:COG2319 295 ------AFSPdgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 84662738 246 KTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRT 283
Cdd:COG2319 369 TGHT---GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-322 3.80e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 3.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 174 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 253
Cdd:cd00200  18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 254 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:cd00200  95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-235 3.03e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 3.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738   7 PPPGPRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHggQGVIW-LKTLPQGHQLLSQ 85
Cdd:cd00200 123 ETGKCLTTLRGHTDWVNSVAFSPDGT-----FVASSSQDGTIKLWDLRTGKCVATLTGH--TGEVNsVAFSPDGEKLLSS 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  86 GRDLRLCLWDLeegrntimdsvqldSVGFCRGSILVRGQQCWMLAVpgkgsdevqilempsktsvctlkpeadarpgmpm 165
Cdd:cd00200 196 SSDGTIKLWDL--------------STGKCLGTLRGHENGVNSVAF---------------------------------- 227

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 166 clglwqtnSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWS 235
Cdd:cd00200 228 --------SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
11-97 6.08e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 6.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWSLQTRRIVTTLNGHGGqGVIWLKTLPQGHQLLSQGRDLR 90
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGT 395


                ....*..
gi 84662738  91 LCLWDLE 97
Cdd:COG2319 396 VRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 9.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 9.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738  173 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 251
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84662738  252 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 322
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 3.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 84662738    283 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
284-321 1.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 84662738   284 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-325 1.30e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 1.30e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 84662738 293 HSAPVYCVAFAADG-LLAAGSKDQRISIWSLYPC 325
Cdd:cd00200   8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
238-319 5.68e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 5.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84662738 238 DQQSLQVKKTHELtNPGIAEVTIRPD-HKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPvYCVAFAADG--LLAAGSKD 314
Cdd:COG3391  96 DLATGKVVATIPV-GGGPRGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGkrLYVANSGS 173


                ....*
gi 84662738 315 QRISI 319
Cdd:COG3391 174 NTVSV 178
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-52 6.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.99e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 84662738     11 PRFVLRGTQSAVNTLHFCPPSQaagnpLLFSGSQNGLVHIWS 52
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGK-----YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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