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Conserved domains on  [gi|11528512|ref|NP_071309|]
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aquaporin-9 isoform 1 [Mus musculus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
24-266 1.24e-66

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member PTZ00016:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 294  Bit Score: 209.98  E-value: 1.24e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   24 KETLSEFLGTFIMIVLGCGSIAQAVLSREKaGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:PTZ00016  51 REYVAEFLGTFVLLFFGEGVVATTHTVGNN-GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  104 FYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLL-ITGENGTAFIFATYPKpfVSVPGAFVDQVVSTMFLLLIVFAIFDS 182
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPwETMANGFAGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  183 RNLGvPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAgWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIY 262
Cdd:PTZ00016 208 NNCP-AFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAVLGMFLY 285

                 ....
gi 11528512  263 VLFI 266
Cdd:PTZ00016 286 DKFI 289
 
Name Accession Description Interval E-value
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
24-266 1.24e-66

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 209.98  E-value: 1.24e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   24 KETLSEFLGTFIMIVLGCGSIAQAVLSREKaGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:PTZ00016  51 REYVAEFLGTFVLLFFGEGVVATTHTVGNN-GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  104 FYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLL-ITGENGTAFIFATYPKpfVSVPGAFVDQVVSTMFLLLIVFAIFDS 182
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPwETMANGFAGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  183 RNLGvPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAgWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIY 262
Cdd:PTZ00016 208 NNCP-AFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAVLGMFLY 285

                 ....
gi 11528512  263 VLFI 266
Cdd:PTZ00016 286 DKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
24-265 5.91e-65

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 203.25  E-value: 5.91e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  24 KETLSEFLGTFIMIVLGCGSIAQAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 104 FYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLLITGengtafIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSR 183
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 184 NLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAgwgfevftFGNNFWWIPVVGPMIGAVLGGLIYV 263
Cdd:cd00333 155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226

                ..
gi 11528512 264 LF 265
Cdd:cd00333 227 YV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
22-266 1.26e-64

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 202.66  E-value: 1.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  22 LAKETLSEFLGTFIMIVLGCGSIAqaVLSREKAG-GIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWF 100
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVA--VLAGTKGGiGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 101 KFPFYVGAQLLGAFVGAATVFGIYYDGLMAFADGkllitgeNGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIF 180
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGIT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 181 DSRNlgVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVftfgnNFWWIPVVGPMIGAVLGGL 260
Cdd:COG0580 153 DKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSDW-----GYLWVPIVAPILGAALAAL 225

                ....*.
gi 11528512 261 IYVLFI 266
Cdd:COG0580 226 LYRALF 231
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
28-262 1.74e-48

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 160.54  E-value: 1.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512    28 SEFLGTFIMIVLGCGSIAQAVLSREK----AGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   104 FYVGAQLLGAFVGAATVFGIYYDGLmafadgkllitgenGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSR 183
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF--------------PGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDR 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 11528512   184 NLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWgfevftfgnNFWWIPVVGPMIGAVLGGLIY 262
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW---------GNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
24-262 3.19e-41

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 142.07  E-value: 3.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512    24 KETLSEFLGTFIMIVLGCGSIA--QAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFK 101
Cdd:pfam00230   9 RAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   102 FPFYVGAQLLGAFVGAATVFGIYYDGLMAFAdgkllitgengtafiFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFD 181
Cdd:pfam00230  89 AIFYIVAQLLGAIAGAALLYGVTVGLQRAGL---------------FANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   182 SRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTalagWGFEVFtfgnnfwWIPVVGPMIGAVLGGLI 261
Cdd:pfam00230 154 DRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAALGALV 222

                  .
gi 11528512   262 Y 262
Cdd:pfam00230 223 Y 223
 
Name Accession Description Interval E-value
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
24-266 1.24e-66

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 209.98  E-value: 1.24e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   24 KETLSEFLGTFIMIVLGCGSIAQAVLSREKaGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:PTZ00016  51 REYVAEFLGTFVLLFFGEGVVATTHTVGNN-GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  104 FYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLL-ITGENGTAFIFATYPKpfVSVPGAFVDQVVSTMFLLLIVFAIFDS 182
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPwETMANGFAGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  183 RNLGvPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAgWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIY 262
Cdd:PTZ00016 208 NNCP-AFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAVLGMFLY 285

                 ....
gi 11528512  263 VLFI 266
Cdd:PTZ00016 286 DKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
24-265 5.91e-65

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 203.25  E-value: 5.91e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  24 KETLSEFLGTFIMIVLGCGSIAQAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 104 FYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLLITGengtafIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSR 183
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 184 NLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAgwgfevftFGNNFWWIPVVGPMIGAVLGGLIYV 263
Cdd:cd00333 155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226

                ..
gi 11528512 264 LF 265
Cdd:cd00333 227 YV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
22-266 1.26e-64

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 202.66  E-value: 1.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  22 LAKETLSEFLGTFIMIVLGCGSIAqaVLSREKAG-GIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWF 100
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVA--VLAGTKGGiGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 101 KFPFYVGAQLLGAFVGAATVFGIYYDGLMAFADGkllitgeNGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIF 180
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGIT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512 181 DSRNlgVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVftfgnNFWWIPVVGPMIGAVLGGL 260
Cdd:COG0580 153 DKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSDW-----GYLWVPIVAPILGAALAAL 225

                ....*.
gi 11528512 261 IYVLFI 266
Cdd:COG0580 226 LYRALF 231
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
28-262 1.74e-48

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 160.54  E-value: 1.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512    28 SEFLGTFIMIVLGCGSIAQAVLSREK----AGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   104 FYVGAQLLGAFVGAATVFGIYYDGLmafadgkllitgenGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSR 183
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF--------------PGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDR 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 11528512   184 NLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWgfevftfgnNFWWIPVVGPMIGAVLGGLIY 262
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW---------GNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
24-262 3.19e-41

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 142.07  E-value: 3.19e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512    24 KETLSEFLGTFIMIVLGCGSIA--QAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFK 101
Cdd:pfam00230   9 RAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   102 FPFYVGAQLLGAFVGAATVFGIYYDGLMAFAdgkllitgengtafiFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFD 181
Cdd:pfam00230  89 AIFYIVAQLLGAIAGAALLYGVTVGLQRAGL---------------FANTLAPGVNAGQAFVVEIILTFQLVYCVFATTD 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   182 SRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTalagWGFEVFtfgnnfwWIPVVGPMIGAVLGGLI 261
Cdd:pfam00230 154 DRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAALGALV 222

                  .
gi 11528512   262 Y 262
Cdd:pfam00230 223 Y 223
PRK05420 PRK05420
aquaporin Z; Provisional
22-265 5.23e-21

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 89.26  E-value: 5.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   22 LAKETLSEFLGTFIMIVLGCGSiaqAVLsrekAGGIITINIGFA--------TAVVMAlYATFGVSGGHINPAVSFAMCT 93
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCGS---AVL----AAAFPELGIGFLgvalafglTVLTMA-YAVGHISGGHFNPAVSVGLWA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   94 FGRMEWFKFPFYVGAQLLGAFVGAATVFGIyydglmafADGKlliTGENGTAFIFAT------YPKPFvSVPGAFVDQVV 167
Cdd:PRK05420  73 GGRFPAKELVPYIIAQVVGGIAAAAVLYLI--------ASGK---AGFDLAGSGFASngygehSPGGY-SLLAALVCEVV 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  168 STMFLLLIVFAIFDSRnlgVPRGLEPiviglliivISCSLGLN---------SGCAMNPARDLSPRLFtaLAGWGFEVFT 238
Cdd:PRK05420 141 LTAFFLLVILGATDKR---APAGFAP---------IAIGLALTlihlisipvTNTSVNPARSTGVALF--VGGWALEQLW 206
                        250       260
                 ....*....|....*....|....*..
gi 11528512  239 FgnnFWwipvVGPMIGAVLGGLIYVLF 265
Cdd:PRK05420 207 L---FW----VAPIVGAIIGGLIYRLL 226
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
23-262 9.48e-21

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 89.53  E-value: 9.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   23 AKETLSEFLGTFIMIVLGCGSIAQAVLSREKAGGIITINIGFATAVVMaLYATFGVSGGHINPAVSFAMCTFGRMEWFKF 102
Cdd:PLN00183  45 ARMVLAEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVV-VFSIGSISGAHVNPSVTIAFATFGHFPWSKV 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  103 PFYVGAQLLGAFvgAATVFGIYYDGLMAfadgKLLITgengtafifatypKPFVSVPGAFVDQVVSTMFLLLIVFAI-FD 181
Cdd:PLN00183 124 PLYITAQTVGSV--LATYVGVSVYGVKA----DLMTT-------------KPAQGCSSAFWVEFIATFIVMFLAASLtSQ 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  182 SRNLGVPRGLEPIVIGLLIIVIScslGLNSGCAMNPARDLSPrlftALAGWGFEVFtfgnnfwWIPVVGPMIGAVLGGLI 261
Cdd:PLN00183 185 PQSLGHLSGFVIGIAIGLAVLIT---GPVSGGSMNPARSLGP----AIVSWDFKDI-------WIYITAPTIGAVAGALM 250

                 .
gi 11528512  262 Y 262
Cdd:PLN00183 251 F 251
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
21-264 3.69e-19

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 85.35  E-value: 3.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   21 CLAKETLSEFLGTFIMIVLGCGSIAQAVLSrekaGGIIT---INIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRM 97
Cdd:PLN00182  40 CLTQKLIAEMIGTYFIIFSGCGVVVVNVLY----GGTITfpgICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   98 EWFKFPFYVGAQLLGAFVGAATVfgiyydGLMafadgkLLITGEngtAFiFATYPkpfVSVPG-AFVDQVVSTMFLLLIV 176
Cdd:PLN00182 116 PWYQVPLYIGAQLTGSLLASLTL------RLM------FNVTPE---AF-FGTTP---TDSSGqALVAEIIISFLLMFVI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  177 FAI-FDSRNLGVPRGLEPIVIGLLIIVIScslGLNSGCAMNPARDLSPRLFTALAgwgfevftfgnNFWWIPVVGPMIGA 255
Cdd:PLN00182 177 SGVaTDSRAVGELAGIAVGMTIILNVFVA---GPISGASMNPARSLGPAIVMGRY-----------KGIWVYIVGPFVGI 242

                 ....*....
gi 11528512  256 VLGGLIYVL 264
Cdd:PLN00182 243 IAGGFVYNL 251
PLN00184 PLN00184
aquaporin NIP1; Provisional
24-262 3.42e-17

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 80.07  E-value: 3.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   24 KETLSEFLGTFIMIVLGCGSIAqAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFP 103
Cdd:PLN00184  55 QKLIAEVLGTYFLVFTGCASVV-VNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  104 FYVGAQLLGAFVGAAT---VFGIYYDglmafadgklLITGENgTAFIFATypkPFVSVPGAFVDQVVSTMFLLLIVFAI- 179
Cdd:PLN00184 134 AYVISQVIGSTLAAATlrlLFGLDHD----------VCSGKH-DVFIGSS---PVGSDLQAFVMEFIVTFYLMFIISGVa 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  180 FDSRNLGVPRGLEPIVIGLLIIVISCSLglnSGCAMNPARDLSPRL-FTALAGwgfevftfgnnfWWIPVVGPMIGAVLG 258
Cdd:PLN00184 200 TDNRAIGELAGLAIGSTVLLNVLIAAPV---SSASMNPGRSLGPAMvYGCYKG------------IWIYIVAPTLGAIAG 264

                 ....
gi 11528512  259 GLIY 262
Cdd:PLN00184 265 AWVY 268
PLN00026 PLN00026
aquaporin NIP; Provisional
22-279 6.40e-14

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 70.66  E-value: 6.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   22 LAKETLSEFLGTFIMIVLGcgsIAQAVLSrEKAGGIITInIGFAT----AVVMALYATFGVSGGHINPAVSFAMCTFGRM 97
Cdd:PLN00026  70 LTRKLGAEFVGTFILIFAA---TAGPIVN-QKYDGAETL-IGNAAcaglAVMIVILSTGHISGAHLNPSLTIAFAALRHF 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   98 EWFKFPFYVGAQLLGAFVGAATVFGIYYdglmAFADGKLLItgengtafifatypkPFVSVPGAFVDQVVSTMFLLLIVF 177
Cdd:PLN00026 145 PWKHVPAYIAAQVSASICASFALKGVFH----PFMSGGVTV---------------PSVSTGQAFALEFIITFNLLFVVT 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  178 AI-FDSRNLGVPRGLEPIVIGLLIIVIScslGLNSGCAMNPARDLSPrlftALAGWGFEVFtfgnnfwWIPVVGPMIGAV 256
Cdd:PLN00026 206 AVaTDTRAVGELAGIAVGATVMLNILVA---GPSTGGSMNPVRTLGP----AVAAGNYRAI-------WIYLVAPTLGAL 271
                        250       260
                 ....*....|....*....|...
gi 11528512  257 LGGLIYVLfIQMHHSNPDPEVKA 279
Cdd:PLN00026 272 AGAGTYTA-VKLREEDGDPPRPV 293
PLN00166 PLN00166
aquaporin TIP2; Provisional
24-279 1.86e-13

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 68.42  E-value: 1.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   24 KETLSEFLGTFIMIVLGCGS-IAQAVLSREKA---GGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEW 99
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSaIAFAKLTSDAAldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  100 FKFPFYVGAQLLGAFVGAAtvfgiyydglmafadgkLLITGENGTAFIFATYPKPFVSVPGAfVDQVVSTMFLLLIVFAI 179
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACL-----------------LLVFVTNGESVPTHGVAAGLGAIEGV-VMEIVVTFALVYTVYAT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  180 FDSRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTAlagwgfevfTFGNNfwWIPVVGPMIGAVLGG 259
Cdd:PLN00166 161 AADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSG---------DFSQI--WIYWVGPLVGGALAG 229
                        250       260
                 ....*....|....*....|.
gi 11528512  260 LIY-VLFIQMHHSNPDPEVKA 279
Cdd:PLN00166 230 LIYgDVFIGSYAAAPTSEDYA 250
PLN00027 PLN00027
aquaporin TIP; Provisional
23-275 2.00e-13

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 68.66  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   23 AKETLSEFLGTFIMIVLGCGS-IAQAVLSREKA---GGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRME 98
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSgMAFNKLTDNGSttpAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   99 WFKFPFYVGAQLLGAFVGAAtvfgiyydgLMAFADGkllitGENGTAFIFAtypkPFVSVPGAFVDQVVSTMFLLLIVFA 178
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACL---------LLKFSTG-----GLETSAFSLS----SGVGVWNAFVFEIVMTFGLVYTVYA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  179 IFDSRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPrlftALAGWgfevfTFGNNfwWIPVVGPMIGAVLG 258
Cdd:PLN00027 162 TAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGP----AVVSW-----TWTNH--WVYWAGPLIGGGIA 230
                        250
                 ....*....|....*...
gi 11528512  259 GLIY-VLFIQMHHSNPDP 275
Cdd:PLN00027 231 GLVYeLIFIGSTTHEQLP 248
PLN00167 PLN00167
aquaporin TIP5; Provisional
27-262 9.01e-11

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 61.07  E-value: 9.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512   27 LSEFLGTFIMIVLGCGSI--AQAVLSREKAG--GIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKF 102
Cdd:PLN00167  26 LAEFISTFFFVFAAVGSAmsSRKLMPDAASDpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  103 PFYVGAQLLGAfvgaatvfgiyydgLMAFADGKLLITGENGTAFIFATYPKPFvsvpGAFVDQVVSTMFLLLIVFAIFDS 182
Cdd:PLN00167 106 MFYWISQMLAS--------------VMACLFLKVTTVGQHVPTYKIAEEMTGF----GASVLEGVLTFGLVYTVYAAGDP 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11528512  183 RNlGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSprlfTALAGWGFEvftfGNNFWWipvVGPMIGAVLGGLIY 262
Cdd:PLN00167 168 RR-GLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFG----SAVVAGSFK----NQAVYW---VGPLLGGAVAGLLY 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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