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Conserved domains on  [gi|112181162|ref|NP_067518|]
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protocadherin-8 isoform 1 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-605 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  501 VYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVeaevgrsGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQ 580
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  581 ASDGGSPQLSSNALVQVRVLDQNDH 605
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 252-350 3.92e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  252 EVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGP 331
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 112181162  332 GPRTATCKVIVRIRDVNDN 350
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 9.95e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 9.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  139 QIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAE--PHSPFRVELQTradgaqcADLVLLQELDRESQASYSLELV 216
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  217 AQDGGRPPRSATAALSVRVLDANDH 241
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-493 3.04e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 3.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  401 VPEGAARESLVALVSTSDRDSGANGQVRCALYG---HEHFRLQPAyagSYLVVTAASLDRERIAEYNLTLVAEDRGTPPL 477
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 112181162  478 RTVRPYTVRVGDENDN 493
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 618-711 5.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 5.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  618 SLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPgRVFKALLVISDGGR 697
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|....
gi 112181162  698 PPLTTTATVSFVVT 711
Cdd:cd11304    80 PPLSSTATVTITVL 93
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-109 1.02e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 58.69  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    31 TVRYSTFEEDAPGTVIGTLAEDLHMKVsGDTS---FRLMKQFNSSLLRVREGDGQLTVGDAgLDRERLCGPSPQCVLAFD 107
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEV-GELAargARVVSKGNKQYFQLNPETGDLLLNEK-LDREELCGSTEPCVLHFQ 78


                   ..
gi 112181162   108 VV 109
Cdd:pfam08266   79 VL 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-605 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  501 VYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVeaevgrsGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQ 580
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  581 ASDGGSPQLSSNALVQVRVLDQNDH 605
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 252-350 3.92e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  252 EVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGP 331
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 112181162  332 GPRTATCKVIVRIRDVNDN 350
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 9.95e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 9.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  139 QIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAE--PHSPFRVELQTradgaqcADLVLLQELDRESQASYSLELV 216
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  217 AQDGGRPPRSATAALSVRVLDANDH 241
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 1.60e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 1.60e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    270 AADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVND 349
Cdd:smart00112    2 ATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 112181162    350 NAP 352
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-493 3.04e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 3.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  401 VPEGAARESLVALVSTSDRDSGANGQVRCALYG---HEHFRLQPAyagSYLVVTAASLDRERIAEYNLTLVAEDRGTPPL 477
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 112181162  478 RTVRPYTVRVGDENDN 493
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 521-607 6.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 6.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    521 ARDPDVGRNGQVTYRLVeaevgrsGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVL 600
Cdd:smart00112    2 ATDADSGENGKVTYSIL-------SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 112181162    601 DQNDHSP 607
Cdd:smart00112   75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
252-344 7.54e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 7.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   252 EVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGP 331
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 112181162   332 GPRTATCKVIVRI 344
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
502-600 1.47e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   502 YEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSgeavstyVSVDPATGAIYALRSFDYETLRQLDVRVQA 581
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-------FRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 112181162   582 SDGGSPQLSSNALVQVRVL 600
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 415-495 3.56e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.56e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    415 STSDRDSGANGQVRCAL---YGHEHFRLQPayaGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDEN 491
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 112181162    492 DNAP 495
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 618-711 5.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 5.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  618 SLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPgRVFKALLVISDGGR 697
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|....
gi 112181162  698 PPLTTTATVSFVVT 711
Cdd:cd11304    80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-243 5.19e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 5.19e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    160 VDEDVGANGLQSVRLA--EPHSPFRVELQTradgaqcADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLD 237
Cdd:smart00112    3 TDADSGENGKVTYSILsgNDDGLFSIDPET-------GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 112181162    238 ANDHSP 243
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
401-487 9.30e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   401 VPEGAARESLVALVSTSDRDSGANGQVRCALYGHE---HFRLQPAyagSYLVVTAASLDRERIAEYNLTLVAEDRGTPPL 477
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpggNFRIDPD---TGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 112181162   478 RTVRPYTVRV 487
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
620-711 3.53e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 3.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   620 EVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRvFKALLVISDGGRPP 699
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 112181162   700 LTTTATVSFVVT 711
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-236 2.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   140 IPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSP--FRVELQTRadgaqcaDLVLLQELDRESQASYSLELVA 217
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 112181162   218 QDGGRPPRSATAALSVRVL 236
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 637-711 1.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.23e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112181162    637 QARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEpPGRVFKALLVISDGGRPPLTTTATVSFVVT 711
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-109 1.02e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 58.69  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    31 TVRYSTFEEDAPGTVIGTLAEDLHMKVsGDTS---FRLMKQFNSSLLRVREGDGQLTVGDAgLDRERLCGPSPQCVLAFD 107
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEV-GELAargARVVSKGNKQYFQLNPETGDLLLNEK-LDREELCGSTEPCVLHFQ 78


                   ..
gi 112181162   108 VV 109
Cdd:pfam08266   79 VL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 38-131 2.84e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   38 EEDAPGTVIGTL-AEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVgDAGLDRERlcgpspQCVLAFDVVSFSQEQF 116
Cdd:cd11304     8 ENAPPGTVVLTVsATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT-AKPLDREE------QSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 112181162  117 RL---VHVEVEVRDVNDH 131
Cdd:cd11304    81 PLsstATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 50-133 2.07e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 2.07e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162     50 AEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAgLDRERLcgpsPQC---VLAFDVVSFSQEQFRLVHVEVEvr 126
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQ----PEYtltVEATDGGGPPLSSTATVTITVL-- 74


                    ....*..
gi 112181162    127 DVNDHAP 133
Cdd:smart00112   75 DVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-605 4.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  501 VYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVeaevgrsGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQ 580
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  581 ASDGGSPQLSSNALVQVRVLDQNDH 605
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 252-350 3.92e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  252 EVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGP 331
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 112181162  332 GPRTATCKVIVRIRDVNDN 350
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 9.95e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 9.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  139 QIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAE--PHSPFRVELQTradgaqcADLVLLQELDRESQASYSLELV 216
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST-------GEITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 112181162  217 AQDGGRPPRSATAALSVRVLDANDH 241
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 1.60e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 1.60e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    270 AADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVND 349
Cdd:smart00112    2 ATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 112181162    350 NAP 352
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 401-493 3.04e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.07  E-value: 3.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  401 VPEGAARESLVALVSTSDRDSGANGQVRCALYG---HEHFRLQPAyagSYLVVTAASLDRERIAEYNLTLVAEDRGTPPL 477
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgneDGLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 112181162  478 RTVRPYTVRVGDENDN 493
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 521-607 6.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 6.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    521 ARDPDVGRNGQVTYRLVeaevgrsGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVL 600
Cdd:smart00112    2 ATDADSGENGKVTYSIL-------SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 112181162    601 DQNDHSP 607
Cdd:smart00112   75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
252-344 7.54e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 7.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   252 EVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFgarTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGP 331
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 112181162   332 GPRTATCKVIVRI 344
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
502-600 1.47e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   502 YEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSgeavstyVSVDPATGAIYALRSFDYETLRQLDVRVQA 581
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-------FRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 112181162   582 SDGGSPQLSSNALVQVRVL 600
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 415-495 3.56e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.56e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    415 STSDRDSGANGQVRCAL---YGHEHFRLQPayaGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDEN 491
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 112181162    492 DNAP 495
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 618-711 5.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 5.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162  618 SLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPgRVFKALLVISDGGR 697
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|....
gi 112181162  698 PPLTTTATVSFVVT 711
Cdd:cd11304    80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-243 5.19e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 5.19e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    160 VDEDVGANGLQSVRLA--EPHSPFRVELQTradgaqcADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLD 237
Cdd:smart00112    3 TDADSGENGKVTYSILsgNDDGLFSIDPET-------GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 112181162    238 ANDHSP 243
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
401-487 9.30e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   401 VPEGAARESLVALVSTSDRDSGANGQVRCALYGHE---HFRLQPAyagSYLVVTAASLDRERIAEYNLTLVAEDRGTPPL 477
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpggNFRIDPD---TGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 112181162   478 RTVRPYTVRV 487
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
620-711 3.53e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 3.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   620 EVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRvFKALLVISDGGRPP 699
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 112181162   700 LTTTATVSFVVT 711
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-236 2.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.56  E-value: 2.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   140 IPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSP--FRVELQTRadgaqcaDLVLLQELDRESQASYSLELVA 217
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 112181162   218 QDGGRPPRSATAALSVRVL 236
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 637-711 1.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.23e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112181162    637 QARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEpPGRVFKALLVISDGGRPPLTTTATVSFVVT 711
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-109 1.02e-10

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 58.69  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162    31 TVRYSTFEEDAPGTVIGTLAEDLHMKVsGDTS---FRLMKQFNSSLLRVREGDGQLTVGDAgLDRERLCGPSPQCVLAFD 107
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEV-GELAargARVVSKGNKQYFQLNPETGDLLLNEK-LDREELCGSTEPCVLHFQ 78


                   ..
gi 112181162   108 VV 109
Cdd:pfam08266   79 VL 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 38-131 2.84e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.62  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162   38 EEDAPGTVIGTL-AEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVgDAGLDRERlcgpspQCVLAFDVVSFSQEQF 116
Cdd:cd11304     8 ENAPPGTVVLTVsATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT-AKPLDREE------QSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 112181162  117 RL---VHVEVEVRDVNDH 131
Cdd:cd11304    81 PLsstATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 50-133 2.07e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 2.07e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112181162     50 AEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAgLDRERLcgpsPQC---VLAFDVVSFSQEQFRLVHVEVEvr 126
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQ----PEYtltVEATDGGGPPLSSTATVTITVL-- 74


                    ....*..
gi 112181162    127 DVNDHAP 133
Cdd:smart00112   75 DVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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