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Conserved domains on  [gi|10946936|ref|NP_067490|]
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adenylate kinase isoenzyme 1 isoform 1 [Mus musculus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 1.12e-127

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 357.59  E-value: 1.12e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   102 SSNGFLIDGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 10946936   182 KRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 1.12e-127

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 357.59  E-value: 1.12e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   102 SSNGFLIDGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 10946936   182 KRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 26-198 2.89e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 225.19  E-value: 2.89e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSNG 105
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936 106 FLIDGYPREVKQGEEFEQKI---GQPTLLLYVDAGAETMTQRLLKRGET-------------------SGRVDDNEETIK 163
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 10946936 164 KRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTV 198
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
29-183 6.25e-70

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 211.01  E-value: 6.25e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlAKVDSSNGFLI 108
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   109 DGYPREVKQGEEFEQKIG---QPTLLLYVDAGAETMTQRLLKRGET---------------------------SGRVDDN 158
Cdd:pfam00406  80 DGFPRTVPQAEALEELLErgiKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 10946936   159 EETIKKRLETYYNATEPVISFYDKR 183
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 25-206 7.48e-67

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 204.21  E-value: 7.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSN 104
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936 105 GFLIDGYPREVKQGEEFE---QKIGQP-TLLLYVDAGAETMTQRLLKR---------------------------GETSG 153
Cdd:COG0563  80 GFILDGFPRTVAQAEALDellAELGIKlDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 10946936 154 RVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYL 206
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 25-209 2.16e-65

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 200.76  E-value: 2.16e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSN 104
Cdd:PRK00279   2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  105 GFLIDGYPREVKQGEEFE---QKIGQP-TLLLYVDAGAETMTQRLLKR---------------------------GETSG 153
Cdd:PRK00279  80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946936  154 RVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:PRK00279 160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 22-209 1.12e-127

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 357.59  E-value: 1.12e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVD 101
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   102 SSNGFLIDGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFYD 181
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 10946936   182 KRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 26-198 2.89e-75

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 225.19  E-value: 2.89e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSNG 105
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936 106 FLIDGYPREVKQGEEFEQKI---GQPTLLLYVDAGAETMTQRLLKRGET-------------------SGRVDDNEETIK 163
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 10946936 164 KRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTV 198
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
29-183 6.25e-70

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 211.01  E-value: 6.25e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlAKVDSSNGFLI 108
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   109 DGYPREVKQGEEFEQKIG---QPTLLLYVDAGAETMTQRLLKRGET---------------------------SGRVDDN 158
Cdd:pfam00406  80 DGFPRTVPQAEALEELLErgiKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 10946936   159 EETIKKRLETYYNATEPVISFYDKR 183
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 26-202 5.50e-69

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 208.76  E-value: 5.50e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVS-SGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKvDSSN 104
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   105 GFLIDGYPREVKQGEEFEQKIGQ---PTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFYD 181
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 10946936   182 KRGIVRKVNAEGTVDTVFSEV 202
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 25-206 7.48e-67

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 204.21  E-value: 7.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSN 104
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKER-LAQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936 105 GFLIDGYPREVKQGEEFE---QKIGQP-TLLLYVDAGAETMTQRLLKR---------------------------GETSG 153
Cdd:COG0563  80 GFILDGFPRTVAQAEALDellAELGIKlDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 10946936 154 RVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYL 206
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 25-209 2.16e-65

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 200.76  E-value: 2.16e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSN 104
Cdd:PRK00279   2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKER-LAQPDCKN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  105 GFLIDGYPREVKQGEEFE---QKIGQP-TLLLYVDAGAETMTQRLLKR---------------------------GETSG 153
Cdd:PRK00279  80 GFLLDGFPRTIPQAEALDemlKELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 10946936  154 RVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:PRK00279 160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 25-207 1.77e-55

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 175.50  E-value: 1.77e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDSSN 104
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   105 GFLIDGYPREVKQGEEFEQKI-GQPTLLLYVDAGAETMTQRLLKRG--ETSGRV-------------------------D 156
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLeEPIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10946936   157 DNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYLD 207
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PLN02200 PLN02200
adenylate kinase family protein
 10-202 1.43e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 168.92  E-value: 1.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   10 QEEGGRKTGEKlkKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVL 89
Cdd:PLN02200  31 LEERGSSSKEK--TPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   90 DMLRDAMlaKVDSSNGFLIDGYPREVKQGEEFEQKIG-QPTLLLYVDAGAETMTQRLLKRGEtsGRVDDNEETIKKRLET 168
Cdd:PLN02200 109 KLIQKEM--ESSDNNKFLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKV 184

                        170       180       190
                 ....*....|....*....|....*....|....
gi 10946936  169 YYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PLN02200 185 FNALNLPVIDYYSKKGKLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 23-207 3.91e-49

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 158.44  E-value: 3.91e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   23 KAKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlaKVDS 102
Cdd:PRK14531   2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  103 SNGFLIDGYPREVKQGEEFE---QKIGQP---TLLLYVDagAETMTQRLLKRgetsGRVDDNEETIKKRLETYYNATEPV 176
Cdd:PRK14531  79 SGGWLLDGFPRTVAQAEALEpllEELKQPieaVVLLELD--DAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPL 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 10946936  177 ISFYDKRGIVRKVNAEGTVDTVFSEVCTYLD 207
Cdd:PRK14531 153 IDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 23-202 8.68e-47

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 152.64  E-value: 8.68e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   23 KAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDS 102
Cdd:PRK14527   5 KNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  103 SNgFLIDGYPREVKQGEEFE---QKIGQPTL-LLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVIS 178
Cdd:PRK14527  84 VR-VIFDGFPRTLAQAEALDrllEELGARLLaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVD 162

                        170       180
                 ....*....|....*....|....
gi 10946936  179 FYDKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PRK14527 163 YYEARGHLKRVDGLGTPDEVYARI 186
PRK14532 PRK14532
adenylate kinase; Provisional
 26-202 9.81e-45

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 147.28  E-value: 9.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   26 IIFvvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDaMLAKVDSSNG 105
Cdd:PRK14532   4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEE-RLPEAEAAGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  106 FLIDGYPREVKQGEEFEQ---KIGQP---TLLLYVDagAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISF 179
Cdd:PRK14532  81 AIFDGFPRTVAQAEALDKmlaSRGQKidvVIRLKVD--DEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPY 158

                        170       180
                 ....*....|....*....|...
gi 10946936  180 YDKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PRK14532 159 YAGQGKLTEVDGMGSIEAVAASI 181
adk PRK02496
adenylate kinase; Provisional
 24-202 5.92e-44

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 145.28  E-value: 5.92e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   24 AKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDaMLAKVDSS 103
Cdd:PRK02496   2 TRLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQE-RLQQPDAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  104 NGFLIDGYPREVKQG---EEFEQKIGQPT-LLLYVDAGAETMTQRLLKRgetsGRVDDNEETIKKRLETYYNATEPVISF 179
Cdd:PRK02496  80 NGWILDGFPRKVTQAaflDELLQEIGQSGeRVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                        170       180
                 ....*....|....*....|...
gi 10946936  180 YDKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAVTTEL 178
PRK14528 PRK14528
adenylate kinase; Provisional
 25-202 2.41e-41

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 138.61  E-value: 2.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDaMLAKVDSSN 104
Cdd:PRK14528   3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKD-RIREADCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  105 GFLIDGYPREVKQGEEFEQKIGQPTL----LLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFY 180
Cdd:PRK14528  81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170       180
                 ....*....|....*....|..
gi 10946936  181 DKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEVTSLI 182
AAA_17 pfam13207
AAA domain;
30-163 2.71e-41

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 136.60  E-value: 2.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    30 VGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSerGKKLSAIMEKGELVPLDTVLDMLRDAmLAKVDSSNGFLID 109
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAER-IAEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   110 GYPREVKQGEEFE------QKIGQPTLLLYVDAGAETMTQRLLKRgETSGRVDDNEETIK 163
Cdd:pfam13207  78 GHPRIKTPAGYLPglpvevLRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14530 PRK14530
adenylate kinase; Provisional
 27-208 8.83e-36

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 125.29  E-value: 8.83e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRA---------EVSSGSERgkklsAIMEKGELVPlDTVLDMLRDAML 97
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVP-DAVVNEIVEEAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   98 akvDSSNGFLIDGYPREVKQGEEFEQkIGQPTLLLYVDAGAETMTQRLLKR---------------------------GE 150
Cdd:PRK14530  80 ---SDADGFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGE 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 10946936  151 TSGRVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDS 208
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PLN02842 PLN02842
nucleotide kinase
 29-207 1.13e-35

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 131.14  E-value: 1.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   29 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDSSNGFLI 108
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  109 DGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKR-------------------GETSGRV----DDNEETIKKR 165
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 10946936  166 LETYYNATEPVISFYDKrgIVRKVNAEGTVDTVFSEVCTYLD 207
Cdd:PLN02842 162 LQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLS 201
PRK13808 PRK13808
adenylate kinase; Provisional
 27-209 3.07e-33

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 121.53  E-value: 3.07e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDaMLAKVDSSNGF 106
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  107 LIDGYPREVKQGEEFEQKIGQPTLL------LYVDAGA-----ETMTQRLLKRGETSgRVDDNEETIKKRLETYYNATEP 175
Cdd:PRK13808  82 ILDGFPRTVPQAEALDALLKDKQLKldavveLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 10946936  176 VISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDSL 209
Cdd:PRK13808 161 LVHYYSEKRKLLTVDGMMTIDEVTREIGRVLAAV 194
PLN02674 PLN02674
adenylate kinase
 22-202 6.51e-31

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 113.44  E-value: 6.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   22 KKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlAKVD 101
Cdd:PLN02674  29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  102 SSNGFLIDGYPREVKQGEEFEQKIGQ------PTLLLYVDAG--AETMTQRLLKrgETSGRV------------------ 155
Cdd:PLN02674 108 CQKGFILDGFPRTVVQAQKLDEMLAKqgakidKVLNFAIDDAilEERITGRWIH--PSSGRTyhtkfappkvpgvddvtg 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 10946936  156 -------DDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEV 202
Cdd:PLN02674 186 epliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PLN02459 PLN02459
probable adenylate kinase
 31-184 1.34e-25

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 99.92  E-value: 1.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   31 GGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDS-SNGFLID 109
Cdd:PLN02459  36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFILD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  110 GYPREVKQGEEFEqKIGQPTLLLYVDAGAETMTQRLLKR---GETSG--------------------------------- 153
Cdd:PLN02459 116 GFPRTVRQAEILE-GVTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                        170       180       190
                 ....*....|....*....|....*....|...
gi 10946936  154 --RVDDNEETIKKRLETYYNATEPVISFYDKRG 184
Cdd:PLN02459 195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK14526 PRK14526
adenylate kinase; Provisional
 25-198 1.80e-24

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 95.69  E-value: 1.80e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   25 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAkVDSSN 104
Cdd:PRK14526   2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINT-IKNND 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  105 GFLIDGYPREVKQGEEFEQKIGQPTLLLYVdAGAETMTQRLLKR---------------------------GETSGRVDD 157
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 10946936  158 NEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTV 198
Cdd:PRK14526 159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 20-185 6.91e-23

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 91.78  E-value: 6.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   20 KLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlAK 99
Cdd:PTZ00088   2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI-AK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  100 V--DSSNGFLIDGYPREVKQGEEFeQKIGQPTLLLYVDAGAETMTQRLLKR----------------------------G 149
Cdd:PTZ00088  81 VtdDCFKGFILDGFPRNLKQCKEL-GKITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppA 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 10946936  150 ETSG---------RVDDNEETIKKRLETYYNATEPVISFYDKRGI 185
Cdd:PTZ00088 160 DCEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 27-173 8.92e-20

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 83.62  E-value: 8.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMlaKVDSSNGF 106
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  107 LIDGYPREVKQGEEFEQKIGQPTLLL-YV--------DAGAETMTQRLLKR------------------------GETSG 153
Cdd:PRK14529  81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                        170       180
                 ....*....|....*....|.
gi 10946936  154 RVDD-NEETIKKRLETYYNAT 173
Cdd:PRK14529 161 RADDqDEEAINKRHDIYYDTE 181
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 25-208 3.10e-08

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 51.50  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  25 KIIFVVGGPGSGKGTQCEKIVQ---KYGYTHLSTGDLlraevsSGSERGKKLSAIMEKGELVPLDTVLDML-----RDAM 96
Cdd:cd01672   1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  97 LAKV-----------------DSS---NGFLIDGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVD 156
Cdd:cd01672  75 VEEVikpalargkivlsdrfvDSSlayQGAGRGLGEALIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 10946936 157 DNEETIKKRLETYYNatepVISFYDKRGIVrkVNAEGTVDTVFSEVCTYLDS 208
Cdd:cd01672 155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 27-169 3.34e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 50.77  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAImekGELVPlDTVLDMLRDAMLAKVDssngF 106
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYYTDA---TDRTY-ERLHELARIALRAGRP----V 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10946936   107 LIDG---YPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSG-RVDDNEETIKKRLETY 169
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
26-198 2.12e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.76  E-value: 2.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTgDLLRAEVssgseRGKKLSAIMEKGELVPL--DTVLDMLRDAMLAKVDSs 103
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEATARtyARLLALARELLAAGRSV- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936 104 ngfLIDG---YPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYynatEPVISFY 180
Cdd:COG0645  74 ---ILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE----EPLTEDE 146

                       170
                ....*....|....*...
gi 10946936 181 DKRGIVRKVNAEGTVDTV 198
Cdd:COG0645 147 GFLLVVDTSGLEEALAAL 164
PRK04182 PRK04182
cytidylate kinase; Provisional
 26-206 2.36e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 45.95  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR--AEvssgsERGKKLSAIMEKGELVP-LDTVLD-MLRDAMLAK-- 99
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRelAK-----ERGMSLEEFNKYAEEDPeIDKEIDrRQLEIAEKEdn 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936  100 --VDSS-NGFLIDGYprevkqgeefeqkigqPTLLLYVDAGAETMTQRLLKRGETSgrVDDN-EETI------KKRLETY 169
Cdd:PRK04182  77 vvLEGRlAGWMAKDY----------------ADLKIWLKAPLEVRAERIAEREGIS--VEEAlEETIereeseAKRYKEY 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 10946936  170 YNatepvI-----SFYDkrgIV---RKVNAEGTVDTVFSEVCTYL 206
Cdd:PRK04182 139 YG-----IdiddlSIYD---LVintSRWDPEGVFDIILTAIDKLL 175
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
25-165 2.99e-06

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 45.71  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936   25 KIIFVVGGPGSGKGtQCEKIVQKYGYTHLSTGDLLRAEVssgSERGKKLS-------AIMEKGELVPlDTV----LDMLR 93
Cdd:PRK01184   2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEV---KKRGLEPTdenigkvAIDLRKELGM-DAVakrtVPKIR 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946936   94 DAmlakvdSSNGFLIDGYpREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRgetsGRVDDNE--ETIKKR 165
Cdd:PRK01184  77 EK------GDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 26-69 2.34e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 42.86  E-value: 2.34e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 10946936  26 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSER 69
Cdd:cd02020   1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
Nitrogenase_VnfN_like cd01971
Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN ...
 118-189 1.36e-03

Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. NifEN participates in the synthesis of the iron-molybdenum cofactor (FeMoco) of MoFe protein of the molybdenum(Mo)-nitrogenase. NifB-co (an iron and sulfur containing precursor of the FeMoco) from NifB is transferred to NifEN where it is further processed to FeMoco. VnfEN may similarly be a scaffolding protien for the iron-vanadium cofactor (FeVco) of the vanadium-dependent (V)-nitrogenase. NifE and NifN are essential for the Mo-nitrogenase, VnfE and VnfN are not essential for the V-nitrogenase. NifE and NifN can substitute when the vnfEN genes are inactivated.


Pssm-ID: 238931 [Multi-domain]  Cd Length: 427  Bit Score: 38.94  E-value: 1.36e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946936 118 GEEFEQKIGQPTLLL-YVDAGAETMTQRLLKRGETSGRVDDNEET-IKKRLETYYNATEPVISFYDKRGIVRKV 189
Cdd:cd01971 223 AQHLEEKYGQPYIHSpTLPIGAKATAEFLRQVAKFAGIEKAKVEAfIKAEEKRYYHYLERFSDFMARWGLPRRF 296
AAA_18 pfam13238
AAA domain;
27-160 3.87e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 36.25  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946936    27 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDSSNGF 106
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGNLIIDGH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 10946936   107 LIDGYPREVKQGEEFeqkigqptlllYVDAGAETMTQRLLKRGETSGRVDDNEE 160
Cdd:pfam13238  81 LAELEPERAKDLVGI-----------VLRASPEELLERLEKRGYEEAKIKENEE 123
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 26-75 9.31e-03

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 36.70  E-value: 9.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 10946936   26 IIFVVGGP-GSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSA 75
Cdd:PRK09518   2 IIVAIDGPaGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDA 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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