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Conserved domains on  [gi|10518506|ref|NP_063916|]
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coagulation factor VIII isoform b [Homo sapiens]

Protein Classification

discoidin domain-containing protein; discoidin domain-containing protein kinase; discoidin domain-containing protein; discoidin domain-containing protein kinase( domain architecture ID 11736611)

discoidin domain-containing protein kinase is a receptor protein-tyrosine kinase, similar to discoidin domain-containing receptors 1 (DDR1) and 2 (DDR2); discoidin domain-containing protein kinase is a receptor protein-tyrosine kinase, similar to discoidin domain-containing receptors 1 (DDR1) and 2 (DDR2); discoidin domain-containing protein similar to human retinoschisin (aka X-linked juvenile retinoschisis protein) that plays a crucial role in the cellular organization of the retina; discoidin domain-containing protein similar to human retinoschisin (aka X-linked juvenile retinoschisis protein) that plays a crucial role in the cellular organization of the retina

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 60-209 2.48e-64

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 195.65  E-value: 2.48e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506  60 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSM 139
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506 140 YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 209
Cdd:cd00057  74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C super family cl25480
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 4-52 1.44e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


The actual alignment was detected with superfamily member cd00057:

Pssm-ID: 330301 [Multi-domain]  Cd Length: 143  Bit Score: 78.55  E-value: 1.44e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 10518506   4 QDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 52
Cdd:cd00057  95 KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 60-209 2.48e-64

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 195.65  E-value: 2.48e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506  60 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSM 139
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506 140 YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 209
Cdd:cd00057  74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 57-210 5.92e-38

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 128.40  E-value: 5.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506     57 SCSMPLGMESkaisDAQITASSyftnmfATWSPSKARLHlQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLL 136
Cdd:smart00231   1 PCNEPLGLES----DSQITASS------SYWAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNG 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10518506    137 TsmYVKEFLISSSqDGHQWTlFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGC 210
Cdd:smart00231  70 D--WVTYKLEYSD-DGVNWT-TYKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 73-207 3.58e-33

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 116.01  E-value: 3.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506    73 QITASSYFTNmfaTWSPSKArlhLQG-RSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSlLTSMYVKEFLISSSQD 151
Cdd:pfam00754   1 QITASSSYSG---EGPAAAA---LDGdPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSLD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 10518506   152 GHQWTLFFQNGkvkvFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQ--IALRMEV 207
Cdd:pfam00754  74 GENWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 4-52 1.44e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 78.55  E-value: 1.44e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 10518506   4 QDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 52
Cdd:cd00057  95 KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 7-53 8.53e-17

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 73.70  E-value: 8.53e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 10518506      7 GKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 53
Cdd:smart00231  93 SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 12-50 4.52e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 50.14  E-value: 4.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 10518506    12 GNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS--TLRMEL 50
Cdd:pfam00754  87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgiALRAEL 127
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 60-209 2.48e-64

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 195.65  E-value: 2.48e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506  60 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSM 139
Cdd:cd00057   1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506 140 YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 209
Cdd:cd00057  74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 57-210 5.92e-38

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 128.40  E-value: 5.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506     57 SCSMPLGMESkaisDAQITASSyftnmfATWSPSKARLHlQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLL 136
Cdd:smart00231   1 PCNEPLGLES----DSQITASS------SYWAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNG 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10518506    137 TsmYVKEFLISSSqDGHQWTlFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGC 210
Cdd:smart00231  70 D--WVTYKLEYSD-DGVNWT-TYKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 73-207 3.58e-33

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 116.01  E-value: 3.58e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10518506    73 QITASSYFTNmfaTWSPSKArlhLQG-RSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSlLTSMYVKEFLISSSQD 151
Cdd:pfam00754   1 QITASSSYSG---EGPAAAA---LDGdPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSLD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 10518506   152 GHQWTLFFQNGkvkvFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQ--IALRMEV 207
Cdd:pfam00754  74 GENWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 4-52 1.44e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 78.55  E-value: 1.44e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 10518506   4 QDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 52
Cdd:cd00057  95 KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 7-53 8.53e-17

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 73.70  E-value: 8.53e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 10518506      7 GKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 53
Cdd:smart00231  93 SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 12-50 4.52e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 50.14  E-value: 4.52e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 10518506    12 GNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS--TLRMEL 50
Cdd:pfam00754  87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgiALRAEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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