Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 257196201  634 YQCSICNKRFTQKSSLNVHMRLH 656
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 257196201 608 CSICWRSFSLKDYLIKHMVTHTgvraYQCSICNKRFTQKSSLNVH-MRLHR 657
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHK 50

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201   94 LNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVLrVSQSE 169
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEItlddVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*..
gi 257196201  170 ALQILTAASILQIKTVIDECTRIVSQN 196
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKS 106

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 257196201  634 YQCSICNKRFTQKSSLNVHMRLH 656
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 257196201  648 SLNVHMRLHRGEKSYECYICKKKFSH 673
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 257196201 608 CSICWRSFSLKDYLIKHMVTHTgvraYQCSICNKRFTQKSSLNVH-MRLHR 657
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHK 50

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 257196201  578 YECTLCNKTFTAKQNYVKHMFVH 600
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  86 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRV 165
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 257196201 166 SQSEALQILTAASILQIKTVIDECTRIVSQN 196
Cdd:cd18229   81 AQSEALQILTAASILQIKTVIDECTQIISQS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  85 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLL-GYSDIEIPSVVSVQSVQKLIDFMYSGVL 163
Cdd:cd18210    3 EITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLkNMSSISLPGVMDPGAFESVLASAYTGKL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 257196201 164 RVSQSEALQILTAASILQIKTVIDECTRIV 193
Cdd:cd18210   83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  86 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-IEIPSVVSVQSVQKLIDFMYSGVLR 164
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNcLVLPSVIEAAAFENLLQLIYSGRLT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 257196201 165 VSQSEALQILTAASILQIKTVIDECTRIVSQ 195
Cdd:cd18200   81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  74 MTERIHsINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDkLLLGYSD--IEIPSVVSVQSV 151
Cdd:cd18289    1 MSQMLH-IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRD-LFSGNSKsaFELPATVPPACF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 257196201 152 QKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIV 193
Cdd:cd18289   79 QQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  86 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG-YSDIEIPSVVSVQSVQKLIDFMYSGVLR 164
Cdd:cd18220    8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALStMSGLSISVIKNPNVFEQLLSFCYTGRMS 87

                         90       100
                 ....*....|....*....|....*....
gi 257196201 165 VSQSEALQILTAASILQIKTVIDECTRIV 193
Cdd:cd18220   88 LQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  82 NLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFMYS 160
Cdd:cd18214    4 RFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSrEVQISILQNSEVGRQLLLSCYT 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 257196201 161 GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 195
Cdd:cd18214   84 GVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEI------PSVVSVQSV-----QKLI 155
Cdd:cd18228    3 SQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagKCVLDLHHVtvtgfAPLL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 257196201 156 DFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNV 197
Cdd:cd18228   83 EYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLL----LGYSDIEIPSVVSVQSVQKLIDFMYSGV 162
Cdd:cd18332    3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSgrvgEGVSVLTLPSGLEARGFQLLLDFMYTSR 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 257196201 163 LRVSQSEALQILTAASILQIKTVIDECTRIV 193
Cdd:cd18332   83 LPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  90 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIpSVVSVQSVQK-----LIDFMYSGVLR 164
Cdd:cd18256    7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK-DVVQIHGVEPdifhiLLDFIYTGVVE 85

                         90       100
                 ....*....|....*....|....*
gi 257196201 165 VSQSEALQILTAASILQIKTVIDEC 189
Cdd:cd18256   86 VTVSNVQELLVAADMLQLTEVVEIC 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201   105 DVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG----YSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASIL 180
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 257196201   181 QIKTVIDECTRIVSQN 196
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  91 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEI--PSVVSVQSVQKLIDFMYSGVLRVSQS 168
Cdd:cd18217    6 LERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFldQSQVSADGFQKLLEFIYTGNLNLDSW 85

                         90       100
                 ....*....|....*....|..
gi 257196201 169 EALQILTAASILQIKTVIDECT 190
Cdd:cd18217   86 NVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  88 NSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFMYSGVLRVS 166
Cdd:cd18197   10 DAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSkQVRITILQSAEVGRKLLLSCYTGALEVK 89

                         90       100
                 ....*....|....*....|....
gi 257196201 167 QSEALQILTAASILQIKTVIDECT 190
Cdd:cd18197   90 KKELLKYLTAASYLQMVHIVEKCT 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLLGYSDIEIPSV-----VSVQSVQKLIDFMYSG 161
Cdd:cd18326    9 SSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFK-KLFTSGAVVDQQNVyeidfVSAEALTALLDFAYTA 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 257196201 162 VLRVSQSEALQILTAASILQIKTVIDECTRIV 193
Cdd:cd18326   88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSvQSVQKLIDFMYSGVLRV 165
Cdd:cd18232    2 SVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSgSVVLPESFA-EVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*.
gi 257196201 166 SQSEALQILTAASILQIKTVIDECTR 191
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQR 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  86 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF------------QDKLLLGysDIEiPSVVSVqsvqk 153
Cdd:cd18247    2 LPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFhamfthdmveskQDEITMQ--GIE-PSALEA----- 73

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 257196201 154 LIDFMYSGVLRVSQSEALQILTAASILQIKTVIDEC 189
Cdd:cd18247   74 LINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDAC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQ-------DKLLLGYSDIEIpsvVSVQSVQKLIDFMY 159
Cdd:cd18323    7 SRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHmfykeqlDKRDLVCINNEI---VTAPAFSLLLEFMY 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 257196201 160 SGVLRVSQSEALQILTAASILQIKTVIDECTR 191
Cdd:cd18323   84 EGRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  91 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSvVSVQSVQKLIDFMYSGVLRV 165
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAEskqdsITIKD-IDEEAVELLVDFAYTGKLTL 81

                         90       100
                 ....*....|....*....|....*.
gi 257196201 166 SQSEALQILTAASILQIKTVIDECTR 191
Cdd:cd18238   82 TVDNVQSLLYAASLLQVEEVAKACCE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  90 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF-----QDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLR 164
Cdd:cd18230    8 LLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktlycQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA 87

                         90       100
                 ....*....|....*....|....*
gi 257196201 165 VSQSEALQILTAASILQIKTVIDEC 189
Cdd:cd18230   88 LTSKNVIEVMSAASYLQMTDIVQAC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKlLLGYSD----IEIPSVVSVQSVQKLIDFMYSGV 162
Cdd:cd18277   11 STNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSR-IVGQADaelnITLPEEVTVKGFEPLIQFAYTAK 89

                         90       100
                 ....*....|....*....|....*..
gi 257196201 163 LRVSQSEALQILTAASILQIKTVIDEC 189
Cdd:cd18277   90 LILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGV 162
Cdd:cd18242    5 AKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVelqgLTASTMEILLDFVYTET 84

                         90       100
                 ....*....|....*....|....*....
gi 257196201 163 LRVSQSEALQILTAASILQIKTVIDECTR 191
Cdd:cd18242   85 VHVTVENVQELLPAACLLQLKGVKQACCE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  87 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVS 166
Cdd:cd18206    6 SQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFR-MLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLS 84

                         90       100
                 ....*....|....*....|....*...
gi 257196201 167 QSEALQILTAASILQIKTVIDECTRIVS 194
Cdd:cd18206   85 PENVDDVLAVATFLQMQDIVTACHALKS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201  91 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFqdKLLLGYSDIEIPS--------VVSVQSVQKLIDFMYSGV 162
Cdd:cd18245    2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYF--RAKLNYNPPKDDGstykieleGISVEVMEEILDYIYTGQ 79

                         90       100
                 ....*....|....*....|....*..
gi 257196201 163 LRVSQSEALQILTAASILQIKTVIDEC 189
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196201 103 FCDVTVRIHGSMLRAHRCVLAAGSPFFQDkLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS 178
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAA-LLKETPPDEHPVIilpdVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*
gi 257196201 179 ILQIK 183
Cdd:cd18315   80 LLQIK 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.