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Conserved domains on  [gi|9789957|ref|NP_062724|]
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N-alpha-acetyltransferase 80 [Mus musculus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
96-217 3.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 68.57  E-value: 3.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789957   96 RPELMSACADLINDQWPRSRASRLHSLGQSSDAFPLCLMLLspqptpgAAPVVVGHARLSRV--LDQPHSLLVETVVVAR 173
Cdd:COG3153   5 TPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGLSLVAE-------DDGEIVGHVALSPVdiDGEGPALLLGPLAVDP 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 9789957  174 PLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLY-FYAHLGYQ 217
Cdd:COG3153  78 EYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLpFYERFGFR 122
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
96-217 3.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 68.57  E-value: 3.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789957   96 RPELMSACADLINDQWPRSRASRLHSLGQSSDAFPLCLMLLspqptpgAAPVVVGHARLSRV--LDQPHSLLVETVVVAR 173
Cdd:COG3153   5 TPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGLSLVAE-------DDGEIVGHVALSPVdiDGEGPALLLGPLAVDP 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 9789957  174 PLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLY-FYAHLGYQ 217
Cdd:COG3153  78 EYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLpFYERFGFR 122
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 147-216 1.42e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.31  E-value: 1.42e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9789957    147 VVVGHARLSRVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ----LYFYAHLGY 216
Cdd:pfam00583  43 ELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADnlaaIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 148-203 4.35e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 57.67  E-value: 4.35e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 9789957  148 VVGHARLSRVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLT 203
Cdd:cd04301  10 IVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 171-217 1.37e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.15  E-value: 1.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 9789957   171 VARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTH----DQLYFYAHLGYQ 217
Cdd:PRK03624  76 VHPDFRGRGIGRALVARLEKKLIARGCPKINLQVRedndAVLGFYEALGYE 126
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
96-217 3.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 68.57  E-value: 3.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789957   96 RPELMSACADLINDQWPRSRASRLHSLGQSSDAFPLCLMLLspqptpgAAPVVVGHARLSRV--LDQPHSLLVETVVVAR 173
Cdd:COG3153   5 TPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGLSLVAE-------DDGEIVGHVALSPVdiDGEGPALLLGPLAVDP 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 9789957  174 PLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLY-FYAHLGYQ 217
Cdd:COG3153  78 EYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLpFYERFGFR 122
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 147-216 1.42e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.31  E-value: 1.42e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9789957    147 VVVGHARLSRVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ----LYFYAHLGY 216
Cdd:pfam00583  43 ELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADnlaaIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 148-217 1.75e-12

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 63.53  E-value: 1.75e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9789957  148 VVGHARLSRvLDQPHsLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLY----FYAHLGYQ 217
Cdd:COG0454  45 PIGFAGLRR-LDDKV-LELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPaairFYERLGFK 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 148-221 1.86e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 63.47  E-value: 1.86e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9789957  148 VVGHARLsrVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHL-TTHDQLYFYAHLGYQLGEP 221
Cdd:COG1246  39 IVGCAAL--HPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLlTTSAAIHFYEKLGFEEIDK 111
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
148-221 1.75e-11

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 60.58  E-value: 1.75e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9789957  148 VVGHARLsRVLDQPHSLLvETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLttHDQLY---FYAHLGYQ-LGEP 221
Cdd:COG2153  45 LVATARL-LPPGDGEAKI-GRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVL--SAQAHavgFYEKLGFVpVGEE 118
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
148-237 3.18e-11

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 60.78  E-value: 3.18e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789957  148 VVGHARLSRVLDQP--HSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ----LYFYAHLGYQLGEP 221
Cdd:COG1247  63 VVGFASLGPFRPRPayRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADneasIALYEKLGFEEVGT 142

                        90
                ....*....|....*.
gi 9789957  222 VQGLAFTNRRLSTTVL 237
Cdd:COG1247 143 LPEVGFKFGRWLDLVL 158
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 148-203 4.35e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 57.67  E-value: 4.35e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 9789957  148 VVGHARLSRVLDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLT 203
Cdd:cd04301  10 IVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 150-217 1.14e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 57.36  E-value: 1.14e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9789957  150 GHARLSRVlDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ----LYFYAHLGYQ 217
Cdd:COG0456   1 GFALLGLV-DGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaaIALYEKLGFE 71
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 148-217 1.18e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 54.38  E-value: 1.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9789957    148 VVGHARLSRVLDQPHSLLVEtVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ-LYFYAHLGYQ 217
Cdd:pfam13508  14 IVGFAALLPLDDEGALAELR-LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRaAAFYEKLGFE 83
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
148-217 6.07e-08

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 49.52  E-value: 6.07e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9789957  148 VVGHARLSRvlDQPHSLLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQ----LYFYAHLGYQ 217
Cdd:COG3393   2 LVAMAGVRA--ESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADnpaaRRLYERLGFR 73
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 149-233 7.94e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 50.35  E-value: 7.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789957    149 VGHARLSrvlDQPH-SLLVetvvVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLY---FYAHLGYQLGEPVQ- 223
Cdd:pfam13673  43 VGVIALR---DRGHiSLLF----VDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYavpFYEKLGFRATGPEQe 115

                          90
                  ....*....|..
gi 9789957    224 --GLAFTNRRLS 233
Cdd:pfam13673 116 fnGIRFVPMEKE 127
PRK03624 PRK03624
putative acetyltransferase; Provisional
 171-217 1.37e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 44.15  E-value: 1.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 9789957   171 VARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTH----DQLYFYAHLGYQ 217
Cdd:PRK03624  76 VHPDFRGRGIGRALVARLEKKLIARGCPKINLQVRedndAVLGFYEALGYE 126
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
169-198 1.59e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 37.06  E-value: 1.59e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 9789957  169 VVVARPLRGRGFGRRLMEGLEAFARARGFR 198
Cdd:COG2388  38 TEVPPALRGQGIASALVEAALDDARERGLK 67
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
164-200 1.75e-03

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 38.38  E-value: 1.75e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 9789957  164 LLVETVVVARPLRGRGFGRRLMEGLEAFARARGFRRL 200
Cdd:COG3818  85 LYIDRIVVAPSARGRGLGRALYADVFSYARARGVPRV 121
PRK07922 PRK07922
amino-acid N-acetyltransferase;
166-222 2.34e-03

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 37.98  E-value: 2.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 9789957   166 VETVVVARPLRGRGFGRRLMEGLEAFARARGFRRLHLTTHDQLYFYAHlGYQL--GEPV 222
Cdd:PRK07922  73 IRTVAVDPAARGRGVGHAIVERLLDVARELGLSRVFVLTFEVEFFARH-GFVEidGTPV 130
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 170-198 4.11e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 35.57  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|....*....
gi 9789957    170 VVARPLRGRGFGRRLMEGLEAFARARGFR 198
Cdd:pfam14542  30 EVPPALRGQGIASKLVKAALDDAREEGLK 58
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
176-204 4.91e-03

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 37.60  E-value: 4.91e-03
                         10        20
                 ....*....|....*....|....*....
gi 9789957   176 RGRGFGRRLMEGLEAFARARGFRRLHLTT 204
Cdd:PRK10975 139 QGRGIGARLMQAALNWCQARGLTRLRVAT 167
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 148-205 4.98e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 37.29  E-value: 4.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9789957  148 VVGHARLSRVLDQPHSLLVeTVVVARPLRGRGFGRRLMEGLEAFA-RARGFRRLHLTTH 205
Cdd:COG1670  73 LIGVVGLYDIDRANRSAEI-GYWLAPAYWGKGYATEALRALLDYAfEELGLHRVEAEVD 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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