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Conserved domains on  [gi|20127580|ref|NP_060267|]
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BTB/POZ domain-containing protein 2 [Homo sapiens]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13033317)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and PHR (PAM, highwire, and RPM) domain-containing protein similar to Homo sapiens BTB/POZ domain-containing (BTBD) proteins, such as BTBD1, BTBD2, BTBD3 and BTBD6, which may function as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-221 1.60e-93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 280.48  E-value: 1.60e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  95 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 174
Cdd:cd18281   1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20127580 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18281  81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 375-524 1.84e-81

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


:

Pssm-ID: 462339  Cd Length: 150  Bit Score: 250.23  E-value: 1.84e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   375 NRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGSASTF 449
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580   450 RVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESpttgaKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 524
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTCDG-----GVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 217-322 3.73e-72

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


:

Pssm-ID: 350598  Cd Length: 106  Bit Score: 224.86  E-value: 3.73e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18523   1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                        90       100
                ....*....|....*....|....*.
gi 20127580 297 QQLQVTPENRRKVLGKALGLIRFPLM 322
Cdd:cd18523  81 QQLQVTPENKRKVLGKALSLIRFPLM 106
 
Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-221 1.60e-93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 280.48  E-value: 1.60e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  95 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 174
Cdd:cd18281   1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20127580 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18281  81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 375-524 1.84e-81

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 250.23  E-value: 1.84e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   375 NRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGSASTF 449
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580   450 RVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESpttgaKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 524
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTCDG-----GVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 217-322 3.73e-72

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 224.86  E-value: 3.73e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18523   1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                        90       100
                ....*....|....*....|....*.
gi 20127580 297 QQLQVTPENRRKVLGKALGLIRFPLM 322
Cdd:cd18523  81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 110-217 7.64e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 7.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   110 LFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVqIGPE 188
Cdd:pfam00651   4 LREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESEsSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 20127580   189 TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 118-217 6.37e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 6.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580    118 DVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYT 196
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 20127580    197 AKKYAVPALEAHCVEFLKKNL 217
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 229-328 9.45e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.06  E-value: 9.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580    229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSEAEcqrqqlqvtPENRR 307
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD---------PEKRR 78

                           90       100
                   ....*....|....*....|.
gi 20127580    308 KVLGKALGLIRFPLMTIEEFA 328
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLL 99
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 229-323 1.33e-08

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 52.55  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWseaecqrqqLQVTPENRR 307
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRW---------VKHDVERRK 78

                          90
                  ....*....|....*.
gi 20127580   308 KVLGKALGLIRFPLMT 323
Cdd:pfam07707  79 KHLPELLSAVRLPLLS 94
PHA03098 PHA03098
kelch-like protein; Provisional
 109-325 2.19e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  109 FLFNNEVLCD--VHFLVGKGlssqRIPAHRFVLAVGSAVFDAMFNGGMATTstEIELP-DVEpaAFLALLKFLYSDEVQI 185
Cdd:PHA03098   2 YSFELQKFCDesIIIVNGGG----IIKVHKIILSSSSEYFKKMFKNNFKEN--EINLNiDYD--SFNEVIKYIYTGKINI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  186 GPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDT 265
Cdd:PHA03098  74 TSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNE 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20127580  266 LVAVLERDTLGI-REVRLFNAVVRWSEaecqrqqlqVTPENRRKVLGKALGLIRFPLMTIE 325
Cdd:PHA03098 154 LIKILSDDKLNVsSEDVVLEIIIKWLT---------SKKNNKYKDICLILKVLRITFLSEE 205
 
Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-221 1.60e-93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 280.48  E-value: 1.60e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  95 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 174
Cdd:cd18281   1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVEPAAFLAL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20127580 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18281  81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-221 2.09e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 254.61  E-value: 2.09e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  95 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 174
Cdd:cd18347   1 NWQATKPTVQERFAFLFNNEVLSDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLAL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20127580 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18347  81 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 375-524 1.84e-81

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 250.23  E-value: 1.84e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   375 NRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTD----SNTVLGQNDTGFSCDGSASTF 449
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDGErwesLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580   450 RVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESpttgaKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 524
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREVTCDG-----GVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-221 1.19e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 242.66  E-value: 1.19e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  95 NWQASKPTVQERFAFLFNNEVLCDVHFLVGKG------LSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEP 168
Cdd:cd18346   1 NWQATKSSLKERFAFLFNNELLSDVRFVVGKGrprgpgPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 20127580 169 AAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18346  81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 217-322 3.73e-72

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 224.86  E-value: 3.73e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18523   1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                        90       100
                ....*....|....*....|....*.
gi 20127580 297 QQLQVTPENRRKVLGKALGLIRFPLM 322
Cdd:cd18523  81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 217-311 1.20e-66

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 209.90  E-value: 1.20e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18487   1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                        90
                ....*....|....*
gi 20127580 297 QQLQVTPENRRKVLG 311
Cdd:cd18487  81 QGLSVTPENQRKVLG 95
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 217-323 1.33e-63

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 202.61  E-value: 1.33e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18522   1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                        90       100
                ....*....|....*....|....*..
gi 20127580 297 QQLQVTPENRRKVLGKALGLIRFPLMT 323
Cdd:cd18522  81 QQLPVTSENKQKVLGKALSLIRFPLMT 107
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-217 1.32e-51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 171.42  E-value: 1.32e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPET 189
Cdd:cd18282   1 MFNNELMADVHFIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                        90       100
                ....*....|....*....|....*...
gi 20127580 190 VMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18282  81 VLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-217 3.16e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 157.07  E-value: 3.16e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPET 189
Cdd:cd18349   2 MFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADT 81

                        90       100
                ....*....|....*....|....*...
gi 20127580 190 VMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18349  82 VLATLYAAKKYIVPALAKACVNFLETSL 109
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-226 9.80e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 154.02  E-value: 9.80e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  96 WQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALL 175
Cdd:cd18348   1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAML 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 20127580 176 KFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLL 226
Cdd:cd18348  81 KYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 217-311 2.49e-37

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 132.88  E-value: 2.49e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18488   1 LSARNACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQR 80

                        90
                ....*....|....*
gi 20127580 297 QQLQVTPENRRKVLG 311
Cdd:cd18488  81 RGLEPTPENKRKVLG 95
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 217-311 1.13e-29

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 112.10  E-value: 1.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18525   1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                        90
                ....*....|....*
gi 20127580 297 QQLQVTPENRRKVLG 311
Cdd:cd18525  81 QGLPPTARNKRNVLG 95
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 217-311 1.72e-29

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 111.36  E-value: 1.72e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQR 296
Cdd:cd18524   1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 80

                        90
                ....*....|....*
gi 20127580 297 QQLQVTPENRRKVLG 311
Cdd:cd18524  81 QELQPTIENKRKVLG 95
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 110-217 7.64e-29

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 7.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   110 LFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVqIGPE 188
Cdd:pfam00651   4 LREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESEsSVSEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 20127580   189 TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-200 1.01e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 97.62  E-value: 1.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18186   1 LCDVTLVVGG----REFPAHRAVLAARSPYFRAMFSSGMKEsSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76


                ....*.
gi 20127580 195 YTAKKY 200
Cdd:cd18186  77 AAADKL 82
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-213 1.88e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 89.23  E-value: 1.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 105 ERFAFLFNNEVLCDVHFLVGKglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELP--DVEPAAFLALLKFLYSDE 182
Cdd:cd18294   3 ADMKSLINNPEFSDVKFLVGP--ERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlsDIEPEVFRAVLEFIYTNC 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 183 VQIGPETVMTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18294  81 VTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 118-217 6.37e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 6.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580    118 DVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYT 196
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 20127580    197 AKKYAVPALEAHCVEFLKKNL 217
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-213 5.35e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 85.37  E-value: 5.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 105 ERFAFLFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18287  11 EDIGALFLNEEYSDVTFVVEE----KRFPAHRVILAARSEYFRALLYGGMReSQQSEIELKDTNAEAFKALLKYIYTGRL 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 20127580 184 QIG---PETVMTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18287  87 TLTdlkEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-221 1.91e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 84.08  E-value: 1.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 113 NEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18237  18 QKTLCDVILIV----EGREIKAHRVVLAAASHFFHLMFTSNMTESKSsEVELKDAEPDIIELLVEFAYTARISVNSNNVQ 93

                        90       100       110
                ....*....|....*....|....*....|
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18237  94 SLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-222 7.30e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 82.34  E-value: 7.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18238   9 FYENGELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEMAeSKQDSITIKDIDEEAVELLVDFAYTGKLTLTVD 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18238  85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNC 118
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-212 8.49e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 81.95  E-value: 8.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 100 KPTVQERFAFLFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMF--NGGMATTSTEIELpdVEP----AAFLA 173
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGG----KVFHAHRLILAKSSDVFRVMLsnDWWSESKQSEIEL--VEDpecaAVFEK 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 20127580 174 LLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 212
Cdd:cd18292  75 FLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 111-209 1.06e-18

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 81.24  E-value: 1.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 111 FNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPET 189
Cdd:cd18314   1 YNDSEFSDVVLCVG----DRKFFAHRIVLCARSPVFRSMLTGSMIESNlKEVTLEDVEPEIFETVLKYMYTGQVTLSEEN 76

                        90       100
                ....*....|....*....|
gi 20127580 190 VMTTLYTAKKYAVPALEAHC 209
Cdd:cd18314  77 VLDLLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 4.20e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 79.72  E-value: 4.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18234   1 LCDVILIAG----DRRIPAHRLVLSAVSDYFAAMFTNDVrEATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18234  77 ATACLLQLSEVVEACCGFLMKQLHPSN 103
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 109-217 2.85e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 77.28  E-value: 2.85e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 109 FLFNNEVLCDVHFLVGKGLssqrIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGP 187
Cdd:cd18300   2 LFLNKGLFSDVTFIVEDGT----IPAHKALLVARCDVMAAMFGGNFrESSAKEVELPGVSKETFLALLEYLYTDQAPILE 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 188 E-TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18300  78 DgDCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-222 1.06e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 76.29  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18256  21 CDVQLQVGM----ELFSVHRLVLAASSPYFAALFAGGMSESSKDvVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLV 96

                        90       100
                ....*....|....*....|....*..
gi 20127580 196 TAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18256  97 AADMLQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-217 1.25e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 75.93  E-value: 1.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 113 NEVLCDVhFLVGKGLssqRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18235  18 QNLLCDV-ILVADGV---EIPAHRVVLASCSPYFHAMFTGDLSESRANrVTLQDVDGKALLLLIDYVYTAEIQVTEENVQ 93

                        90       100
                ....*....|....*....|....*.
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18235  94 VLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-221 6.94e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 73.85  E-value: 6.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 107 FAFLFNNEVLCDVHFLV-GKglssqRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYS---D 181
Cdd:cd18297   3 DPHYVNNPEMSDVTFLVeGR-----PFYAHKIVLVTASDRFKSMLSSGSTEAQtPVIEIPDIRYDIFQLMMQYLYTggvE 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 20127580 182 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18297  78 SLDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-215 1.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 72.70  E-value: 1.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18247  18 KLCDVTLKVG----DQKFSAHRIVLAATIPYFHAMFTHDMVeSKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

                        90       100
                ....*....|....*....|..
gi 20127580 194 LYTAKKYAVPALEAHCVEFLKK 215
Cdd:cd18247  94 LVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-217 5.00e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 71.64  E-value: 5.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 113 NEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18248  18 SQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGmEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVL 97

                        90       100
                ....*....|....*....|....*.
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18248  98 HVLPGAVMYQMDSVVKACCDFLEQQL 123
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 229-328 9.45e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.06  E-value: 9.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580    229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSEAEcqrqqlqvtPENRR 307
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD---------PEKRR 78

                           90       100
                   ....*....|....*....|.
gi 20127580    308 KVLGKALGLIRFPLMTIEEFA 328
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLL 99
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-241 1.63e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 70.05  E-value: 1.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 107 FAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVqi 185
Cdd:cd18280   5 FGALLESEEGADVTFNV----DGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIEDVEPPVFKALLHFIYKDEL-- 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20127580 186 gPETVMTTLYTAKKYAVPaLEAHcveflkknlradnafmLLTQARLFDEPQLASLC 241
Cdd:cd18280  79 -PDDVEPAGSDSSSLDTT-MAQH----------------LLAAADRYALERLRLLC 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 3.97e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 69.01  E-value: 3.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18242  21 LCDVTLRVE----GKEFPAHRIVLAACSDYFCAMFTSEMSeKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELL 96

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18242  97 PAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-221 2.71e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 66.58  E-value: 2.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDamfNGGMATTStEIELPDVEPAAFLALLKFLYSDEVQIG--P 187
Cdd:cd18303  12 LFDKELYSDITIKLAD----KSIPAHKFVLAARSEKWS---NENLASTN-ELDLSDISYEVVLALLRWLYTDELDLTldD 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 20127580 188 ETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18303  84 EFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 3.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 66.20  E-value: 3.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18240  17 LCDVVIRVN----GVEFPAHRNILCACSPYFRALFTNGWNETEkKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELL 92

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18240  93 PAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-221 1.00e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 65.24  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18259  26 LRSNPKLSDVTLLVG----GREFPCHRSVLALCSHYFNAMFTGDFVESiSARVEIKDVDPAVMESLIDFAYTGKLTINQG 101

                        90       100       110
                ....*....|....*....|....*....|...
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18259 102 NVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 217-326 1.30e-12

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 63.79  E-value: 1.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAEcqr 296
Cdd:cd14822   1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHN--- 77

                        90       100       110
                ....*....|....*....|....*....|
gi 20127580 297 qqlQVTPENRRKVlgkaLGLIRFPLMTIEE 326
Cdd:cd14822  78 ---PDSKEDAKEI----LEAVRLPLMSLTE 100
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 118-217 2.94e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 63.47  E-value: 2.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 118 DVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE------IELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18296  19 DVCFQVE----GHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENAY 94

                        90       100
                ....*....|....*....|....*.
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18296  95 DVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-221 4.67e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 62.93  E-value: 4.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18279  12 LWENSRFTDCCLCVG----GQEFQAHKAILAARSPVFSAMFEHEMEeSKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18279  88 MADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-221 7.46e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 62.41  E-value: 7.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18255  17 QLLDVTLIA----DGQRFQAHKVVLASCSDYFRAMFTGGMRESSqDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDV 92

                        90       100
                ....*....|....*....|....*....
gi 20127580 194 LYTAKKYAV-PALEAhCVEFLKKNLRADN 221
Cdd:cd18255  93 LGAAVHLQMlPVVEL-CEEFLKSAMSVEN 120
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 110-205 7.95e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 62.28  E-value: 7.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18286  11 LFLNGEDSDITIKVD----GKTFKAHRCILCARSSYFAAMLSGSwAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDD 86

                        90
                ....*....|....*...
gi 20127580 189 TVMTTL-YTAKKYAVPAL 205
Cdd:cd18286  87 VNLGELlSLADMYGLDGL 104
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-214 1.30e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 61.59  E-value: 1.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 112 NNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFN---GGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18245  10 EEPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNynpPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

                        90       100
                ....*....|....*....|....*.
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLK 214
Cdd:cd18245  86 NIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 112-221 1.69e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 61.34  E-value: 1.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 112 NNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETV 190
Cdd:cd18352   9 NNATLSDVTFLV----EGRRFYAHRIALLASSDAFRAMFDGGYrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIA 84

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 191 MTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18352  85 KDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-219 1.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 61.02  E-value: 1.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18257  18 LCDVVLRVG----DVKIHAHKVVLASCSPYFKAMFTGNLSEKENsEVEFQCIDETALQAIVEYAYTGTVFISQATVESLL 93

                        90       100
                ....*....|....*....|....*
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRA 219
Cdd:cd18257  94 PAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-221 3.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 61.00  E-value: 3.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 133 PAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVE 211
Cdd:cd18340  40 PCHRLVLAACSPYFRAMFLSDLEeSKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVS 119

                        90
                ....*....|
gi 20127580 212 FLKKNLRADN 221
Cdd:cd18340 120 FLQKRLCLSN 129
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 3.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 60.93  E-value: 3.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18249  23 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 98

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18249  99 PAACLLQLAEIQEVCCEFLKRQLDPSN 125
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-225 4.38e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 60.68  E-value: 4.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  94 YNWQASKPTVQERFAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFL 172
Cdd:cd18266   3 YRWADHSNLVLQGLNEQRQRGLFCDVVLVA----DEQRVPAHRNLLAVCSDYFNSMFTIGMREAhQKEVELVGASYIGLK 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 20127580 173 ALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFML 225
Cdd:cd18266  79 AVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYL 131
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-221 8.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 59.63  E-value: 8.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 105 ERFAFLFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18343  10 EDLGNLWENSRFTDCSLFVG----GQEFKAHKSILAARSPVFNAMFEHEMEeSKKNRVEINDVDPEVFKEMMRFIYTGKA 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 20127580 184 QIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18343  86 PNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 9.91e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 59.29  E-value: 9.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18336  19 LCDVLLIAG----NLKIPAHRLVLSAVSDYFAAMFtNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLL 94

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18336  95 AAACLLQLSQVIDVCCNFLMKQLHPSN 121
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 110-217 1.38e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 58.67  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGKGlssqRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18263   7 LWEKGVGCDVQLEADGS----IFRVHRVILAAGSDYFRAMFTSGMkESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWE 82

                        90       100
                ....*....|....*....|....*....
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18263  83 NLFEATCTALQLQISGALALCLDFLQREI 111
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-226 1.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 59.25  E-value: 1.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18270  12 SLLEQLKFFYEQQLLTDIVLIV----EGTEFPCHKMVLATCSSYFRAMFMSGLSeSKQTHVHLRNVDAATLQIIITYAYT 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLL 226
Cdd:cd18270  88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-222 1.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 58.63  E-value: 1.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 130 QRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 208
Cdd:cd18250  31 REFPCHRTVLAAASSYFRAMFAGELRESRADrVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEA 110

                        90
                ....*....|....
gi 20127580 209 CVEFLKKNLRADNA 222
Cdd:cd18250 111 CCAYLQQRLDVSNC 124
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-221 1.77e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 58.96  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 133 PAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVE 211
Cdd:cd18269  40 PCHRLVLAACSPYFRAMFLSDLEeSKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVS 119

                        90
                ....*....|
gi 20127580 212 FLKKNLRADN 221
Cdd:cd18269 120 YLQKRLSLSN 129
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 108-217 3.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 57.81  E-value: 3.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 108 AFLFNNEV-----LCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSD 181
Cdd:cd18339   8 AFKVMNELrskqlLCDVTIVA----EDVEIEAHRVVLAACSPYFCAMFTGDMSeSKAKKIEIKDVDGQTLSKLIDYIYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20127580 182 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18339  84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 109-221 3.54e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 58.30  E-value: 3.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 109 FLFNNEVLCDVHFLV----GKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18273  19 SFYDARLLTDVTIEVngpgSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQEtVTIHDVDSESMALIIDYCYTGRV 98

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 20127580 184 QIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18273  99 TLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSN 136
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 110-214 3.81e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 56.84  E-value: 3.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVGKGlssQRIPAHRFVLAVGSAVFDAMFNggmatTSTEIEL-PDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18299   6 LLHSPSCADVVFILQGG---VRIFAHRIVLAAASSVFADLFL-----MMTVVTLdSDITPEAFRRVLEFLYTGVLDENED 77

                        90       100
                ....*....|....*....|....*.
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLK 214
Cdd:cd18299  78 DLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-222 3.90e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 57.66  E-value: 3.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFN----GGMATTSteiELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18306  18 FCDVILQVGG----HEIPAHRAVLACASPYLFELFSsdsdGESILTV---KLDGLDPDAVEVLVNYAYTSRLEVPADLVK 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18306  91 SVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-217 5.51e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 57.00  E-value: 5.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 106 RFAFLFNNE-----VLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLY 179
Cdd:cd18338   6 KKAFKVMNElrsqnLLCDVTIVA----EDVEIAAHRVVLAACSPYFHAMFTGEMSESrAKRVRIKEVDGWTLKMLIDYVY 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 20127580 180 SDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18338  82 TAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 127-200 7.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 55.37  E-value: 7.60e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580 127 LSSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKY 200
Cdd:cd01165   5 VEGEKFHVNKELLAQSSEYFRALFRGGFRESGqAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 100-213 1.12e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 57.00  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 100 KPTVQERFAFLFNNEVLCDVHFLVGKglSSQRIPAH--------------------------RFVLAVGSAVFDAMFNGG 153
Cdd:cd18308   7 KCTLHDDFGRLLESRQFCDVEFIVGE--EEERIPAHiafvaarskwlrnkilqarerqkqkaEQEVEDEGSEADSSSASK 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20127580 154 MATTSTEIELPDVEPAAFLALLKFLYSDEVQI--------GPETV--MTTLYT-AKKYAVPALEAHCVEFL 213
Cdd:cd18308  85 NDSPMLEVRLPEADPEAFELILSFIYTDKIDPtrkgqdpgSNEVVllMMDVYRlALQFQMSRLEQLCVQYL 155
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-221 1.42e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 55.97  E-value: 1.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVHFLVGKGlsSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18239   9 VVLQGFDQLRGEGLLCDVTLVPGDG--DETFPVHRAMMASASDYFKAMFTGGMKEQElMCIKLHGVSKIGLKNIIDFIYT 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18239  87 AKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-221 1.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 55.93  E-value: 1.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18265  22 TFTDVVLLVD----GKDFPCHRATLSANSAYFRAMFGGHLKESRQAvVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESV 97

                        90       100
                ....*....|....*....|....*...
gi 20127580 194 LYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18265  98 LEASDLLQVSKLREACVRFLEGQLHPCN 125
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-222 1.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 55.62  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 105 ERFAFLFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18345   7 DDLGLLFERSAFSDVTLCVG----GREFQAHKAILAARSPVFNAMFEHEMEERKqNRVEITDVDHEVMREMLRFIYTGKA 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 20127580 184 QIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18345  83 PNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-211 2.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 55.18  E-value: 2.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 112 NNEVLCDVhFLVGKGLSsqrIPAHRFVLAVGSAVFDAMFNGGMATTSTE--IELPDVEPAAFLALLKFLYSDEVQIGPET 189
Cdd:cd18293  11 NSGVFCDV-LLQAEGES---VPAHCCVLSACSPYLTERLSSEPPPAGQKvvLELQGLKAHTLLKLVDFLYTSELEVSSEE 86

                        90       100
                ....*....|....*....|..
gi 20127580 190 VMTTLYTAKKYAVPALEAHCVE 211
Cdd:cd18293  87 AQDVLAAARRLQISELESLCLE 108
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-222 4.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 54.72  E-value: 4.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 127 LSSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPAL 205
Cdd:cd18342  29 VAGQEFQAHKAILAARSPVFSAMFEHEMEeSKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERL 108

                        90
                ....*....|....*..
gi 20127580 206 EAHCVEFLKKNLRADNA 222
Cdd:cd18342 109 KVMCEDALCSNLSVENA 125
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-221 4.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 54.99  E-value: 4.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 129 SQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALE 206
Cdd:cd18267  49 NRSFPCHRAVLAACSRYFEAMFSGGLkESQDSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIR 128

                        90
                ....*....|....*
gi 20127580 207 AHCVEFLKKNLRADN 221
Cdd:cd18267 129 DACAEFLEKNLHPTN 143
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 7.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 54.30  E-value: 7.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18337  23 LCDVVLVAG----DRRIPAHRLVLSSVSDYFAAMFtNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLL 98

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18337  99 STACLLQLSQVVEACCKFLMKQLHPSN 125
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-221 7.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 54.08  E-value: 7.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 129 SQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 207
Cdd:cd18341  36 DKSLPCHRLILAACSPYFREYFLSEESeEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFT 115

                        90
                ....*....|....
gi 20127580 208 HCVEFLKKNLRADN 221
Cdd:cd18341 116 VCVTYLQKRLSPAN 129
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-217 8.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 54.27  E-value: 8.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18246  38 LLCDIVLHVG----TKEIKAHKVVLASCSPYFHAMFTNEMSESrQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTL 113

                        90       100
                ....*....|....*....|....
gi 20127580 194 LYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18246 114 LPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-213 1.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 53.40  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 112 NNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLALLKFLYSDEVQIGPETV 190
Cdd:cd18326  21 TQGLLCDVVILV----EGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVyEIDFVSAEALTALLDFAYTATLTVSTSNV 96

                        90       100
                ....*....|....*....|...
gi 20127580 191 MTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18326  97 GDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-221 1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 53.28  E-value: 1.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLV-GKGlssqrIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGP 187
Cdd:cd18251  17 LRDSGILFDVVLVVeGKP-----IEAHRILLAASCDYFRGMFAGGLrEMQQTEVLIHGVSYNAMCKILDFIYTSELELSL 91

                        90       100       110
                ....*....|....*....|....*....|....
gi 20127580 188 ETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18251  92 DNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-221 1.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 53.71  E-value: 1.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVGkGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IEL------PDVEPAAFLALLKFLYSDEVQIGPET 189
Cdd:cd18241  24 CDITLAFG-GAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGrVEMrkwssePGPDPDTVEAVIQYMYTGRIRVSTGN 102

                        90       100       110
                ....*....|....*....|....*....|..
gi 20127580 190 VMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18241 103 VHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 229-323 1.33e-08

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 52.55  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580   229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWseaecqrqqLQVTPENRR 307
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRW---------VKHDVERRK 78

                          90
                  ....*....|....*.
gi 20127580   308 KVLGKALGLIRFPLMT 323
Cdd:pfam07707  79 KHLPELLSAVRLPLLS 94
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 116-185 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.78  E-value: 1.57e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKGlssqRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQI 185
Cdd:cd18315   1 LVDVTLACEGG----SLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNV 66
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 2.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 52.74  E-value: 2.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18335  19 LCDVILIAG----NRKIPAHRLVLSAVSDYFAAMFTSDVCeAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLL 94

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18335  95 AAACLLQLSQVVEVCCHFLMKLLHPSN 121
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 118-179 4.75e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 50.97  E-value: 4.75e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20127580 118 DVHFLVGKGLssqRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLY 179
Cdd:cd18191   3 DLRFLLDGGT---QLPASRAALTGASEVFRAMLEGGFAEAQqDLVPLRQVPSGAFLPVLHYLH 62
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-221 5.71e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 51.37  E-value: 5.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18253   4 SILQVFNEFRDSRLFTDVIICVE----GREFPCHRAILSACSSYFRAMFcNDHRESREMLVEINGILAEAMDCFLQYVYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18253  80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 109-209 5.88e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 51.00  E-value: 5.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 109 FLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVqiGP 187
Cdd:cd18360   3 LFFNSPLLADVVFKI----QGTTVPAHRAVLVARCEVMAAMFNGNYAeAKSFLVPIYGVSKDTFLSFLEYLYTDSC--CP 76

                        90       100
                ....*....|....*....|....*
gi 20127580 188 ETV---MTTLYTAKKYAVPALEAHC 209
Cdd:cd18360  77 ASIlqaMALLICAEMYQVSRLQHIC 101
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-222 6.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 51.50  E-value: 6.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18344  17 LWENSLFTDCCLLV----AGHEFRAHKAILAARSPVFRAMFEHEMEERlKNPIEIHDLDPQVFKEMMGFIYTGKAPHLHS 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20127580 189 TVMTT--LYTAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18344  93 HSMACdvLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 219-290 1.02e-07

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 49.43  E-value: 1.02e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20127580 219 ADNAFMLLTQARLFDEPQ----LASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWS 290
Cdd:cd18507   2 VDTVCALLASAERYDQYKctktLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWS 77
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 117-221 1.02e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 50.85  E-value: 1.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLvgkgLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPA--AFLALLKFLYSDEVQIGPETVMtT 193
Cdd:cd18309  21 CDITLL----LDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTvNISIGEMVPSrqAFDSLLRYIYYGDVTMPPEDSL-Y 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 194 LYTAKKY---AVPALEAHCVEFLKKNLRADN 221
Cdd:cd18309  96 LFSAPYFygfTNNRLQAYCKQNLEMNVSFEN 126
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 129-221 1.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 50.78  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 129 SQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALE 206
Cdd:cd18254  31 NRSFPCHRAVLAACSRYFEAMFSNGLrESLDSTVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVR 110

                        90
                ....*....|....*
gi 20127580 207 AHCVEFLKKNLRADN 221
Cdd:cd18254 111 DAAAEFLEKNLYPSN 125
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-221 1.58e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 50.36  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLY---SDEVQIG 186
Cdd:cd18351  18 FLNNKEMSDVTFLV----EGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIK 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20127580 187 PETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18351  94 NNEIMELLSAAKFFQLEALQRHCEIICAKSINTEN 128
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-221 1.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 50.57  E-value: 1.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVhFLVGKGlssQRIPAHRFVLAVGSAVFDAMFNG-GMATTSTEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18264  14 AVLSQYQSLRAEGFLCDV-VLEAEG---NEFPAHRSLLACSSDYFRALFKDyTQESKARVIHLPVVSAAGLQRVLDFIYT 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18264  90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-197 1.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 50.41  E-value: 1.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVgKGlssQRIPAHRFVLAVGSAVFDAMFNGgmaTTSTEIELP-DVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18289  30 CDVSIVV-KG---QAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPaTVPPACFQQILSFCYTGKLTMAASEQLVVMY 102


                ..
gi 20127580 196 TA 197
Cdd:cd18289 103 TA 104
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-217 2.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 49.86  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE--------IELPDVEPAAFLALLKFLYSD 181
Cdd:cd18228  13 LRNEGHFCDVTIRV----QDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspagkcvLDLHHVTVTGFAPLLEYAYTS 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20127580 182 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18228  89 TLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 135-222 2.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 49.60  E-value: 2.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 135 HRFVLAVGSAVFDAMFNGGMA-TTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18274  38 HRNVLAAISPYFRSMFTSGLTeSTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFM 117


                ....*....
gi 20127580 214 KKNLRADNA 222
Cdd:cd18274 118 ISRLDPQNS 126
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 105-215 2.86e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 48.79  E-value: 2.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 105 ERFAFLFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMF----NGGMATTsteIELPDVEPAAFLALLKFLYS 180
Cdd:cd18298   1 DSLRKAFNDPRTSDLKFRVD----GKYIYVHKAILKIRCEYFRSMFqshwNEDDKNV---IEIDQYSYPVYYAFLRYLYT 73

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKK 215
Cdd:cd18298  74 DQVDLPPEDAIGLLDLANSYCEERLKKLCEDIIKQ 108
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-214 3.41e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 49.09  E-value: 3.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFN-GGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18198  25 LCDVVILV----QGREYRTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDIL 100

                        90       100
                ....*....|....*....|
gi 20127580 195 YTAKKYAVPALEAHCVEFLK 214
Cdd:cd18198 101 SAARLLEIPCVSHVCAEILD 120
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 104-181 6.15e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 47.67  E-value: 6.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 104 QERFAFLFNNEVLCD-VH---FLVGkglsSQRIPAHRFVLAVGSAVFDAMF-----NGGMATTSTEIELPDVEPAAFLAL 174
Cdd:cd18301   2 QEDFKKLLDEADEGDnIHdvvFQVG----GKTFPAHKFILASRSDYFRKLFlssllTSEDAVGCDVVHIEKVPPEIFEQL 77


                ....*..
gi 20127580 175 LKFLYSD 181
Cdd:cd18301  78 LQFIYTD 84
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-213 1.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 47.18  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 113 NEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLALLKFLYSDEVQIGPETVM 191
Cdd:cd18328  22 DGLLCDVVLIV----QDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVyEIDFVTPEALSAILEFAYTSTLTITTSNVK 97

                        90       100
                ....*....|....*....|..
gi 20127580 192 TTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18328  98 HILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 135-221 1.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 47.13  E-value: 1.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 135 HRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18252  37 HKAALAACSSYFKVMFTADMKEKSnNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFL 116


                ....*...
gi 20127580 214 KKNLRADN 221
Cdd:cd18252 117 VRHLDIDN 124
PHA03098 PHA03098
kelch-like protein; Provisional
 109-325 2.19e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  109 FLFNNEVLCD--VHFLVGKGlssqRIPAHRFVLAVGSAVFDAMFNGGMATTstEIELP-DVEpaAFLALLKFLYSDEVQI 185
Cdd:PHA03098   2 YSFELQKFCDesIIIVNGGG----IIKVHKIILSSSSEYFKKMFKNNFKEN--EINLNiDYD--SFNEVIKYIYTGKINI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  186 GPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDT 265
Cdd:PHA03098  74 TSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNE 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20127580  266 LVAVLERDTLGI-REVRLFNAVVRWSEaecqrqqlqVTPENRRKVLGKALGLIRFPLMTIE 325
Cdd:PHA03098 154 LIKILSDDKLNVsSEDVVLEIIIKWLT---------SKKNNKYKDICLILKVLRITFLSEE 205
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 226-289 2.23e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 45.26  E-value: 2.23e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580 226 LTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
Cdd:cd18493   9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEdEYTLFQAVEKW 73
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-215 2.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 46.57  E-value: 2.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVgKGlssQRIPAHRFVLAVGSAVFDAMFNggmATTSTEIELP-DVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18290  28 CDVSVVV-KG---HAFKAHRAVLAASSSYFRDLFN---SSRSAVVELPaAVQPQSFQQILSFCYTGRLSMNVGDQFLLMY 100

                        90       100
                ....*....|....*....|
gi 20127580 196 TAKKYAVPALEAHCVEFLKK 215
Cdd:cd18290 101 TAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-225 2.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 46.75  E-value: 2.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 130 QRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 208
Cdd:cd18271  34 ETIPCHRCVLAACSDFFRAMFEVNMKErDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKA 113

                        90
                ....*....|....*..
gi 20127580 209 CVEFLKKNLRADNAFML 225
Cdd:cd18271 114 CSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-206 2.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 46.32  E-value: 2.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQI-GPETVMT 192
Cdd:cd18223  17 ILCDVTIVV----EDTKFKAHKNVLAASSLYFKNAFsSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVkRQETVTD 92

                        90
                ....*....|....
gi 20127580 193 TLYTAKKYAVPALE 206
Cdd:cd18223  93 LVAAGKKLGITFLE 106
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-197 2.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 46.72  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVhFLVGKGlssQRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18276  21 LTDV-VLVAEG---EKFPCHRLVLAAFSPYFKAMFTCGlMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVA 96


                ...
gi 20127580 195 YTA 197
Cdd:cd18276  97 TAA 99
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-216 2.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 46.50  E-value: 2.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFN--GGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18207  27 FCDVLLRVGE----ESFPAHRAVLAACSEYFESVFSaqEGDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPEL 102

                        90       100
                ....*....|....*....|...
gi 20127580 194 LYTAKKYAVPALEAHCVEFLKKN 216
Cdd:cd18207 103 MTAAKFLLMRSVIDICQEVIKQS 125
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-223 3.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 46.32  E-value: 3.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 132 IPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCV 210
Cdd:cd18268  35 IPCHRNVLASSSPYFRAMFcNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACS 114

                        90
                ....*....|...
gi 20127580 211 EFLKKNLRADNAF 223
Cdd:cd18268 115 LYLQDQLTPENCL 127
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-212 3.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 45.56  E-value: 3.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVGKGLSSqripAHRFVLAVGSAVFDAMFNGGMATTSTE----IELPDVEPAAFLALLKFLYSDEVQIGPETVMT 192
Cdd:cd18307   2 CDVVISVDNHSFA----AHRNVLAAVSPFVKSLISSNDMKATDElsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVED 77

                        90       100
                ....*....|....*....|
gi 20127580 193 TLYTAKKYAVPALEAHCVEF 212
Cdd:cd18307  78 LLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-213 4.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 45.83  E-value: 4.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 114 EVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNgGMATTSTEIELP-DVEPAAFLALLKFLYSDEVQIGPETVMT 192
Cdd:cd18277  25 DVLCDVTILV----EGQRFRAHRSVLAACSSYFHSRIV-GQADAELNITLPeEVTVKGFEPLIQFAYTAKLILSKDNVDE 99

                        90       100
                ....*....|....*....|.
gi 20127580 193 TLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18277 100 VCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 7.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 45.02  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNggmaTTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18205  18 LCDVVIMV----DSQEFHAHRTVLACTSKMFEILFH----RNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLY 89

                        90
                ....*....|....*...
gi 20127580 196 TAKKYAVPALEAHCVEFL 213
Cdd:cd18205  90 AAEILEIEYLEEQCLKIL 107
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-214 8.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 44.93  E-value: 8.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIElpDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18218  18 LCDTLITVG----SQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGE--GISPSTFKQLLDFVYGESVEVQPGELRPLLE 91

                        90
                ....*....|....*....
gi 20127580 196 TAKKYAVPALEAHCVEFLK 214
Cdd:cd18218  92 AARALEVESLEEACWRALG 110
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 219-272 9.20e-06

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 43.03  E-value: 9.20e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 20127580 219 ADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLER 272
Cdd:cd14733   2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-217 1.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 44.84  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMF--NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 193
Cdd:cd18211  25 LCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFlnEKISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRM 104

                        90       100
                ....*....|....*....|....
gi 20127580 194 LYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18211 105 LEIAEKLKCLDLSETCFQLKKQML 128
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 1.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 43.61  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGgMATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18955   1 LCDVTIVVE----DQRFRAHRAVLAACSDYFLSRVVG-QTDGDLVITLPEeVTVKGFEPLLQFAYTAKLLLSKENVLEVC 75

                        90
                ....*....|....*....
gi 20127580 195 YTAKKYAVPALEAHCVEFL 213
Cdd:cd18955  76 RCAEFLGVHNIEKACFDFL 94
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-215 1.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 43.78  E-value: 1.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYS 180
Cdd:cd18353   6 TVAESLKKEFDSPETSDLKFRV----DGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEvIEIDQFSYPVYRAFLEYLYT 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKK 215
Cdd:cd18353  82 DSVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKR 116
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 110-197 2.14e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 43.69  E-value: 2.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 110 LFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIEL-PDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18331  18 LRSRDILTDVVIVV----SREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLdPEINPEGFNILLDFMYTSRLNLREG 93


                ....*....
gi 20127580 189 TVMTTLYTA 197
Cdd:cd18331  94 NIMAVMATA 102
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-197 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 43.69  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 114 EVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMT 192
Cdd:cd18332  17 DILTDVTLLVG----GTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSgLEARGFQLLLDFMYTSRLPLTPRTVPA 92


                ....*
gi 20127580 193 TLYTA 197
Cdd:cd18332  93 VLAAA 97
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-221 2.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 44.19  E-value: 2.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 112 NNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETV 190
Cdd:cd18261  24 NDGILCDITLVAEE----QKFHAHKAVLAACSDYFRAMFSLCMVESeADEVNLHGVTSLGLKQALDFAYTGQILLEPGVI 99

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 191 MTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18261 100 QDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 220-290 2.91e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 42.30  E-value: 2.91e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20127580 220 DNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWS 290
Cdd:cd18494   3 ETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-216 3.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 43.04  E-value: 3.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 133 PAHRFVLaVGSAVFDAMFNGG-MATTSTEIEL----PDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 207
Cdd:cd18305  28 KLHKIYL-CQSGYFASMFSGSwKESKETVINLeipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDGLIQ 106


                ....*....
gi 20127580 208 HCVEFLKKN 216
Cdd:cd18305 107 QCSEVMKET 115
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 135-226 3.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 43.73  E-value: 3.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 135 HRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18272  47 HRLVLSAQSCFFRSMFTSNLKEARNRvIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFL 126

                        90
                ....*....|...
gi 20127580 214 KKNLRADNAFMLL 226
Cdd:cd18272 127 ARTVQVRNCLQVM 139
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 118-185 3.66e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 43.01  E-value: 3.66e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 118 DVHFLV-GKglssqRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIELPDVEPAAFLALLKFLYSDEVQI 185
Cdd:cd18295  21 DVTFNVhGE-----SFPAHRCILSARSPYFAEMFETKWKDKREiNLKHPLVNPDAFRALLQYLYTGRLEI 85
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-214 3.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 43.30  E-value: 3.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVHfLVGKGLssqRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI--------ELPDVEPAAFLALLKFLYSDEVQIG 186
Cdd:cd18327  24 LLCDLT-IKTRGL---EYRTHRAVLAACSLYFRKLFTGGGGGSGDLGagggqdvcELDFVGPEALGALLEFAYTATLTIS 99

                        90       100
                ....*....|....*....|....*...
gi 20127580 187 PETVMTTLYTAKKYAVPALEAHCVEFLK 214
Cdd:cd18327 100 SSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 98-205 4.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 43.25  E-value: 4.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  98 ASKPTVQERFAFLFNNEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKF 177
Cdd:cd18212   5 THKDTVLTNFEEQRKKDFLCDITLIVE----NVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMVAETFGALLEF 80

                        90       100
                ....*....|....*....|....*...
gi 20127580 178 LYSDEVQIGPETVMTTLYTAKKYAVPAL 205
Cdd:cd18212  81 IYTGCLQVGEKSLEQILATAQFLKVNDL 108
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-180 7.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 42.17  E-value: 7.45e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18209  18 LCDVLLIVG----DQKFRAHKNVLAASSEYFQSLFTEKENESQSVFQLDFCEPDAFENVLNYIYS 78
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 219-321 7.68e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 41.96  E-value: 7.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 219 ADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWseaecqrq 297
Cdd:cd18447   4 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRaEDQVYDAAVRW-------- 75

                        90       100
                ....*....|....*....|....
gi 20127580 298 qLQVTPENRRKVLGKALGLIRFPL 321
Cdd:cd18447  76 -LKYDEPNRQPYMVDILAKVRFPL 98
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-206 8.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 42.19  E-value: 8.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVGkglsSQRIPAHRFVLAVGSAVF------------DAMFNGGMATTSTE--IELPDVEPAAFLALLKFLYSDE 182
Cdd:cd18195  19 CDVTLIAG----DTKFRAHRSVLAASSPYFrellssplplgaAAVAAAPGATQSPErvLELPGVKAGVFSDVLNFIYSSR 94

                        90       100
                ....*....|....*....|....*
gi 20127580 183 VQI-GPETVMTTLYTAKKYAVPALE 206
Cdd:cd18195  95 VALpGSAAAKELGAAGKRLGIPFLQ 119
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-212 2.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 41.01  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 107 FAFLFNNEVLCDVHFLVGKglssQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELP-DVEPAAFLALLKFLYSDEVQI 185
Cdd:cd18215  10 LNRLRSRDILTDVVLVVGR----EQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDpEIEPEGFRILLDFMYTSRLNL 85

                        90       100
                ....*....|....*....|....*..
gi 20127580 186 GPETVMTTLYTAKKYAVPALEAHCVEF 212
Cdd:cd18215  86 REGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 2.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 40.68  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGKGLSSqrIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
Cdd:cd18231  14 LCDVDIVLVRQRST--FPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLN 91

                        90
                ....*....|....*...
gi 20127580 196 TAKKYAVPALEAHCVEFL 213
Cdd:cd18231  92 AAAVLQMNDIAASCQELI 109
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-221 2.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 41.09  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  94 YNWQASKPTVQERFAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFL 172
Cdd:cd18244   8 YNSSIHDTSVSAGFRALYEEGLLLDVTLVI----EDHQFQAHKALLATQSDYFRIMFTADMRERDQDkIHLKGLTATGFS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 20127580 173 ALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18244  84 HVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDN 132
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 109-222 2.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 41.37  E-value: 2.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 109 FLfNNEVLCDVHFLV-GKGLSsqripAHRFVLAVGSAVFDAMF---NGGMATTSTEIELPDVEPAAFLALLKFLY---SD 181
Cdd:cd18350  18 FL-NNKEMSDVTFLVeGKLFY-----AHKVLLVTASNRFKSLLtnkSEQESQGSKTIEISDIKYHIFQMLMQYLYyggTE 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20127580 182 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNA 222
Cdd:cd18350  92 SMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENA 132
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 118-192 2.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 41.14  E-value: 2.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 118 DVHFLVGKGlssQRIPAHRFVLAVGSAVFDAMFNG---GMATTSTEIELPDVEPA------AFLALLKFLYSDEVQIGPE 188
Cdd:cd18310  20 DAEIIVEGG---RPVPVHRCILAARSPFFRDIFASakaEGANTKPKLELRELIPGgivgydAFMLVLSYLYSGRLRLVPK 96


                ....
gi 20127580 189 TVMT 192
Cdd:cd18310  97 EGSA 100
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 107-209 3.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 40.14  E-value: 3.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 107 FAFLFNNEVLCDVHFLVGKGlssQRIPAHRFVLA-----VGSAVFDAMFNGGMATTST--EIELPDVEPAAFLALLKFLY 179
Cdd:cd18288   9 FSAMVNNPHLSDVQFQTDSG---EVLYAHSFVLYarcplLIQMVHSEGFSVEEEGGVTtrRVLLGDVSGEAARCFLQYLY 85

                        90       100       110
                ....*....|....*....|....*....|
gi 20127580 180 SDEVQIGPETVMTTLYTAKKYAVPALEAHC 209
Cdd:cd18288  86 TADTGLPPGLSPHVSELADRFGVSELVHLC 115
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-221 4.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 40.60  E-value: 4.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18236  24 LTDVILCVD----SQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEkIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVL 99

                        90       100
                ....*....|....*....|....*..
gi 20127580 195 YTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18236 100 EAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-217 4.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 40.31  E-value: 4.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 102 TVQERFAFLFNNEVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNggmATTSTEIELPDVEPAAFLALLKFLYSD 181
Cdd:cd18354   6 TVAESLKREFDNPDTADLKFLV----DGKYIYVHKVLLKIRCEHFRSLLN---ENEEEIIEMSQFSYPVYRAFLEYLYTD 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20127580 182 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
Cdd:cd18354  79 SISLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGI 114
PHA02713 PHA02713
hypothetical protein; Provisional
 110-214 4.57e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 42.69  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580  110 LFNNEVLCDVHFLVGKGlssQRIPAHRFVLAVGSAVFDAMFNGGMATTS--TEIELPDVEPAAFLALLKFLYSDevQIGP 187
Cdd:PHA02713  19 LLDDDILCDVIITIGDG---EEIKAHKTILAAGSKYFRTLFTTPMIIRDlvTRVNLQMFDKDAVKNIVQYLYNR--HISS 93

                         90       100
                 ....*....|....*....|....*..
gi 20127580  188 ETVMTTLYTAKKYAVPALEAHCVEFLK 214
Cdd:PHA02713  94 MNVIDVLKCADYLLIDDLVTDCESYIK 120
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 114-213 4.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 40.32  E-value: 4.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 114 EVLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFnGGMATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMT 192
Cdd:cd18278  29 DILCDVTLIV----EGKEFRAHRAVLAACSEYFLQAL-VGQTENDLVVSLPEeVTARGFGPLLQFAYTAKLLLSRENIQE 103

                        90       100
                ....*....|....*....|.
gi 20127580 193 TLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18278 104 VIRCAEFLRMHNLEDSCFRFL 124
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 245-320 5.78e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 39.33  E-value: 5.78e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20127580 245 IDKNTADAITAEGFTDIDLDTLVAVLERDTL-GIREVRLFNAVVRWSEAEcqrqqlqvtpENRRKVLGKALGLIRFP 320
Cdd:cd18449  29 ILKNFPALLSTGDFVKLPFERLAFVLSSNSLkGCTELELFKAACRWLRHE----------DDRMQFAAKLMENIRFP 95
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 101-221 5.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 39.80  E-value: 5.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 101 PTVQERFAFLFNNEVLCDVHFlvgkGLSSQRIPAHRFVLAVGSAVFDAMFNGGmaTTSTEIELPDVEPAAFLALLKFLYS 180
Cdd:cd18260   3 ANLLEGLNRMRQERFLCDLTI----ATKTKSFDVHKVVMASCSEYFRNILKKD--PSLQRVELNDISPLGLATVITYAYT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20127580 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18260  77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVEN 117
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 7.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 39.65  E-value: 7.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMF-----NGGMATTSTEIELPDVEpaAFLALLKFLYSDEVQIGPETV 190
Cdd:cd18196  21 LCDCVIVVG----NRHFKAHRSVLAACSTHFRALFtvaegDQTMNMIQLDSEVVTAE--AFAALIDMMYTSTLMLGESNV 94

                        90       100
                ....*....|....*....|...
gi 20127580 191 MTTLYTAKKYAVPALEAHCVEFL 213
Cdd:cd18196  95 MDVLLAASHLHLNSVVKACKHYL 117
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 217-323 1.05e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 38.60  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWseaecq 295
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVeKEELVFEAVMKW------ 74

                        90       100
                ....*....|....*....|....*...
gi 20127580 296 rqqLQVTPENRRKVLGKALGLIRFPLMT 323
Cdd:cd18517  75 ---VRTDKENRVKSLGEIFDCIRFRLMP 99
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 117-212 1.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 38.59  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 117 CDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTsteIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYT 196
Cdd:cd18232  19 CDATLDVG----GRVFKAHWSVLACCSHFFQSLYGDGTSGS---VVLPESFAEVFGLLLDFFYTGELALTRENRDRVLLA 91

                        90
                ....*....|....*.
gi 20127580 197 AKKYAVPALEAHCVEF 212
Cdd:cd18232  92 AKELRVPEAVELCQRF 107
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 113-183 1.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 39.04  E-value: 1.11e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20127580 113 NEVLCDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18224  23 SETMCDVTIVVG----NRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDFITPANFEKVLSFIYTSEL 89
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 237-322 1.43e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 37.97  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 237 LASLclenidKNTADAIT---------AEGFTDIDLDTLVAVLERDTL-GIREVRLFNAVVRWseaecqrqqLQVTPeNR 306
Cdd:cd18465  18 LASL------KESVDAFTfrhflqiaeEEDFLHLPLERLVFFLQSNKLkNCSEIDLFRAAIRW---------LQHDP-SR 81

                        90
                ....*....|....*.
gi 20127580 307 RKVLGKALGLIRFPLM 322
Cdd:cd18465  82 RASASHVLCHIRFPLM 97
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 229-289 1.68e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 37.37  E-value: 1.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20127580 229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRW 289
Cdd:cd18463  14 ADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVpKEEEVFEAVMRW 75
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-185 2.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 38.26  E-value: 2.34e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580 116 LCDVHFLVGkglsSQRIPAHRFVLAVGSAVF-----DAMFNGGMATTSTEIelpdVEPAAFLALLKFLYSDEVQI 185
Cdd:cd18194  23 LCDCTVLVG----SAQFPAHRAVLASCSMYFhlfyrDRLDKRDLVRLNSDI----VTAPAFGLLLDFMYEGRLAL 89
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 221-323 3.24e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 37.13  E-value: 3.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 221 NAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWseaecqrqqL 299
Cdd:cd18477   5 NCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVeKEEAVFEAVMKW---------V 75

                        90       100
                ....*....|....*....|....
gi 20127580 300 QVTPENRRKVLGKALGLIRFPLMT 323
Cdd:cd18477  76 REAKENRQKALPTVFESIRFRLLP 99
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 112-183 3.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 37.52  E-value: 3.46e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20127580 112 NNEvLCDVHFLVgkglSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE--IELPDVEPAAFLALLKFLYSDEV 183
Cdd:cd18202  16 NNQ-FCDVTLLI----EGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEavVDLSGFCKSSFLPLLEFAYTSEL 84
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 217-322 4.03e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 37.06  E-value: 4.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 217 LRADNAFMLLtqaRLFDEPQLASL--CLEN-IDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWSEA 292
Cdd:cd18446   1 LHPENCVGIL---RLADAHSLESLkkQVQNyIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVtEEEQVFETVMRWVRY 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 20127580 293 -ECQRQQLqvtpenrrkvLGKALGLIRFPLM 322
Cdd:cd18446  78 kESERLPL----------LPRVLENVRLPLL 98
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 118-215 4.64e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 37.25  E-value: 4.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 118 DVHFLVGKGlssqRIPAHRFVLAVGSAVFDAMFNGG-MATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE-TVMTTLY 195
Cdd:cd18358  22 DVTFKLDDG----TINAHKPLLICSCEWMAAMFGGSfIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADlDPLELIA 97

                        90       100
                ....*....|....*....|....
gi 20127580 196 TAKKYAVPAL----EAHCVEFLKK 215
Cdd:cd18358  98 LANRFCLPHLvaltEQHAVQELTK 121
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 243-298 5.10e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 36.50  E-value: 5.10e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20127580 243 ENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSEAEC-QRQQ 298
Cdd:cd18458  28 EYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRcESEVYNAVIRWVKYDEeNRRQ 85
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-214 5.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 36.79  E-value: 5.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 115 VLCDVhFLVGKGLSSQripAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 194
Cdd:cd18233  17 LLCDC-MLVVKGVCFK---AHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKNVGGIGQILDFMYTSHLDLNQDNVQVML 92

                        90       100
                ....*....|....*....|
gi 20127580 195 YTAKKYAVPALEAHCVEFLK 214
Cdd:cd18233  93 DIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 109-221 7.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 36.94  E-value: 7.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20127580 109 FLFNNEVLCDVHfLVGKGlssQRIPAHRFVLAVGSAVFDAMFnggmatTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 188
Cdd:cd18243  25 LLWRKQLFCDVT-LTAQG---QQFHCHKAVLASCSQYFRSLF------SINNLVLQGCSSIGLRLVLEYLYTANVTLSLD 94

                        90       100       110
                ....*....|....*....|....*....|...
gi 20127580 189 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 221
Cdd:cd18243  95 TVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-198 9.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 36.32  E-value: 9.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20127580 134 AHRFVLAVGSAVFDAMFNGGMATTSteIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAK 198
Cdd:cd18226  36 AHKVVVAVGSSYFHACLSKNPNTDA--VTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAK 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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