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Conserved domains on  [gi|51243055|ref|NP_057582|]
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mitochondrial fission process protein 1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTP18 super family cl11187
Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins ...
 20-146 1.45e-13

Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.


The actual alignment was detected with superfamily member pfam10558:

Pssm-ID: 431357  Cd Length: 169  Bit Score: 64.57  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243055    20 RYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKGKKA------------GEVPSPEAGRSARVTVAVVDTF-- 85
Cdd:pfam10558  19 RYVAYTSDIGESFRPVAHPYLVRAAYGVSWAYILGDVSYEGYKAylrnqrpldpslEPWKDAPPDDLAPLPPSKVPLLed 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51243055    86 ---------VWQALASVAIPGFTINRVCAASLYVLGTA--TRwplaVRKWTTTALGLLTIPIIIHPIDRSVD 146
Cdd:pfam10558  99 yrtvmakraVFQSIASMGLPAFTIHSVVRYSGRAFKNVknPR----IRTWGPIGLGLAVVPALPYLFDEPVE 166
 
Name Accession Description Interval E-value
MTP18 pfam10558
Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins ...
 20-146 1.45e-13

Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.


Pssm-ID: 431357  Cd Length: 169  Bit Score: 64.57  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243055    20 RYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKGKKA------------GEVPSPEAGRSARVTVAVVDTF-- 85
Cdd:pfam10558  19 RYVAYTSDIGESFRPVAHPYLVRAAYGVSWAYILGDVSYEGYKAylrnqrpldpslEPWKDAPPDDLAPLPPSKVPLLed 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51243055    86 ---------VWQALASVAIPGFTINRVCAASLYVLGTA--TRwplaVRKWTTTALGLLTIPIIIHPIDRSVD 146
Cdd:pfam10558  99 yrtvmakraVFQSIASMGLPAFTIHSVVRYSGRAFKNVknPR----IRTWGPIGLGLAVVPALPYLFDEPVE 166
 
Name Accession Description Interval E-value
MTP18 pfam10558
Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins ...
 20-146 1.45e-13

Mitochondrial 18 KDa protein (MTP18); This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.


Pssm-ID: 431357  Cd Length: 169  Bit Score: 64.57  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243055    20 RYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKGKKA------------GEVPSPEAGRSARVTVAVVDTF-- 85
Cdd:pfam10558  19 RYVAYTSDIGESFRPVAHPYLVRAAYGVSWAYILGDVSYEGYKAylrnqrpldpslEPWKDAPPDDLAPLPPSKVPLLed 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 51243055    86 ---------VWQALASVAIPGFTINRVCAASLYVLGTA--TRwplaVRKWTTTALGLLTIPIIIHPIDRSVD 146
Cdd:pfam10558  99 yrtvmakraVFQSIASMGLPAFTIHSVVRYSGRAFKNVknPR----IRTWGPIGLGLAVVPALPYLFDEPVE 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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