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Conserved domains on  [gi|20502976|ref|NP_038558|]
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guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 9.44e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.06  E-value: 9.44e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  48 RRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYT-----TNKVHAIPLRssWVMTCAYapsGNFVACGGLDNMCS 122
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 123 IYNLKSREgnvkVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDyKLFIS 201
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 202 GAC-DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL-TAYSQESIICgitSVAFS 279
Cdd:cd00200 152 SSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20502976 280 LSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 9.44e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.06  E-value: 9.44e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  48 RRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYT-----TNKVHAIPLRssWVMTCAYapsGNFVACGGLDNMCS 122
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 123 IYNLKSREgnvkVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDyKLFIS 201
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 202 GAC-DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL-TAYSQESIICgitSVAFS 279
Cdd:cd00200 152 SSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20502976 280 LSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 5.02e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.63  E-value: 5.02e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 126 LKSRegnvKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIicGITSVAFSLSGRL 284
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20502976 285 LFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-196 2.59e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976   40 VGRVQMRTRrtLRGHLAKIYAMHWAT-DSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSwvMTCAYAPS--GNFVACGG 116
Cdd:PLN00181 562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  117 LDNMCSIYNLKsregNVKVSR-ELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIE---TGQQKT---VFVGHTG--DC 187
Cdd:PLN00181 638 ADHKVYYYDLR----NPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsiSGINETplhSFMGHTNvkNF 713


                 ....*....
gi 20502976  188 MSLAVSPDY 196
Cdd:PLN00181 714 VGLSVSDGY 722
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-254 2.55e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20502976    216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
216-254 6.32e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 6.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20502976   216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-340 9.44e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.06  E-value: 9.44e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  48 RRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYT-----TNKVHAIPLRssWVMTCAYapsGNFVACGGLDNMCS 122
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 123 IYNLKSREgnvkVSRELSAHTGYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDyKLFIS 201
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 202 GAC-DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL-TAYSQESIICgitSVAFS 279
Cdd:cd00200 152 SSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVN---SVAFS 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20502976 280 LSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 5.02e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.63  E-value: 5.02e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 126 LKSRegnvKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIicGITSVAFSLSGRL 284
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20502976 285 LFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
46-340 8.41e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.15  E-value: 8.41e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 126 LKSRegnvKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:COG2319 149 LATG----KLLRTLTGHSGAVTSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESiiCGITSVAFSLSGRL 284
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKL 302

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20502976 285 LFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-254 1.10e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 1.10e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 126 LKSRegnvKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:cd00200 164 LRTG----KCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 20502976 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-256 2.54e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.54e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 126 LKSREgnvkVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:COG2319 275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 20502976 205 DASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLR 256
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
64-340 8.47e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 8.47e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  64 ATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNmcsiYNLKSREGNVKVSRELSAHT 143
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDL----TLLLLDAAAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 144 GYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTF 222
Cdd:COG2319  79 AAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 223 TGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIicGITSVAFSLSGRLLFAGYDDFNCNVWDSLKC 302
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 20502976 303 ERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
150-340 6.74e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 6.74e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 150 RFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESiiCGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGILS 309
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190
                ....*....|....*....|....*....|.
gi 20502976 310 GHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 218-340 1.89e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.89e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 218 CRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIicGITSVAFSLSGRLLFAGYDDFNCNVW 297
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 20502976 298 DSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
46-173 1.23e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.23e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  46 RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYN 125
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 20502976 126 LKSRegnvKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIET 173
Cdd:COG2319 359 LATG----ELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-212 3.99e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 3.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  45 MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGgldnmcsiy 124
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG--------- 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976 125 nlksregnvkvsrelsahtgylsccrflddnnivtsSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGAC 204
Cdd:cd00200 238 ------------------------------------SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                ....*...
gi 20502976 205 DASAKLWD 212
Cdd:cd00200 282 DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-196 2.59e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976   40 VGRVQMRTRrtLRGHLAKIYAMHWAT-DSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSwvMTCAYAPS--GNFVACGG 116
Cdd:PLN00181 562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  117 LDNMCSIYNLKsregNVKVSR-ELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIE---TGQQKT---VFVGHTG--DC 187
Cdd:PLN00181 638 ADHKVYYYDLR----NPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsiSGINETplhSFMGHTNvkNF 713


                 ....*....
gi 20502976  188 MSLAVSPDY 196
Cdd:PLN00181 714 VGLSVSDGY 722
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-254 2.55e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20502976    216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
216-254 6.32e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 6.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20502976   216 GTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-331 6.80e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 6.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976   97 SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKS-----REGNVKVSrELSAHTGYLSCC-RFLDDNNIVTSSGDTTCALWD 170
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  171 IETGQQKTVFVGHTGDCMSLAVSP-DYKLFISGACDASAKLWDVREGTCRQTFtghESDINAICF-FPN--GEAICTGSD 246
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI---KTKANICCVqFPSesGRSLAFGSA 638

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  247 DASCRLFDLRADQ----ELTAYSQEsiicgITSVAFSLSGRLLFAGYDDfNCNVWDsLKCERVGI-------LSGHDNRV 315
Cdd:PLN00181 639 DHKVYYYDLRNPKlplcTMIGHSKT-----VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVK 711

                        250
                 ....*....|....*.
gi 20502976  316 SCLGVTADGMAVATGS 331
Cdd:PLN00181 712 NFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-83 2.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 20502976     49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD 83
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 5.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.95e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 20502976    173 TGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWD 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-83 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 20502976    49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD 83
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
174-212 1.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.55e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20502976   174 GQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWD 212
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 153-303 2.26e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  153 DDNNIVTSSGDTTCALWDI-ETGQQKTV------FVGHTGDCMSLAVSPDYK-LFISGACDASAKLWDVREGTCRQTFTG 224
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20502976  225 HESDINAICFFPNGEAICTGSDDASCRLFDLRadqeltaysQESIICGITSVAFSLSGRLLFAGYDD----FNCN----- 295
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR---------DGTIVSSVEAHASAKSQRCLWAKRKDliitLGCSksqqr 237

                        170
                 ....*....|.
gi 20502976  296 ---VWDSLKCE 303
Cdd:PTZ00421 238 qimLWDTRKMA 248
WD40 pfam00400
WD domain, G-beta repeat;
303-340 3.18e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20502976   303 ERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-340 8.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 20502976    303 ERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-170 2.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.64e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 20502976    134 KVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWD 170
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 311-339 2.68e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 20502976   311 HDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
134-170 8.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 8.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20502976   134 KVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWD 170
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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