|
Name |
Accession |
Description |
Interval |
E-value |
| SEC21 |
COG5240 |
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]; |
7-866 |
0e+00 |
|
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];
Pssm-ID: 227565 [Multi-domain] Cd Length: 898 Bit Score: 647.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 7 KKDEESGSGSNPfqhlEKSAVLQEAR-IFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLR 85
Cdd:COG5240 7 KKFMKTKVFTTL----TERTLLQDMNeSFNKSPVSTRSARKLLSNLFYLLSTGELFPEATATNLFFAILKLFQHKDLYLR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 86 RMCYLTIKEMATISEDVIIVTSSLTKDM-TGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSL 164
Cdd:COG5240 83 QCVYSAIKELSKLTEDVLMGTSSIMKDLnGGVPDDVKPMAIRSLFSVIDGETVYDFERYLNQAFVSTSMARRSAALVVAY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 165 HMMKISYDVVKRWINEAQEAASS----------------DNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTK-SGLKSQF 227
Cdd:COG5240 163 HLLPNNFNQTKRWLNETQEAVLDlkqfpnqhgnegyepnGNPISQYHALGLLYQSKRTDKMAQLKLVEHFRGnASMKNQL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 228 AYCMLIRIASRLLKETEDGHeSPLFDFIESCLRNKHEMVIYEAASAIIHLP--NCTARELAPAVSVLQLFCSSPKPALRY 305
Cdd:COG5240 243 AGVLLVRATVELLKENSQAL-LQLRPFLNSWLSDKFEMVFLEAARAVCALSeeNVGSQFVDQTVSSLRTFLKSTRVVLRF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 306 AAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISA 385
Cdd:COG5240 322 SAMRILNQLAMKYPQKVSVCNKEVESLISDENRTISTYAITTLLKTGTEETIDRLVNLIPSFVHDMSDGFKIIAIDALRS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 386 LCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPR 465
Cdd:COG5240 402 LSLLFPSKKLSYLDFLGSSLLQEGGLEFKKYMVDAISDAMENDPDSKERALEVLCTFIEDCEYHQITVRILGILGREGPR 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 466 TPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNES--LLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQmALN 543
Cdd:COG5240 482 AKTPGKYVRHIYNRLILENNIVRSAAVQALSKFALNISDvvSPQSVENALKRCLNDQDDEVRDRASFLLRNMRLSD-ACE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 544 ATYIFNGLTvSVPGMEKALHQYTLEPS-EKPFDMKSIP------LAMAPVFEQKAEITLVATK--PEKLAPSRQD----- 609
Cdd:COG5240 561 PLFSSDELG-DIPSLELELIGYISEDSfATAFDVNQVRkftedeMKAINLKRKKSETTLDTTEsvPKEDANSKADpnikt 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 610 IFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLSC 689
Cdd:COG5240 640 KYADELLSIEQIKPFGQLVNSSREIILTEPEAEFVVKVVKHVFKDRLVLQFLLENTLEGIQLSNGIVVLTPTGGDKKEES 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 690 IPAPSLPYNQPGICYTLVRLPDDDPtaVAGSFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKVLKPNF 769
Cdd:COG5240 720 IKVDQIDSSEGTLSIVRFKKLDWDI--EEGYVVNGLFFTTKEIEGDTSEPEDEGFQDEYSIDPFQITAGDFVRPVRIKNF 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 770 AAAWeevgDTFEKEETFAL--SSTKTLEEAVNNIITFLGMQPCErSDKVPENKNSHSLYLAGIFRGGYDLLVRSRLA--L 845
Cdd:COG5240 798 PATF----DRLKREITFVLqgDIYASGKKILDKILLNSMKIPTE-ETETPNDSNTHVMKLNGKAYHGTKVSIRVKMVysM 872
|
890 900
....*....|....*....|.
gi 109134349 846 ADGVTMQVTVRSKERTPVDVI 866
Cdd:COG5240 873 ACGCTVKVYCDGESLYVTQLV 893
|
|
| Adaptin_N |
pfam01602 |
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ... |
23-539 |
1.70e-162 |
|
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 484.05 E-value: 1.70e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 23 EKSAVLQE-ARIFNETPINPRRCLHILTKILYLLNQGEHFGtteatEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISED 101
Cdd:pfam01602 1 EEKRIQQElARILNSFRDDPRKKKNAVKKLLYLIMLGEDIS-----FLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 102 V-IIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINE 180
Cdd:pfam01602 76 LaILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 181 AQEAASSDNIMVQYHALGVLYHLRKNDRLAVsKMLNKFTK-----SGLKSQFAYCMLIRIASRLLKETEDGhESPLFDFI 255
Cdd:pfam01602 156 LKELLSDKDPGVQSAAVALLYEICKNDRLYL-KLLPLLFRrlcnlLGVLNPWLQVKILRLLTRLAPLDPLL-PKELLEDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 256 ESCLRNKHEMVIYEAASAIIHLPNCTAReLAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITD 335
Cdd:pfam01602 234 LNLLQNSNNAVLYETANTIVHLAPAPEL-IVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPKAVQHLDLIIFCLKTD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 336 SNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISD-EFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFeYK 414
Cdd:pfam01602 313 DDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIADpDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY-VV 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 415 RAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTP---VPSKYIRFIFNRVVLENEAVRAAA 491
Cdd:pfam01602 392 DEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPngsSPPDLLRSILEVFVLESAKVRAAA 471
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 109134349 492 VSALAKFGAQN--ESLLPSILVLLQRCMM--DTDDEVRDRATFYLNVLQQRQ 539
Cdd:pfam01602 472 LTALAKLGLTSpeETTQNLIIQLLLTLATqdSLDLEVRDRAVEYLRLLSLAD 523
|
|
| COP-gamma_platf |
pfam08752 |
Coatomer gamma subunit appendage platform subdomain; COPI-coated vesicles function in ... |
609-756 |
1.77e-84 |
|
Coatomer gamma subunit appendage platform subdomain; COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport. This is the platform subdomain of the coatomer gamma subunit appendage domain. It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2.
Pssm-ID: 462588 Cd Length: 149 Bit Score: 266.33 E-value: 1.77e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 609 DIFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLS 688
Cdd:pfam08752 1 QKYAEQLAAIPEFASLGPLFKSSKPVELTESETEYVVSCVKHIFKEHIVLQFNIKNTLNDQVLENVSVVMEPSEEFEDVF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109134349 689 CIPAPSLPYNQPGICYTLVRLPD-DDPTAVAGSFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVT 756
Cdd:pfam08752 81 IIPIPSLPPNEPGSVYVSFERPDpEEEYLVSGTFSNTLKFTVKEIDPSTGEPEEEGYEDEYQLEDLELT 149
|
|
| Coatomer_g_Cpla |
pfam16381 |
Coatomer subunit gamma-1 C-terminal appendage platform; Coatomer_g_Cpla is the very C-terminal ... |
758-870 |
9.08e-48 |
|
Coatomer subunit gamma-1 C-terminal appendage platform; Coatomer_g_Cpla is the very C-terminal domain of the eukaryotic Coatomer subunit gamma-1 proteins. It acts as a platform domain to the C-terminal appendage. It carries one single protein/protein interaction site, which is the binding site for ARFGAP2 or ADP-ribosylation factor GTPase-activating protein. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The gamma-COPI is part of one of two subcomplexes that make up the heptameric coatomer complex along with the beta, delta and zeta subunits.
Pssm-ID: 406717 Cd Length: 114 Bit Score: 165.08 E-value: 9.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 758 SDHIQKVLKPNFAAAWEEVGDTFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGIFRGGYDL 837
Cdd:pfam16381 1 GDYIQPVFVGNFAAAWDELPSEGEASETFALSSVKSLQEAVDKLIELLGMQPLEGSDVVPENASSHTLKLSGKFVGGGKV 80
|
90 100 110
....*....|....*....|....*....|....
gi 109134349 838 LVRSRLALAD-GVTMQVTVRSKERTPVDVILASV 870
Cdd:pfam16381 81 LVRARLAISSgGVTMKLTVRSESEEVCELVLSAV 114
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
291-386 |
8.23e-05 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 41.94 E-value: 8.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 291 VLQLFCSSPKPALRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISsfvse 370
Cdd:pfam13646 4 LLQALLRDPDPEVRAAAIRAL--GRIGDPEAVPA----LLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLR----- 72
|
90
....*....|....*.
gi 109134349 371 iSDEFKVVVVQAISAL 386
Cdd:pfam13646 73 -DDDDDVVRAAAAEAL 87
|
|
| UNC45-central |
pfam11701 |
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ... |
325-497 |
8.71e-04 |
|
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.
Pssm-ID: 432011 Cd Length: 151 Bit Score: 40.60 E-value: 8.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 325 CNLDLEnlITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALcqkYPrkhsVMMTFLSNM 404
Cdd:pfam11701 8 KFLDLR--LPESVRSLALLILSKLLEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAAL---FP----VPPDVASAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 405 LRDDGgfeykraivdciisIVEEnpeskeagLAHLCEFIEDcehTVLATKILHLL----GKEGPRTPVPSKYIRFIFNRV 480
Cdd:pfam11701 79 FLSEG--------------FLES--------LLPLVESKKS---RKVELAALELLsaacIDKACREAISKNYVDWLEELL 133
|
170
....*....|....*..
gi 109134349 481 VLENEAVRAAAVSALAK 497
Cdd:pfam11701 134 KSSDDEIKALAAVVLAK 150
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
266-388 |
1.48e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 39.61 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 266 VIYEAASAIIHLPNctarelAPAVSVLQLFCSSPKPALRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAI 345
Cdd:COG1413 1 VRRAAARALGRLGD------PAAVPALIAALADEDPDVRAAAARAL--GRLGDPRAVPA----LLEALKDPDPEVRAAAA 68
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 109134349 346 TTLLKTGSESSVDRLMKQissfvseISDEFKVVVVQAISALCQ 388
Cdd:COG1413 69 EALGRIGDPEAVPALIAA-------LKDEDPEVRRAAAEALGR 104
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
436-532 |
1.94e-03 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 38.09 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 436 LAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPskyirFIFNRVVLENEAVRAAAVSALAKFGaqNESLLPsilVLLQR 515
Cdd:pfam13646 1 LPALLQALLRDPDPEVRAAAIRALGRIGDPEAVP-----ALLELLKDEDPAVRRAAAEALGKIG--DPEALP---ALLEL 70
|
90
....*....|....*..
gi 109134349 516 CMMDTDDEVRDRATFYL 532
Cdd:pfam13646 71 LRDDDDDVVRAAAAEAL 87
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
252-352 |
5.68e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 38.07 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 252 FDFIESCLRNKHEMVIYEAASAIIHLPNctarelAPAVSVLQLFCSSPKPALRYAAVRTLNKvaMKHPSAVTAcnldLEN 331
Cdd:COG1413 49 VPALLEALKDPDPEVRAAAAEALGRIGD------PEAVPALIAALKDEDPEVRRAAAEALGR--LGDPAAVPA----LLE 116
|
90 100
....*....|....*....|.
gi 109134349 332 LITDSNRSIATLAITTLLKTG 352
Cdd:COG1413 117 ALKDPDWEVRRAAARALGRLG 137
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
303-532 |
7.35e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 37.69 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 303 LRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISsfvseisDEFKVVVVQA 382
Cdd:COG1413 1 VRRAAARAL--GRLGDPAAVPA----LIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK-------DPDPEVRAAA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 383 ISALCQkyprkhsvmmtflsnmLRDdggfeykraivdciisiveenpeskEAGLAHLCEFIEDcehtvlatkilhllgke 462
Cdd:COG1413 68 AEALGR----------------IGD-------------------------PEAVPALIAALKD----------------- 89
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109134349 463 gprtpvpskyirfifnrvvlENEAVRAAAVSALAKFGaqNESLLPSILVLLQrcmmDTDDEVRDRATFYL 532
Cdd:COG1413 90 --------------------EDPEVRRAAAEALGRLG--DPAAVPALLEALK----DPDWEVRRAAARAL 133
|
|
| |
