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Conserved domains on  [gi|6755915|ref|NP_035792|]
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TYRO protein tyrosine kinase-binding protein precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAP10 super family cl06308
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 22-72 6.29e-03

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


The actual alignment was detected with superfamily member pfam07213:

Pssm-ID: 284598  Cd Length: 79  Bit Score: 33.35  E-value: 6.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6755915     22 LSPVQAQSDTFPRCD-CSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSR 72
Cdd:pfam07213  12 LLPVAAAQTTPGSCSgCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSR 63
 
Name Accession Description Interval E-value
DAP10 pfam07213
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 22-72 6.29e-03

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


Pssm-ID: 284598  Cd Length: 79  Bit Score: 33.35  E-value: 6.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6755915     22 LSPVQAQSDTFPRCD-CSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSR 72
Cdd:pfam07213  12 LLPVAAAQTTPGSCSgCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSR 63
 
Name Accession Description Interval E-value
DAP10 pfam07213
DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In ...
 22-72 6.29e-03

DAP10 membrane protein; This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.


Pssm-ID: 284598  Cd Length: 79  Bit Score: 33.35  E-value: 6.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6755915     22 LSPVQAQSDTFPRCD-CSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSR 72
Cdd:pfam07213  12 LLPVAAAQTTPGSCSgCGPLSLPLLAGLVAADAVASLLIVGVVFVCARLRSR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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