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Conserved domains on  [gi|110625645|ref|NP_035566|]
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sortilin-related receptor isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 771.58  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    124 SLALARPKSSDVYVSYDYGKSFSKISEKLnfgvGNNSEAVISQFYHSPADNKRYIFvdaYAQYLWITFDFCSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDEIE----GVIIETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNAIYIERHEPFGFSTVLR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADAAE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 110625645    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 8.66e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 8.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1651 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 110625645 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.67e-14

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 69.20  E-value: 1.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110625645  1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.55e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.55e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.88e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.99  E-value: 1.88e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 110625645 1373 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 2.05e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 2.05e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 110625645  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 5.89e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.89e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 9.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 9.06e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 110625645 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.98e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 2.98e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1419 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1630 3.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1630
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 7.49e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 7.49e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.42e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110625645 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1690-2100 5.13e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1690 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1769
Cdd:COG3401     5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1770 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1849
Cdd:COG3401    80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1850 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1928
Cdd:COG3401   158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1929 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 2007
Cdd:COG3401   229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 2008 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 2078
Cdd:COG3401   303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                         410       420
                  ....*....|....*....|..
gi 110625645 2079 TDNFFKVSNLKMGHNYTFTVQA 2100
Cdd:COG3401   378 TTTSYTDTGLTPGTTYYYKVTA 399
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 1.04e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 1.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    913 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 1.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1471 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1514-1549 5.29e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 5.29e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1514 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 1.18e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 1.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 110625645   890 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.72e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 2.72e-05
                            10        20
                    ....*....|....*....|....*...
gi 110625645   1281 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.37e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 3.13e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 3.13e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110625645    780 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 9.91e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 9.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110625645    953 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 771.58  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    124 SLALARPKSSDVYVSYDYGKSFSKISEKLnfgvGNNSEAVISQFYHSPADNKRYIFvdaYAQYLWITFDFCSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDEIE----GVIIETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNAIYIERHEPFGFSTVLR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADAAE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 110625645    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 7.92e-131

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 418.53  E-value: 7.92e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   133 SDVYVSYDYGKSFSKISEKLNfgvgnnsEAVISQFYHSPADNKRYIFVDAyAQYLWITFDFCSTIHGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   209 LLLHSKASNLLLGFDR----SHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNAIYIERHEP------FGFSTVL 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGGkcfsGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   279 RSTDFFQSREnqEVILEEVRDFQLRDKYMFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADAAEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   359 VFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   432 SMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625645   512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNEGETWKTFVFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 8.66e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 8.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1651 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 110625645 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.67e-14

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 69.20  E-value: 1.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110625645  1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 3.47e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 65.31  E-value: 3.47e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1158 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.55e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.55e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.88e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.99  E-value: 1.88e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 110625645 1373 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 2.05e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 2.05e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 110625645  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.27e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 63.04  E-value: 2.27e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 5.89e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.89e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1231 6.69e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.69e-12
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110625645 1199 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 1231
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 9.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 9.06e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 110625645 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.70e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 1.70e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.98e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 2.98e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1419 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1630 3.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1630
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 7.63e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 7.63e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 110625645  1373 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 9.00e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 9.00e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 110625645  1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1324-1356 9.95e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.41  E-value: 9.95e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1324 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
fn3 pfam00041
Fibronectin type III domain;
1652-1735 1.11e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645  1652 DAPRNLQLSLNSEEEGVIlgHWAPPVHTHGLIREYIVEYSRSGS-KMWASQRAASN--STEIKNLLLNALYTVRVAAVTS 1728
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTV--SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 110625645  1729 RGIGNWS 1735
Cdd:pfam00041   79 GGEGPPS 85
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 1.15e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.15e-10
                            10        20
                    ....*....|....*....|....*...
gi 110625645   1373 QFHCENGHCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1542-1753 1.24e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1542 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 1614
Cdd:COG3401   213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1615 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNSEEEGVILGhWAPPvhTHGLIREYIVEYS 1691
Cdd:COG3401   290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645 1692 RSGSKMWASQRAASNSTE--IKNLLLNALYTVRVAAVTSRgiGNWSD-SKSITTIKGKVIQAPNI 1753
Cdd:COG3401   364 TSGGGTYTKIAETVTTTSytDTGLTPGTTYYYKVTAVDAA--GNESApSEEVSATTASAASGESL 426
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 1.70e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.70e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110625645  1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 1.93e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.93e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 3.03e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 3.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1417 STCLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 3.25e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.25e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 110625645   1239 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 3.41e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.41e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1418 TCLPNYFHCSSGACVMGTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1558-1630 3.60e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 3.60e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110625645   1558 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 1630
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 7.49e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 7.49e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.42e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110625645 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1651-1732 3.09e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 3.09e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   1651 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGL--IREYIVEYSRSGSKmWASQRAASNSTE--IKNLLLNALYTVRVAAV 1726
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 110625645   1727 TSRGIG 1732
Cdd:smart00060   78 NGAGEG 83
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 3.59e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 3.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110625645  1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1690-2100 5.13e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1690 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1769
Cdd:COG3401     5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1770 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1849
Cdd:COG3401    80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1850 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1928
Cdd:COG3401   158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1929 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 2007
Cdd:COG3401   229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 2008 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 2078
Cdd:COG3401   303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                         410       420
                  ....*....|....*....|..
gi 110625645 2079 TDNFFKVSNLKMGHNYTFTVQA 2100
Cdd:COG3401   378 TTTSYTDTGLTPGTTYYYKVTA 399
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 1.04e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 1.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    913 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 1.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1471 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
fn3 pfam00041
Fibronectin type III domain;
1557-1628 2.51e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.51e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110625645  1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 1628
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 3.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 3.51e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1514-1549 5.29e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 5.29e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1514 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 6.97e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 6.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1470 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1935-2022 7.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1935 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTvEYSLSKLEPGGKYHIIVQLGNMSK 2014
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 110625645 2015 DS----SIKITT 2022
Cdd:cd00063    82 ESppseSVTVTT 93
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1513-1546 1.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 1.37e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1513 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 1546
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 4.52e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 4.52e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1470 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1935-2008 6.22e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 6.22e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645   1935 PPRHLHAVHIGKTSALIKWESPYDspDQDLFYAIAVKDLIRKTDRSYK-VRSRNSTVEYSLSKLEPGGKYHIIVQ 2008
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1117-1153 7.25e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 7.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
fn3 pfam00041
Fibronectin type III domain;
1935-2008 7.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.83e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625645  1935 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLiRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQ 2008
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1513-1549 7.93e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 7.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1513 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 1.18e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 1.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 110625645   890 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.72e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 2.72e-05
                            10        20
                    ....*....|....*....|....*...
gi 110625645   1281 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 8.34e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.42  E-value: 8.34e-05
                          10        20
                  ....*....|....*....|....*....
gi 110625645 1281 FVCKNRQqCLFHSMVCDGIVQCRDGSDED 1309
Cdd:cd00112     6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.37e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 3.13e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 3.13e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110625645    780 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 9.91e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 9.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110625645    953 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
124-753 0e+00

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 771.58  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    124 SLALARPKSSDVYVSYDYGKSFSKISEKLnfgvGNNSEAVISQFYHSPADNKRYIFvdaYAQYLWITFDFCSTIHGFSIP 203
Cdd:smart00602    1 SLLLGSAEESSVYISEDYGKTWKKIDEIE----GVIIETVISDFFNSSANKFKTIL---VKGYIFISSDEGKSFQKFTLP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    204 F-RAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDP-YDQPNAIYIERHEPFGFSTVLR 279
Cdd:smart00602   74 FpPLPSLLYHPKHPDYVLAYSKDCNYKVLYVSKDFGKTWTEIQENVESceFSWGSMGvYDFPDLVHISVKENSGALTELV 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    280 STDFFQSRENQEVILEEVRDFQLRDKYMFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINE---YYIADAAE 356
Cdd:smart00602  154 SSIDFFQRYDQSTIFLDIVGFLLTDEYLFVAVT-----DEDTTSRKLYVSNDRSTFAMAKFPKYHALGKqqaYTILDSDE 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    357 DQVFVCVSHS--NNSTNLYISEAEGLKFSLSLENVLYYSPGgagsdtlvryfanepFADFHRVEGLQGVYIATLINGsmN 434
Cdd:smart00602  229 DSVFLHVSENnqNDTGNLYISDSRGTKFSLSLENVNRYTGG---------------YIDFYKVEGLKGIYIANIVSK--V 291

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    435 EENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNlqlrRMPILSKESAPGLIIATGSVGK 512
Cdd:smart00602  292 DKQLQTKITFDKGGDWSLLKPPDVDNEGKKFNCDLTslEKCSLHLHLRYSESPY----SGDIASSKSAPGIIIASGNVGD 367

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    513 NLAS--KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEP 590
Cdd:smart00602  368 GLASywEPSTFISSDGGLTWRLVFDGPHLYAYGDHGGIIVAIEYNSPTNELKYSTDEGKTWKTYTFTSTPVFVKGLLTEP 447

                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    591 GEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGN--ECLLGHKTVFKRRTPHATCFNGE-DFD 667
Cdd:smart00602  448 GGSTLVFTLFGFTKERGSSWSLYTIDFKDIFERQCEEDDYKTWNLDDKRGSrdGCLLGHKTIFKRRKPTSQCLVGKsDYD 527

                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645    668 RPVVVSNCSCTREDYECDFGFkMSEDLSLEVCVPDPEFSGKPYspPVPCPVGSSYRR---TRGYRKISGDTCSGGdVEAR 744
Cdd:smart00602  528 LSLVSSPCSCTREDFECDFGF-YRLSEGDSTCVPDPNLSGNPL--SDDCKKGKSYTEyvkSLGYRKIPGDKCKGG-VKLE 603


                    ....*....
gi 110625645    745 LEGELVPCP 753
Cdd:smart00602  604 AEDIPHPCP 612
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 133-586 7.92e-131

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 418.53  E-value: 7.92e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   133 SDVYVSYDYGKSFSKISEKLNfgvgnnsEAVISQFYHSPADNKRYIFVDAyAQYLWITFDFCSTIHGFSIPFRAA----D 208
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   209 LLLHSKASNLLLGFDR----SHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNAIYIERHEP------FGFSTVL 278
Cdd:pfam15902   73 LSFHPKDPDWLIWYGGkcfsGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   279 RSTDFFQSREnqEVILEEVRDFQLRDKYMFATKVvhlpgSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADAAEDQ 358
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   359 VFVCVSHSNNS--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 431
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   432 SMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLNlqlRRMPILSKESAPGLIIATGSVG 511
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVN---IGRDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625645   512 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNEGETWKTFVFSEKPVFVYGL 586
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444
Sortilin_C pfam15901
Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of ...
 588-752 2.85e-58

Sortilin, neurotensin receptor 3, C-terminal; Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.


Pssm-ID: 464928 [Multi-domain]  Cd Length: 164  Bit Score: 198.70  E-value: 2.85e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   588 TEPGEKSTVFTIFGSNKESVHSWLIL-QVNATDALGVPCTENDYKLWSPS-DERGNECLLGHKTVFKRRTPHATCFNGED 665
Cdd:pfam15901    1 TEPDDTSLKFLLFGSSSSSRSDWEVVyTIDFSGLFDRKCTDDDYELWSPRhDQDGPKCLLGHKQKYRRRKPDADCFNGKD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   666 FDRPVVVSNCSCTREDYECDFGFKMSEDLSleVCVPDPEFSgKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARL 745
Cdd:pfam15901   81 FKDPKIEENCECTREDFECDYGFERSANDG--KCVLVPGLL-PPDGPKEDCKPGTYYLGSSGYRKIPGNTCEGGLELDKD 157


                   ....*..
gi 110625645   746 EGELVPC 752
Cdd:pfam15901  158 EPVEHPC 164
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1651-1742 8.66e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.54  E-value: 8.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1651 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGLIREYIVEYSRSGSKMW---ASQRAASNSTEIKNLLLNALYTVRVAAVT 1727
Cdd:cd00063     1 PSPPTNLRVTDVTSTS-VTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 110625645 1728 SRGIGNWSDSKSITT 1742
Cdd:cd00063    79 GGGESPPSESVTVTT 93
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1192 1.67e-14

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 69.20  E-value: 1.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110625645  1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1158-1192 3.47e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 65.31  E-value: 3.47e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1158 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1325-1359 1.55e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 63.38  E-value: 1.55e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1373-1403 1.88e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.99  E-value: 1.88e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 110625645 1373 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1198-1230 2.05e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 63.04  E-value: 2.05e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 110625645  1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1198-1230 2.27e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 63.04  E-value: 2.27e-12
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1198 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 1230
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1112 5.89e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.89e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1199-1231 6.69e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 6.69e-12
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110625645 1199 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 1231
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1240-1271 9.06e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 9.06e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 110625645 1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1189 1.70e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 1.70e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1157 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1419-1453 2.98e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 2.98e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110625645 1419 CLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1557-1630 3.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645 1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 1630
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1373-1403 7.63e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 7.63e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 110625645  1373 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1325-1359 9.00e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 9.00e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 110625645  1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1324-1356 9.95e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.41  E-value: 9.95e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1324 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
fn3 pfam00041
Fibronectin type III domain;
1652-1735 1.11e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645  1652 DAPRNLQLSLNSEEEGVIlgHWAPPVHTHGLIREYIVEYSRSGS-KMWASQRAASN--STEIKNLLLNALYTVRVAAVTS 1728
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTV--SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 110625645  1729 RGIGNWS 1735
Cdd:pfam00041   79 GGEGPPS 85
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1373-1400 1.15e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.15e-10
                            10        20
                    ....*....|....*....|....*...
gi 110625645   1373 QFHCENGHCIPNRWKCDRENDCGDWSDE 1400
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1542-1753 1.24e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1542 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 1614
Cdd:COG3401   213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1615 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNSEEEGVILGhWAPPvhTHGLIREYIVEYS 1691
Cdd:COG3401   290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645 1692 RSGSKMWASQRAASNSTE--IKNLLLNALYTVRVAAVTSRgiGNWSD-SKSITTIKGKVIQAPNI 1753
Cdd:COG3401   364 TSGGGTYTKIAETVTTTSytDTGLTPGTTYYYKVTAVDAA--GNESApSEEVSATTASAASGESL 426
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1240-1271 1.70e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.70e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110625645  1240 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 1271
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1077-1109 1.93e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 1.93e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE 1109
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1417-1453 3.03e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 3.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1417 STCLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEAC 1453
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1239-1268 3.25e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.25e-10
                            10        20        30
                    ....*....|....*....|....*....|
gi 110625645   1239 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 1268
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1418-1450 3.41e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 3.41e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110625645   1418 TCLPNYFHCSSGACVMGTWVCDGYRDCADGSDE 1450
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1558-1630 3.60e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 3.60e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110625645   1558 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 1630
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 824-866 7.49e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 7.49e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    824 EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1117-1153 1.42e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 1.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 110625645 1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:cd00112     1 CPPN-EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1651-1732 3.09e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 3.09e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   1651 PDAPRNLQLSLNSEEEgVILgHWAPPVHTHGL--IREYIVEYSRSGSKmWASQRAASNSTE--IKNLLLNALYTVRVAAV 1726
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTL-SWEPPPDDGITgyIVGYRVEYREEGSE-WKEVNVTPSSTSytLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 110625645   1727 TSRGIG 1732
Cdd:smart00060   78 NGAGEG 83
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1077-1112 3.59e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 3.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110625645  1077 TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1690-2100 5.13e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1690 YSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPnihidSYDENSLSFTLTM 1769
Cdd:COG3401     5 YLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGG-----LGTGGRAGTTSGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1770 DGDIKVNGYVVNLFWSFDAHKQEKKTlSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSl 1849
Cdd:COG3401    80 AAVAVAAAPPTATGLTTLTGSGSVGG-ATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1850 kaKAINQTAVECIWTGPKNVVYGIFYATSFldlyrnpKSVTTSLHNKTVIVSKDEQYLFLVRVL-IPYQGPSSDYVVVKM 1928
Cdd:COG3401   158 --TTASSVAGAGVVVSPDTSATAAVATTSL-------TVTSTTLVDGGGDIEPGTTYYYRVAATdTGGESAPSNEVSVTT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1929 IPDSRLPPRHLHAVHIGKTSALIKWEspyDSPDQDL-FYAIAVKDlirKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIV 2007
Cdd:COG3401   229 PTTPPSAPTGLTATADTPGSVTLSWD---PVTESDAtGYRVYRSN---SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRV 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 2008 QL----GNMSKDSSIKITTVSLSAPDA---LKI-ITENDHVLLFWKSLAlkekQFNETrGYEIHMSDSAVNLTAYLGNT- 2078
Cdd:COG3401   303 TAvdaaGNESAPSNVVSVTTDLTPPAApsgLTAtAVGSSSITLSWTASS----DADVT-GYNVYRSTSGGGTYTKIAETv 377

                         410       420
                  ....*....|....*....|..
gi 110625645 2079 TDNFFKVSNLKMGHNYTFTVQA 2100
Cdd:COG3401   378 TTTSYTDTGLTPGTTYYYKVTA 399
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 913-953 1.04e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 1.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    913 YRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQR 953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1471-1506 1.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 1.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1471 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1594-1914 1.68e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1594 VVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEgVILgHW 1673
Cdd:COG3401   176 ATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGS-VTL-SW 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1674 APpvHTHGLIREYIVEYSRSGSKMWaSQRAASNSTEI--KNLLLNALYTVRVAAVTSRGI-GNWSDSKSITTIKGKVIQA 1750
Cdd:COG3401   254 DP--VTESDATGYRVYRSNSGDGPF-TKVATVTTTSYtdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAP 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1751 PNIHIDSYDENSLSFTLTMDGDIKVNGYVVnlfwsfdaHKQEKKTLSFRG----GSALSHRVSNLTAHTS--YEISAWAK 1824
Cdd:COG3401   331 SGLTATAVGSSSITLSWTASSDADVTGYNV--------YRSTSGGGTYTKiaetVTTTSYTDTGLTPGTTyyYKVTAVDA 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1825 TDLGdSPLAFEHILTRGSSPPAPSLKA--KAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSVTTSLHNKTVIVSK 1902
Cdd:COG3401   403 AGNE-SAPSEEVSATTASAASGESLTAsvDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481

                         330
                  ....*....|..
gi 110625645 1903 DEQYLFLVRVLI 1914
Cdd:COG3401   482 TDTTTANLSVTT 493
fn3 pfam00041
Fibronectin type III domain;
1557-1628 2.51e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 2.51e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110625645  1557 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 1628
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1117-1150 3.51e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 3.51e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 1150
Cdd:smart00192    2 CPPG-EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1514-1549 5.29e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 5.29e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110625645 1514 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1470-1506 6.97e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 6.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1470 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 1506
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1935-2022 7.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1935 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTvEYSLSKLEPGGKYHIIVQLGNMSK 2014
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 110625645 2015 DS----SIKITT 2022
Cdd:cd00063    82 ESppseSVTVTT 93
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1513-1546 1.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 1.37e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1513 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 1546
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1470-1503 4.52e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 4.52e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110625645   1470 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 1503
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1935-2008 6.22e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 6.22e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110625645   1935 PPRHLHAVHIGKTSALIKWESPYDspDQDLFYAIAVKDLIRKTDRSYK-VRSRNSTVEYSLSKLEPGGKYHIIVQ 2008
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVEYREEGSEWKeVNVTPSSTSYTLTGLKPGTEYEFRVR 75
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1117-1153 7.25e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 7.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1117 CDADtQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1153
Cdd:pfam00057    3 CSPN-EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
fn3 pfam00041
Fibronectin type III domain;
1935-2008 7.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.83e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625645  1935 PPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLiRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQ 2008
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK-NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1513-1549 7.93e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 7.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 110625645  1513 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 1549
Cdd:pfam00057    2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 890-929 1.18e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 1.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 110625645   890 MFWTDWGdLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD 929
Cdd:pfam00058    3 LYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1281-1308 2.72e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 2.72e-05
                            10        20
                    ....*....|....*....|....*...
gi 110625645   1281 FVCKNRQqCLFHSMVCDGIVQCRDGSDE 1308
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1281-1309 8.34e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.42  E-value: 8.34e-05
                          10        20
                  ....*....|....*....|....*....
gi 110625645 1281 FVCKNRQqCLFHSMVCDGIVQCRDGSDED 1309
Cdd:cd00112     6 FRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 1166-1240 1.57e-04

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 44.78  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645  1166 SSGMCIRSSWVCDGDNDCRDWSDEANCTAiyhtCEASNFQCHN-GHC---IPQRWACDGDAD---CQDGSDEDPVSCEKK 1238
Cdd:pfam12999   43 HSEIKLSFDQVNDDYCDCPDGSDEPGTNA----CSNGKFYCANeGFIpgyIPSFKVDDGVCDydiCCDGSDEALGKCPNK 118


                   ..
gi 110625645  1239 CN 1240
Cdd:pfam12999  119 CG 120
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2026-2113 2.14e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 2026 SAPDALKII-TENDHVLLFWKSLALKEKQFnetRGYEIHMSDSAVN--LTAYLGNTTDNFFKVSNLKMGHNYTFTVQARC 2102
Cdd:cd00063     2 SPPTNLRVTdVTSTSVTLSWTPPEDDGGPI---TGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 110625645 2103 LFGsqiCGEPA 2113
Cdd:cd00063    79 GGG---ESPPS 86
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 868-910 2.37e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.37e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110625645    868 TIVNSSvLDRPRALVLVPQEGVMFWTDWGdlKPGIYRSYMDGS 910
Cdd:smart00135    2 TLLSSG-LGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGT 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2026-2106 2.76e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.76e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   2026 SAPDALKII-TENDHVLLFWKSlALKEKQFNETRGYEIHMSDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLF 2104
Cdd:smart00060    2 SPPSNLRVTdVTSTSVTLSWEP-PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ..
gi 110625645   2105 GS 2106
Cdd:smart00060   81 GE 82
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 780-821 3.13e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 3.13e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110625645    780 EQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGST 821
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1752-1831 1.50e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645 1752 NIHIDSYDENS--LSFTLTMDGDIKVNGYVVNLFwsfDAHKQEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGD 1829
Cdd:cd00063     6 NLRVTDVTSTSvtLSWTPPEDDGGPITGYVVEYR---EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82


                  ..
gi 110625645 1830 SP 1831
Cdd:cd00063    83 SP 84
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 798-937 2.66e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645  798 ERNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLetVEALAFEPLSQL--------LYWVDAGFKKIEVANPDGDFRLTI 869
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGR--PNGLAFDPDGRLlvadhgrgLVRFDPADGEVTVLADEYGKPLNR 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110625645  870 VNSSVLDRpralvlvpqEGVMFWTDWGDLKP--GIYRsyMDGSAAYRLVSEDVKWPNGI--SVDSQWIYWTD 937
Cdd:COG3386    95 PNDGVVDP---------DGRLYFTDMGEYLPtgALYR--VDPDGSLRVLADGLTFPNGIafSPDGRTLYVAD 155
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1751-1830 2.92e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 2.92e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625645   1751 PNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLSfRGGSALSHRVSNLTAHTSYEISAWAKTDLGDS 1830
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 953-987 9.91e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 9.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110625645    953 RSVILDSLPHPYAIAV--FKNEIYWDDWSQLSIFRAS 987
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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