DNA polymerase epsilon subunit 2 [Mus musculus]
Protein Classification
Dpoe2NT and DNA_pol_E_B domain-containing protein( domain architecture ID 10573583)
Dpoe2NT and DNA_pol_E_B domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
287-489 | 1.29e-44 | ||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. : Pssm-ID: 461142 Cd Length: 210 Bit Score: 156.32 E-value: 1.29e-44
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| Dpoe2NT | pfam12213 | DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately ... |
2-74 | 1.07e-34 | ||||
DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains. : Pssm-ID: 463494 Cd Length: 73 Bit Score: 124.88 E-value: 1.07e-34
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| Name | Accession | Description | Interval | E-value | ||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
287-489 | 1.29e-44 | ||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. Pssm-ID: 461142 Cd Length: 210 Bit Score: 156.32 E-value: 1.29e-44
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| Dpoe2NT | pfam12213 | DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately ... |
2-74 | 1.07e-34 | ||||
DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains. Pssm-ID: 463494 Cd Length: 73 Bit Score: 124.88 E-value: 1.07e-34
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| PTZ00235 | PTZ00235 | DNA polymerase epsilon subunit B; Provisional |
282-482 | 6.75e-16 | ||||
DNA polymerase epsilon subunit B; Provisional Pssm-ID: 185521 Cd Length: 291 Bit Score: 78.12 E-value: 6.75e-16
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| Name | Accession | Description | Interval | E-value | ||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
287-489 | 1.29e-44 | ||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. Pssm-ID: 461142 Cd Length: 210 Bit Score: 156.32 E-value: 1.29e-44
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| Dpoe2NT | pfam12213 | DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately ... |
2-74 | 1.07e-34 | ||||
DNA polymerases epsilon N terminal; This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains. Pssm-ID: 463494 Cd Length: 73 Bit Score: 124.88 E-value: 1.07e-34
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| PTZ00235 | PTZ00235 | DNA polymerase epsilon subunit B; Provisional |
282-482 | 6.75e-16 | ||||
DNA polymerase epsilon subunit B; Provisional Pssm-ID: 185521 Cd Length: 291 Bit Score: 78.12 E-value: 6.75e-16
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| Blast search parameters | ||||
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