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Conserved domains on  [gi|6754876|ref|NP_035060|]
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CCN family member 3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 203-246 1.29e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 75.45  E-value: 1.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6754876    203 CIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPC 246
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-89 2.91e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.33  E-value: 2.91e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876      28 RCPSRCPPKCPSISPTCAPGVRsvLDGCSCCPVCARQRGESCS-EMRPCdqSSGLYCDRSADP 89
Cdd:smart00121   2 RCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 266-335 1.75e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 56.64  E-value: 1.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876     266 KSLKAIHLQFENCTSLyTYKPRFC-GVCSD------------GRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYS 332
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 6754876     333 NCP 335
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
104-164 2.96e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.04  E-value: 2.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876     104 CVFDGVIYRNGEKFEPNCQYFCTCRDGQ-IGCLPR-CQldvllPGPDCPAPRKVAVPGECCEK 164
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 203-246 1.29e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 75.45  E-value: 1.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6754876    203 CIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPC 246
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-89 2.91e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.33  E-value: 2.91e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876      28 RCPSRCPPKCPSISPTCAPGVRsvLDGCSCCPVCARQRGESCS-EMRPCdqSSGLYCDRSADP 89
Cdd:smart00121   2 RCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
IGFBP pfam00219
Insulin-like growth factor binding protein;
29-83 1.63e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.79  E-value: 1.63e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754876     29 CPSRCPP-KCPSISPTCAPGVrsVLDGCSCCPVCARQRGESCSEM-RPCDqsSGLYC 83
Cdd:pfam00219   1 CPPPCDPeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYtPPCG--KGLRC 53
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 266-335 1.75e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 56.64  E-value: 1.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876     266 KSLKAIHLQFENCTSLyTYKPRFC-GVCSD------------GRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYS 332
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 6754876     333 NCP 335
Cdd:smart00041  80 NCP 82
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 258-341 1.22e-06

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 46.63  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876    258 GKKCLRTKKSlkaIHLQFENCTSLYTYKPRFC-GVC--------------SDGRCCTPHNTKTIQVEFQCLPGEIIKKPV 322
Cdd:pfam00007   1 RKKCIPTNYT---ISVEKEGCTSCKTINTTICaGYCytrdpvykdgrravSQRVCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90
                  ....*....|....*....
gi 6754876    323 MVIGTCTCySNCPQNNEAF 341
Cdd:pfam00007  78 PVALSCHC-GNCPTDNSDC 95
VWC smart00214
von Willebrand factor (vWF) type C domain;
104-164 2.96e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.04  E-value: 2.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876     104 CVFDGVIYRNGEKFEPNCQYFCTCRDGQ-IGCLPR-CQldvllPGPDCPAPRKVAVPGECCEK 164
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 104-163 4.29e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 4.29e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876    104 CVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPrcqldVLLPGPDCPAPRKVAVPGECCE 163
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCP 55
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 203-246 1.29e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 75.45  E-value: 1.29e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6754876    203 CIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPC 246
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-89 2.91e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.33  E-value: 2.91e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876      28 RCPSRCPPKCPSISPTCAPGVRsvLDGCSCCPVCARQRGESCS-EMRPCdqSSGLYCDRSADP 89
Cdd:smart00121   2 RCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
IGFBP pfam00219
Insulin-like growth factor binding protein;
29-83 1.63e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.79  E-value: 1.63e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6754876     29 CPSRCPP-KCPSISPTCAPGVrsVLDGCSCCPVCARQRGESCSEM-RPCDqsSGLYC 83
Cdd:pfam00219   1 CPPPCDPeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYtPPCG--KGLRC 53
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 266-335 1.75e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 56.64  E-value: 1.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876     266 KSLKAIHLQFENCTSLyTYKPRFC-GVCSD------------GRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYS 332
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 6754876     333 NCP 335
Cdd:smart00041  80 NCP 82
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 258-341 1.22e-06

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 46.63  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876    258 GKKCLRTKKSlkaIHLQFENCTSLYTYKPRFC-GVC--------------SDGRCCTPHNTKTIQVEFQCLPGEIIKKPV 322
Cdd:pfam00007   1 RKKCIPTNYT---ISVEKEGCTSCKTINTTICaGYCytrdpvykdgrravSQRVCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90
                  ....*....|....*....
gi 6754876    323 MVIGTCTCySNCPQNNEAF 341
Cdd:pfam00007  78 PVALSCHC-GNCPTDNSDC 95
VWC smart00214
von Willebrand factor (vWF) type C domain;
104-164 2.96e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.04  E-value: 2.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6754876     104 CVFDGVIYRNGEKFEPNCQYFCTCRDGQ-IGCLPR-CQldvllPGPDCPAPRKVAVPGECCEK 164
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 104-163 4.29e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 4.29e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754876    104 CVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPrcqldVLLPGPDCPAPRKVAVPGECCE 163
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCP 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 208-246 4.55e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 34.95  E-value: 4.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 6754876    208 TEWSACSKSCGMGVSTRV-------TNRNRQCEMVKQTRLCIVRPC 246
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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