NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6754490|ref|NP_034800|]
View 

keratin-associated protein 12-1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-130 7.36e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 50.94  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      7 SSGCQPSCCVSSSCQPSCCVSSPCQASCFVSSPCQPSCCVSSSCQSAccRPAICIPVRYQVACCVPVSCGPTVCMAPSCQ 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6754490     87 SSVCVPVSCRPVCVTSSCQSSGCCQPSCPTLVCKPVTCSNPSCC 130
Cdd:pfam01500 100 TRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-130 7.36e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 50.94  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      7 SSGCQPSCCVSSSCQPSCCVSSPCQASCFVSSPCQPSCCVSSSCQSAccRPAICIPVRYQVACCVPVSCGPTVCMAPSCQ 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6754490     87 SSVCVPVSCRPVCVTSSCQSSGCCQPSCPTLVCKPVTCSNPSCC 130
Cdd:pfam01500 100 TRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-130 7.36e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 50.94  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      7 SSGCQPSCCVSSSCQPSCCVSSPCQASCFVSSPCQPSCCVSSSCQSAccRPAICIPVRYQVACCVPVSCGPTVCMAPSCQ 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6754490     87 SSVCVPVSCRPVCVTSSCQSSGCCQPSCPTLVCKPVTCSNPSCC 130
Cdd:pfam01500 100 TRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-114 6.87e-07

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 45.55  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      2 CHTSCSSGCQPSCCVSSSCQPSCCVSSPCQASCFVSSPCQPSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCGPTVCM 81
Cdd:pfam01500  50 FQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQ 129

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6754490     82 APSCQSSVCVPVSCRPVCVTSSCqSSGCCQPSC 114
Cdd:pfam01500 130 LHHAQASCCRPSYCGQSCCRPAC-CCQCSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-119 1.71e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.78  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      7 SSGCQPSCCVSSSCQPSCCVSSPCQASCFVS--------SPCQPSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCGPT 78
Cdd:pfam01500  32 SSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCcqtsccqpTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEG 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 6754490     79 VCMAPSCQSSVCVPVSCRPVCVTSSCQSSGCCQPSCPTLVC 119
Cdd:pfam01500 112 TCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPAC 152
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 3-116 6.91e-06

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 43.27  E-value: 6.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490      3 HTSCSSGCQPSCCVSSSCQPSCC----------VSSPCQASC------FVSSPCQPSCCVSSSCQSACCRPAICIPVRYQ 66
Cdd:pfam05287  49 GSSLRDNCQETCGEPTSCQTSSCepctsstsycVPSPCQRSCysprtsCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQ 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 6754490     67 VACCVPVSCGPTVCMAPSCQSSVCVPVSCRPVCVTSSCQSSGCCQPSCPT 116
Cdd:pfam05287 129 PLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSCGS 178
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-42 3.63e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 3.63e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6754490     10 CQPSCCVSSSCQPSCCVSSPCQASCFVSSPCQP 42
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRP 34
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 12-127 2.21e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754490     12 PSCCVSSSCQPSCCVSSPCQASCFVSSPCQPSCCVSSSCQSACCRPAI---CIPVRYQVACCVPVSCGPTVCMAPSCQSS 88
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEG 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 6754490     89 VCVPVSCRPVCVTSSCQSSGCCQPSCPTLVCKPVTCSNP 127
Cdd:pfam01500  92 SSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQL 130
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
7-34 7.99e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 32.35  E-value: 7.99e-03
                          10        20
                  ....*....|....*....|....*...
gi 6754490      7 SSGCQPSCCVSSSCQPSCCVSSPCQASC 34
Cdd:pfam13885  14 PSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH