NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|160358845|ref|NP_034639|]
View 

interferon alpha/beta receptor 2 isoform a precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-228 3.19e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 82.78  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845  132 APLEPPEFEIVGFTDHINVTMEFPPVtskIIQEKMKTTPFVIKEQIGDSVRKKHEP-KVNNVTGNFTF-VLRDLLPKTNY 209
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET---REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFvVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|...
gi 160358845  210 CVSLYF----DDDPAIKSPLKCI 228
Cdd:pfam09294  78 CVSVQAfsplDNKSSQRSPPQCI 100
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 16-107 1.89e-11

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 60.86  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845   16 CLVVSASLETITPSAFDGYPDEPCTINITI--RNSRLILSWELENKSGPPANYTLWYTvMSKDENLTKVKNCSDTTKSSC 93
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFqsTNFKNILTWEPGPNSPPDVVYTVQYK-IYGSGDWKNVPNCTNITRTEC 79

                          90
                  ....*....|....
gi 160358845   94 DVTDKWLEGMESYV 107
Cdd:pfam01108  80 DLTDETSDLTETYY 93
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-228 3.19e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 82.78  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845  132 APLEPPEFEIVGFTDHINVTMEFPPVtskIIQEKMKTTPFVIKEQIGDSVRKKHEP-KVNNVTGNFTF-VLRDLLPKTNY 209
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET---REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFvVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|...
gi 160358845  210 CVSLYF----DDDPAIKSPLKCI 228
Cdd:pfam09294  78 CVSVQAfsplDNKSSQRSPPQCI 100
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 16-107 1.89e-11

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 60.86  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845   16 CLVVSASLETITPSAFDGYPDEPCTINITI--RNSRLILSWELENKSGPPANYTLWYTvMSKDENLTKVKNCSDTTKSSC 93
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFqsTNFKNILTWEPGPNSPPDVVYTVQYK-IYGSGDWKNVPNCTNITRTEC 79

                          90
                  ....*....|....
gi 160358845   94 DVTDKWLEGMESYV 107
Cdd:pfam01108  80 DLTDETSDLTETYY 93
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-228 3.19e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 82.78  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845  132 APLEPPEFEIVGFTDHINVTMEFPPVtskIIQEKMKTTPFVIKEQIGDSVRKKHEP-KVNNVTGNFTF-VLRDLLPKTNY 209
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET---REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFvVLSDLEPGTTY 77

                          90       100
                  ....*....|....*....|...
gi 160358845  210 CVSLYF----DDDPAIKSPLKCI 228
Cdd:pfam09294  78 CVSVQAfsplDNKSSQRSPPQCI 100
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 16-107 1.89e-11

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 60.86  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358845   16 CLVVSASLETITPSAFDGYPDEPCTINITI--RNSRLILSWELENKSGPPANYTLWYTvMSKDENLTKVKNCSDTTKSSC 93
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFqsTNFKNILTWEPGPNSPPDVVYTVQYK-IYGSGDWKNVPNCTNITRTEC 79

                          90
                  ....*....|....
gi 160358845   94 DVTDKWLEGMESYV 107
Cdd:pfam01108  80 DLTDETSDLTETYY 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH