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Conserved domains on  [gi|29789014|ref|NP_034177|]
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protein DGCR6 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DGCR6 super family cl46389
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
 9-167 3.44e-79

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


The actual alignment was detected with superfamily member pfam07324:

Pssm-ID: 480729  Cd Length: 194  Bit Score: 233.55  E-value: 3.44e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789014     9 SSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQ 88
Cdd:pfam07324  36 SSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQRLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLK 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29789014    89 AAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 167
Cdd:pfam07324 116 AKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGVPGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Name Accession Description Interval E-value
DGCR6 pfam07324
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
 9-167 3.44e-79

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


Pssm-ID: 462145  Cd Length: 194  Bit Score: 233.55  E-value: 3.44e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789014     9 SSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQ 88
Cdd:pfam07324  36 SSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQRLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLK 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29789014    89 AAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 167
Cdd:pfam07324 116 AKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGVPGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Name Accession Description Interval E-value
DGCR6 pfam07324
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
 9-167 3.44e-79

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


Pssm-ID: 462145  Cd Length: 194  Bit Score: 233.55  E-value: 3.44e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789014     9 SSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQ 88
Cdd:pfam07324  36 SSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQRLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLK 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29789014    89 AAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 167
Cdd:pfam07324 116 AKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGVPGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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