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Conserved domains on  [gi|31981847|ref|NP_033973|]
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cytotoxic T-lymphocyte protein 4 isoform 1 precursor [Mus musculus]

Protein Classification

IgV_CTLA-4 domain-containing protein( domain architecture ID 10146090)

IgV_CTLA-4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 4.65e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


:

Pssm-ID: 409386  Cd Length: 115  Bit Score: 247.61  E-value: 4.65e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  39 QVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981847 119 LRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
 
Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 4.65e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 247.61  E-value: 4.65e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  39 QVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981847 119 LRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 41-151 4.09e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 68.64  E-value: 4.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847    41 TQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFC-SGTFNESRVNLTIQGL 119
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSgRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 31981847   120 RAVDTGLYLCKVelmyPPPYFVGMGNGTQIYV 151
Cdd:pfam07686  81 TLSDSGTYTCAV----IPSGEGVFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
54-131 4.71e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.22  E-value: 4.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847     54 ASFPCEYSPSHNTDEVrVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPF---CSGTFNESRVNLTIQGLRAVDTGLYLCK 130
Cdd:smart00406   2 VTLSCKFSGSTFSSYY-VSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGrftISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 31981847    131 V 131
Cdd:smart00406  81 V 81
 
Name Accession Description Interval E-value
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 39-153 4.65e-85

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 247.61  E-value: 4.65e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  39 QVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQG 118
Cdd:cd05721   1 HVAQPAVVLASSRGVASFVCEYASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSICTGTSSGNQVNLTIQG 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 31981847 119 LRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVID 153
Cdd:cd05721  81 LRAMDTGLYICKVELMYPPPYYVGMGNGTQIYVID 115
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 41-151 4.09e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 68.64  E-value: 4.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847    41 TQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFC-SGTFNESRVNLTIQGL 119
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSgRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 31981847   120 RAVDTGLYLCKVelmyPPPYFVGMGNGTQIYV 151
Cdd:pfam07686  81 TLSDSGTYTCAV----IPSGEGVFGKGTRLTV 108
IgV_CD28 cd20925
Immunoglobulin Variable (IgV) domain Cluster of Differentiation (CD) 28; The members here are ...
 38-151 2.00e-09

Immunoglobulin Variable (IgV) domain Cluster of Differentiation (CD) 28; The members here are composed of the immunoglobulin variable region (IgV) of Cluster of Differentiation (CD) 28). CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. CD28 consists of a paired V-set of immunoglobulin (Ig) superfamily domains attached to single-transmembrane domains and cytoplasmic domains that contain the MYPPY motif, which is involved in binding B7.1 or B7.2. CD28 is very similar to CTLA-4 (cytotoxic T-lymphocyte-associated protein 4, also known as CD152 (cluster of differentiation 152)), which is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 also binds the B7 molecules (B7.1 and B7.2) with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The N-terminal Ig-like domain of CD28 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other. However, each CD28-B7 family member is slightly different, some have an IgV domain which lacks an A' or C" strand.


Pssm-ID: 409519  Cd Length: 117  Bit Score: 53.79  E-value: 2.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  38 IQVTQpSVVLASSHGVASFPCEYSPSHNTDEVRVTvLRQTNDQMTEVC------ATTFTEKNTVGFldypFCSGTFNESR 111
Cdd:cd20925   1 ILVKQ-SPMLVVYNNAVNLSCKYTYNLFSKEFRAS-LHKGLDSAVEVCvvygnySQQLQVYSNTGF----NCDGKLGNES 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 31981847 112 VNLTIQGLRAVDTGLYLCKVELMYPPPYFVG-MGNGTQIYV 151
Cdd:cd20925  75 VTFYLWNLYVNQTDIYFCKIEVMYPPPYLDNeKSNGTIIHV 115
IGv smart00406
Immunoglobulin V-Type;
54-131 4.71e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.22  E-value: 4.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847     54 ASFPCEYSPSHNTDEVrVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPF---CSGTFNESRVNLTIQGLRAVDTGLYLCK 130
Cdd:smart00406   2 VTLSCKFSGSTFSSYY-VSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGrftISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 31981847    131 V 131
Cdd:smart00406  81 V 81
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 37-151 8.79e-06

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 43.42  E-value: 8.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  37 AIQVTQPSVVLASSHGVASFPCEYSPSHNTDEV-RVTVLRQTNDQMTEVCATTFTEKNTVGfldyPFCSGTF-NESRVNL 114
Cdd:cd20926   1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIgSVTWFRDEVAPGKEVRNGTPEFRGRLA----PLASSRFlRDHQAEL 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 31981847 115 TIQGLRAVDTGLYLCKVELMyppPYFVGMGNGTQIYV 151
Cdd:cd20926  77 HIWDVRGHDAGIYVCRVEVL---GLGVGTGNGTRLVV 110
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 39-129 2.06e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 36.79  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847  39 QVTQPSV-VLASSHGVASFPCEYSPSHNTD--EVR---------VTVLR----QTNDQMTEvcattFTEKNTvgfldypF 102
Cdd:cd05713   2 SVIGPTEpILALVGEDAELPCHLSPKMSAEhmEVRwfrsqfspvVHLYRdgqdQEEEQMPE-----YRGRTE-------L 69

                        90       100
                ....*....|....*....|....*..
gi 31981847 103 CSGTFNESRVNLTIQGLRAVDTGLYLC 129
Cdd:cd05713  70 LKDAIAEGSVALRIHNVRPSDEGQYTC 96
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-132 7.10e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.79  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981847     43 PSVVLASSHGVASFPCEYSPSHNtdeVRVTVLRQTNDQMTEVcattftekntvgfldyPFCSGTFNESRVNLTIQGLRAV 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP---PEVTWYKQGGKLLAES----------------GRFSVSRSGSTSTLTISNVTPE 61

                           90
                   ....*....|
gi 31981847    123 DTGLYLCKVE 132
Cdd:smart00410  62 DSGTYTCAAT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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