Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 168
Cdd:cd08707     1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2026820933 169 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08707    77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  11 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFcSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTP 80
Cdd:cd11582     1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 168
Cdd:cd08707     1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2026820933 169 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08707    77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933   88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIlDSNGIVSRQTKPATKSF 167
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2026820933  168 IKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEY 210
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  781 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 858
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 2026820933  859 VEKVD 863
Cdd:smart00021  79 LVSVE 83

Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of Axin-1.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026820933  11 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPY 82
Cdd:pfam16646   4 DGGGSFREDAPRPPVPGEEGEVPGCGPQHGSFGPSSKKEALKKEASVASTPRRNEDGLGEEPEGSASPDPPL 75

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDsneEKRLKLARAIYRKYILDsNGIVSRQTKPATKSFI 168
Cdd:cd08707     1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIKD-NGIVSRQLKPATKSFI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2026820933 169 KDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08707    77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933   88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIlDSNGIVSRQTKPATKSF 167
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2026820933  168 IKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEY 210
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118

Domain present in Dishevelled and axin; Domain of unknown function.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  781 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 858
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78

                   ....*
gi 2026820933  859 VEKVD 863
Cdd:smart00021  79 LVSVE 83

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  11 DLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFcSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTP 80
Cdd:cd11582     1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPcdsnEEKRLKLARAIYRKYI---------LDSngivsrq 159
Cdd:cd08713     1 LEKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKS----QSKMASRAKKIFAEYIaiqsckevnLDS------- 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2026820933 160 tkpATKSFIKDCVmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08713    70 ---YTREHTKENL--QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKlARAIYRKYIlDSNGI----VSRQTKPAT 164
Cdd:cd08715     1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTE----SDLLPCK-AEEIYKEFV-QSDAAkqinIDFRTREST 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2026820933 165 KSFIKDCVmkqqidPAMFDQAQTEIQSTMEENTYPSFLKSDIYL 208
Cdd:cd08715    75 AKKIKAPT------PTCFDEAQKVIYILMERDSYPRFLKSDIYL 112

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsngivsrQTKPATK--- 165
Cdd:cd08717     1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPLKMATK----AKKIYEEFI---------QTEAPKEvni 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2026820933 166 -SFIKDCVMKQQIDPAM--FDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08717    68 dHFTKDVTMKNLVEPSSssFDLAQKRIFALMEKDSLPRFVRSEFYQE 114

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  85 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsnGIVSRQtKPAT 164
Cdd:cd08745     1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEK----ARLIYEDYI----SILSPK-EVSL 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2026820933 165 KSFIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 207
Cdd:cd08745    72 DSRVREGINRKMQEPSshTFDDAQLQIYTLMHRDSYPRFLNSPIY 116

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdSNEEKRLKlARAIYRKYildsngIVSRQTKPATKSF-IKD 170
Cdd:cd08723     1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTK---SSTEIALK-AQMIYSEF------IQADAPKEINIDFhTRD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2026820933 171 CVMKQQIDPAM--FDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08723    71 LISQNISEPTLkcFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  84 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYI---LDSNGIVSRQT 160
Cdd:cd08711     7 RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVSKAHRIFEEFVdvqAPREVNIDFQT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2026820933 161 KPATKSFIkdcvmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08711    83 REATRKNL------QEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsngivsrqTKPATKSFI 168
Cdd:cd08714     1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPSKLSPK----ARKIYEEFI----------SVQATKEVN 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2026820933 169 KDCVMKQQIDPAM-------FDQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08714    67 LDSCTREETSRNMleptiscFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYIL-----DSNgiVSRQTKPATKS 166
Cdd:cd08710     4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIR----SATKLASRAHHIFEEFIRseapkEVN--IDHETRELTRT 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2026820933 167 FIkdcvmkQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIY 207
Cdd:cd08710    78 NL------QAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAY 112

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  85 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKrlklARAIYRKYIldsnGIVSRQtKPAT 164
Cdd:cd08744     1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEK----ARLIYEDYI----SILSPK-EVSL 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2026820933 165 KSFIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 207
Cdd:cd08744    72 DSRVREVINRNLLDPNphMYEDAQLQIYTLMHRDSFPRFLNSQIY 116

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  84 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKlepCDSNEEKRlkLARAIYRKYI---------LDSNg 154
Cdd:cd08705     4 RWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKY---GPQSQVPE--KVQEIYQEFLapgapswinIDSK- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2026820933 155 ivsrqtkpatksfIKDCVMKQQIDPA--MFDQAQTEIQSTMEENTYPSFLKSDIY 207
Cdd:cd08705    78 -------------TMEITLKNLKDPHryTFDAAQEHIYMLMKKDSYPRFLRSDIY 119

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  84 RWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKlepcdSNEEKRLKLARAIYRKYIldsngivsrqtKPA 163
Cdd:cd08739     4 RWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEEIYKLFL-----------APG 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2026820933 164 TKSFIK------DCVMKQQIDPAMF--DQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08739    68 ARRWINidgktmDITVKGLKHPHRYvlDAAQTHIYMLMKKDSYARYLKSPIYKE 121

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  93 LDDQDGISLFRTFLKQEGCADLLDFWFACSGF--RKLEPcDSNEEKRLKL---ARAIYRKYILD------------SNGI 155
Cdd:cd08722     2 LDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFnrRILNP-DLTDEEKQSLhkeAQEIYKTYFLPeapdrihfppdiVEEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2026820933 156 VSRQTKPATKsfikdcVMKQQIDPAMFdQAQTEIQSTMEENTYPSFLKSDIYLE 209
Cdd:cd08722    81 KQILEGGPEK------IVKLRTSRPLF-EAYEHVYSLLESVFCPLFCHSDEYFI 127

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3); The RGS domain is an essential part of the GRK2 (G protein-coupled receptor kinases 2) and the GRK3 proteins, which are members of the beta-adrenergic receptor kinases subfamily. GRK2 and GRK3 are ubiquitously expressed and can phosphorylate many different GPCR. The C-terminus of GRK2 and 3 contains a plekstrin homology domain (PH) with binding sites for the membrane phospholipid PIP2 and free G#? subunits. These specific interactions could help to maintain a membrane-bound population of GRK2 prior to the agonist-dependent overt GRK2 translocation. GRK2 and GRK3 are members of the GRK kinase family which includes three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  98 GISLFRTFLKQ--EGCADLLDFWFACSGFRKLEpcdsNEEKRLKLARAIYRKYILDSngIVSrQTKPATKS---FIKDCV 172
Cdd:cd08747    35 GYLLFKDFCENvsEEPVPQLKFYEEIKKYEKLD----TEEERIKKAREIYDNYIMKE--LLS-CSHPFSKSaveHVQKHL 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2026820933 173 MKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDiylEYTR 212
Cdd:cd08747   108 SKKEVPVDLFEPYIEEICDSLRGDVFQKFLESD---KFTR 144

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  98 GISLFRTFLKQEGCADLLDFWFACSGFRKlEPCdSNEEKRLKLARAIYRKYILdsngivsrqtkpaTKSFIKDCVMKQQI 177
Cdd:cd08730     7 GMRRFRQFLAGTLGEDYLKFWLDVEMYRR-DYK-FGEIKRLDFFRSVVTKYLL-------------KNSPYCLPVFKRIE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933 178 DPAMFDQ-AQTEIQSTMeentypSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPtlnEDEEWKCDQDADED 256
Cdd:cd08730    72 SNIGLDEsAIMEVMSPM------TEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKRSYCEYIQ---QEALFILDDANHEV 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2026820933 257 dgrdplppsrLTQKLLLETA-APRAPSSRRY 286
Cdd:cd08730   143 ----------SRQTVLIPTQmSARLSNGLTS 163

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  93 LDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLA------------RAIYRKYILDSNGI--VSR 158
Cdd:cd08729     1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkediAMIYETYFSDPSPSlnVPK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2026820933 159 QTKPATKSFIKdcvMKQQIDP---------AMFdQAQTEIQSTMEENTYPSFLKSDIYL 208
Cdd:cd08729    81 ASRDPIRLFLN---AGVNASPneqyrkarrAVL-MAQRAVYEEMEEEDFPEFKKSELFY 135

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933  88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFR-------------------------------KLEPC------ 130
Cdd:cd08735     4 TLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKsaawsrirahslntvkhssleepvspsldrkVLESKstdsls 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026820933 131 ----DSNEEKRLKL----ARAIYRKYIldsngiVSRQTKP-----ATKSFI--KDCVMKQQIDPAMFDQAQTEIQSTMEE 195
Cdd:cd08735    84 qrltDDDDEKSMKSierdAVSIYTKYI------SPDAAKPipiteEIRNDIvaKICGEDGQVDPNCFVEAQSFVFSAMEQ 157

                         170
                  ....*....|..
gi 2026820933 196 NTYPSFLKSDIY 207
Cdd:cd08735   158 DHFTEFLRSHFF 169