|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
34-1457 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1688.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 34 TKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 110
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 111 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 189
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 190 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNG 268
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 269 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIE 348
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 349 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 428
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 429 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 508
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 509 QIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFITPIV 587
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNpGFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 588 KASK-NKQELSFYSIPEFDEWKKHIeNQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKK 666
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 667 IDDRKEWLTNFMedrrqrrlhglPEQFLyGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRN 746
Cdd:PTZ00108 637 VEDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRN 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 747 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 826
Cdd:PTZ00108 705 LKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYI 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 827 FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKG 906
Cdd:PTZ00108 785 FPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 907 TIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEpmlNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKL 986
Cdd:PTZ00108 865 TIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLNDGVL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 987 AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE 1066
Cdd:PTZ00108 941 EQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKH 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1067 KIQGKITIENRSKKDLIQMLVQRGYESDP----VKAWKEAQEKAAEEEDSQNQhDDSSSDSGTPSGPDFNYILNMSLWSL 1142
Cdd:PTZ00108 1021 VINGELVITNAKKKDLVKELKKLGYVRFKdiikKKSEKITAEEEEGAEEDDEA-DDEDDEEELGAAVSYDYLLSMPIWSL 1099
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1143 TKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETM 1222
Cdd:PTZ00108 1100 TKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEK 1179
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1223 PSpygrrivpeiTAMKADASRKLLKKKKGDPDTTVVKVEFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKkepgtrv 1302
Cdd:PTZ00108 1180 KK----------KKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKR------- 1242
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1303 rktPTSTGKTNAKKVKKRNPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKytfDFSEEEDDDAAAADDSNDLEEL 1382
Cdd:PTZ00108 1243 ---LKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDG---ESNGGSKPSSPTKKKVKKRLEG 1316
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34328148 1383 KVKASPITNDGEDEFVPSDGLDKDEYAF---SSGKSKATPEKSSNDKKSQDfgnlfSFPSYSQKSEDDSakfDSNEED 1457
Cdd:PTZ00108 1317 SLAALKKKKKSEKKTARKKKSKTRVKQAsasQSSRLLRRPRKKKSDSSSED-----DDDSEVDDSEDED---DEDDED 1386
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
89-678 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 806.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 89 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 168
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 169 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 248
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 249 TRRAYDLAGSCKGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 320
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 321 SFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 398
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 399 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 473
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 474 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQ 553
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFD----IEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 554 DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQ--ELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTA 630
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 34328148 631 KEAKEYFADMERHRILFRYAGPEDDA-AITLAFSKKKIDDRKEWLTNFM 678
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
720-1180 |
7.89e-172 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 524.44 E-value: 7.89e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 720 NERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSaYHHGEQALMMTIVNLAQNFvgSNNINLLQPI 796
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 797 GQFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPN 875
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 876 YDAREIVNNVRRMLEGLDP-------HPMLPNYKNFkGTIQ---------ELGQNQYAVSGEIFVVD---RNTVEITELP 936
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEgragireayETGRGRYIIRGKYEIEDdegRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 937 VRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNsMVLFDHMG 1016
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1017 CLKKYeTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE--KIQGKITIENRSKKDLIQMLVQRGYESD 1094
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1095 pvkawkeaqekaaeeedsqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKS-----P 1169
Cdd:cd00187 390 -----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILaseerP 434
|
490
....*....|.
gi 34328148 1170 SDLWKEDLAAF 1180
Cdd:cd00187 435 KDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
722-1177 |
6.04e-151 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 468.18 E-value: 6.04e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFVGsnNINLLQPIGQ 798
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 799 FGTRLHGGKDAAsPRYIFTMLSSLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 877
Cdd:pfam00521 77 FGSRIDGDKDAA-MRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 878 AREIVNNVRRMLEGLDP-----HPMLPNYKNFKGTIQEL--------GQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY 944
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGgikeayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 945 KEQVLEPMLNGTDKtpaLISDYKEYhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETV 1024
Cdd:pfam00521 236 IEKIEELVKNGKIK---GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDG---GPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1025 QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN------NQARFILEKIQGKItIENRSKKDLIQMLvqrgyesdpvka 1098
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1099 wkeaqekaaeeedSQNQhddsssdsgtpsgpdFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPS-----DLW 1173
Cdd:pfam00521 376 -------------SEIQ---------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLW 427
|
....
gi 34328148 1174 KEDL 1177
Cdd:pfam00521 428 IEEL 431
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
49-673 |
1.97e-41 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 163.28 E-value: 1.97e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 49 LEHILLRPDTYIGSVepltqlmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 120
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 121 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 198
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 199 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMFNGKKLPV----- 273
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 274 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 335
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 336 --DYVVDQvvsKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 400
Cdd:COG0187 294 inDYARKN---GLL---KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 401 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 466
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 467 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTL 540
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFD----LEKL 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 541 RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK 618
Cdd:COG0187 489 RYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGKKKVE 566
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 34328148 619 IKYYKGLGTSTAKEAKEYFADMErHRILFRyAGPEDDAAITLAFSK---KKIDDRKEW 673
Cdd:COG0187 567 IQRYKGLGEMNPEQLWETTMDPE-TRTLLQ-VTIEDAAEADEIFSLlmgDKVEPRREF 622
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1495-1597 |
2.01e-30 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 116.01 E-value: 2.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1495 KRAPKQKKIVETINSDSDSEFGIPKKTTTPKGkgRGAKKRKASGSENEGDYNPGRKPSKTASKKPKKTSFDQDSdvdiFP 1574
Cdd:pfam08070 1 KAAPKAAKAADKSSSDSDSDAGASKKPAPPKG--RKARKRKPSSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDD----FS 74
|
90 100
....*....|....*....|...
gi 34328148 1575 SDFTSEPPALPRTGRARKEVKYF 1597
Cdd:pfam08070 75 VDLDSEVAPRARPGRAKKPVKYL 97
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
722-1043 |
1.34e-17 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 89.29 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 797
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 798 QFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPN 875
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 876 YDAREIVNNVRRMLEGLD----------PHPMLP-----NYKnfKGTIQ--ELGQNQYAVSGEIFV----VDRNTVEITE 934
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiiLGR--SGIRSayETGRGSIVIRARAEIeedsKGREAIIVTE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 935 LPVrtwtQVYKEQVLEPMLN-GTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1013
Cdd:TIGR01063 256 IPY----QVNKARLIEKIAElVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVK 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 34328148 1014 HmgcLKKYETVQDILKEFFDLRL------SYYGLRK 1043
Cdd:TIGR01063 332 G---LPKVLNLKELLEAFVEHRKdvitrrTIFELRK 364
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
34-1457 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1688.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 34 TKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 110
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 111 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 189
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 190 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNG 268
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 269 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIE 348
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 349 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 428
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 429 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 508
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 509 QIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFITPIV 587
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNpGFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 588 KASK-NKQELSFYSIPEFDEWKKHIeNQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKK 666
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 667 IDDRKEWLTNFMedrrqrrlhglPEQFLyGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRN 746
Cdd:PTZ00108 637 VEDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRN 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 747 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLL 826
Cdd:PTZ00108 705 LKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYI 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 827 FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKG 906
Cdd:PTZ00108 785 FPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 907 TIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEpmlNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKL 986
Cdd:PTZ00108 865 TIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLNDGVL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 987 AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE 1066
Cdd:PTZ00108 941 EQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKH 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1067 KIQGKITIENRSKKDLIQMLVQRGYESDP----VKAWKEAQEKAAEEEDSQNQhDDSSSDSGTPSGPDFNYILNMSLWSL 1142
Cdd:PTZ00108 1021 VINGELVITNAKKKDLVKELKKLGYVRFKdiikKKSEKITAEEEEGAEEDDEA-DDEDDEEELGAAVSYDYLLSMPIWSL 1099
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1143 TKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETM 1222
Cdd:PTZ00108 1100 TKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEK 1179
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1223 PSpygrrivpeiTAMKADASRKLLKKKKGDPDTTVVKVEFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKkepgtrv 1302
Cdd:PTZ00108 1180 KK----------KKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKR------- 1242
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1303 rktPTSTGKTNAKKVKKRNPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKytfDFSEEEDDDAAAADDSNDLEEL 1382
Cdd:PTZ00108 1243 ---LKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDG---ESNGGSKPSSPTKKKVKKRLEG 1316
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34328148 1383 KVKASPITNDGEDEFVPSDGLDKDEYAF---SSGKSKATPEKSSNDKKSQDfgnlfSFPSYSQKSEDDSakfDSNEED 1457
Cdd:PTZ00108 1317 SLAALKKKKKSEKKTARKKKSKTRVKQAsasQSSRLLRRPRKKKSDSSSED-----DDDSEVDDSEDED---DEDDED 1386
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
38-1185 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1649.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 38 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYdEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVS 117
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 118 IDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 197
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 198 SFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG-SCKGVKVMFNGKKLPVNG 275
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 276 FRSYVDLYVKDKLDETGvaLKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNK 355
Cdd:PLN03128 241 FQDYVGLYLGPNSREDP--LPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 356 AGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLnKK 435
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 436 CSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAE 515
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 516 INNIIKIVGLQYKKSYDdAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKASKNKQ 594
Cdd:PLN03128 478 ITNIKQILGLQFGKTYD-EENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 595 ELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEW 673
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLEGEtKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 674 LTNFMEDrrqrrlhglpeQFLYGTATKhLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKV 753
Cdd:PLN03128 637 LNNYEPG-----------TFLDQTGNG-ISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 754 AQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDN 833
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 834 LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQE--- 910
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEvst 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 911 LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAE 990
Cdd:PLN03128 865 SRSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 991 AAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQG 1070
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1071 KITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHDDSSSDSgtpSGPDFNYILNMSLWSLTKEKVEEL 1150
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFPKTAKISETNVVGDRDGEASEEEEASDNE---LAKSYDYLLGMPISSLTLEKVDEL 1100
|
1130 1140 1150
....*....|....*....|....*....|....*
gi 34328148 1151 IKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELD 1185
Cdd:PLN03128 1101 RAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
20-1609 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1467.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 20 TKKEELETANKNDSTKKL-------SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDvGMNCREVTFVPGLYK 92
Cdd:PLN03237 2 AEKLPLQESNSANVAAAPaassggkTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETD-KMVQRSVTYVPGLYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 93 IFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRN 172
Cdd:PLN03237 81 IFDEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 173 GYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKI-KHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRR 251
Cdd:PLN03237 161 GYGAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPVItKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 252 AYDLAGSC-KGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTK 330
Cdd:PLN03237 241 VVDIAGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 331 GGRHVDYVVDQVVSKLIEVVKKKNKAGvSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKA 410
Cdd:PLN03237 321 GGTHVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 411 ASNCGIVESILNWVKFKAQTQLnKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRY 490
Cdd:PLN03237 400 VMKSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYY 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 491 GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNW 570
Cdd:PLN03237 479 GVFPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQY---ESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFW 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 571 PSLLK-HGFLEEFITPIVKASK-NKQELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILF 647
Cdd:PLN03237 556 PSLLKvPSFLVEFITPIVKATRrGKKVLSFYSMPEYEEWKESLGgNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDF 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 648 RYAGPEDDAAITLAFSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYGTAtKHLTYNDFINKELILFSNSDNERSIPSL 727
Cdd:PLN03237 636 VWEDEQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHLDQTQ-KDVKYSDFVNKELILFSMADLQRSIPSM 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 728 VDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGK 807
Cdd:PLN03237 704 VDGLKPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGK 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 808 DAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRR 887
Cdd:PLN03237 784 DHASARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRR 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 888 MLEGLDPHPMLPNYKNFKGTIQE----LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPA-L 962
Cdd:PLN03237 864 LLNGESMEPMHPWYRGFKGTIEKtaskEGGCTYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpF 942
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 963 ISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLR 1042
Cdd:PLN03237 943 IKDVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKR 1022
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1043 KEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHD--DSS 1120
Cdd:PLN03237 1023 KEVLLKNLEFELLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKAKSVEAAVAGATDDAAEEEEeiDVS 1102
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1121 SDSGTPsGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKveaQEREDilagms 1200
Cdd:PLN03237 1103 SSSGVR-GSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDK---LDKED------ 1172
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1201 gkaikgkvgkpkvkklqleetmpspygrrivpeitaMKADASRKLLKKKKGDPDTtvvkvefdeefsgtpaegtgeetlt 1280
Cdd:PLN03237 1173 ------------------------------------AKAEEAREKLQRAAARGES------------------------- 1191
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1281 psapvNKGPKPKREKKEPGTRvrktptstgKTNAKKVKKRNPWSDDESKSESDLEEAEPVVIP--RDSLLRRAAAERPKY 1358
Cdd:PLN03237 1192 -----GAAKKVSRQAPKKPAP---------KKTTKKASESETTEETYGSSAMETENVAEVVKPkgRAGAKKKAPAAAKEK 1257
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1359 TFDFseeedddaaaaddsnDLEELKVKASPITNDGEdefvPSDGLDKDEyafssgKSKATPEKSSNDKKSQdfgnLFSFP 1438
Cdd:PLN03237 1258 EEED---------------EILDLKDRLAAYNLDSA----PAQSAKMEE------TVKAVPARRAAARKKP----LASVS 1308
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1439 SYSQKSEDDsakfdsneEDTASVFAPSFGLKQTDKLPSKTVAAKKGKPPSDT--APKAKRAPKQKKIVETINSDSDSEfg 1516
Cdd:PLN03237 1309 VISDSDDDD--------DDFAVEVSLAERLKKKGGRKPAAANKKAAKPPAAAkkRGPATVQSGQKLLTEMLKPAEAIG-- 1378
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1517 ipkktTTPKGKGRGAKKRKASgsenegdynpgRKPSKTASKKPKKTSFDQDSDVDIFPSDFTSE--PPALPRTGRARKE- 1593
Cdd:PLN03237 1379 -----ISPEKKVRKMRASPFN-----------KKSGSVLGRAATNKETESSENVSGSSSSEKDEidVSAKPRPQRANRKq 1442
|
1610
....*....|....*....
gi 34328148 1594 ---VKYFAESDEEEDVDFA 1609
Cdd:PLN03237 1443 ttyVLSDSESESADDSDFD 1461
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
89-678 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 806.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 89 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 168
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 169 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 248
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 249 TRRAYDLAGSCKGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 320
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 321 SFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 398
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 399 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 473
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 474 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQ 553
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFD----IEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 554 DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQ--ELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTA 630
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 34328148 631 KEAKEYFADMERHRILFRYAGPEDDA-AITLAFSKKKIDDRKEWLTNFM 678
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
702-1175 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 564.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 702 LTYNDFINKELILFSNS-DNERSIPSLVDGFKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSAYH-HGEQALMMTIV 778
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 779 NLAQNFVgsNNINLLQPIGQFGTRLhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMV 857
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 858 LINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHP----MLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEIT 933
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 934 ELPVRTWTQVYKEQVLEPMLNGtdKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1013
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1014 HmGCLKKYETVQdILKEFFDLRLSYYGLRKEWLVGMLGAEsTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYES 1093
Cdd:smart00434 316 N-GRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1094 DpvkawkeaqekaaeeedsqnqhddsssdsgTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLW 1173
Cdd:smart00434 393 F------------------------------ELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEW 442
|
..
gi 34328148 1174 KE 1175
Cdd:smart00434 443 LN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
720-1180 |
7.89e-172 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 524.44 E-value: 7.89e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 720 NERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSaYHHGEQALMMTIVNLAQNFvgSNNINLLQPI 796
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 797 GQFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPN 875
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 876 YDAREIVNNVRRMLEGLDP-------HPMLPNYKNFkGTIQ---------ELGQNQYAVSGEIFVVD---RNTVEITELP 936
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEgragireayETGRGRYIIRGKYEIEDdegRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 937 VRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNsMVLFDHMG 1016
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1017 CLKKYeTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE--KIQGKITIENRSKKDLIQMLVQRGYESD 1094
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1095 pvkawkeaqekaaeeedsqnqhddsssdsgtpsgpDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKS-----P 1169
Cdd:cd00187 390 -----------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILaseerP 434
|
490
....*....|.
gi 34328148 1170 SDLWKEDLAAF 1180
Cdd:cd00187 435 KDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
722-1177 |
6.04e-151 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 468.18 E-value: 6.04e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFVGsnNINLLQPIGQ 798
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 799 FGTRLHGGKDAAsPRYIFTMLSSLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 877
Cdd:pfam00521 77 FGSRIDGDKDAA-MRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 878 AREIVNNVRRMLEGLDP-----HPMLPNYKNFKGTIQEL--------GQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY 944
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGgikeayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 945 KEQVLEPMLNGTDKtpaLISDYKEYhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETV 1024
Cdd:pfam00521 236 IEKIEELVKNGKIK---GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDG---GPKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1025 QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN------NQARFILEKIQGKItIENRSKKDLIQMLvqrgyesdpvka 1098
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1099 wkeaqekaaeeedSQNQhddsssdsgtpsgpdFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPS-----DLW 1173
Cdd:pfam00521 376 -------------SEIQ---------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnDLW 427
|
....
gi 34328148 1174 KEDL 1177
Cdd:pfam00521 428 IEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
86-231 |
3.89e-97 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 308.50 E-value: 3.89e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 86 FVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 165
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34328148 166 KVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHF-DGEDYTCITFQPD 231
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
274-426 |
1.18e-85 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 276.09 E-value: 1.18e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 274 NGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKK 353
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34328148 354 NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKF 426
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
50-635 |
2.03e-85 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 292.81 E-value: 2.03e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 50 EHILLRPDTYIGSV--EPLTQLMwvydedVGmNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISI 127
Cdd:PHA02569 11 EHILKRPGMYIGSVayEAHERFL------FG-KFTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 128 WNNGKGIP---VVEHKVEKVYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTwm 204
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCS-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 205 NNM----MKTSEAKIKHfdgedyTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNgFRSYV 280
Cdd:PHA02569 161 NGAenisWSTKPGKGKG------TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 281 DLYVKDKldetgvalkVIHElaNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVSv 360
Cdd:PHA02569 234 KQFGDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHKIEVT- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 361 KPfQVKN--HIWVFINCLIeNPTFDSQTKENMTLQPKSFGSKCQLSEKFF--KAASNCGIVESILNWVKFK-------AQ 429
Cdd:PHA02569 302 KA-RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakQILKTEAIIMPIIEAALARklaaekaAE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 430 TQLNKKCSSVKYSK-IKgipklddANDAGgkHSLECTLILTEGDSAKSLAVSglgVIGRDRYGVFPLRGKILNVREASHK 508
Cdd:PHA02569 380 TKAAKKAKKAKVAKhIK-------ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYA 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 509 QIMENAEINNIIKIVGLQYKksyDDAESLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLLKHGFLEEFITPIV 587
Cdd:PHA02569 448 DILKNKELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGRIRFVKTPVI 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 34328148 588 KASKNKQELSFYSIPEFDEWKkhiENQKAWKIKYYKGLGTSTAKEAKE 635
Cdd:PHA02569 521 IAQVGKETKWFYSLDEFEKAK---DSLKKWSIRYIKGLGSLRKSEYRR 565
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
464-584 |
6.68e-79 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 255.69 E-value: 6.68e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 464 CTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaESLKTLRYG 543
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDY--ESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 34328148 544 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFIT 584
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIpGFLVEFIT 120
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
706-1186 |
5.65e-76 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 259.99 E-value: 5.65e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 706 DFINKELILFSNSD-NERSIPSLVDGFKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSaYHHGEQALMMTIVNLA 781
Cdd:PHA02592 10 SIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQDAGALMA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 782 QNFvgSNNINLLQPIGQFGTRLhgGKDAASPRYIFTMLSSLARLLFPAVDdnlLKFLYDDNQRVEPEWYIPIIPMVLING 861
Cdd:PHA02592 89 NTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDED---LAPVHEDPEHIPPAFYLPIIPMVLLNG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 862 AEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWT 941
Cdd:PHA02592 162 VSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEIPVKYDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 942 QVYKEqVLEPMLNgtdktPALISDYKEYHTDtTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLfDHMGCLKKY 1021
Cdd:PHA02592 242 ETYVA-VLDPLEE-----KGKIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NENGKLKVY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1022 ETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLvqrgyesdpvkawke 1101
Cdd:PHA02592 314 ENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL--------------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1102 aqekaaeeedsqNQHDDsssdsgtpSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLaafv 1181
Cdd:PHA02592 379 ------------SDNKD--------FGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEYIKDL---- 434
|
....*
gi 34328148 1182 EELDK 1186
Cdd:PHA02592 435 EELKK 439
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
582-720 |
1.96e-73 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 240.11 E-value: 1.96e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 582 FITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLA 661
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 34328148 662 FSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYgTATKHLTYNDFINKELILFSNSDN 720
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
464-584 |
1.56e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 211.21 E-value: 1.56e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 464 CTLILTEGDSAKSLAVSGLGVIgrdRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLktlRYG 543
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFDLDKL---RYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 34328148 544 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFIT 584
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
49-676 |
5.42e-59 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 215.74 E-value: 5.42e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 49 LEHILLRPDTYIGSvepltqlmwvYDEDvgmncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 121
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 122 sNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSF 199
Cdd:PRK05559 69 -GSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKrdGKVYRQRF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 200 KqtwmNNMMKTSEAKI-KHFDGEDYTCITFQPDLS-----KFKMEKLDKdivalMTRR-AYdLagsCKGVKVMFNGKKLP 272
Cdd:PRK05559 148 E----GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKifdspKFSPERLKE-----RLRSkAF-L---LPGLTITLNDERER 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 273 V-----NGFRSYVDLYVKDK--LDETGVAlKVIHELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHVDYVVDQVVS 344
Cdd:PRK05559 215 QtfhyeNGLKDYLAELNEGKetLPEEFVG-SFEGEAEGEAVEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 345 KLIEVVKKKN--KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENM-TLQPKSFGSKcQLSEKF-FKAASNCGIVESI 420
Cdd:PRK05559 294 AVREFAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRFVSG-VVKDAFdLWLNQNPELAEKL 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 421 LNWVKFKAQTQLNKKCSSVKYSKIKGI---PKLddaNDAGGKHSLECTLILTEGDSAkslavSGLGVIGRDRY--GVFPL 495
Cdd:PRK05559 373 AEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILPL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 496 RGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK 575
Cdd:PRK05559 445 RGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFD----LEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVE 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 576 HGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKA-WKIKYYKGLGTSTAKEAKEYFADmERHRILFRYAgP 652
Cdd:PRK05559 521 AGHV--YIalPPLYRVDKGKKKIYALDEEEKEELLKKLGKKGGkPEIQRFKGLGEMNPDQLWETTMD-PETRRLVRVT-I 596
|
650 660
....*....|....*....|....*..
gi 34328148 653 EDDAAITLAFSK---KKIDDRKEWLTN 676
Cdd:PRK05559 597 DDAEETEKLVDMlmgKKAEPRREWIEE 623
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
49-673 |
1.97e-41 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 163.28 E-value: 1.97e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 49 LEHILLRPDTYIGSVepltqlmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 120
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 121 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 198
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 199 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMFNGKKLPV----- 273
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 274 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 335
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 336 --DYVVDQvvsKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 400
Cdd:COG0187 294 inDYARKN---GLL---KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 401 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 466
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 467 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTL 540
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFD----LEKL 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 541 RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK 618
Cdd:COG0187 489 RYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGKKKVE 566
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 34328148 619 IKYYKGLGTSTAKEAKEYFADMErHRILFRyAGPEDDAAITLAFSK---KKIDDRKEW 673
Cdd:COG0187 567 IQRYKGLGEMNPEQLWETTMDPE-TRTLLQ-VTIEDAAEADEIFSLlmgDKVEPRREF 622
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
49-626 |
9.73e-40 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 158.33 E-value: 9.73e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 49 LEHILLRPDTYIGSVEP--LTQLMW-VYDEDVgmncrevtfvpglykifDEILVNAADNkqrdknmtcIKVSIDPEsNII 125
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGErgLHHLVYeIVDNSI-----------------DEALAGYCDH---------IEVTINED-GSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 126 SIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSFKQ 201
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKrdGKIYYQEYER 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 202 TwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMF----NGKKLPV---- 273
Cdd:PRK05644 150 G-----VPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEEtfhy 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 274 -NGFRSYVDLYVKDKldetgvalKVIHE----LANERWDVCLtlsEKGFQQ--------ISFVNSIATTKGGRHV----- 335
Cdd:PRK05644 222 eGGIKEYVEYLNRNK--------EPLHEepiyFEGEKDGIEV---EVAMQYndgyseniLSFANNINTHEGGTHEegfkt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 336 -------DYVVDqvvSKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTK------ENM 390
Cdd:PRK05644 291 altrvinDYARK---NKLL---KEKDDnltgedvregltAVISVK---------------HPEPQFEGQTKtklgnsEVR 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 391 TLQPKSFGSKcqLSEkFFKaaSNCGIVESILNWVKFKAQT--------QLNKKCSSVKYSkikGIP-KLDD--ANDAGgk 459
Cdd:PRK05644 350 GIVDSVVSEA--LSE-FLE--ENPNVAKKIVEKAILAARAreaarkarELTRRKSALESS---SLPgKLADcsSKDPE-- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 460 hslECTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesL 537
Cdd:PRK05644 420 ---ESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDFD----I 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 538 KTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFIT--PIVKASKNKQELsFYSIPEFDEWKKHIENQ- 614
Cdd:PRK05644 488 SKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKIKKGGKEY-AYSDEELDEILAELKLKg 564
|
650
....*....|...
gi 34328148 615 -KAWKIKYYKGLG 626
Cdd:PRK05644 565 nPKYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
275-435 |
1.24e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 122.34 E-value: 1.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 275 GFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTL---SEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVK 351
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 352 KKN---KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFK-AASNCGIVESILNWVKFK 427
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEfLEENPEIAKKILEKALQA 160
|
....*...
gi 34328148 428 AQTQLNKK 435
Cdd:pfam00204 161 AKARLAAR 168
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1495-1597 |
2.01e-30 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 116.01 E-value: 2.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1495 KRAPKQKKIVETINSDSDSEFGIPKKTTTPKGkgRGAKKRKASGSENEGDYNPGRKPSKTASKKPKKTSFDQDSdvdiFP 1574
Cdd:pfam08070 1 KAAPKAAKAADKSSSDSDSDAGASKKPAPPKG--RKARKRKPSSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDD----FS 74
|
90 100
....*....|....*....|...
gi 34328148 1575 SDFTSEPPALPRTGRARKEVKYF 1597
Cdd:pfam08070 75 VDLDSEVAPRARPGRAKKPVKYL 97
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
464-579 |
1.27e-26 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 105.81 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 464 CTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLR 541
Cdd:cd03366 1 SELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|....*...
gi 34328148 542 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFL 579
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIENGHV 109
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
721-1082 |
7.82e-26 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 114.80 E-value: 7.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 721 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSAYH-HGEQALMMTIVNLAqnfvgsNNINLLQPIGQF 799
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 800 GTrLHGGKDAASPRYIFTMLSSLAR--LLFPAVDDNLLKFlydDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 877
Cdd:PRK09631 93 GN-LFTGDPASAARYIECRLTPLAKevLYNKEITEYEPSY---DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 878 AREIVNNVRRMLEGlDPHPMLPNYKNfkGTIQELgqNQYA-------VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLE 950
Cdd:PRK09631 169 FNEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYAdgngkvlVRAKIETKDEKTIVIREIPFGTTTESLIASIEK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 951 PMLNGTDKTPAlISDYkeyhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETVQDILKe 1030
Cdd:PRK09631 244 AARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK- 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 34328148 1031 ffdlrlsyygLRKEWLVGMLGAEstkLNNQARFILEKIQGK----ITIENRSKKDL 1082
Cdd:PRK09631 315 ----------FHAEHLQKVLKME---LELERAKLLEKIFAKtleqIFIEERIYKRI 357
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
49-596 |
1.69e-20 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 98.24 E-value: 1.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 49 LEHILLRPDTYIGsvepltqlmwvyDEDVGMncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 121
Cdd:PRK14939 18 LDAVRKRPGMYIG------------DTDDGT---------GLHHMVYEVVDNAIDealaghcDD--------ITVTIHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 122 sNIISIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKH 197
Cdd:PRK14939 69 -GSVSVSDNGRGIPTDIHPEEGV--SAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLelTIRRDGKIHEQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 198 SFKQTWMNNMMKTSEAKIKHfdGedyTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMF----NGKKLP- 272
Cdd:PRK14939 146 EFEHGVPVAPLKVVGETDKT--G---TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLkderDGKEEEf 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 273 -----VNGFRSYVDlyvKDKldeTGVALKVIHeLANERWDVCLTLS---EKGFQQ--ISFVNSIATTKGGRHV------- 335
Cdd:PRK14939 218 hyeggIKAFVEYLN---RNK---TPLHPNIFY-FSGEKDGIGVEVAlqwNDSYQEnvLCFTNNIPQRDGGTHLagfraal 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 336 -----DYVVDQVVSKlievvKKKNK-----------AGVSVKpfqvknhiwvfinclIENPTFDSQTKENMtlqpksfGS 399
Cdd:PRK14939 291 trtinNYIEKEGLAK-----KAKVSltgddaregltAVLSVK---------------VPDPKFSSQTKDKL-------VS 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 400 kcqlSE-KffkaasncGIVESILNwvkfkaqTQL------NKKCSSVKYSKI-------------------KGIpkLDDA 453
Cdd:PRK14939 344 ----SEvR--------PAVESLVN-------EKLsefleeNPNEAKIIVGKIidaarareaarkareltrrKGA--LDIA 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 454 N------DAGGKHSLECTLILTEGDSA----KSlavsglgviGRDRygVF----PLRGKILNVREASHKQIMENAEINNI 519
Cdd:PRK14939 403 GlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDR--KFqailPLKGKILNVEKARFDKMLSSQEIGTL 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 520 IKI----VGlqyKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNK 593
Cdd:PRK14939 472 ITAlgcgIG---RDEFN----PDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaqPPLYKVKKGK 542
|
...
gi 34328148 594 QEL 596
Cdd:PRK14939 543 QEQ 545
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
275-577 |
3.47e-18 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 91.10 E-value: 3.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 275 GFRSYVDLYVKDKL----DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTkGGRHVD---YVVDQVVSKLI 347
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDgfkYAITRCVNGNI 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 348 evvKKKNKAGVSVKPFQ---VKNHIWVFINCLIENPTFDSQTKEnmtlqpksfgskcQLSEKFFKAasncgIVESILNWv 424
Cdd:PTZ00109 455 ---KKNGYFKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE- 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 425 KFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAG-----------------GKHSlECT--------LILTEGDSAkslAV 479
Cdd:PTZ00109 513 QLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirqknnqyystilpGKLV-DCIsddierneLFIVEGESA---AG 588
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 480 SGLGVIGRDRYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGL----QYKKSYDDAESLK---------------- 538
Cdd:PTZ00109 589 NAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLsvnpVTWRQYDLSHGTKaskdesvqnnnstltk 668
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 34328148 539 --------TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHG 577
Cdd:PTZ00109 669 kknslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHG 715
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
722-1043 |
1.34e-17 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 89.29 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 797
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 798 QFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPN 875
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 876 YDAREIVNNVRRMLEGLD----------PHPMLP-----NYKnfKGTIQ--ELGQNQYAVSGEIFV----VDRNTVEITE 934
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiiLGR--SGIRSayETGRGSIVIRARAEIeedsKGREAIIVTE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 935 LPVrtwtQVYKEQVLEPMLN-GTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1013
Cdd:TIGR01063 256 IPY----QVNKARLIEKIAElVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVK 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 34328148 1014 HmgcLKKYETVQDILKEFFDLRL------SYYGLRK 1043
Cdd:TIGR01063 332 G---LPKVLNLKELLEAFVEHRKdvitrrTIFELRK 364
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
721-873 |
4.72e-16 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 83.02 E-value: 4.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 721 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSAYHHGEQALMMTIVNLAqnfvgsNNINLLQPIGQFG 800
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 34328148 801 TRLHGGKDAASpRYIFTMLSSLAR-LLFpavDDNLLKF--LYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKL 873
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKeVLF---NTDLMTFhdSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKI 164
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
90-267 |
4.67e-13 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 69.10 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 90 LYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDD 162
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLHED-NSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 163 DEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKHSFKqtwmnNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKL 240
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLevEVKRDGKIYRQEFS-----RGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEF 146
|
170 180
....*....|....*....|....*..
gi 34328148 241 DKDIVAlmtRRAYDLAGSCKGVKVMFN 267
Cdd:cd16928 147 DFDTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
721-896 |
6.76e-11 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 67.05 E-value: 6.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 721 ERSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 796
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 797 GQFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 874
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180
....*....|....*....|..
gi 34328148 875 NYDAREIVNNVRRMLEgldpHP 896
Cdd:PRK05561 186 PHNLREVIDAAIHLID----NP 203
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
721-958 |
7.56e-11 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 67.34 E-value: 7.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 721 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMsAYH-HGEQALMMTIVNLAQNFVgsnninLLQPIGQF 799
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHT--M-QYHpHGDASIGDALVQLGQKDL------LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 800 GTRLhGGKDAASPRYIFTMLSSLA-RLLF-PAVDDNLLKFlydDNQRVEPEwYIPI-IPMVLINGAEGIGTGWACKLPNY 876
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPH 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 877 DAREIVNNVRRMLEGlDPHPMLPNYKNfKGTIQELGQNQYAVSGEIFV------VDRNTVEITELPVRTWTqvykEQVLE 950
Cdd:PRK12758 187 NFNELIDASIAYLKG-KEFKLYPDFPT-GGIIDVSNYNDGERGGRVRVrakiekLDKKTLVITEIPYGTTT----SSLID 260
|
....*...
gi 34328148 951 PMLNGTDK 958
Cdd:PRK12758 261 SILKANDK 268
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
276-388 |
1.74e-10 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 59.58 E-value: 1.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 276 FRSYVDLYVKDKldetgVALKVIH---ELANERWDVCLTLSE----KGFQQISFVNSIATTKGGRHVDYVVDQVVSKLie 348
Cdd:cd00329 1 LKDRLAEILGDK-----VADKLIYvegESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 34328148 349 vvkkknkagvsvKPFQVKNHIWVFINCLIEN--PTFD-SQTKE 388
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
722-890 |
1.16e-08 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 60.06 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 797
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 798 QFGTRlhGGKDAASPRYIFTMLSSLARLLFP-----AVD--DNllkflYDDNQRvEPEwYIP-IIPMVLINGAEGIGTGW 869
Cdd:COG0188 110 NFGSI--DGDPAAAMRYTEARLAKIAEELLAdidkdTVDfvPN-----YDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVGM 180
|
170 180
....*....|....*....|.
gi 34328148 870 ACKLPNYDAREIVNNVRRMLE 890
Cdd:COG0188 181 ATNIPPHNLGEVIDACIALID 201
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
721-885 |
1.97e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 59.35 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 721 ERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 796
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 797 GQFGTRlhGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 874
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170
....*....|.
gi 34328148 875 NYDAREIVNNV 885
Cdd:PRK13979 189 PHNLKEVIDGT 199
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
722-890 |
2.79e-08 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 58.89 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 722 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgsnniNLLQPI- 796
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 797 -GQ--FGTRlhGGKDAASPRYIFTMLSSLARLLFP-----AVD--DNllkflYDDNQRvEPEwYIPI-IPMVLINGAEGI 865
Cdd:PRK05560 101 dGQgnFGSI--DGDPAAAMRYTEARMSKIAHELLAdidkeTVDfvPN-----YDGSEQ-EPT-VLPArFPNLLVNGSSGI 171
|
170 180
....*....|....*....|....*
gi 34328148 866 GTGWACKLPNYDAREIVNNVRRMLE 890
Cdd:PRK05560 172 AVGMATNIPPHNLGEVIDACLALID 196
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
89-186 |
1.47e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 48.52 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 89 GLYKIFDEILVNAADNKQrdkNMTCIKVSIDPESNI-ISIWNNGKGIPVVEHKvekvyvpaLIFGQLLTSSnydddekKV 167
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAA---KAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|....*....
gi 34328148 168 TGGRNGYGAKLCNIFSTKF 186
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELL 85
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
465-565 |
2.06e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.35 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 465 TLILTEGDS-AKSLAvsglGVIGRDRYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKsyddaeslktlryg 543
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 34328148 544 kIMIMTDQDQDGSHIKGLLINF 565
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
89-189 |
3.74e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 47.26 E-value: 3.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 89 GLYKIFDEILVNAADNKQRDKNMTcIKVSIDPESNIISIWNNGKGIPvvEHKVEKVYVPaliFGQLltssnyddDEKKVT 168
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRIT-VTLERDGDHVEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRSRK 70
|
90 100
....*....|....*....|.
gi 34328148 169 GGRNGYGAKLCNIFSTKFTVE 189
Cdd:smart00387 71 IGGTGLGLSIVKKLVELHGGE 91
|
|
| PHA03151 |
PHA03151 |
hypothetical protein; Provisional |
1344-1582 |
1.95e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 177546 [Multi-domain] Cd Length: 259 Bit Score: 45.15 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1344 RDSLLRRAAAERPKYT--FDFSEeedddaaaadDSNDLEELKVKASPITNDGEDEFVPSDGLDKdeyAFSSGKSKATPEK 1421
Cdd:PHA03151 18 RRKLAPLPGAPREKLTnvFKFPT----------DEDDSTPSENTKAESSSIDEDGLLTSSGSDS---VFNSTDYESTPEP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1422 SSN----DKKSQDFGNLFSFPSYSQkSEDDSAKFDSNEEDTASVFAPSFGLKQTDKLPSKTVAAKKGKPPSDTAPKAKRA 1497
Cdd:PHA03151 85 SKTpgfsDSNVSDSNNDKDFDFKPQ-DEDTSSDDSSAPDFITSLVSSDCEARGLSSSEEDGEPYSKQKMSQPLTIDAKTE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 1498 PKQKKIVETINSDS-DSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPgRKPSKTasKKPKKTSFDQDSDVDIFPSD 1576
Cdd:PHA03151 164 EITSEEDCCVQEDSsDSEEDVVEAFIRQRAQMAGKKKKGKRSISTSDDEPP-RKSRRK--RHSHRISSSTDSDDEEPRHK 240
|
....*.
gi 34328148 1577 FTSEPP 1582
Cdd:PHA03151 241 MTGTPP 246
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
464-566 |
4.05e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.87 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328148 464 CTLILTEGDS-AKSLAVsglgvIGRDRYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykksyddaeslktlRY 542
Cdd:cd00188 1 KKLIIVEGPSdALALAQ-----AGGYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100
....*....|....*....|....
gi 34328148 543 GKIMIMTDQDQDGSHIKGLLINFI 566
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELL 71
|
|
| |
