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Conserved domains on  [gi|112420990|ref|NP_032917|]
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pinin [Mus musculus]

Protein Classification

Pinin_SDK_N and Pinin_SDK_memA domain-containing protein( domain architecture ID 11152401)

Pinin_SDK_N and Pinin_SDK_memA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pinin_SDK_N pfam04697
pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to ...
 1-130 4.78e-43

pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to localize at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing. pinin has also been implicated as a tumour suppressor. The conserved region is found at the N-terminus of the member proteins.


:

Pssm-ID: 461397  Cd Length: 132  Bit Score: 151.92  E-value: 4.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990    1 MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFS-DSGGGPPAKQRDL 79
Cdd:pfam04697   1 MAVAVRALQEQIEKAKENLKGVDENIKKLTGRDPNERRPGAARRLELQMSGPGRGRGRGQVLLRRGwSDSGGPPVKRRDL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 112420990   80 EGAVSRLGGERRTRRESRQESDPEDDD-VKKPALQSSVVATSKERTRRDLIQ 130
Cdd:pfam04697  81 GGAVRRLAGNRRARRDSRRDDSEEEDDlPKKPALQSSVVATSKERTRKDLID 132
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 136-261 9.18e-24

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


:

Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 97.36  E-value: 9.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990  136 EKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEER----KQVENERRELFEERRAKQTELRLLEQ 211
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQKEKEERRAEIEKRLEEKAKQEKeeleERKREEREELFEERRAEQIELRALEE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 112420990  212 KVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQR 261
Cdd:pfam04696  81 KLELKELMETWHENLKALANFLKTKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Name Accession Description Interval E-value
Pinin_SDK_N pfam04697
pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to ...
 1-130 4.78e-43

pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to localize at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing. pinin has also been implicated as a tumour suppressor. The conserved region is found at the N-terminus of the member proteins.


Pssm-ID: 461397  Cd Length: 132  Bit Score: 151.92  E-value: 4.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990    1 MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFS-DSGGGPPAKQRDL 79
Cdd:pfam04697   1 MAVAVRALQEQIEKAKENLKGVDENIKKLTGRDPNERRPGAARRLELQMSGPGRGRGRGQVLLRRGwSDSGGPPVKRRDL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 112420990   80 EGAVSRLGGERRTRRESRQESDPEDDD-VKKPALQSSVVATSKERTRRDLIQ 130
Cdd:pfam04697  81 GGAVRRLAGNRRARRDSRRDDSEEEDDlPKKPALQSSVVATSKERTRKDLID 132
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 136-261 9.18e-24

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 97.36  E-value: 9.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990  136 EKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEER----KQVENERRELFEERRAKQTELRLLEQ 211
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQKEKEERRAEIEKRLEEKAKQEKeeleERKREEREELFEERRAEQIELRALEE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 112420990  212 KVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQR 261
Cdd:pfam04696  81 KLELKELMETWHENLKALANFLKTKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Name Accession Description Interval E-value
Pinin_SDK_N pfam04697
pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to ...
 1-130 4.78e-43

pinin/SDK conserved region; SDK2/3 is localized in nuclear speckles where as pinin is known to localize at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing. pinin has also been implicated as a tumour suppressor. The conserved region is found at the N-terminus of the member proteins.


Pssm-ID: 461397  Cd Length: 132  Bit Score: 151.92  E-value: 4.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990    1 MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFS-DSGGGPPAKQRDL 79
Cdd:pfam04697   1 MAVAVRALQEQIEKAKENLKGVDENIKKLTGRDPNERRPGAARRLELQMSGPGRGRGRGQVLLRRGwSDSGGPPVKRRDL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 112420990   80 EGAVSRLGGERRTRRESRQESDPEDDD-VKKPALQSSVVATSKERTRRDLIQ 130
Cdd:pfam04697  81 GGAVRRLAGNRRARRDSRRDDSEEEDDlPKKPALQSSVVATSKERTRKDLID 132
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 136-261 9.18e-24

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 97.36  E-value: 9.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420990  136 EKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEER----KQVENERRELFEERRAKQTELRLLEQ 211
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQKEKEERRAEIEKRLEEKAKQEKeeleERKREEREELFEERRAEQIELRALEE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 112420990  212 KVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQR 261
Cdd:pfam04696  81 KLELKELMETWHENLKALANFLKTKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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